Autoimmune Polyendocrine Syndromes (EXPERT OPINION)

[gzbking]

last year i had my worst medical year of my life my body i was near dying for a while and was going regularly to doctors and specialists back to back this is when i got a permission to consult with a specialist professor of rheumatology in india he was a pioneer of rheumatological research in india and is one of the leading researchers in the field, the wait was 5 months and he ordered a bunch of tests for every organ possible and a genetic test.

i recently have gotten a consult back from him and after running several tests and a detailed history he is considering a very very rare trigger for Autoimmune Polyendocrine Syndromes type disease, this is corroborated with a genetic test of gene CYP11A1 and adrenal tests over a period of couple of months. although a lot of research is needed to be done in my case to fully understand the physiology, although he is not actively working on my case anymore but if i get sick like that again he might be able to help me better i have gotten a permission to see him anytime i have an emergency hope we can get a answer very soon i just wanted to tell you guys cause it might help you too.

i am doing well my pois is well under controlled for now, i am on my drug regime as usual but a cure is what i want for the future.

[Progecitor]

If you specifically wanted to check for a possible connection to CYP11A1 activity then you could consider the following information. CYP11A1 converts cholesterol to pregnenolone which is considered to be the first step of steroidogenesis. It is also responsible for the production of 20OHD, which is an anti-inflammatory vitamin D3 metabolite. Estragole and trans-anethole may increase its activity, while omega-3 fatty acids can decrease it. Estragole can be mainly found in basil and tarragon, while trans-anethole in fennel seeds and dill seeds. Estragole is a possible carcinogen so long-term use may be better avoided. As a reference in an acute test I had noticeable success with fennel seeds and to a lesser extent with basil. Tarragon, dill seeds and fish oil were less useful, while pregnenolone was more like harmful. Of course your experience may differ as other POISers had good success with fish oils and pregnenolone as well.

Estragole and trans-anethole are considered the biologically active compounds within basil and fennel seed essential oils, respectively. Using RT-qPCR, estragole and trans-anethole were shown to significantly alter the expression of several key steroidogenic enzymes, such as those involved in cholesterol transport and steroid hormone biosynthesis, including StAR, CYP11A1, HSD3B1/2, SULT2A1, and HSD17B1, -4, and -5. In BeWo cells, CYP11A1 gene expression was significantly increased at all concentrations of estragole and trans-anethole we studied. CYP11A1 cleaves the side-chain of cholesterol to form pregnenolone; the precursor for all steroid enzymes and since we noted increased hormone production in our co-culture, it is reasonable to suggest that this effect is linked.
https://sci-hub.st/https://www.sciencedirect.com/science/article/abs/pii/S0303720719302850

Omega-3 fatty acids reduced the levels of sterol regulatory molecules in both cell types. It also reduced cytochrome 450 family member—CYP11A1, the mitochondrial enzyme that catalyzes the conversion of cholesterol to pregnenolone.
https://www.mdpi.com/2077-0383/9/5/1479

Animals and cells treated with lipopolysaccharide (LPS) exhibit infection- and infammation-induced testicular dysfunction. qRT-PCR revealed that, in MLTC1 cells, Cyp19a1 and Hsd3b3 were strongly induced after LPS treatment. In contrast, all of the enzymes (Cyp11a1, Cyp17a1, Cyp19a1, Hsd3b3 and Hsd17b4) were slightly downregulated in TM4 cells.
https://sci-hub.se/https://link.springer.com/article/10.1007/s11033-019-05196-6

During the past 5 years, there has been an increasing amount of literature on an alternative pathway of metabolism of vitamin D by a steroidogenic cytochrome P450scc, also called CYP11A1. UVB or UVC (100–280 nm wavelength) radiation upregulates this novel pathway. Recent studies have provided in vivo data demonstrating the activity of the CYP11A1 system, by identifying 20OHD as the major product of vitamin D3 metabolism by CYP11A1 in areas of the body expressing high levels of this P450scc enzyme. These organs include the steroidogenic adrenal glands, placenta and germ cells, as well as skin.
https://www.sciencedirect.com/science/article/abs/pii/S0960076014002702