Testosterone

[berlin1984]

If anyone wants to pursue such a theory should know that an analogous phrase for the refractory period is post-ejaculatory interval (PEI). PEI is one component of the sexual behavior that aphrodisiacs may positively regulate. Some herbs specifically found to reduce PEI are Devil's beggartick, White goosefoot, White sapote, Mucuna pruriens, Camel thistle, nutmeg, African basil, Tribulus and Damiana, but probably many of the other aphrodisiacs do so.

Damiana is interesting. I've been using it for a few weeks now (patented extract, marketed for female libido)and I think it improves recovery time.
Here is some rat studies:
https://pubmed.ncbi.nlm.nih.gov/19501274/
https://pubmed.ncbi.nlm.nih.gov/23298455/

[demografx]

I’m vacationing for the month of August, so my new POIS doctors prescribed this for self-injecting my testosterone while traveling! (No nurse required )

I thought I was too fearful to self-inject, but this [new method] is sooooo easy & 100% painless, safe & foolproof!! (You never see the needle!).

And no, I’m not an advertising spokesperson for the product!

My insurance co. (Medicare +etc.) FINALLY approved (not easily!!) with a $50 monthly co-pay. Till now, I’ve been spending outrageous sum$ with Uber to get injected at my POIS doctors’ clinic.

Great “holiday present” for me!

[hurray]

My insurance co. (Medicare +etc.) FINALLY approved (not easily!!) with a $50 monthly co-pay. Till now, I’ve been spending outrageous sum$ with Uber to get injected at my POIS doctors’ clinic.

Great “holiday present” for me!

Well done Demo, fighting POIS takes persistance 

[demografx]

My insurance co. (Medicare +etc.) FINALLY approved (not easily!!) with a $50 monthly co-pay. Till now, I’ve been spending outrageous sum$ with Uber to get injected at my POIS doctors’ clinic.

Great “holiday present” for me!

Well done Demo, fighting POIS takes persistence 

Thanks, hurray!

[b_jim]

I'm less present on the forum. But I see a new study :
 https://www.sciencedirect.com/science/article/pii/S221444201930453X
Very interesting.
I want to test my sulphur theory next months . But I keep this HCG/Testo theory in memory  . This is exactly my testosterone state (low free T bordeline total T ...)

[demografx]

I'm less present on the forum. But I see a new study :
 https://www.sciencedirect.com/science/article/pii/S221444201930453X
Very interesting.
I want to test my sulphur theory next months . But I keep this HCG/Testo theory in memory  . This is exactly my testosterone state (low free T bordeline total T ...)

I think HCG is very interesting.

[less_fogged]

Hi, I'm not here to promote this product but thought it be a good idea to inform about this product I found online claiming to contribute to normal testosterone levels. Maybe interesting for POISers with testosterone issues. It's interesting to read about the ingredients of this product named as Proxerex. I suppose it must be something newish.

Ingredients :
- L-arginine 2500 mg
- Propionyl-L-carnitine 250 mg
- Vitamin B3 (Niacin) 8 mg
- Acetyl-L-carniti ne 125 mg
- Cocoa flavanols 200 mg
- Maca 150 mg
- Zinc 10 mg
- Selenium 50 mcg

P.S: If you want to try this product I'd recommend you to first discus it with your doctor.

[demografx]

At POIS onset, I take 20mg of Cialis - - (double my normal dose).

Forum member Animus - - who underwent successful surgery for POIS - - and I share similar POIS theories: semen re-generation problems cause POIS.

Since TRT (my main POIS treatment) and Cialis stimulate arousal, I believe that - -
in turn - - the chemical stimulation of Cialis hastens my healthy semen re-generation.

[demografx]

At POIS onset, I take 20mg of Cialis - - (double my normal dose).

Forum member Animus - - who underwent successful surgery for POIS - - and I share similar POIS theories: semen re-generation problems cause our POIS.

Since TRT (my main POIS treatment) and Cialis stimulate arousal, I believe that - -
in turn - - the chemical stimulation of Cialis hastens my healthy semen re-generation.

This continues to work for me!

Recently did a 6-month treatment review with my POIS medical team. When I explained my theory above, it was deemed reasonable by their NP-C.

It’s about time! (I just recently turned 78).

[Progecitor]

At POIS onset, I take 20mg of Cialis - - (double my normal dose).

Forum member Animus - - who underwent successful surgery for POIS - - and I share similar POIS theories: semen re-generation problems cause our POIS.

Since TRT (my main POIS treatment) and Cialis stimulate arousal, I believe that - -
in turn - - the chemical stimulation of Cialis hastens my healthy semen re-generation.

This continues to work for me!

Recently did a 6-month treatment review with my POIS medical team. When I explained my theory above, it was deemed reasonable by their NP-C.

It’s about time! (I just recently turned 78).

I don't believe tadalafil has been mentioned in relation to prostatitis or at least its role has not been appreciated properly. It is clear that there is a strong association between POIS and CP/CPPS as well. As POIS possibly stems from a very severe autoimmune prostatitis, the following could be useful information.

Experimental autoimmune prostatitis (EAP) rats developed pelvic pain, prostatic inflammation and increased plasma IgG concentrations. Tadalafil inhibited the chronic pelvic pain and prostatic inflammation, suggesting that its anti-inflammatory action may contribute to its blocking of pain development in the EAP model.
https://onlinelibrary.wiley.com/doi/abs/10.1002/pros.23514

Tadalafil is sufficiently effective in the treatment of patients with benign prostatic hyperplasia and severe chronic prostatitis/chronic pelvic pain syndrome.
https://onlinelibrary.wiley.com/doi/abs/10.1111/iju.14122

Chronic prostatitis associated chronic pelvic pain syndrome (CP/CPPS) is one of the most common medical conditions in urology with estimated prevalence of 2.2–13.8% in men from different societies. The exact etiology of CP/CPPS is still not-completely recognized. Different reports referred to non-recognized bacterial infection, psychogenic factors, retrograde flow of urine in prostatic ducts or pelvic floor dysfunction as possible etiologies
The common pathophysiological pathways of sexual dysfunction and prostatic pain/voiding symptoms is not yet clear. Increased Rho-kinase activation and impaired nitric oxidase synthase in pelvic structure (including prostate and penis) may increase intraprostatic pressure and decrease smooth muscle relaxation of penile tissues causing prostatitis symptoms and erectile dysfunction, respectively. Also, autonomic hyperactivity, atherosclerosis and metabolic syndrome may play a main or a co-mechanism for prostate associated sexual dysfunction.
Based on previous pathways, PDE5-inhibitors could be expected to have a role in treatment of CP/CPPS. It was proven that tadalafil can down-regulate Rho-kinase activity. Rat model of chronic non-bacterial prostatitis had significantly suppressed pelvic pain and prostatic inflammation after tadalafil medications. Also, tadalafil can upregulate NO/cGMP resulting in reduced prostatic smooth muscles contractions. PDE5-inhibitors can also reduce atherosclerosis and inflammation by decreasing expression of various inflammatory markers.
https://link.springer.com/article/10.1007/s00345-022-04074-4

There are also indications for dysregulation of Ca2+ homeostasis and PKC to be involved in POIS. Specifically lycopene is a PKC inhibitor that proved to be useful for several of us.
Rho-associated protein kinase (ROCK) is a kinase belonging to the AGC (PKA/ PKG/PKC) family of serine-threonine specific protein kinases. It is involved mainly in regulating the shape and movement of cells by acting on the cytoskeleton.
Protein kinase C and Rho-associated protein kinase are involved in regulating calcium ion intake; these calcium ions, in turn stimulate a myosin light chain kinase, forcing a contraction.
https://en.wikipedia.org/wiki/Rho-associated_protein_kinase

Grimsley and colleagues found that patients with erectile dysfunction treated with phosphodiesterase 5 inhibitors (PDE5) reported a concomitant improvement in their prostatitis symptoms; their paper advanced the hypothesis that the relaxation of prostatic duct smooth muscles, increasing wash-out of prostatic reflux products, could significantly reduce prostatic inflammation.
Nitric oxide synthase, required for NO formation, has been localized biochemically and immunohistochemically in the transitional and peripheral zone of the prostate, specifically in the nerve fibres and ganglia located in the prostatic smooth muscles. PDE5, the target of PDE5 inhibitors, has been localized in the transitional zone. Uckert and colleagues showed how PDE5 inhibitors reverse tension in prostatic smooth muscles, suggesting that both NO and PDE5 mediate smooth muscle relaxation.
Kirby and colleagues show a retrograde flow of urine into the prostatic ducts of transitional and peripheral zones in patients affected by prostatitis. This study suggested that urinary reflux was the primum movens for both bacterial and abacterial prostatitis.
We hypothesized that the good results in terms of pain reduction and improvement in the quality of life were due to smooth muscle relaxation in prostatic ducts. This could guarantee a greater wash-out of oxidant elements from prostatic tissue, reducing irritant urinary elements and consequent prostatic inflammation.
https://journals.sagepub.com/doi/full/10.1177/1756287218808677

Tadalafil for the treatment of benign prostatic hyperplasia
Expert opinion: Preclinical and clinical data have clearly demonstrated that PDE5 inhibitors induce bladder and prostate relaxation, which contributes to the improvement seen in storage symptoms in both animal models of bladder and prostate hypercontractility. Tadalafil is effective both as a monotherapy and add-on therapy in patients with lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH). Furthermore, as LUTS-BPH and erectile dysfunction (ED) are urological disorders that commonly coexist in aging men, tadalafil is more advantageous than alpha1-adrenoceptors and should be used as the first option. Tadalafil is a safe and tolerable therapy and unlike alpha1- adrenoceptors and 5-alpha reductase inhibitors, which can cause sexual dysfunctions, tadalafil improves sexual function.
https://www.tandfonline.com/doi/abs/10.1080/14656566.2019.1589452

Anti-inflammatory effect of tadalafil, a phosphodiesterase 5 (PDE5) inhibitor, in autoimmune prostatitis
Biochemical and immunohistochemical analyses using an inflammation-related proteome assay and immunostaining showed decreased levels of M-CSF, TREM-1, TIMP-1, CCL2, CCL3 and CXCL2 in tadalafil-treated mice compared with control mice.
Tadalafil has an inhibitory effect on tissue fibrosis and decreases cytokine levels after an inflammatory response. These results suggest that PDE5 inhibitors might be effective as therapy for prostatitis.
https://kwmed.repo.nii.ac.jp/records/3022

In this study, focused on the prostate, we examined the effect of tadalafil on the pathological changes and inflammatory factors in a rat nonbacterial prostatitis (NBP) model.
In the NBP group, the stroma-to-epithelium (S/E) ratio in the ventral prostate was significantly higher than in the control group. In the NBP-tadalafil group, the S/E ratio was significantly lower than in the NBP group. The macrophage levels and the extent of T-cell infiltration in the NBP-tadalafil group were significantly lower than in the NBP group. Compared with the NBP group, tissue concentrations of inflammatory cytokines, such as tumor necrosis factor-alpha, interleukin-8, and interleukin-1beta, were significantly downregulated in the NBP-tadalafil group.
Tadalafil suppressed stromal predominance and showed anti-inflammatory effects in a rat NBP model in association with downregulation of inflammatory cytokines.
Single or repeated dosing with tadalafil improves prostate hypoxia in spontaneously hypertensive rats. In the prostate of rabbits fed a high-fat diet, chronic tadalafil treatment produces inhibition of inflammation, fibrosis, and hypoxia.
IL-8 also seems to be a key mediator in human BPH: its concentrations in prostatic secretions from patients with BPH accompanied by inflammation are higher than in patients with BPH alone.
The latest evidence on the pathophysiology of LUTS/BPH has provided the rationale for use of PDE5-Inhibitors, which bring about improvement of LUT oxygenation, smooth muscle relaxation, negative regulation of proliferation, transdifferentiation of LUT stroma, and reduction of bladder afferent nerve activity.
It has been hypothesized that PDE5-Is could reduce inflammation and the associated fibrosis and improve oxygenation in the human prostate and bladder, with normalization of prostatic and bladder structural anatomy and physiologic activity.
https://link.springer.com/article/10.1186/s12894-019-0525-x

[demografx]

Thank you, Progecitor!

[Poiscurse]

At POIS onset, I take 20mg of Cialis - - (double my normal dose).

Forum member Animus - - who underwent successful surgery for POIS - - and I share similar POIS theories: semen re-generation problems cause POIS.

Since TRT (my main POIS treatment) and Cialis stimulate arousal, I believe that - -
in turn - - the chemical stimulation of Cialis hastens my healthy semen re-generation.

Dear Demografx,

Can you please elaborate on the semen re generation problem theory.

[demografx]

Dear Demografx,

Can you please elaborate on the semen re generation problem theory.

In my case (just my hunch since the forum began in 2007) I believe that the sluggishness of my semen re-generation, i.e., building back up of the semen supply after it’s been depleted via sex - - is somehow associated with my POIS: a very slow semen replenishment. During the refractory period.

In turn, I think that my weekly testosterone boost and Cialis at the time that my POIS begins , pushes my body into a more rapid, and therefore healthier restoration of semen, causing fewer POIS symptoms.

[demografx]

At POIS onset, I take 20mg of Cialis - - (double my normal dose).

Forum member Animus - - who underwent successful surgery for POIS - - and I share similar POIS theories: semen re-generation problems cause our POIS.

Since TRT (my main POIS treatment) and Cialis stimulate arousal, I believe that - -
in turn - - the chemical stimulation of Cialis hastens my healthy semen re-generation.

This continues to work for me!

Recently did a 6-month treatment review with my POIS medical team. When I explained my theory above, it was deemed reasonable by their NP-C.

It’s about time! (I just recently turned 78).

I just “survived” 2 POIS events in 2 days, without horrendous symptoms!

My POIS medical team’s NP-C just explained to me why Cialis might be responsible for greatly reducing one of my most distressing POIS symptoms: in POIS, all 10 of my fingertips’ nerve endings go “haywire” and cause me great psychic agony (hard to explain fully). Decades of mental pain, including useless treatment from a self-styled local “King of Dermatology” were…futile.

The NP-C explained to me that Cialis IMPROVES NERVE CONDUCTION!

That simple? Happy ending? Time will tell!

[Muon]

The NP-C explained to me that Cialis IMPROVES NERVE CONDUCTION!

NEVER TRUST AN NPC! 

[demografx]

The NP-C explained to me that Cialis IMPROVES NERVE CONDUCTION!

NEVER TRUST AN NPC! 

Why? (Can’t tell if you’re joking).

[Muon]

I was joking, I referred to a Non-Player Character. Needed some laughs.

[demografx]

I was joking, I referred to a Non-Player Character. Needed some laughs.

[demografx]

[TRT + Cialis Update]
…I just “survived” 2 4 POIS events in 2 5 days, without horrendous symptoms!…

[demografx]

Edited

…Another interesting experiment could be the combination of Aspirin and Tadalafil [Cialis]…

Interesting, Progecitor!

Can you say more? (I take a nightly dose of 81mg aspirin per my cardiologist).

Of course I can't claim this combination to be necessarily useful, only that there are some empirical indications that it may be. It is even more difficult to say why it works exactly…

In my case, the tadalafil (Cialis) - - taken in the first 2-3 days of POIS - -  improves nerve conduction

And that improvement, I believe, reverses a lifetime of one of my absolute worst POIS symptoms: all 10 fingertips became grossly “flared-up”, inexplicably causing me severe mental anguish.

My dermatologist told me that there are hundreds of thousands of nerve endings in our fingertips! (But sadly, my seeking dermatology/POIS treatment in the past proved to be futile).

To younger POISers: don’t give up. I’m 78 and just now might finally have found some additional POIS relief! (Testosterone is still my main POIS treatment, which I “discovered” for POIS - - as a result of this forum - - only when I was already in my 60’s).

But we are all much more fortunate today with POIS support!