Mast Cell Activation Syndrome

[Ani1946]

excerpt from a research paper - "Incubation of mast cells with steroids did not alter the release of histamine, prostaglandin D2, or leukotriene C4; however, they were able to inhibit the production of some proinflammatory cytokines like IL-1, IL-6, and TNF-α"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136699/

[Ani1946]

yeah most important is flush, without flush no benefit for most of niacin users

[demografx]

Niacin flush also releases serotonin from blood platelets. I can imagine someone who is low on serotonin might benefit from niacin flushes.

Interesting…vs. depression!

[Ani1946]

I couldn't find pseudoephederine, so decided to try a beta 2 agonist before orgasm. Beta 2 agonists are potent mast cell stabilizer. I took 10mg terbutaline oral 1 hour before orgasm. Unfortunately it didn't work and now I'm exhausted like never before with exteme anxiety brainfog and doom like feeling and also palpitations and joint pain.

I think pseudoephederine worked for some not because it works on mast cell but because it affects central nervous system. Terbutaline can't cross blood brain barrier so may be that's why it didn't work for me.

[Muon]

Beneficial effects of the first case of washed microbiota transplantation for postorgasmic illness syndrome: a case report

B-type ultrasonography and brain magnetic resonance imaging showed the left varicocele and a microadenoma in the right pterygoid of the pituitary gland

MC Growth factors?

[Muon]

Dr. Theoharides is among the world's top mast cell researchers and speaks with Dr. Dempsey about his recent article reviewing how mast cells may drive dysautonomia and vice verse.

https://the-potscast.castos.com/episodes/e203

[Muon]

Dr. Theoharides is among the world's top mast cell researchers and speaks with Dr. Dempsey about his recent article reviewing how mast cells may drive dysautonomia and vice verse.

https://the-potscast.castos.com/episodes/e203

Apparently there are mast cells in cardiac pacemakers.

[Muon]

Found a website where you can order Kaempferol which is hard to come by.
https://exendo-epigenomics.com/snel-bestellen/
Or
https://www.gezondheidaanhuis.nl/nl/product/60649/Kaempferol-PhytoQ-Exendo-Epigenomics-30-capsules
Free shipping for 2 bottles within NL/BE/DE

[Muon]

Vitamin K3

https://www.sciencedirect.com/science/article/abs/pii/S1567576924010117

The anti-pseudo-allergic activity of VK3 was confirmed in vitro and in vivo. VK3 can inhibit SP-induced mast cell activation by directly targeting GAB1. This study provides new insights on the activity of VK3 and the mechanism of pseudoallergic reaction.

[Muon]

Researchers have discovered a hidden talent of mast cells: they can capture and use another type of immune cell called neutrophils. This surprising discovery sheds new light on how our immune system works, particularly during allergic reactions.
https://x.com/vipintukur/status/1819592020547326450

Neutrophil trapping and nexocytosis, mast cell-mediated processes for inflammatory signal relay

[Muon]

https://www.reddit.com/r/MCAS/comments/1fz1v9a/mcas_and_spine_stuff/

"I posted a while ago about how my foot drop and incontinence were worse in an MCAS flare. Turns out this is a known issue. Wanted to share what I learned after spending many thousands of dollars traveling to see specialist MCAS-aware neurosurgeons.

mast cell activation can change how stretchy the filium terminale is (the tissue that connects the spinal cord to the bottom of the spinal canal). So a flare can make it more rigid, which causes occult tethered cord (weakness, gait changes, incontinence, back pain, etc). These doctors were totally unsurprised when I said my walking was better on MCAS meds.

there's some evidence that mast cells can mess with discs, eg causing inflammation in spinal discs. In a repeat MRI, we saw a reduction in my bulging discs after I went on an OTC MCAS drug protocol.

per these doctors, MCAS seems to exacerbate neck or spinal instability. So one of the recommended treatments for my AAI (c2-c3 instability) is to treat the MCAS, and I should be cautious with my neck during flares.

Hope this helps some of you! Totally wild how far-reaching and damaging MCAS can be on our bodies."

[Muon]

https://poiscenter.com/forums/index.php?topic=3345.msg49450#msg49450

There is no proven relationship between POIS and MCAS, only hints regarding medication and trigger like nonspecific chronic multisystem inflammatory symptoms. The AI is wrong about the spectrum of POIS symptoms, it is much broader than given by this AI.

[Muon]

https://www.perplexity.ai/search/what-are-the-top-5-mast-cell-m-1uoEyUTZRGCHXeGc1.32Mg

Based on the search results, here are the top 5 mast cell mediators in terms of quantities a mast cell can produce:

1. Tryptase: Tryptases are the most abundant proteases in human mast cells, comprising up to 20% of the total cell protein[3]. Some human mast cells can contain up to 35 micrograms of tryptase per 10^6 cells[3].

2. Histamine: While exact quantities are not specified, histamine is one of the key preformed mediators stored in mast cell granules and rapidly released upon activation[1][3].

3. Carboxypeptidase A (CPA3): Human foreskin mast cells are estimated to contain about 16 micrograms of CPA per 10^6 cells[3].

4. Chymase: Found in the MCTC and rare MCC subpopulations of human mast cells[3]. While exact quantities are not provided, it is mentioned as one of the important mast cell proteases.

5. Heparin: Although specific quantities are not given, heparin is listed as one of the preformed mediators stored in large amounts in mast cell granules[5].

It's worth noting that mast cells contain 50-200 large granules storing these and other inflammatory mediators[5]. The exact quantities can vary depending on the mast cell subtype, location, and activation state. Additionally, mast cells can produce and release hundreds of different mediators (390 identified in humans)[2][4], but the search results don't provide specific quantities for most of them.

Citations:
[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231949/
[2] https://link.springer.com/article/10.1007/s00210-023-02545-y
[3] https://medilib.ir/uptodate/show/3972
[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567897/
[5] https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2015.00620/full
[6] https://www.sciencedirect.com/science/article/pii/S221321982400271X
[7] https://www.mdpi.com/1422-0067/23/22/14004
[8] https://onlinelibrary.wiley.com/doi/10.1111/imj.80_16230

Paper 4, table 1 is quite handy: Check the supplementary information ESM 1 for all the mediators, this is some sick stuff. This knowledge is far above the level at which clinical doctors operate.

[Muon]

Testosterone search on MCAS reddit: https://www.reddit.com/r/MCAS/search/?q=testosterone

[demografx]

…There is no proven relationship between POIS and MCAS…

Muon, then why are we spending so much time on it at a
*P  O  I  S*   forum?? (83 POIScenter posts on MCAS)

[Muon]

Yes way too much time. I would have done it differently if I could turn back time. Hints and arguments have been given why it could be related to POIS, not going to rehash that. You could ask that same question for the remaining topics as well, nothing has been proven yet.

[berlin1984]

....and under the assumption that there is different POISes, maybe one of them is MCAS and the others are not...

[Hopeoneday]

I think that we even now hawe evidence that pois is immune driven condition.
Maybe all of them is MCAS, but different underlying condition on
each poiser for MCAS, and main trigger for all is arosaul, OE?
And it is posible that not yust MC degranulating mediators, but alsou
other immune cells.

[Hopeoneday]

Or one part of poisers hawe MCAS but other part hawe
SACM (self activation cells must ).

[berlin1984]

MCAS = Marvelous Coitus Ache Syndrome? :-)