I'm very interested in understanding what is actually going on with XN / niacin realted products in relation to POIS.
Granted, it is excellent that XN seems to have helped some, and have much hope that it will help a good number more. Our tests I'm sure are aimed at finding, not only a solution to our suffering and symptoms, but I imagine the to illness itself.
I was reading what seemed to be a very informed (albeit) salesman, describe the function of niacin. Apparantly it doesn't produce histamines in and of itself, it dilates the capillaries (very small blood vessels) so that istead of letting blood cells pass, in many cases, in sinlge file, the capillaries open to let pass two or more times the volume.
This has a better capacity to clean out the toxins at the cellular level. Some cells are so plugged up that they can't do their housekeeping under normal conditions, but with the better irrigation, they unclog, and only then do they reach a level at which they can produce and release their own histamines. You know that's happening when you feel the itch with the "flush" of the openned capillaries.
But a given dose, produces the flush and itch only for a couple of days. This leads to question 1), "does this mean that the system has cleaned itself to a level that more histamines are not required to clean the cells"?
Question 2), "What happens when taking XN just prior to orgasm? Does it flush the system and begin a histamine cycle, which somehow blocks the histamine reaction of orgasm, or of a potential type I reaction to semen?
That question is two part I think, in that there ore two potential histaminic reactions, one that is natural with orgasm (although for some reason could cause probelms for a POIS suffere), and one that could relate to an alergic reaction to semen.
The difference is quite important I would imagin, although the effect of XN/niacin is similar in both. Is XN a cure in this scenario, NO I don't think so, unless it breaks some malivolent cycle. Some cause of a malivolent cycle still exists.
What do you think? All? LC?