Hello, I have found evidence for my POIS. Here are my datas:
After I tried Mirapexin (Pramipexole - dopamine agonist) and got same symptoms as with orgasm, it is pretty clear that my symptoms start when my levels of dopamine get high. Connecting this information with diseases of my mother and grandmother (schizophrenia), I have strong evidence that my problem is:
OVERSTIMULATION OF DOPAMINE D3 RECEPTORS IN HIPPOCAMPUS AND STRIATUM, WHICH LEADS TO EXCESSIVE GLUTAMATE RELEASE IN THE SAME PART OF THE BRAIN. Glutamate activates NMDA receptors or simply my chronic pain, which I got with infection when I was teenager. Escalating levels of glutamate can lead to overactivation of NMDA receptors, which leads to pain syndrome that I got with Mirapexine and antibiotic Ciprofloxacine, lasting for 2-3 years. When NMDA receptors are overactivating I can trigger my symptoms/pain with sitting, reading and walking.
Orgasm - increases dopamine, than drops fast (will not drop so fast if you have POIS)
Mirapexin (dopamine agonist) - increases dopamine with stimulating d3 receptors
Schizophrenia (my mother, my grandmother)- the main cause is believed to be a gene DRD3, that is encoding dopamine receptor D3
High levels of dopamine increases striatal glutamate.My EEG is abnormal:
Sharp bursts of Theta waves in centrotemporal part of the brain - Theta waves derive from
hippocampus, showing it is overactive like schizophrenic hippocampus. Theta waves affecting centrotemporal part, showing they are the reason for affecting my chronic pain. (Chronic pain connected with centrotemporal part of the brain).
My pain progressed into restless leg syndrome, shows that
caudate nucleus was affected. Caudate nucleus is strongly conected with hippocampus.
Medications:
Doctor suggested me:
Duloxetine (antidepressant medicine known as a serotonin-noradrenaline reuptake inhibitor) -
enhances glutamatergic activation, but not dopaminergic,, thats why I think it is not perfect for POIS.
Pregabaline (anticonvulsant, analgesic and anxiolytic medication used to treat epilepsy, neuropathic pain, fibromyalgia, restless leg syndrome, opioid withdrawal and generalized anxiety disorder) -
inhibiting certain calcium channels, thats why I think it would work for POIS like Carbamazepine helped in this topic
https://poiscenter.com/forums/index.php?topic=4271.msg45771#msg45771. It means it blocks NMDA receptors. Also inhibiting dopamine and glutamate.
Cariprazine ( atypical antipsychotic medication indicated for the treatment of schizophrenia and bipolar mania) -
Cariprazine acts to inhibit overstimulated dopamine receptors (acting as an antagonist), it means I would have to take this medication for whole my life, just to have normal sex. Side effects are worse as POIS, so I think it's not worth it.
I WONT TRY ANY OF THIS MEDICATIONS, BECAUSE OF PAST BAD EXPERIENCE!
You can try to check my theory with alcohol. Alcohol blocks NMDA receptors. If you drink alcohol before sex, you wont get POIS symptoms after sex. This works only once or twice in a short time (cca. 1 week)! If you do that often it wont work and POIS will get worse, because with alcohol you block only NMDA receptors and not dopamine and glutamate release, which are the main cause of your problem. Excessive glutamate will than activate your NMDA receptors (symptoms) even after light physical activity!
