Mast Cell Activation Syndrome

[Ani1946]

excerpt from a research paper - "Incubation of mast cells with steroids did not alter the release of histamine, prostaglandin D2, or leukotriene C4; however, they were able to inhibit the production of some proinflammatory cytokines like IL-1, IL-6, and TNF-α"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136699/

[Ani1946]

yeah most important is flush, without flush no benefit for most of niacin users

[demografx]

Niacin flush also releases serotonin from blood platelets. I can imagine someone who is low on serotonin might benefit from niacin flushes.

Interesting…vs. depression!

[Ani1946]

I couldn't find pseudoephederine, so decided to try a beta 2 agonist before orgasm. Beta 2 agonists are potent mast cell stabilizer. I took 10mg terbutaline oral 1 hour before orgasm. Unfortunately it didn't work and now I'm exhausted like never before with exteme anxiety brainfog and doom like feeling and also palpitations and joint pain.

I think pseudoephederine worked for some not because it works on mast cell but because it affects central nervous system. Terbutaline can't cross blood brain barrier so may be that's why it didn't work for me.

[Muon]

Beneficial effects of the first case of washed microbiota transplantation for postorgasmic illness syndrome: a case report

B-type ultrasonography and brain magnetic resonance imaging showed the left varicocele and a microadenoma in the right pterygoid of the pituitary gland

MC Growth factors?

[Muon]

Dr. Theoharides is among the world's top mast cell researchers and speaks with Dr. Dempsey about his recent article reviewing how mast cells may drive dysautonomia and vice verse.

https://the-potscast.castos.com/episodes/e203

[Muon]

Dr. Theoharides is among the world's top mast cell researchers and speaks with Dr. Dempsey about his recent article reviewing how mast cells may drive dysautonomia and vice verse.

https://the-potscast.castos.com/episodes/e203

Apparently there are mast cells in cardiac pacemakers.

[Muon]

Found a website where you can order Kaempferol which is hard to come by.
https://exendo-epigenomics.com/snel-bestellen/
Or
https://www.gezondheidaanhuis.nl/nl/product/60649/Kaempferol-PhytoQ-Exendo-Epigenomics-30-capsules
Free shipping for 2 bottles within NL/BE/DE

[Muon]

Vitamin K3

https://www.sciencedirect.com/science/article/abs/pii/S1567576924010117

The anti-pseudo-allergic activity of VK3 was confirmed in vitro and in vivo. VK3 can inhibit SP-induced mast cell activation by directly targeting GAB1. This study provides new insights on the activity of VK3 and the mechanism of pseudoallergic reaction.

[Muon]

Researchers have discovered a hidden talent of mast cells: they can capture and use another type of immune cell called neutrophils. This surprising discovery sheds new light on how our immune system works, particularly during allergic reactions.
https://x.com/vipintukur/status/1819592020547326450

Neutrophil trapping and nexocytosis, mast cell-mediated processes for inflammatory signal relay