The Taurine laboratory

[Warrior]

My functional medicine specialist today recommended to do a gallbladder/bile experiment, to take 2-5g/d of taurine, along with fresh broccoli sprouts 2-5 Tblspns/d, Tru Fiber by Master Supplements, Dandelion leaf/root, and SAM-e 400mg x 2/d on the basis (if I'm correct from memory) that it may improve POIS by helping with the detox of fat-soluble toxins.

He also reiterated that taurine is very safe.

Hi Warrior.  It sure sounds like a liver detox program.   Back in 2017, I posted here about my liver detox program, and how it helped me lower my POIS symptoms. See the thread at https://poiscenter.com/forums/index.php?topic=2431.msg20521#msg20521

Very interesting. Thanks for sharing!

[b_jim]

Hi all, I hope you are fine and you got some positive evolutions.
I'm less present on the forum :/
Warrior I'm really happy to read your  experience with taurine.
The Question is : does taurine work with detox or metabolic pathway ?

I"m currently trying to prove my Pois is a metabolic problem and then trying to repair all the methylation way from sulfur to amino-acids like taurine.
Luckily I like onions, leeks and garlic

[b_jim]

Several months later I'm not conviced that sufur helps Pois.
But it seems vitamin C/ D /magnesium + taurine works better than taurine only.

Is it all about testosterone ?

[b_jim]

Drop of nitric oxide (NO) ?
Taurine might boost NO level. Green tea polyphenol too (Epigallocatechin gallate).
White sugar seems to reduce level.
NO and premature ejaculation.

[demografx]

Drop of nitric oxide (NO) ?
Taurine might boost NO level. Green tea polyphenol too (Epigallocatechin gallate).
White sugar seems to reduce level.
NO and premature ejaculation.

b_jim, very interesting!

[b_jim]

I'm very optimistic about nitric oxid theory !
Everything that increase NO seems to decrease my Pois.

[demografx]

I'm very optimistic about nitric oxid theory !
Everything that increase NO seems to decrease my Pois.

Excellent, b_jim!

[Andre2505]

I throw it there.
I believe that at least in a part of sufferers the p.o.i.s is the consequent response to an excitatory state (endorphins and other pleasure-related neurotransmitters) EXTREMELY amplified compared to the average. I think of the mental fog and the overwhelming sensation of celestial bliss, my almost UNIQUE symptoms. Has anyone ever tried DEPRESSIVE agents as a cure? Greetings from Italy.
 
Maestro Stefano Petrini

Ciaoo anche io sono Italiano

[b_jim]

I try to increase legumes consumption (lentils, chickpeas...) and decrease meat (too much iron)
This creates symptoms of depression in and out of Pois.
The weakness of legume is the lack of methionine/taurine.
I

[b_jim]

Cysteine dioxygenase is essential for mouse sperm osmoadaptation and male fertility


Abstract

Sperm entering the epididymis are immotile and cannot respond to stimuli that will enable them to fertilize. The epididymis is a highly complex organ, with multiple histological zones and cell types that together change the composition and functional abilities of sperm through poorly understood mechanisms. Sperm take up taurine during epididymal transit, which may play antioxidant or osmoregulatory roles. Cysteine dioxygenase (CDO) is a critical enzyme for taurine synthesis. A previous study reported that male CDO?/? mice exhibit idiopathic infertility, prompting us to investigate the functions of CDO in male fertility. Immunoblotting and quantitative reverse transcription-polymerase chain reaction analysis of epididymal segments showed that androgen-dependent CDO expression was highest in the caput epididymidis. CDO?/? mouse sperm demonstrated a severe lack of in vitro fertilization ability. Acrosome exocytosis and tyrosine phosphorylation profiles in response to stimuli were normal, suggesting normal functioning of pathways associated with capacitation. CDO?/? sperm had a slight increase in head abnormalities. Taurine and hypotaurine concentrations in CDO?/? sperm decreased in the epididymal intraluminal fluid and sperm cytosol. We found no evidence of antioxidant protection against lipid peroxidation. However, CDO?/? sperm exhibited severe defects in volume regulation, swelling in response to the relatively hypo-osmotic conditions found in the female reproductive tract. Our findings suggest that epididymal CDO plays a key role in post-testicular sperm maturation, enabling sperm to osmoregulate as they transition from the male to the female reproductive tract, and provide new understanding of the compartmentalized functions of the epididymis.

- Lack of taurine is a factor of infertility
-  Cysteine dioxygenase is important for taurine synthesis.
- Taurine is "pumped", absorbed by sperm in the épithélium of the testicules.
- The lack of taurine/CDO causes abnormal spermatozoons morphology.