Author Topic: Xanthiol Nicotinate - Benefits, Risks and Function in POIS  (Read 314368 times)

0002ppdnuos

  • Jr. Member
  • **
  • Posts: 55
Re: Xanthiol Nicotinate - Benefits, Risks and Function in POIS
« Reply #500 on: June 18, 2012, 01:12:43 PM »
oic, thanks.
It started ever since my first orgasm. It lasts exactly for 7 days. Symptoms mainly in the brain: extreme mental  fatigue, difficulty concentrating, inability to comprehend/retain what is read,shortened attention span, loss of speech fluency, cloudy mindedness, mild headache, and anxiousness

Starsky

  • NDL_Group
  • Full Member
  • ***
  • Posts: 240
Re: Xanthiol Nicotinate - Benefits, Risks and Function in POIS
« Reply #501 on: June 19, 2012, 04:04:31 AM »
From Wikipedia: Niacin flushing means a realese of prostaglandin PGD2, which is involved in the regulation of reducing body temperature in sleep, and acts opposite to prostaglandin E2. Prostaglandin E2 is a compound of semen: Although PGD2 had a potent immunosuppressive effect on male rats, human semen was almost devoid of PGD2 (<0.2 pug/ml). On the other hand,
PGE2 was the major PG among the three PGs in human semen, a result was confirmed by gas chromatography/mass spectrometry (unpublished data). The concentration ofPGE2 in human semen was 61 ± 15 ,ug/ml (mean ± SEM, n = 7) in this study. The concentration of PGF2. was 5 ± 1 ,ug/ml. PGE2 is also the prostaglandin that ultimately induces fever. Perhaps we do have too much PGE2 in semen?


PGE2 and testosterone: http://www.ncbi.nlm.nih.gov/pubmed/1446608


How to reduce PGE2 in semen without taking testosterone patches? With NSAIDs we have too low concentrations in the prostate.
« Last Edit: June 19, 2012, 04:25:05 AM by Starsky »

Starsky

  • NDL_Group
  • Full Member
  • ***
  • Posts: 240

Daveman

  • Administrator
  • Hero Member
  • *****
  • Posts: 1631
WITHOUT RESEARCH THERE WILL BE NO CURE!
Sessions 5 to 9 days, mostly Flu-like, joints, digestion problems, light cognitive.
Niacin has changed my lif though, now 1 day MAX.
Somewhere in this interaction with Niacin is the answer!

Starsky

  • NDL_Group
  • Full Member
  • ***
  • Posts: 240
Re: Xanthiol Nicotinate - Benefits, Risks and Function in POIS
« Reply #504 on: June 19, 2012, 11:25:42 AM »
Did the niacin worked for you if you have taken too much o niacin? If you are having a very strong flush that last for 1 hour does it work for POIS?

vandam

  • Newbie
  • *
  • Posts: 4
Re: Xanthiol Nicotinate - Benefits, Risks and Function in POIS
« Reply #505 on: June 19, 2012, 11:28:16 AM »
As you guys know, I`m a new member and I was wondering what the best thing is to start with. Like a long before an `O` should I take niacine and should I take also something else with it??
What do you guys recommend me?

Thank you.

Daveman

  • Administrator
  • Hero Member
  • *****
  • Posts: 1631
Re: Xanthiol Nicotinate - Benefits, Risks and Function in POIS
« Reply #506 on: June 19, 2012, 12:51:24 PM »
Did the niacin worked for you if you have taken too much o niacin? If you are having a very strong flush that last for 1 hour does it work for POIS?

If I have taken too much and the flush lasts for an hour or more, it hasn't worked as well, but that's usually because I haven't let the flush subside a bit I think.

If I have one of those that last at least an hour, I'm going to wait until a good part of the redness goes from the arms and legs, until I don't feel much of the burning sensation when I touch some part of the body.

But I think it should be enough to wait an hour, perhaps an hour and a half. I have usually "started in" on the fun before half and hour. Thinking that it was enough that the flush had arrived.

 
WITHOUT RESEARCH THERE WILL BE NO CURE!
Sessions 5 to 9 days, mostly Flu-like, joints, digestion problems, light cognitive.
Niacin has changed my lif though, now 1 day MAX.
Somewhere in this interaction with Niacin is the answer!

Daveman

  • Administrator
  • Hero Member
  • *****
  • Posts: 1631
Re: Xanthiol Nicotinate - Benefits, Risks and Function in POIS
« Reply #507 on: June 19, 2012, 12:56:03 PM »
As you guys know, I`m a new member and I was wondering what the best thing is to start with. Like a long before an `O` should I take niacine and should I take also something else with it??
What do you guys recommend me?

Thank you.

Shouldn't be necessary to take anything with it.

With empty stomach (no eating or drinking alcohol about 3 hrs at least before taking niacin)

Just take 100 to 200 mg niacin, wait for the flush, then about an hour after taking the first niacin "do your thing"!

Should be flush type niacin.
WITHOUT RESEARCH THERE WILL BE NO CURE!
Sessions 5 to 9 days, mostly Flu-like, joints, digestion problems, light cognitive.
Niacin has changed my lif though, now 1 day MAX.
Somewhere in this interaction with Niacin is the answer!

Starsky

  • NDL_Group
  • Full Member
  • ***
  • Posts: 240
Re: Xanthiol Nicotinate - Benefits, Risks and Function in POIS
« Reply #508 on: June 19, 2012, 01:43:04 PM »
Do you get symptoms of prostatits when you take niacin or you dont get this symptoms of POIS anymore?

Daveman

  • Administrator
  • Hero Member
  • *****
  • Posts: 1631
Re: Xanthiol Nicotinate - Benefits, Risks and Function in POIS
« Reply #509 on: June 19, 2012, 02:39:30 PM »
Do you get symptoms of prostatits when you take niacin or you dont get this symptoms of POIS anymore?

Yeah I still do a bit. I think it's  less, but it's there, for about 4 days.
WITHOUT RESEARCH THERE WILL BE NO CURE!
Sessions 5 to 9 days, mostly Flu-like, joints, digestion problems, light cognitive.
Niacin has changed my lif though, now 1 day MAX.
Somewhere in this interaction with Niacin is the answer!

Starsky

  • NDL_Group
  • Full Member
  • ***
  • Posts: 240
Re: Xanthiol Nicotinate - Benefits, Risks and Function in POIS
« Reply #510 on: June 20, 2012, 06:22:49 AM »
http://www.researchgate.net/publication/24038104_The_Anti-Inflammatory_Effects_of_Prostaglandins

This theory gives us a better understanding of the problem: Ejaculation while we are flushing (PGD2 in its inflammatory phase) makes POIS worse, after the flush (PGD2 as antinflammatory factor or its metabolites) no POIS.
« Last Edit: June 20, 2012, 09:01:34 AM by Starsky »

Daveman

  • Administrator
  • Hero Member
  • *****
  • Posts: 1631
Re: Xanthiol Nicotinate - Benefits, Risks and Function in POIS
« Reply #511 on: June 20, 2012, 09:05:07 AM »
http://www.researchgate.net/publication/24038104_The_Anti-Inflammatory_Effects_of_Prostaglandins

This theory gives us a better understanding of the problem: Ejaculation while we are flushing (PGD2 in its inflammatory phase) makes POIS worse, after the flush (PGD2 as antinflammatory factor or its metabolites) no POIS.

Great find Starsky.

This is at the center of POIS I'm sure. We just have to find out WHY US?

But very exciting!!

WITHOUT RESEARCH THERE WILL BE NO CURE!
Sessions 5 to 9 days, mostly Flu-like, joints, digestion problems, light cognitive.
Niacin has changed my lif though, now 1 day MAX.
Somewhere in this interaction with Niacin is the answer!

demografx

  • Administrator
  • Hero Member
  • *****
  • Posts: 6391
  • All of us working together to defeat POIS!
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

  • Administrator
  • Hero Member
  • *****
  • Posts: 6391
  • All of us working together to defeat POIS!
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

vonstermommy

  • Newbie
  • *
  • Posts: 24
Re: Xanthiol Nicotinate - Benefits, Risks and Function in POIS
« Reply #514 on: July 29, 2012, 02:57:13 AM »
My husband has taken Niacin about 5 times. This is because of the POIS forums - thanks!!  He told me that the first day he was at 90% free of POIS.  He was so happy - first time since puberty.

Last night he crushed it up onto a teaspoon.  It tasted awful. Went to sleep about 45 minutes.  He thought he had awoken because of the flush. We had sex. Today, he had all of his symptoms.  So flush or No flush?  It must depend on the person and the amount.
Im the wife of a man suffering from POIS. 300 Niacin. Feel free to give your wife my email address!

Observer

  • Global Moderator
  • Sr. Member
  • *****
  • Posts: 386
Re: Xanthiol Nicotinate - Benefits, Risks and Function in POIS
« Reply #515 on: July 29, 2012, 03:58:55 AM »
My husband has taken Niacin about 5 times. This is because of the POIS forums - thanks!!  He told me that the first day he was at 90% free of POIS.  He was so happy - first time since puberty.

Last night he crushed it up onto a teaspoon.  It tasted awful. Went to sleep about 45 minutes.  He thought he had awoken because of the flush. We had sex. Today, he had all of his symptoms.  So flush or No flush?  It must depend on the person and the amount.

So, did he experience the flush? Otherwise, experiencing the flush doesn´t equal 100% free of symptoms. I believe it works if you take the adequate amount and if you experience the flush.

Daveman has reported that the flush is not 100% neccessary if he takes an high amount. How much is he taking? Send regards to him  :D (and regards to you of course!)

Daveman

  • Administrator
  • Hero Member
  • *****
  • Posts: 1631
Re: Xanthiol Nicotinate - Benefits, Risks and Function in POIS
« Reply #516 on: July 29, 2012, 07:02:47 AM »
My husband has taken Niacin about 5 times. This is because of the POIS forums - thanks!!  He told me that the first day he was at 90% free of POIS.  He was so happy - first time since puberty.

Last night he crushed it up onto a teaspoon.  It tasted awful. Went to sleep about 45 minutes.  He thought he had awoken because of the flush. We had sex. Today, he had all of his symptoms.  So flush or No flush?  It must depend on the person and the amount.

Great to hear from a partner, hear the other side of the story!

As far a niacin, when it works it usually works quite well, but it is pretty finicky! There's a procedure here:
http://poiscenter.com/forums/index.php?topic=319.msg4160#msg4160

that is pretty good! These would be the basic guidlines, but are quite strict.

As Observer says, the flush is a good guidline, it USUALLY indicates when you have had enough, but not always.

We say "on an empty stomach", but in my experience, it relates to how hard the liver is working. I think, that even just alcohol
for instance can reduce the effect. I don't mean whether you are drunk or not, but if you've had a couple of drinks, like after a nice
dinner, those too need to be considered in the pre-niacin "fast".

If you have a light sandwich one hour before the niacin, probably it won't affect things much, but if you have barbecued pork ribs you
might have to wait a good 4 hrs. (or take more niacin)

I've noticed that if I have eaten too closely to taking the niacin, that I may not ever reach the flush, or just barely. But as Observer says
in those cases I have to take near 500mg. And usually I'm protected anyways.

Also if you take too large a dose on an empty stomach and have a real heavy flush, you may try to start in on the sex before your body is ready,
and even though you have had a big flush, you are not protected.

So besides the "waiting 20 minutes" after the peak of the flush, you should add, Wait 1 hour from the first tingling of the flush (and if you don't get flush)
about 1 hour and 20 since starting to take the niacin.

All very complicated, but worth it.
In hubbies case. He isn't sure of he got the flush, so it would be difficult to know if he was "protected". Try the above techniques.

The whole niacin process can sometimes take the spontaneity out the the moment. We are working on a new B complex treatment which has
much less strict rules. You take the vitamins daily and here is no flush. But it is fairly new and we are working out the details.

See this exciting thread!:
http://poiscenter.com/forums/index.php?topic=468.0

Thanks from all of us for being such a patient and involved wife!
WITHOUT RESEARCH THERE WILL BE NO CURE!
Sessions 5 to 9 days, mostly Flu-like, joints, digestion problems, light cognitive.
Niacin has changed my lif though, now 1 day MAX.
Somewhere in this interaction with Niacin is the answer!

demografx

  • Administrator
  • Hero Member
  • *****
  • Posts: 6391
  • All of us working together to defeat POIS!
Re: Xanthiol Nicotinate - Benefits, Risks and Function in POIS
« Reply #517 on: July 29, 2012, 09:08:01 AM »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

vonstermommy

  • Newbie
  • *
  • Posts: 24
Re: Xanthiol Nicotinate - Benefits, Risks and Function in POIS
« Reply #518 on: July 30, 2012, 06:58:25 PM »


So, did he experience the flush? Otherwise, experiencing the flush doesn´t equal 100% free of symptoms. I believe it works if you take the adequate amount and if you experience the flush.

Daveman has reported that the flush is not 100% neccessary if he takes an high amount. How much is he taking? Send regards to him  :D (and regards to you of course!)
[/quote]

Thank you for your reply. We dont know whether he flushed or not.  When he has flushed, he is not 100% free but what a relief to have some of the symptoms go away.  He takes Tylenol every four hours of if really bad a Maxalt for the headaches.  Nothing for diarrhea. As we speak he is coming home early as he is not feeling well (same episode).
Im the wife of a man suffering from POIS. 300 Niacin. Feel free to give your wife my email address!

vonstermommy

  • Newbie
  • *
  • Posts: 24
Re: Xanthiol Nicotinate - Benefits, Risks and Function in POIS
« Reply #519 on: July 30, 2012, 07:17:20 PM »


As far a niacin, when it works it usually works quite well, but it is pretty finicky! There's a procedure here:
http://poiscenter.com/forums/index.php?topic=319.msg4160#msg4160


Hi, Im not sure how to reply...so I clicked "quote"  Thank you for the article - I will read with my husband.  I am seriously thinking of writing a book, well, probably a blog - A he said, she said.  Because we "waited" before marriage (1998), I didnt out about his POIS until the honeymoon.  After one O,  he didnt want to go there again for the rest of the 2 weeks.

Me: Why?
Him "well you know" 
Me: Uh, no? what?
Him "you feel sick afterwards"
Me: "after what?"

and well you can figure out the rest of the conversation.  Poor guy - its been tough - NO info on google searches or doctors, so we gave up trying to "google" it. Then a few months ago we saw the video newscast of a man (that is on this forum) suffering from POIS. The one where he tells his "first date" about POIS. And he found you!   Boo to his doctor and specialist and sex therapist - we have hope.  Hope! He read about Niacin (specifically on the page where you tell how many tried it and the success rate) and that first morning after...he smiled! But whats just as big? He is not alone anymore.
Im the wife of a man suffering from POIS. 300 Niacin. Feel free to give your wife my email address!