List of conditions

[Muon]

The thread has been updated with hyperlinks.

The parasitic infection rate is pretty low compared to other types of infection. I know that mediators from eosinophils are toxic to parasites. I'm not aware if this is true for MC mediators as well.

[Muon]

Role of mast cells in IBS, coeliac disease and ulcerative colitis:

Coeliac Disease and Mast Cells

Mast Cells in Irritable Bowel Syndrome and Ulcerative Colitis: Function Not Numbers Is What Makes All the Difference

The role of mast cells in functional GI disorders

[Muon]

Increased mast cell counts are found in the GI tract of IBS patients. An innate anti-microbial intestinal inflammatory response can recruit mast cells to areas of inflammation via LL-37:

A cathelicidin family of human antibacterial peptide LL‐37 induces mast cell chemotaxis

Participation of mammalian defensins and cathelicidins in anti‐microbial immunity: receptors and activities of human defensins and cathelicidin (LL‐37)

Human-derived cathelicidin LL-37 directly activates mast cells to proinflammatory mediator synthesis and migratory response

Bream got increased fecal hBD2. Is this process possible in the UT as well?
β-Defensins Activate Human Mast Cells via Mas-Related Gene X2

"In a subgroup of patients with irritable bowel syndrome, a 10.7-fold change in MRGPRX2 expression was found in colon descendens biopsies"
The pseudo-allergic/neurogenic route of mast cell activation via MRGPRX2: discovery, functional programs, regulation, relevance to disease, and relation with allergic stimulation

Dumping this here as well:

A paper has been published including a Mast Cell Mediator Release Syndrome Questionnaire:

Mast Cell Activation Syndrome: A Primer for the Gastroenterologist

[Muon]

Nerve growth factor (NGF) and IBS:

"Nerve fiber density and sprouting, as well as expression of NGF and NTRK1, are significantly increased in mucosal tissues of patients with IBS. Mucosal mediators participate to these neuroplastic changes."

Nerve Fiber Outgrowth Is Increased in the Intestinal Mucosa of Patients With Irritable Bowel Syndrome

I wonder if something similar can happen to the penis, like increased nerve fiber density due to NGF leading to premature ejaculation.

[Muon]

Prevalence of chronic prostatitis in men with premature ejaculation

ORIGINAL RESEARCH?EJACULATORY DISORDERS: Chronic Prostatitis in Premature Ejaculation: A Cohort Study in 153 Men

The Frequency of Premature Ejaculation in Patients with Irritable Bowel Syndrome

"Premature ejaculation is more common in patients with IBS. Drug abuse, family history of psychiatric disorder, and severe emotional stress during the past year, significantly increase the frequency of premature ejaculation."

[Muon]

Nerve Fiber Outgrowth Is Increased in the Intestinal Mucosa of Patients With Irritable Bowel Syndrome

Endocannabinoids inhibit release of nerve growth factor by inflammation-activated mast cells

Cannabinoids cool the intestine

[Muon]

https://en.wikipedia.org/wiki/Estrogen

"Compulsions in male lab mice, such as those in obsessive-compulsive disorder (OCD), may be caused by low estrogen levels. When estrogen levels were raised through the increased activity of the enzyme aromatase in male lab mice, OCD rituals were dramatically decreased. Hypothalamic protein levels in the gene COMT are enhanced by increasing estrogen levels which are believed to return mice that displayed OCD rituals to normal activity. Aromatase deficiency is ultimately suspected which is involved in the synthesis of estrogen in humans and has therapeutic implications in humans having obsessive-compulsive disorder"

Cytokine regulation of tight junctions

Atopic irritable bowel syndrome: a novel subgroup of irritable bowel syndrome with allergic manifestations

Oral Cromolyn Sodium in Comparison with Elimination Diet in the Irritable Bowel Syndrome, Diarrheic Type Multicenter Study of 428 Patients

[Muon]

Vitamin D receptor is overexpressed in the duodenum of patients with irritable bowel syndrome

"Indeed, vitamin D deficiency might lead to increased VDR expression."

Vit D poll

[Muon]

Autonomic function/vagus nerve dysfunction in IBS: Search for keywords like Autonomic, vagus, IBS, IBD etc. Tons of papers:

https://scholar.google.com/scholar?hl=nl&as_sdt=0%2C5&q=vagus+IBS&btnG=