Author Topic: Testosterone  (Read 217957 times)

demografx

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Re: Testosterone
« Reply #700 on: April 17, 2021, 06:30:36 AM »
Great to hear, joelawerence!
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

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Re: Testosterone
« Reply #701 on: April 17, 2021, 06:33:59 AM »

There is also a bit of Chicken and Egg scenario here. Is the Low Testosterone causing POIS or is POIS causing Testosterone to become low  ???


Interesting, joelawerence!

Never thought of it that way.

Demo
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

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Re: Testosterone
« Reply #702 on: May 07, 2021, 03:42:33 AM »



With my newfound 30-day supply of TRT patches, I continue my old POIS treatment regimen.

It’s still working for me: today is POIS Day Zero (POIS symptom onset began this morning).

For details, read my recent posts at this Testosterone thread. I have been using this protocol (TRT + Benadryl - note: a Benadryl side effect for me is nightmares for the last 10 years.

Can it work for you? That’s for you and your doctor to explore. We are all different.

This continues to work for me. But...I slept 17 hours - Benadryl-aided - since last night, plus “rested” the rest of today. Sleep for me is extremely effective, but I’m retired, so everyone can’t easily do this. I’m lucky in that respect. But not so lucky in my decades of working!

• I do not exceed Benadryl’s published dose guidelines.

But you should be aware of some risks, e.g.,
Benadryl’s increased dementia risk
in this Harvard Medical School article:

https://www.health.harvard.edu/blog/common-anticholinergic-drugs-like-benadryl-linked-increased-dementia-risk-201501287667

• I work closely under my endocrinologist’s supervision. I recently asked for - and received - an increase in TRT dosage. But only after a new blood test which confirmed my still-low T.

• After many failed attempts, it was only the guidance of this forum’s predecessor, Naked Science Forum/POIS thread, that led me to a successful treatment.
« Last Edit: May 07, 2021, 10:42:59 PM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

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Re: Testosterone
« Reply #703 on: May 10, 2021, 11:11:58 AM »




One doctor’s opinion:

Unpacking the Dangers of TRT
(Testosterone Replacement Therapy)


Before approaching testosterone replacement therapy, I also strongly believe men should look into natural ways to increase their testosterone. This begins and ends with losing weight, as we already mentioned, but here are a few more methods to consider.

By Dr. David Samadi 152, Contributor
HuffPost [blog]
https://tinyurl.com/86t9mhuv

« Last Edit: May 10, 2021, 11:17:31 AM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

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Re: Testosterone
« Reply #704 on: May 11, 2021, 06:52:51 PM »
My feeling of the ups & downs of being...

IN-POIS vs. OUT-OF-POIS
IN-POIS vs. OUT-OF-POIS
IN-POIS vs. OUT-OF-POIS
Repeat above year after year in-and-out-of-POIS...since you were a teenager!



« Last Edit: May 11, 2021, 06:56:23 PM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

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Re: Testosterone
« Reply #705 on: June 19, 2021, 12:47:44 PM »

2 cortisone shots to my feet yesterday (pain from metatarsal stress).

Today: shots seem to have helped my POIS?!?!

Could be placebo effect. Will update this when I feel I “know” more.
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

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Re: Testosterone
« Reply #706 on: July 02, 2021, 09:36:43 AM »


Sleep study last night. As expected (this was my 2nd study), I showed severe sleep apnea

Improved POIS symptom relief (took regular dose of 6mg testosterone & Tylenol PM - - includes 50mg Benadryl - - right before study)

Slept better than in YEARS. Mood lifted. Chronic fatigue lifted as well.

Resisted mask wearing for years. Now ready to wear it!!
« Last Edit: July 02, 2021, 10:36:54 AM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

amstro

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Re: Testosterone
« Reply #707 on: July 16, 2021, 01:36:19 PM »
Hi,

I'm trying to find an endocrinologist who would like to take me (the one I saw basically gave up on the second appointment asking me to see a sexologist and didn't charge me).
I got normal levels of "free testosterone" but didn't get the serum testosterone tested.

I wonder if some of us suffer from POIS not because of a lack of testosterone but because of an issue with androgen receptors.
A study in rats (study and sci-hub unlocked version) showed that sexual activity decreased "androgen receptor density (ARd) in the medial preoptic area (MPOA) and in the ventromedial hypothalamic nucleus (VMH), but not in the bed nucleus of the stria terminalis (BST)".

So the theory would be that POIS can be the result of two different mechanisms:
A) Patient has a low testosterone level, but still high enough not to provoke symptoms. However, after ejaculation, the androgen receptor density decreases. Low testosterone * low receptor density -> POIS

B) Patient has normal testosterone level but ejaculation decreases the androgen receptor density more than usual. Normal testosterone * very low receptor density -> POIS

Type A) and B) POIS could both be cured by increasing testosterone level (Normal testosterone * low receptor density -> still OK / High testosterone * very low receptor density -> still OK).

Muon

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Re: Testosterone
« Reply #708 on: July 16, 2021, 01:43:49 PM »


Sleep study last night. As expected (this was my 2nd study), I showed severe sleep apnea

Improved POIS symptom relief (took regular dose of 6mg testosterone & Tylenol PM - - includes 50mg Benadryl - - right before study)

Slept better than in YEARS. Mood lifted. Chronic fatigue lifted as well.

Resisted mask wearing for years. Now ready to wear it!!

You should compile this info in a personal thread/summary. People are unable to get a proper overview of your case. you could copy and dump it in that thread.

demografx

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Re: Testosterone
« Reply #709 on: July 16, 2021, 04:01:19 PM »
You should compile this info in a personal thread/summary. People are unable to get a proper overview of your case. you could copy and dump it in that thread.
This testosterone thread basically tells my story. People have been fine with the overview, simply by skimming it.

Thanks.
« Last Edit: July 16, 2021, 04:03:27 PM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

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Re: Testosterone
« Reply #710 on: July 28, 2021, 07:16:04 PM »
My most recent testosterone results (last week)

Component   Value   Ref Range & Units   Status

Sex Hormone Binding Globulin   25   11 - 80 nmol/L   Final

REFERENCE INTERVAL: Sex Hormone Binding Globulin


Testosterone, LC-MS/MS   187   300 - 720 ng/dL   Final

REFERENCE INTERVAL: Testosterone, LC-MS/MS


Testosterone, Free LC-MS/MS   35.6   47.0 - 244.0 pg/mL   Final

To convert to pmol/L, multiply pg/mL by 3.47

Note from my old endocrinologist’s office
(who has moved to another city)

Dear Demografx,

I am covering for [the endocrinologist who has left my city] since she is no longer with [our Medical Group]. Your testosterone levels are still low with the increase in dose of the patches [to 6mg/day Androderm]. You might need to change the type of testosterone you are using or increase the dose further. You can discuss this in your upcoming appointment with [my new endocrinologist].

Let me know if any questions.
Sincerely,

Dr. XYZ

 
« Last Edit: July 28, 2021, 07:27:21 PM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business