Post Orgasmic Illness Syndrome (P.O.I.S.)
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September 21, 2019, 12:09:01 PM

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+  Post Orgasmic Illness Syndrome (P.O.I.S.)
|-+  POIS Cause/Treatment Discussions
| |-+  Hormonal Causes and Treatments
| | |-+  Testosterone
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: Testosterone  ( 154186 )
Vandemolen
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« #405 : July 19, 2019, 10:19:24 AM »

Something weird happened. In my latest test my testosterone was 29! In the last 10 years it was always around 10. But I took those previous tests in the afternoon. The latest test I did was at noon. I know there is a difference between a test in the morning and the afternoon. But so big?
Does anybody have an explantion for this? The tests were at the same hospital. Can there be such a big difference in testossterone at the end of the morning and the afternoon? There were only a few weeks between the two tests. And both were out of POIS.

POIS since 2000. Very bad since 2008. I knew that I have POIS since June 2010. Desensitization since March 2011. I stopped with desens in July 2016. I have 50% less POIS. And only 1 day of POIS. Purified CBD works for me, but I am allergic for CBD.
Muon
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« #406 : July 19, 2019, 10:30:28 AM »

Something weird happened. In my latest test my testosterone was 29! In the last 10 years it was always around 10. But I took those previous tests in the afternoon. The latest test I did was at noon. I know there is a difference between a test in the morning and the afternoon. But so big?
What is your doctor's opinion on this?
Vandemolen
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« #407 : July 20, 2019, 09:12:59 AM »

I saw the results of the bloodtest on the website of the hospital. The doctor will call me next week.

POIS since 2000. Very bad since 2008. I knew that I have POIS since June 2010. Desensitization since March 2011. I stopped with desens in July 2016. I have 50% less POIS. And only 1 day of POIS. Purified CBD works for me, but I am allergic for CBD.
Muon
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« #408 : July 21, 2019, 01:09:38 PM »

Check this review article Demo, very interesting overview especially table 2.
The Anti-Inflammatory Effects of Testosterone

Adipokines are increased in men with low T. These are pro-inflammatory. TRT lowers these cytokines. I wonder if leptin and/or adiponectin play a role in pois. Leptin also regulates hunger/appetite which vanishes in POIS for me.

https://en.wikipedia.org/wiki/Adipokine
https://en.wikipedia.org/wiki/Leptin
demografx
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« #409 : July 21, 2019, 03:06:39 PM »

Muon, thanks, the anti-inflammatory aspect of T is intriguing!

10 years of major POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks associated with it.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business.
Muon
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« #410 : July 22, 2019, 04:21:36 AM »

This still doesn't explain POIS. However Leptin does affect the adaptive immune system. It inhibits the proliferation of FOXP3+ Treg cells. Low values of these cells changes your immune tolerance and cause autoimmune disease. TRT--->lowers leptin--->stops inhibition of Tregs--->improves POIS (I'm making assumptions here of course). TRT also works directly on Tregs and can stimulate proliferation via androgen receptors. Leptin also crosses the BBB and is able to cause cognitive symptoms.

Leptin and Inflammation
demografx
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« #411 : August 20, 2019, 02:49:15 PM »

Just slept 15 hours (much of it Benadryl-induced) trying to “shake off” POIS - - also doubled my TRT dose. Combo not 100% but it helps. Downside: shaking off the sleepiness.

Yesterday (Day Zero) was a very similar routine.

After many DECADES of POIS garbage, I’m hoping for a cure in my lifetime. Medical Research World: please hurry!!
:) :)
« : August 20, 2019, 08:31:21 PM demografx »

10 years of major POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks associated with it.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business.
demografx
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« #412 : September 12, 2019, 10:16:42 PM »

Today, POIS Day Zero, felt like a POIS “cure”. No symptoms! Not completely sure why.

This morning I took enough Benadryl to give me a fair amount of
forced daytime sleep (1st 1/2 of my POIS-onset treatment strategy).
Before nodding off I took...TOO MUCH TESTOSTERONE. (EXTRA TRT is the 2nd 1/2 of my onset treatment strategy).
I called my pharmacist and she confirmed that I shouldn’t take more than 6mg TRT. I took 8mg, plus I was only halfway through yesterday’s TRT dose cycle. My “normal” dose (out-of-POIS) is 4mg/day. Every single day of the year I’m “on” TRT.

Needless to say, I recommend overdosing TO NO ONE!! Next time I will stick to the medical guidelines. I’ve had emergency open heart surgery and a near-fatal diverticulitis attack, so I’m not taking chances.

I kept my appointments, which I normally cancel on Day Zero & Day 1.

My mental attitude this morning was better than normal.

« : September 13, 2019, 08:05:34 PM demografx »

10 years of major POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks associated with it.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business.
Vandemolen
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« #413 : September 16, 2019, 08:18:19 PM »

Something weird happened. In my latest test my testosterone was 29! In the last 10 years it was always around 10. But I took those previous tests in the afternoon. The latest test I did was at noon. I know there is a difference between a test in the morning and the afternoon. But so big?
My urologist could not explain why my testosterone was so high. I will have a new bloodtest about a month. When it is high again then my testosterone is ok. When it is low again, then I will get a medicine to raise my testosterone. I also will have a semen and a urine test to check if I have a UTI.

POIS since 2000. Very bad since 2008. I knew that I have POIS since June 2010. Desensitization since March 2011. I stopped with desens in July 2016. I have 50% less POIS. And only 1 day of POIS. Purified CBD works for me, but I am allergic for CBD.
b_jim
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« #414 : September 17, 2019, 01:49:22 PM »

I guess the nurse taking your blood for the test was very sexy :)


Taurine = Anti-Pois
demografx
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« #415 : September 17, 2019, 02:35:36 PM »

I guess the nurse taking your blood for the test was very sexy :)

;D ;D
- - - - - - - - -

b_jim, when my urologist’s nurse first submitted my blood for testosterone long ago, she incorrectly marked my case as “Female”!!!!

Talk about dumb, skewed results!!! ;D


Switching from urologists to endocrinology was my ticket to far better POIS help!!
« : September 18, 2019, 12:27:14 AM demografx »

10 years of major POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks associated with it.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business.
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