Author Topic: Mast Cell Activation Syndrome  (Read 30584 times)

Hopeoneday

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Re: Mast Cell Activation Syndrome
« Reply #315 on: December 07, 2020, 02:51:26 PM »
https://www.researchgate.net/publication/233983858

Inhibitory effects of benzodiazepines on the adenosine A2B receptor mediated secretion of interleukin-8 in human mast cells

My only cure in thouse times :)  small those to survive anaplaxes.
« Last Edit: December 07, 2020, 02:53:08 PM by Hopeoneday »
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Muon

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Re: Mast Cell Activation Syndrome
« Reply #316 on: December 07, 2020, 03:04:44 PM »
https://www.researchgate.net/publication/233983858

Inhibitory effects of benzodiazepines on the adenosine A2B receptor mediated secretion of interleukin-8 in human mast cells

My only cure in thouse times :)  small those to survive anaplaxes.

Interesting, benzo's worked for my brother's POIS, he had to quit because they were too addictive. Need to ask him again how good they worked compared to other meds he tried. His IL-8 is slightly elevated. I could put benzo's on my list just to see if I get a response. The next one on my list is Neuroprotek (can reduce IL-8 and IFN-g in whole blood). That begs the question what the source of IL-8 is.  Endothelial cells are able to release IL-8 and 11-b-PG-F2a as well but the symptomatology fits mast cells much better. MCs also express peripheral benzodiazepine receptors.

Edit: He did not only stop due to the addictive effect but he built up a tolerance to it as well.
« Last Edit: December 07, 2020, 04:22:45 PM by Muon »

Hopeoneday

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Re: Mast Cell Activation Syndrome
« Reply #317 on: December 07, 2020, 03:10:47 PM »
Yes, i dont want to take them because of adiction, only when needed.
Nothing else realy work from me but coffe in pois , for pain and cfs,
but coffe hawe side effects if not dozing smart.
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Muon

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Re: Mast Cell Activation Syndrome
« Reply #318 on: December 07, 2020, 03:22:45 PM »
I suspect you and I got the same root cause of POIS. Note: Mast cell mediators don't necessarily have to be dumped into circulation.

"The rank order of potency was diazepam > 4'-chlorodiazepam > flunitrazepam > clonazepam with clonazepam causing only a minor effect at a high concentration." Ref
« Last Edit: December 07, 2020, 08:51:31 PM by Muon »

Muon

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Re: Mast Cell Activation Syndrome
« Reply #319 on: December 08, 2020, 08:52:13 AM »
What benzodiazepines have you tried HOD?

Muon

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Re: Mast Cell Activation Syndrome
« Reply #320 on: December 08, 2020, 10:04:31 AM »
Mast cells and the CNS:

An Overview of the Physiological and Pathological Role of Mast Cells in the Central Nervous System

"Clemastine, for instance, is associated with reduced microgliosis, modulation of microglia-related inflammatory genes and enhanced motor neuron survival."

Clemastine is the only antihistamine that had a minor effect on my POIS. Microglia involvement? Microglia as IL-8 source?

Mast cells and liver disease:

The emerging role of mast cells in liver disease

Random stuff:

Cromolyn Inhibits the Secretion of Inammatory Cytokines by Human Microglia (HMC3)

Propolis suppresses cytokine production in activated basophils and basophil-mediated skin and intestinal allergic inflammation in mice

Propolis (bee glue)
« Last Edit: December 08, 2020, 12:41:43 PM by Muon »

Hopeoneday

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Re: Mast Cell Activation Syndrome
« Reply #321 on: December 08, 2020, 03:45:52 PM »
What benzodiazepines have you tried HOD?
Apaurine 2mg
Xanax 0.25mg

Tested bee propolis in a lot of version, even cro patent native propolis,
god for imunyty colds etc, nothing for pois.
I will see active ingre.. in clemastin an test for pois in future...
Liver is crucial for "ewrything in body" main detox factory...
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Muon

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Re: Mast Cell Activation Syndrome
« Reply #322 on: December 11, 2020, 12:11:36 PM »
So which of those two are you using for POIS? Which one is more effective? What is the timing. I can add that info to the treatment thread.

"MCAS has been estimated to affect as many as 17% of the population with a severity ranging from mild to life-threatening." Ref
« Last Edit: December 11, 2020, 03:13:24 PM by Muon »

Muon

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Re: Mast Cell Activation Syndrome
« Reply #323 on: December 15, 2020, 09:55:00 AM »
Yes, I share the non-O POIS symptoms from all of the items you've mentioned as well as sometimes defecating also triggering some symptoms. have skin sensitivity as well, head, scalp, legs. Almost as if the hair follicles get inflamed.

Friction can trigger mast cells. Mast cell numbers per unit surface area are roughly twice as high in the GI tract compared to the skin.

Note: Clicking just above the quote can launch you to the original post.
« Last Edit: December 15, 2020, 08:50:39 PM by demografx »

Muon

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Re: Mast Cell Activation Syndrome
« Reply #324 on: December 15, 2020, 10:26:50 AM »
I think we had 1 or 2 POISers with aspirin intolerance:
Cellular interactions in aspirin-exacerbated respiratory disease

Willem did sublingual hyposensitization therapy with autologous semen, similar mechanism?:
Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy.

Hopeoneday

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Re: Mast Cell Activation Syndrome
« Reply #325 on: December 17, 2020, 06:31:58 PM »
www.frontiersin.org/articles/10.3389/fimmu.2012.00147/full
Mast cells are important modifiers of autoimmune disease: with so much evidence, why is there still controversy?
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Hopeoneday

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Re: Mast Cell Activation Syndrome
« Reply #326 on: December 17, 2020, 06:36:37 PM »
https://www.jimmunol.org/content/163/2/947
Neutrophil Defensins Induce Histamine Secretion from Mast Cells: Mechanisms of Action
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EnriqueM075

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Re: Mast Cell Activation Syndrome
« Reply #327 on: December 18, 2020, 07:35:34 AM »
Many people with these symptoms are diagnosed with anxiety, and are medicated with antidepressants or anxiolytics without knowing the real cause, some improve, others do not, the illogical thing is that currently there are millions of people taking these drugs for life, when before they were only for days in the case of anxiolytics or benzodiazepines or months in the case of antidepressants. I took clonazepam for 13 years for a supposed cerebral dysrhythmia, when leaving them abruptly it generated anxiety and after months POIS

Journey

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Re: Mast Cell Activation Syndrome
« Reply #328 on: December 18, 2020, 09:40:30 AM »
Many people with these symptoms are diagnosed with anxiety, and are medicated with antidepressants or anxiolytics without knowing the real cause, some improve, others do not, the illogical thing is that currently there are millions of people taking these drugs for life, when before they were only for days in the case of anxiolytics or benzodiazepines or months in the case of antidepressants. I took clonazepam for 13 years for a supposed cerebral dysrhythmia, when leaving them abruptly it generated anxiety and after months POIS
That clonazepam gave you POIS after discontinuing the usage of that?

Muon

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Re: Mast Cell Activation Syndrome
« Reply #329 on: December 18, 2020, 03:18:32 PM »
That clonazepam gave you POIS after discontinuing the usage of that?

Click on his profile name and go to 'show posts' for post history.