Author Topic: Xanthiol Nicotinate - Benefits, Risks and Function in POIS  (Read 203246 times)

Starsky

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Re: Xanthiol Nicotinate - Benefits, Risks and Function in POIS
« Reply #510 on: June 20, 2012, 06:22:49 AM »
http://www.researchgate.net/publication/24038104_The_Anti-Inflammatory_Effects_of_Prostaglandins

This theory gives us a better understanding of the problem: Ejaculation while we are flushing (PGD2 in its inflammatory phase) makes POIS worse, after the flush (PGD2 as antinflammatory factor or its metabolites) no POIS.
« Last Edit: June 20, 2012, 09:01:34 AM by Starsky »

Daveman

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Re: Xanthiol Nicotinate - Benefits, Risks and Function in POIS
« Reply #511 on: June 20, 2012, 09:05:07 AM »
http://www.researchgate.net/publication/24038104_The_Anti-Inflammatory_Effects_of_Prostaglandins

This theory gives us a better understanding of the problem: Ejaculation while we are flushing (PGD2 in its inflammatory phase) makes POIS worse, after the flush (PGD2 as antinflammatory factor or its metabolites) no POIS.

Great find Starsky.

This is at the center of POIS I'm sure. We just have to find out WHY US?

But very exciting!!

WITHOUT RESEARCH THERE WILL BE NO CURE!
Sessions 5 to 9 days, mostly Flu-like, joints, digestion problems, light cognitive.
Niacin has changed my lif though, now 1 day MAX.
Somewhere in this interaction with Niacin is the answer!

demografx

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10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

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10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

vonstermommy

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Re: Xanthiol Nicotinate - Benefits, Risks and Function in POIS
« Reply #514 on: July 29, 2012, 02:57:13 AM »
My husband has taken Niacin about 5 times. This is because of the POIS forums - thanks!!  He told me that the first day he was at 90% free of POIS.  He was so happy - first time since puberty.

Last night he crushed it up onto a teaspoon.  It tasted awful. Went to sleep about 45 minutes.  He thought he had awoken because of the flush. We had sex. Today, he had all of his symptoms.  So flush or No flush?  It must depend on the person and the amount.
Im the wife of a man suffering from POIS. 300 Niacin. Feel free to give your wife my email address!

Observer

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Re: Xanthiol Nicotinate - Benefits, Risks and Function in POIS
« Reply #515 on: July 29, 2012, 03:58:55 AM »
My husband has taken Niacin about 5 times. This is because of the POIS forums - thanks!!  He told me that the first day he was at 90% free of POIS.  He was so happy - first time since puberty.

Last night he crushed it up onto a teaspoon.  It tasted awful. Went to sleep about 45 minutes.  He thought he had awoken because of the flush. We had sex. Today, he had all of his symptoms.  So flush or No flush?  It must depend on the person and the amount.

So, did he experience the flush? Otherwise, experiencing the flush doesn´t equal 100% free of symptoms. I believe it works if you take the adequate amount and if you experience the flush.

Daveman has reported that the flush is not 100% neccessary if he takes an high amount. How much is he taking? Send regards to him  :D (and regards to you of course!)

Daveman

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Re: Xanthiol Nicotinate - Benefits, Risks and Function in POIS
« Reply #516 on: July 29, 2012, 07:02:47 AM »
My husband has taken Niacin about 5 times. This is because of the POIS forums - thanks!!  He told me that the first day he was at 90% free of POIS.  He was so happy - first time since puberty.

Last night he crushed it up onto a teaspoon.  It tasted awful. Went to sleep about 45 minutes.  He thought he had awoken because of the flush. We had sex. Today, he had all of his symptoms.  So flush or No flush?  It must depend on the person and the amount.

Great to hear from a partner, hear the other side of the story!

As far a niacin, when it works it usually works quite well, but it is pretty finicky! There's a procedure here:
http://poiscenter.com/forums/index.php?topic=319.msg4160#msg4160

that is pretty good! These would be the basic guidlines, but are quite strict.

As Observer says, the flush is a good guidline, it USUALLY indicates when you have had enough, but not always.

We say "on an empty stomach", but in my experience, it relates to how hard the liver is working. I think, that even just alcohol
for instance can reduce the effect. I don't mean whether you are drunk or not, but if you've had a couple of drinks, like after a nice
dinner, those too need to be considered in the pre-niacin "fast".

If you have a light sandwich one hour before the niacin, probably it won't affect things much, but if you have barbecued pork ribs you
might have to wait a good 4 hrs. (or take more niacin)

I've noticed that if I have eaten too closely to taking the niacin, that I may not ever reach the flush, or just barely. But as Observer says
in those cases I have to take near 500mg. And usually I'm protected anyways.

Also if you take too large a dose on an empty stomach and have a real heavy flush, you may try to start in on the sex before your body is ready,
and even though you have had a big flush, you are not protected.

So besides the "waiting 20 minutes" after the peak of the flush, you should add, Wait 1 hour from the first tingling of the flush (and if you don't get flush)
about 1 hour and 20 since starting to take the niacin.

All very complicated, but worth it.
In hubbies case. He isn't sure of he got the flush, so it would be difficult to know if he was "protected". Try the above techniques.

The whole niacin process can sometimes take the spontaneity out the the moment. We are working on a new B complex treatment which has
much less strict rules. You take the vitamins daily and here is no flush. But it is fairly new and we are working out the details.

See this exciting thread!:
http://poiscenter.com/forums/index.php?topic=468.0

Thanks from all of us for being such a patient and involved wife!
WITHOUT RESEARCH THERE WILL BE NO CURE!
Sessions 5 to 9 days, mostly Flu-like, joints, digestion problems, light cognitive.
Niacin has changed my lif though, now 1 day MAX.
Somewhere in this interaction with Niacin is the answer!

demografx

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Re: Xanthiol Nicotinate - Benefits, Risks and Function in POIS
« Reply #517 on: July 29, 2012, 09:08:01 AM »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

vonstermommy

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Re: Xanthiol Nicotinate - Benefits, Risks and Function in POIS
« Reply #518 on: July 30, 2012, 06:58:25 PM »


So, did he experience the flush? Otherwise, experiencing the flush doesn´t equal 100% free of symptoms. I believe it works if you take the adequate amount and if you experience the flush.

Daveman has reported that the flush is not 100% neccessary if he takes an high amount. How much is he taking? Send regards to him  :D (and regards to you of course!)
[/quote]

Thank you for your reply. We dont know whether he flushed or not.  When he has flushed, he is not 100% free but what a relief to have some of the symptoms go away.  He takes Tylenol every four hours of if really bad a Maxalt for the headaches.  Nothing for diarrhea. As we speak he is coming home early as he is not feeling well (same episode).
Im the wife of a man suffering from POIS. 300 Niacin. Feel free to give your wife my email address!

vonstermommy

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Re: Xanthiol Nicotinate - Benefits, Risks and Function in POIS
« Reply #519 on: July 30, 2012, 07:17:20 PM »


As far a niacin, when it works it usually works quite well, but it is pretty finicky! There's a procedure here:
http://poiscenter.com/forums/index.php?topic=319.msg4160#msg4160


Hi, Im not sure how to reply...so I clicked "quote"  Thank you for the article - I will read with my husband.  I am seriously thinking of writing a book, well, probably a blog - A he said, she said.  Because we "waited" before marriage (1998), I didnt out about his POIS until the honeymoon.  After one O,  he didnt want to go there again for the rest of the 2 weeks.

Me: Why?
Him "well you know" 
Me: Uh, no? what?
Him "you feel sick afterwards"
Me: "after what?"

and well you can figure out the rest of the conversation.  Poor guy - its been tough - NO info on google searches or doctors, so we gave up trying to "google" it. Then a few months ago we saw the video newscast of a man (that is on this forum) suffering from POIS. The one where he tells his "first date" about POIS. And he found you!   Boo to his doctor and specialist and sex therapist - we have hope.  Hope! He read about Niacin (specifically on the page where you tell how many tried it and the success rate) and that first morning after...he smiled! But whats just as big? He is not alone anymore.
Im the wife of a man suffering from POIS. 300 Niacin. Feel free to give your wife my email address!

vonstermommy

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Re: Xanthiol Nicotinate - Benefits, Risks and Function in POIS
« Reply #520 on: July 31, 2012, 01:43:38 PM »
Update on my husband.

Short summary - took Niacin 5 times, flushed, 70-90% symptoms gone!
Last weekend - not sure if flushed and POIS :(

Last night he said "This is the worst I have ever felt"  So we will not consider sexual intercourse (I just wanted to use that phrase) for at least two weeks.  My concern is that  "it is the worst" after each time.  He is not whining, it really is worse than the last time.  And, I dont mean to be dramatic or scary, or even humorous, but I honestly think Im killing my husband with sex.  For him, 300mg Niacin is the way to go - just working on tweaking the dose, time, and frequency.

If you have a partner - please tell them to email me.  If you haven't tried Niacin - I would say, "Ask your GP first."  But he may just tell you "Its psychological, here is some Zoloft."
Im the wife of a man suffering from POIS. 300 Niacin. Feel free to give your wife my email address!

Daveman

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Re: Xanthiol Nicotinate - Benefits, Risks and Function in POIS
« Reply #521 on: July 31, 2012, 02:58:00 PM »
Update on my husband.

Short summary - took Niacin 5 times, flushed, 70-90% symptoms gone!
Last weekend - not sure if flushed and POIS :(

Last night he said "This is the worst I have ever felt"  So we will not consider sexual intercourse (I just wanted to use that phrase) for at least two weeks.  My concern is that  "it is the worst" after each time.  He is not whining, it really is worse than the last time.  And, I dont mean to be dramatic or scary, or even humorous, but I honestly think Im killing my husband with sex.  For him, 300mg Niacin is the way to go - just working on tweaking the dose, time, and frequency.

If you have a partner - please tell them to email me.  If you haven't tried Niacin - I would say, "Ask your GP first."  But he may just tell you "Its psychological, here is some Zoloft."



Several have said that if for some reason, like your husband, there is a bad session, that you can do another niacin session with orgasm (correctly) and it will not only protect you but remove the previous POIS. Just taking the niacin though without orgasm does nothing for prexistant POIS. You have to have another orgasm after you take the naicin.

I personally have found that if I am iffy (medium POIS after taking niacin without waiting after eating), I can take the niacin in about 36 hours and have another orgasm, and I feel great. It sort of does a “reset”.

But still, even with niacin, too many orgasms in a row can gang up on you and the niacin is less effective. But I’m talking about maybe 4 times a week… not just a second one to reset the first every once in a while.
WITHOUT RESEARCH THERE WILL BE NO CURE!
Sessions 5 to 9 days, mostly Flu-like, joints, digestion problems, light cognitive.
Niacin has changed my lif though, now 1 day MAX.
Somewhere in this interaction with Niacin is the answer!

demografx

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Re: Xanthiol Nicotinate - Benefits, Risks and Function in POIS
« Reply #522 on: August 06, 2012, 09:30:23 AM »




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10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

poisioq

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Re: Xanthiol Nicotinate - Benefits, Risks and Function in POIS
« Reply #523 on: August 10, 2012, 02:32:07 PM »
I would like to try niacin but i am scared because i am also affected by irritable colon and i've read that xanthiol nicotinate could trigger stomach pain as it happened to some of the members of this forum.
is there a safe way to take it?

Daveman

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Re: Xanthiol Nicotinate - Benefits, Risks and Function in POIS
« Reply #524 on: August 10, 2012, 03:52:47 PM »
I would like to try niacin but i am scared because i am also affected by irritable colon and i've read that xanthiol nicotinate could trigger stomach pain as it happened to some of the members of this forum.
is there a safe way to take it?


In my experience, I’ve only had strange things happen to the stomach with a very strong flush (taking too much). Even then the effect is very transient and goes away quickly. It’s like it causes temporary muscle spasms.

It's not like an acid producing thing.

WITHOUT RESEARCH THERE WILL BE NO CURE!
Sessions 5 to 9 days, mostly Flu-like, joints, digestion problems, light cognitive.
Niacin has changed my lif though, now 1 day MAX.
Somewhere in this interaction with Niacin is the answer!