Author Topic: Things we would like to be able to tell Dr. Komisaruk  (Read 56409 times)

Bizzy

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Re: Things we would like to be able to tell Dr. Komisaruk
« Reply #80 on: September 03, 2015, 12:42:46 PM »
Hi Outsider

If you read my above post carefully, im suggesting that antihistamines may actually cause this condition by upregulating the histamine system. What happens if you block histamine receptors ?, if your lucky then just the blockade, but if not then your cells can begin to upregulate over time, making you a lot more sensitive to histamine. So you begin to develop a pathalogical disease of the very kind that you were trying to prevent with the use of antihistamines. What I have just told has actually been seen in animal studies with regards to increased sensitivity, which brings into question, did drug companies know this when they were marketing the classical antihistamines back in the 1960s and 70s.
Work done by Dr David Healy has shown that drug companies have selectively chosen to hide clinical data, in order to help market new drugs in a better light. It is upto the FDA and MHRA to ensure a system where nothing is hidden when it comes to clinical trial data. When this kind of data is manipulated, its like stealing billions from the public, its white collar crime of the highest level.


Bizzy
« Last Edit: September 03, 2015, 01:03:04 PM by Bizzy »

Quantum

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Re: Things we would like to be able to tell Dr. Komisaruk
« Reply #81 on: September 04, 2015, 08:33:09 AM »
Hi Outsider

If you read my above post carefully, im suggesting that antihistamines may actually cause this condition by upregulating the histamine system. What happens if you block histamine receptors ?, if your lucky then just the blockade, but if not then your cells can begin to upregulate over time, making you a lot more sensitive to histamine. So you begin to develop a pathalogical disease of the very kind that you were trying to prevent with the use of antihistamines. What I have just told has actually been seen in animal studies with regards to increased sensitivity, which brings into question, did drug companies know this when they were marketing the classical antihistamines back in the 1960s and 70s.
Work done by Dr David Healy has shown that drug companies have selectively chosen to hide clinical data, in order to help market new drugs in a better light. It is upto the FDA and MHRA to ensure a system where nothing is hidden when it comes to clinical trial data. When this kind of data is manipulated, its like stealing billions from the public, its white collar crime of the highest level.


Bizzy

Hi Bizzy,

I totally understand your trust issues toward Big Pharma.  They are not angels floating in the sky, only willing the good of humanity - they are corporations, and they are in for profit.  However, it is up to every individual to get good information, which is available, and to make up is own mind, and medication in general can be very useful tools.  It may take time and is not always easy to make an informed opinion about a specific drug, but it worths it.  You can ask questions to your physician, your pharmacist, and any other health professional, you can add in the opinion of alternative health advisers, and make up your own mind.  Ultimately, once we are adults, we are the one who choose or not to swallow the pill.

The best way to avoid upregulating or downregulating from a drug or supplement is not taking it on a daily and regular basis, but only when needed. That prevent our body, which is alive and constantly adjusting itself to the situation, to create a new baseline level of anything through a constant exposure to a particular drug.  However, it is not possible in any medical condition - it wouldn't be appropriate to treat high blood pressure or diabetes in an on and off regimen.  But in the case of POIS, it is possible to time the prevention and treatment, as POIS is not a chronic, constant condition.   

That is why I currently do not take any supplement for POIS on a daily basis, but use pre-pack and post-packs, before and after release time.

As a side note, to clarify what I have just written above about POIS not being a constant condition, I have already express my opinion that a chronic, constant POIS lasting 365 days a year is not a POIS case only, but another chronic condition is hiding behind POIS.  I stick to Dr Waldinger criteria, that POIS is a self-limiting syndrome that usually disappear a week or so after ejaculation ( less for some, longer for others).  When no release and no NE for weeks, POIS symptoms should not be present, and if they do, my opinion is that another chronic disease or syndrome is also present ( like depression, CFS, inflammatory bowel issues, or others ), and need to be diagnosed.  Of course, if you have release every few days, POIS cycles are so near from one another that POIS becomes a chronic constant state, but that's not what I am referring to, obviously.

« Last Edit: September 04, 2015, 08:38:24 AM by Quantum »
You are 100% responsible for what you do with anything I post on this forum and of any consequence it could have for you.  Forum rule: ""Do not use POISCenter as a substitute for, or to give, medical advice" Read the remaining part at http://poiscenter.com/forums/index.php?topic=1.msg10259#msg10259

Bizzy

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Re: Things we would like to be able to tell Dr. Komisaruk
« Reply #82 on: September 06, 2015, 04:55:52 PM »
Hi Quantum

My above post was very specific with regards to pharmaceutical companies, its not about a broad 'mistrust'. When I say classical antihistamines, im refering to antihistamines that are currently commonly in use to suppress allergies. I am quite certain in my mind that theres a problem with histamine upregulation with their use, though there should be a genetic variance to this susceptability.

Bizzy
« Last Edit: September 06, 2015, 05:05:51 PM by Bizzy »