I first developed POIS symptoms around age 15, and it only occured when I masturbated. When I became sexually active with girls, it didnt bother me at all. Even if I used my own hand, then placed hers on it when I ejaculated, I had no symptoms. For a while I was also able to avoid symptoms by masturbating then dry humping my bed to completion, and this lasted several years, then symptoms started again. I would find various toys that worked for some time, but after some time, every self pleasure gave me symptoms. One day at age 37 I had sex with my wife and noticed the same symptoms, and since then, I have POIS with any ejaculation. My symptoms are: tender/puffy left nipple, mood swings, sensitivity to touch, can get itchy but only when I exercise, mainly high levels of irritability and transient depression, after 2 days it self resolves.
For the life of me I can't figure out why some specific acts caused symptoms, others didnt, and progressively developed until every ejaculation became symptomatic. I tried all the supplement stacks (niacin, vitamins, antihistamines, no change). Anyone have anything like this happen to them??