Mast Cell Activation Syndrome

[Muon]

Mast cells and dopamine

[Hopeoneday]

If histamine( sneezing...), prostagladins(pain...) , leukotrines
(short bresth, astma like symp...)... are involved in pois and
 as far  i can see it is atleast in a half of poisers... Then there must
be a way to test this from blod or urine...

[Muon]

How irritation in colon affects other parts in body:
Sensitization of pelvic nerve afferents and mast cell infiltration in the urinary bladder following chronic colonic irritation is mediated by neuropeptides

[Muon]

Intensified Hyposensitization Is an Effective Treatment of Postorgasmic Illness Syndrome (POIS)

"The patient had food allergy to wheat, milk, almonds, in an IgE-independent mechanism, with a mild course. Total serum IgE was 66 IU/ml (normal). Celiac disease was excluded (negative Endomysial antibodies and Tissue Transglutaminase antybodies). Patient reported 3 episodes of anaphylactic shock after wasp-sting."

[Progecitor]

The understanding of visceral pain pathways is important in recognizing the serotonin relation and influence of it in pain modulation in IBS. Pain regulation pathways in visceral pain include vagal and spinal afferents that project into the CNS, both facilitating and/or inhibiting the sensory transmission to the spinal cord. Specifically, in visceral pain, there is an antinociceptive action of estrogen on the serotoninergic system due to afferent-driven vagal inhibition of the pain. On the other hand, the pro-nociceptive action occurs because of the enhancement of serotonin secretion in the intestinal mucosal mast cells (IMMCs); cells in which estrogen receptors have been found and that have been associated with its degranulation, increasing the visceral motor response and spinal or supraspinal processing of visceral nociception, mainly in IBS. Furthermore, as described previously, the interference of serotonin in pain modulation depends on the receptors, route of administration, type of pain, and influence of other substances on the release of this neurotransmitter.
https://scholar.google.com/scholar?hl=hu&as_sdt=0%2C5&q=An+Association+of+Serotonin+with+Pain+Disorders+and+Its+Modulation+by+Estrogens&btnG=

[Muon]

https://www.thenakedscientists.com/forum/index.php?topic=6576.msg330244#msg330244

"For myself I had lots of UTIs and it stopped when I realized that a diet rich in oxalic acid was causing it. I stopped eating soy products and high oxalate foods like rhubarb, parsley, watercress, beet leaves , chard etc. Very occasionally I have the symptoms again and every time I trace it back to a oxalic acid rich food I inadvertently ate. The urethra inflammation really did aggravate the POIS. I am very happy this is basically gone. If you are interested in that topic I can give you more info. I had an urethroscopy back then and my urologist just could not find anything in my urine neither.  He could not help. I am now 99% UTI free.

Pablo"

https://mastcell360.com/low-histamine-foods-list/

"There are other types of foods that people with MCAS or Histamine Intolerance may react to. These include lectins and oxalates"

UTI
https://youtu.be/lrKqlv6VK_w?t=3309

[Muon]

Need to define a subgroup of patients with idiopathic mast cell activation syndrome (2022)

Reply to "Need to define a subgroup of patients with idiopathic mast cell activation syndrome"

[Muon]

NAD+-boosting molecules suppress mast cell degranulation and anaphylactic responses in mice
NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR)

[Muon]

Mast cell-neuron axis in allergy

[Muon]

We focused on my food allergies for the most part, but I'm going to consult with a urologist to see about attempting Dr. Afrin's (mast cell pseudocelebrity) urethral Cromolyn injection protocol. That's intended to stabilize the mast cells lining the urinary tract, so we'll see if it works for seminal allergies too.

https://www.reddit.com/r/POIS/comments/x7qird/anyone_seen_immunologist_yet/

[Muon]

https://youtu.be/rW2K_WPUQTA?t=1262

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465360/table/jpm-11-00860-t003/?report=objectonly

Diagnosis Atopic Diseases

Blood

• IgE, IgG1, IgG4
• Immune IgE (RAST for alpha-gal, casein, gluten, dust mites, fungi, grass, pollen)
• Anti-IgE receptor antibody (basophil activation)
• CCL2, CXCL8 (IL-8)
• Chromogranin A
• Eosinophilic cationic protein (ECP)
  
• Food Intolerance Panel (IgG4)
• Heparin
• IL-4, IL-6, IL-31, IL-33
• PGD2
• Tryptase

Urine 24 hours (must be kept and sent cold)

• Methylhistamine or MIA
• PGD2
• 23BPG=2,3-Dinor-11beta-PGF2alpha

So what will the result show if you run down this panel on a group of POIS patients?

Mast cells and cytokines crash course

All inflammation is not the same

[Muon]

I wonder if Chymase plays a role in POIS. It's a major enzyme in mast cells.

[Muon]

https://www.reddit.com/r/POIS/comments/xckj3r/random_pois_triggered/

"Has anyone else had pois symptoms randomly triggered? I haven't ejaculated in months and I haven't had a wet dream in over 2 weeks but I'm feeling a bit how I feel when I'm having pois symptoms can anyone explain!?"

"I ate some home made Chinese food and it used Worcester sauce I believe that's what messed me up"

[demografx]

Posted in NORD’s October newsletter. I’m re-posting this for those of you who see a possible relationship between POIS and mast cell activation.


MAST CELL DISEASE SOCIETY

The Mast Cell Disease Society’s Patient & Provider Symposium on October 15-16 will bring together an international group of patients, well-renowned physicians, and investigators to discuss the opportunities, challenges, and progress made in research and serving patients affected by mast cell disease. Interactive panel discussions and wellness and support sessions for patients and caregivers will also take place.

To learn more:
https://tinyurl.com/2j7xe6rc

[Progecitor]

https://www.reddit.com/r/POIS/comments/xckj3r/random_pois_triggered/

"Has anyone else had pois symptoms randomly triggered? I haven't ejaculated in months and I haven't had a wet dream in over 2 weeks but I'm feeling a bit how I feel when I'm having pois symptoms can anyone explain!?"

"I ate some home made Chinese food and it used Worcester sauce I believe that's what messed me up"

Worcester sauce has some base ingredients like garlic and tamarind which are considered aphrodisiac. Some optional ingredients could be coriander and clove, which are also aphrodisiac, but there could be more based on the specific recipe.
https://poiscenter.com/forums/index.php?topic=4281.msg45818#msg45818

[Muon]

Multistep IgE Mast Cell Desensitization Is a Dose- and Time-Dependent Process Partially Regulated by SHIP-1

Kaempferol suppresses the activation of mast cells by modulating the expression of Fc?RI and SHIP1

[Progecitor]

Phosphatidylserine (PS) externalized by activated cells or apoptotic cells or extracellular vesicles is a potential source of substrate for the production of unsaturated lysoPS species by PLA1A. Maturation and functions of many immune cells, such as T cells, dendritic cells, macrophages, and mast cells, can be regulated by PLA1A and lysoPS.
The externalization of PS has been reported in viable monocytes, activated mast cells, CD8+ T cells, regulatory B cells, cancer cells and cancer cell-derived extracellular vesicles (EVs).
Compared with secreted phospholipase A2 group IIa (sPLA2-IIa), PLA1A produces lysoPS more efficiently and is more potent in inducing histamine release from rat peritoneal mast cells and stimulating alkaline phosphatase-tagged TGFalpha release. 2-acyl-lysoPS is a lipid mediator for mast cells, T cells, and neural cells.
Kawamoto et al. found that nerve growth factor (NGF) could stimulate the release of histamine from rat peritoneal mast cells incubated with activated rat platelets. NGF antibodies or inhibition of NGF receptor tyrosine kinase activity can completely block histamine release by rat peritoneal mast cells. Furthermore, histamine release by rat peritoneal mast cells incubated with PS+ erythrocytes and NGF required the presence of PLA1A, thereby suggesting a role for PLA1A-derived lysoPS in mast cell activation. GPR34 is a highly expressed functional lysoPS receptor in rat mast cells. PLA1A-mediated production of 2-acyl-lysoPS may also contribute to histamine release by rat peritoneal mast cells in response to cross-linking of the high-affinity IgE receptor, known as Fc(epsilon)RI. Histamine release was blocked by heparin, suggesting that PLA1A activity required binding to cellular heparan sulfate proteoglycans.
https://sci-hub.st/https://www.sciencedirect.com/science/article/abs/pii/S016378272100028X

Fisetin (3,30,40,7-tetrahydroxyflavone), another flavonoid, is most highly concentrated in strawberries and is also found in apples, persimmons, and onions. Like luteolin and resveratrol, fisetin has purported anti-inflammatory, antioxidant, and neuroprotective properties. Fisetin exerts anti-inflammatory effects on mast cells and suppresses activation of microglia when stimulated by LPS, blocking LPS-induced production of nitric oxide, TNF-alpha and prostaglandin E2.
https://www.mdpi.com/1660-4601/18/5/2483/htm