Testosterone

[demografx]

It’s Day Zero and I’m (90%) POIS-free.

We can hardly call it 90% when groggy, loopy and “out of it” from too much sleep and drugs!

Therefore, I’m sticking to the much simpler solution (what I said directly above this post).

This time around I once again chose the groggy-loopy-out-of-it existence.

I prefer that to even MILD POIS symptoms!

Best wishes to all,
Demo

[demografx]

Today is Day 3 (POIS starts for me on “Day Zero”) and I’m POIS-free but still groggy from all the extra meds & sleep.

I’m writing this to remind myself next time to *carefully* evaluate all the “extras” vs. just living with a little more POIS.

Demo
Still Experimenting!

[joelawerence]

Today is Day 3 (POIS starts for me on “Day Zero”) and I’m POIS-free but still groggy from all the extra meds & sleep.

I’m writing this to remind myself next time to *carefully* evaluate all the “extras” vs. just living with a little more POIS.

Demo
Still Experimenting!

Hi Demo, exactly! No matter what medicine it will have some side effects, so keeping it to a minimum or right level is always advisable. So I would advise, stay with your recommended dosage and not take extra meds. Go for the extra sleep by all means

[demografx]

joelawerence, thank you very much! I really appreciate that confirmation.

The extra sleep has been induced by Benadryl plus NSAIDS (Aleve), and they have side effects, too.

Plus, even if I forced extra sleep without drugs, the added grogginess is still not worth it.

So, I’m gonna try to live-with-a-little-more-POIS!

This is one reason I’m personally in favor of trying COLM_2’s non-drug Vagus Nerve Stimulation approach. After all, this POIS treatment approach was hypothesized by one of the world’s leading authorities in Orgasm Research, Dr Barry Komisaruk!

[demografx]

I think TRT can benefit SOME poisers with normal testosterone levels. This needs to be tested under controlled conditions.

From another thread:

I  convinced my first urologist about POIS and he gave me [testosterone] injections.

Here’s the full story. Many years ago, desperate about my POIS, I made many contacts, sex experts on Larry King Live, etc. at that time, and I contacted a Czech sexologist, Dr Petr Weiss, by telephone, about my POIS and he seemed to know EXACTLY what was wrong with me! He said, he actually thundered over the phone “You need testosterone!” I thought, ‘is this guy a quack?’ (He didn’t ask about my T-levels!) but...I was desperate...so I went to my urologist, and I had normal T-levels (the lab also mis-labeled me as female!!) but I said to him (the urologist), “Look, I know all about POIS! (I had the confidence instilled in me by Dr Weiss) And I...need...testosterone!!”. So he gave me injections. At first they helped but then stopped working. A few years later (2008), this forum convinced me POIS was a hormonal issue, and a Harvard PhD. biochemist friend who pioneered some AIDS treatments, convinced me that I should see a University-based endocrinologist (he said universities are more research oriented and might be more sympathetic to the poorly-understood POIS). So I did that, had a full range of hormone tests done, plus a brain scan, and was tested with low-FREE-T, diagnosed with hypogonadism, and was convinced to use testosterone patches or cream - not injections - because they are more in sync with the way the body naturally manufactures testosterone, on a smoother 24/7 basis rather than “spiking” in and out of the system, which is what injections do, according to this endo. You can read the rest of my profile story below

[b_jim]

Today I'm on Day 1 (without taurine, nothing). Today I make a normal work day.
And this morning, I felt tired and I asked myself "Damn, why I have low energy today ?!"
I forgot I had orgasm yesterday
Anyway, it's positive because I have less anxiety to do my job than in the past

But if not flu-like symptoms, only low energy makes me think testoterone fluctuation after ejaculation might be a starting point of all.

[demografx]

b_jim, I think that you & I learned in the early days of The Naked Scientists forum, that there is probably a precipitous drop in testosterone immediately as POIS begins.

[b_jim]

yes... dispite it doesn't appear in my bloodtest : after 5 ejaculations  the days and hours before, total T is normal and free T is normal.
But blood test might be non-representative of the levels in other areas of body.

[demografx]

Interesting, b_jim!

[demografx]

b_jim, maybe the TNS hypothesis of T-drop @ POIS onset is wrong?

“Testosterone is linked to your sex drive, whether you're male or female. It's known to have a more direct effect on the male sex drive. T levels naturally rise during masturbation and sex, and fall to normal levels after orgasm. ... This means that T levels don't get lower the more you masturbate.Jan 24, 2018”
https://www.healthline.com/health/masturbation-and-testosterone#research

emphasis mine - Demo

[demografx]

I forgot I had orgasm yesterday

I always want to forget!!

[Nas]

I think therapy is the judge of the role of testosterone. TRT raises testosterone levels which induces a mechanism that needs to be further investigated. What happens when testosterone levels rise and how does that relate to POIS?

[demografx]

I tried to get my testosterone manufacturer (Watson Pharma at the time) to fund a study that would address similar questions. I was unsuccessful. We’re too small a market for them.

[Vandemolen]

I think therapy is the judge of the role of testosterone. TRT raises testosterone levels which induces a mechanism that needs to be further investigated. What happens when testosterone levels rise and how does that relate to POIS?

I think testosterone prevents you for having anxiety. I had POIS like symptoms after taking medicines that causes anxiety like Temazepam and Amitryptiline. So I am not saying POIS is a mental issue. It has to do with the brain and hormones are involved. I think I have a burn out. My POIS now is far worse then when I was relaxed. So in my case cortisol is involved. Cortisol has an interaction with testosterone.

[Nas]

I think testosterone prevents you for having anxiety. I had POIS like symptoms after taking medicines that causes anxiety like Temazepam and Amitryptiline. So I am not saying POIS is a mental issue. It has to do with the brain and hormones are involved. I think I have a burn out. My POIS now is far worse then when I was relaxed. So in my case cortisol is involved. Cortisol has an interaction with testosterone.

I mean, I did take Ketoconazole but it didn't do anything. Note that ketoco also decreases testosterone, and when I took the 800mg dose I felt lacking in energy and harder for me to concentrate.

[Vandemolen]

I also have a very think skin. Since the last 6 months all the time. Before only when I was in POIS. After googling think skin I read that people with low testosterone have a thin skin. I might be that at POIS-patients the testosterone drops very fast after sex. Maybe that is also why we are feeling down when in POIS. Feeling a bit down also brings testosterone down. So there is a double effect. My testosterone level dropped in 3 years from 12 to 9. Maybe also because in the last 3 years I used Amitryptiline against ithching skin, but it is a SSRI. SSRI brings testosterone down.

[Vandemolen]

My testosterone dropped to 8 now! I was unlucky because the internist is specialized in diabetes, not in hormones. So he did not want to give me TRT. He is going to talk with his collegue if I can test Androgel. Testosterone should be at least 12. And I have a lot of symptoms. If the internist does not want to give me TRT I will go to a men’s clinic.

[demografx]

For POIS?

[Vandemolen]

First I want TRT to get rid of the hot flashes and the POIS like state I am in for 6 months. If I am better I will test it for POIS. Maybe it will help me also against POIS.

[demografx]

Thank you for keeping the priority on...POIS.