Thank you for your information and your response. Today feeling slightly better. Maybe i will try increasing MACA dosages. I doubt it can cause any damage.
Also i see many POISers have such a symptom as exercise intolerance. Can you elaborate more on what that is? Is it just muscle fatigue? Because i kinda feel weak when trying to lift dumbbells at first(when i have cold feet, cold hands, almost what i call muscle refusal) but i know that in 100% cases it helps if i push myself through this state, become warmer and eventually warm myself enough to feel energy.
Also, this is w little bit strange but when i start lift i feel like its impossible to lift even one time. I feel like i just don't have energy. But after every time my muscles become more and more energized or what, idk how to explain.
And did you try this method? Hard, physical exercise. I usually help myself with a lot of hot, really hot tea. As i always said my body temperature is always 100% connected with the severity of POIS symptoms.
And last question: do you have a recommendations, any piece of advice on anything which will help with mental symptoms? Especially with anxiety. But also with saving mental clarity. Not like benzos. They just pretty much put me into a 1-5% consciousness mode. Almost like a sleep.
Alcohol also seems to kinda help(even overall on some POIS symptoms. ) But it's a sedative. Same type of dealing with POIS.
Also, progecitor, do you have something that gives you a persistant, consistant and significant result(significant relief, 80-90 or even 100% symptom relief)? I`ve read your posts. I`ve seen your Summary and your list of what helps. Does all of that back your theory up? And is this your theory or is it NORD theory? Where can i check current NORD experiments data?
And have you tried anti-depressants or benzos? Or weed?
Sorry for a stupid questions.
Regarding your question about exercise intolerance. I have a kind of ever present muscle pain/fatigue, especially in my thighs that gets more noticeable when I move around, but less so when I am only sitting and at rest. I also found that a short bout of physical exercise is beneficial for my cognition and circulation, yet even so the pain would increase. When doing physical work for an extended time though the pain would increase even more so and other POIS symptoms like bloodshot eyes and gut issues would also become worse at the same time. This would also lead to a more pronounced depression later. Similarly to you I also have problems with lifting weighs. I have less trouble when holding weighs, but when I want to lift them up, while holding them, I would experience a sudden increase in pain that would make me feel really weak and uncertain if I can hold it just another second more. Of course my colleges would often joke about how weak I am. There were periods when I had to work more than right now and I was quite muscular at some points. I could certainly hold more weighs then, however I had the same pain and lifting issues as always. I think this would suggest some energetic crisis. Nevertheless I often had to do work that was more demanding on endurance. My colleges would more often complain about it than I would ever have, but the reason may be only that I was too accustomed to the pain and at certain points I just couldn’t care anymore. I used shear willpower to survive those demanding days, but at least I had never dropped dead or fainted no matter how terribly I felt.
Yes, I also noticed that drinking warm tea would often temporary help with depression, but this would only last a few minutes at most, thus only a symptomatic aid. The same is true for taking warm baths. It is quite usual for me to take a warm bath right after O. It can help energize me, especially if the weather is cold. It would also exert a temporary inhibition on POIS and would often prevent or delay the evolution of more severe symptoms like chest inflammation. Even so I found cold water showers equally beneficial, that I prefer to use when the weather is hot. Actually I think cleanliness is more important, than the temperature of the water. I was even wondering if removing the grease from my skin would actually help in alleviating at least some of the lipid burden in my body as cholesterol lowering supplements clearly help as well.
Please could you specify which benzo drug you used and in what dosage? In the past I was also thinking like benzos are benzos and what else to say. However after reading so much about them on the site, my opinion became rather differentiated on them. The only one I took in the past is clonazepam (Rivotril) that I took for about 6 years. I had an incessant panic attack at the time and it partially helped with that, however at the same time it made practically all my POIS symptoms much worse, like I had a much stronger photophobia, muscle fatigue/pain, aphasia (incapability to recall words), short-term memory disorder. I think it also induced bloodshot eyes, but I had that practically all the time and this also happened more than 10 years ago, thus I can no longer recall the specifics. Nevertheless recently I have become convinced that lorazepam could potentially help me. Clonazepam and Lorazepam only differ in one single functional ligand and yet they have entirely opposing effects on estrogen receptor beta that I consider a key element in my problems. Quantum once said he had a 90% relief with lorazepam and he only stopped taking it due to some side-effects. I am not a proponent of taking such drugs, but this could be a significant finding in understanding POIS. The best would be to try lorazepam myself to prove such a possibility, but the doctors consistently refuse to help me and I can’t get any prescription drugs for this reason. At least I had success with most other supplements that Quantum uses, like resveratrol, lycopene, beta sitosterol, etc, thus such an association is a certain possibility. Even so others also had reactions both good and bad to other benzos like Diazepam (Valium), Alprazolam (Xanax), Temazepam, Tetrazepam and there were even members who found Clonazepam to be useful. Of course the activation of the benzodiazepine receptors would also affect us in some ways, like I was feeling really sedated in those times and my panic was probably reduced as it blunted my perception of my surroundings. There were times when the phone was ringing loudly (alarm clock) for at least half an hour beside my bed before I even came around to recognize it to be so as I was so knocked out. Regardless of the sedative effect I am pretty sure that specifically clonazepam also increased the POIS inflammation in my system.
As you can see if benzos only affected the benzodiazepine receptors we could regard them as only benzos, but these drugs are nowhere near perfect and have many off target receptors as well, which could easily produce entirely different outcomes in our sensitized state.
I have already described my experiences with the other anti-depressants as well in my post and I don’t think I could add anything else besides. Unfortunately this happened a rather long time ago and I also did not take any notes in those times, so some of my experiences are based on what I found on the official medical papers. However I remember that sometimes they would record my statements in a way that sounded to me the exact opposite to what I was originally trying to convey, so those papers aren’t reliable either.
https://poiscenter.com/forums/index.php?topic=3798.msg40401#msg40401(Ctrl+f: Psychological anamnesis)
I think I made it quite clear that most of the supplements I found to have an anti-depressive effect are in the best and good category. There is also nothing new here as most of these have been traditionally or anecdotally considered to have an anti-depressive effect. However you also shouldn’t expect any miracle either. I would often experience some kind of better mood at the peak of a drugs effect, but often it was short-lived. Supplements may also become less effective over time. Some of the supplements you could try in this regard could be Saffron, MACA (extract only), Resveratrol, Ecdysterone, Mexican wild yam root, Drotaverine, L-Tryptophan, Catuaba bark, Yerba mate, Lycopene + vit. E, Tongkat Ali, Lion’s mane, Tribulus terrestris, Phosphatidylserine, Milk thistle, Ginkgo Biloba, Fennel seed caps, Guggul, Lavender tea.
I have never smoked not even one cigarette in my entire life and especially not weed. When I was young I was in a good community that thought us how to avoid addictive and unhealthy behaviors. Later in life I had too many health issues due to POIS and I did not want to add to them by such practices. At least I had some success with CBD oil, but even that one had contained other ingredients as well. It also has to be mentioned that THC may behave much differently than CBD and some people may actually experience worsening symptoms. Another supplement to try in this regard is saffron that also affects the endocannabinoid system. By the way you should also share your experience with weed if you had any.
I am sorry to say this, but nothing has ever solved my problems more than 80%. My list reflects a partly objective and partly subjective feeling that I had experienced with each supplement in an acute setting. If you want quality information I suggest you check out the methods of other members, who claim to have succeeded more. I said so before, but my aim is to do a quantity research even if it is less reliable. I think this is the only way to find out any correlations and associations to other cases and to possibly figure out the underlying mechanism.
If you mean the theory about senescence then it is only my theory in the way that none had associated it with POIS before. However I think others did so with CFS, long covid and a number of other chronic diseases as well. Due to the convergent evidence I am rather enthusiastic about it and I wish to confirm it as thoroughly as possible.
I am in no way connected to NORD and you should turn to demografx with any such questions:
https://poiscenter.com/forums/index.php?topic=3046.msg46488#msg46488
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