LOW DOSE NALTREXONE

[Starsky]

In the latest study i have read :

The symptoms of POIS are similar to those of “opioid withdrawal syndrome,” which includes physical (flu-like symptoms, perspiration, and rhinitis) and psychological symptoms (anxiety, depression, and difficulty concentrating). These symptoms can last 2–7  days [15]. Opioids are involved in mediation of positive affective states  generated by the execution of sexual behavior [16]. The ?-opioid receptors are thought to play a crucial role in controlling this behavior [17]. We supposed that patients suffering from POIS may have a disorder of the endogenous ?-opioid receptor system. Orgasm consumes large amounts of endogenous opioids in these patients, which causes a series of symptoms similar to opioid withdrawal symptoms."


Did someone try Low Dose Naltrexone cause it is used in many autoimmune conditions?

[demografx]

Interesting, Starsky!

[b_jim]

Can you post the link of the last study you read, please ?
I have wrote several texts about opiate whidrawal syndrome and the "sexual hangover".
But I took low opiate meds for a lumbago (codeine) and the effects were strange and negative. Bad experience with valerian root too and alcohol.

[Starsky]

Its the latest chneese study, PM and i will email you it back.

[b_jim]

Thanks. That's a very, very good study.
I remember I sent a mail to dr Waldinger to ask him if there is a possible role of opioid system in Pois. But once again, my experience with codeine didn't convinced me.
Dr Jiang suggestion is very simple : orgasms use a lot of endorphin and it creates a lack of endorphins like opiate withdawal syndrome. This is not the first time this theory is suggested but the first time by a doctor !
Seeing that 99% Poisers are men and considering animus surgery, is there endorphins in semen; in large quantity ?
Anyway, is this suggestion is correct the cure is a problem. You can't rebalance the system with exogenous endorphins without creating another withdrawal.

The link with sugar is clear.
I don't know if there is a link with taurine.

--

Semen / opiates

But sperm comprise only about 3 percent of semen. The rest is seminal fluid: mostly water, plus about 50 compounds: sugar (to nourish sperm), immunosuppressants (to keep women's immune systems from destroying sperm), and oddly, two female sex hormones, and many mood-elevating compounds: ENDORPHINS, estrone, prolactin, oxytocin, thyrotrpin-releasing hormone, and serotonin.

The basis for all this is two interesting facts. First, semen contains a very large number of chemicals, including ENDORPHINS (which resemble OPIATES and reduce pain and change how we feel emotionally), hormones, and neurotransmitters (which work in the brain).

And the best one for the end :
http://www.ncbi.nlm.nih.gov/pubmed/3156145

Seminal plasma contains high levels of opioid peptides and both seminal plasma and endogenous opioids can influence the immune system.

[Starsky]

So semen injection could be a low dose opiate injection not desensitization?

[b_jim]

Hmm. I read again slowly the study.

1/ Dr Jiang says the treatment (desensitization) efficacy is UNCERTAIN.
2/ Dr Jiang think the level of IgE is too low in the 45 Poisers study of dr Waldinger.
3/ The chinese Poiser in the study has medium to high symptoms.
Important point : he has higher FSH and LH hypophisis hormones but MRI shows nothing on the hypophisis.
4/ The analysis of IgE, if I don't make mistakes :
Total IgE is high but specific IgE to seminal fluid seems NORMAL.
But the patient seems to have high IgE specific to other things (Mold). !!!
5/ Analysis of proteins (I dont understand)
6/ Elisa test. Negative.
7/ Skin tests. The work of dr Jiang is very nice. I hope I will not make mistakes :

- The intracutaneous test shows no real difference between Pois and non-Pois patients.
   (semen causes an "allergy" to everybody )
- Prick test shows a difference between Pois and non-Pois patients.
- Dr Jiang thinks the differences are not really significative.

8/ Dr Jiang seems to think semen of each man (Pois and non-Pois) contains potential allergic/inflammatory molecules like cytokines, chemokines...etc. To say it quickly and basically, SEMEN IS NATURALLY IRRITATING.

9/ Allergy to sperm exists, but according to dr Jiang the cases of allergic women are rare and show REAL AND CLEAR IgE values, unlike this patient.

10/ So, if I don't make mistake, Dr Jiang refutes partially or completely dr Waldinger's theory at least for the patient he studied. And he proposed another hypothesis : a form of opiate whidrawal syndrome.

 

So semen injection could be a low dose opiate injection not desensitization?

You mean, injection as a cure. Why not, I don't know. But how many patients are 100% cured by densitization ? 100% sure, not placebo ?

As I said, if dr Jiang is right, it"s not really a good new for Poisers. Because we can't rebalance endorphins without taking exogenous opioids causing another unbalance.

For my personnal case I have big improvement with taurine/fish and low sugar diet. 
I'm intolerant to alcohol and codeine

The "post-coital hangover" as lot of poisers call it, finds here a strong explanation.

[Starsky]

This was kinda my idea, not to use exogenous opiates but to stimulate the brain to produce own. The whole idea of LDN is to block opiate receptors for a very short time to cause a rebound effect and the body produces more own opiates which seems has a calming effect on the immune system- it helps for SM, Crohns, many claim it helps for HIV too.

[b_jim]

Too complex for me, only a neurologist can answer.
--
Links with taurine :

Eric R. Braverman, M.D., author of "The Healing Nutrients Within" suggests that the amino acid glutamine may help quiet cravings and that taurine may lessen the discomfort of opiate withdrawal. Braverman also recommends melatonin or tryptophan for sleep disturbances and the mineral, magnesium to aid muscle relaxation.

The amino acid taurine, at 3g a day, reduces withdrawal symptoms (alcohol)

It seems opiods activate taurine in some conditions in rats.

[Ccconfucius]

I used ldn for about two weeks, i didnt feel any different, but i also orgasmed way to often so don't look at my experience. But do a google search of nakedscientist and ldn and there should be several post on it.  There was someone else who tried it.

[fidalgo]

Starsky, could you send the chinese stydy for me???

[Colm]

I read the study and to my gut feel, the Chinese study did not read as a highly valid study. Just one humble opinion. A study of one Chinese man in a population of 1.5 BIllion. I don't think we know anything of the credibility of the people involved. Anyone else agree? I think we are desperate to have our theories validated and our best hope is what the good "wise" Dr Nan is hopefully putting some time into.

[joelawerence]

This is a very interesting topic which I think we should continue to investigate. From my research I have come across that this low dose of Naltrexone (LDN) is effective for a lot of conditions including CFS, Fibromyalgia, auto-immune issues and multiple sclerosis.

Dr David Gluck is working on trialing LDN for auto-immune diseases. This is his website which gives more details about LDN:

http://www.ldnresearchtrust.org/content/my-experience-low-dose-naltrexone-david-gluck-md

I have taken some excerpts from the website and posted here:

"The major mechanism of action of LDN involves blocking the body?s opioid/narcotic receptors for just a very few hours (rather than the all-day blockade caused by the 50mg dosage). Those are the same receptors used by the body?s endorphins. The body responds to this by greatly increasing its endorphin production, and those higher levels last all day -- far after the blockade by LDN has ended. Endorphins turn out to be the major normalizer/upregulator of one?s immune system.

This is of critical importance to anyone who has an autoimmune disease. Published studies have demonstrated that all autoimmune disorders thus far tested are marked by weak, dysfunctional immune systems (in contrast to the common belief that they are probably too strong). This makes good sense, because the first commandment of the immune system is ?Thou shalt not attack self!? Only a dysfunctional immune system attacks self. When the LDN normalizes one?s immune system, it halts the further progression of any autoimmune disease. When one takes LDN, one is regaining a normalized immune system ? and it is the immune system that has such a positive effect on such a wide variety of conditions."

The below link has reviews of patients who have used it for their conditions, and I am seeing overwhelming positive reports from patients who have used it for fibromyalgia:

https://www.patientslikeme.com/treatment_evaluations/browse/64-low-dose-naltrexone-ldn-side-effects-and-efficacy?attribute=side_effects&brand=t&page=1&value=2#evaluations

I definitely think our body has endorphin deficiency because previously when I was young and did not have POIS I used to have an intense sense of satisfaction and happiness after orgasm. But offlate after POIS started the sense of satisfaction has turned to a sense of disdain and pain instead of pleasure meaning our body is not producing endorphins.

It would be great if others can also do some research on Endorphins and LDN and post here. Let's have a healthy discussion

[Akaliko]

I'm beginning treatment with LDN as of yesterday, titrating from 1.5 to 4.5 mg over the next six weeks.

[Shep]

I'm beginning treatment with LDN as of yesterday, titrating from 1.5 to 4.5 mg over the next six weeks.

Hello! This decision to try to take LDN is very good. I hope for your improvement! It is especially interesting how the body will behave in the difficult days of POIS when receiving LDN! Write about your tests. Good luck!
P:S:
Perhaps there is a direction key. And then I will revise the theory of porn addiction .

[b_jim]

We wish you the best !

[joelawerence]

I'm beginning treatment with LDN as of yesterday, titrating from 1.5 to 4.5 mg over the next six weeks.

Any update on your treatment, Lee?

[Muon]

I'm beginning treatment with LDN as of yesterday, titrating from 1.5 to 4.5 mg over the next six weeks.

Any update on this?

[Mushnikk]

Any updates?

[Poiscurse]

In the latest study i have read :

The symptoms of POIS are similar to those of “opioid withdrawal syndrome,” which includes physical (flu-like symptoms, perspiration, and rhinitis) and psychological symptoms (anxiety, depression, and difficulty concentrating). These symptoms can last 2–7  days [15]. Opioids are involved in mediation of positive affective states  generated by the execution of sexual behavior [16]. The ?-opioid receptors are thought to play a crucial role in controlling this behavior [17]. We supposed that patients suffering from POIS may have a disorder of the endogenous ?-opioid receptor system. Orgasm consumes large amounts of endogenous opioids in these patients, which causes a series of symptoms similar to opioid withdrawal symptoms."


Did someone try Low Dose Naltrexone cause it is used in many autoimmune conditions?

This theory makes more sense to me, and the reason behind low opiates availability in body due to decreased endogenous production which is caused by gut flora imbalance and epithelial lining of gut disorders. I think we all know now ?thanks to this forum? that alot of neurotransmitters are produced in the intestines, and alot of
Hormone precursors as well.

A lot of poisers found relief after treating a chronic infection, theses infections drain the body out anti inflammatories, endorphins, damages the endothelial lining and god knows what else.., this theory also has a common ground with the opiates withdrawal theory? depletion of endorphins? but for another reason.

One of my symptoms is brain zaps whenever i turn my head, which i experienced once in my life when i was off prozac that a doctor gave to me when i was a teenager. The withdrawal experience is almost the same but to a lesser degree in POIS.