Well lets see. Jokes aside. I don't believe in much except things of my own experience and I am not from a fly-over state either. Also I have tried many supplements (about 62) and I'm going to put the effect they had on me. As one can see I have spent a lot of money and trial and error to cure this damn curse. This is my story. It's kind of long. You can read the story, the list, or both.
Thanks for the detailed post, Gluton.
It is good information that you have kept track of all that you have been tried, and the results you got. I have myself a file with over 70 supplements I have tried through the years, with the scientific reason I tried them, the dosage, the results ( level of relief, side effects, ...). I often re-try products that are theoretically suppose to be good, but either showed no results or mild side effects, to see if they could do better when my body is in another state, some more weeks later. For sure, I usually try to test a new substance when I feel relatively good, to be able to discern between the effect of this substance, and the state I am in currently. I have also to deal with my tricky mind... if my anxiety level is high, it is not a good time to try a substance that has not passed yet my "safety" test, meaning that I know I can take it without ill effects, and without my mind messing with me taking it. For me, it is an important first step, because my anxious mind can easily create somatic side effects that has nothing to do with the product itself ( headache, dizziness, more anxiety, tension, ....). Slow process, but it led me to found products that are safe for me, and among them, some that brings me relief.
Unlike you, I have never stumbled upon a product giving such a high level of relief as 90% ( like you currently have with DAO). I found things giving me 30%, or 40% relief, and stacking them, taking them 20 mins or so before release, and after release, as needed, and I got to a consistent 80% to 100% of relief ( I have the same, stable, pre-pack and overall method for over a year now, like described at
http://poiscenter.com/forums/index.php?topic=2090.msg16604#msg16604 . ). It took time to get there. For years, I had only magnesium and green tea extract in my "pack", and this was only 40%-50% relief - good, but only to be able to go through my day at work, but not feeling well, and with fatigue.
My use of multiple supplements reflects my vision that POIS physiopathology is complex, and more than only one physiologic pattern, be it about cytokines or neurotransmitters, has to be act upon in order to address all symptoms. This is reflected in the "clusters" of symptoms I have defined, also. For example, I use TDO inhibitors ( like quercetin or milk thistle) along with IDO inhibitor ( rosemary extract or curcumin), in order to block both paths as once, both leading to kynurenine productions.
Well, I hope DAO will keep its effectiveness for you, keep us updated, in particular when a month or so has passed. Along with details about when you take it ( daily? or just before release?).
