No POIS after this (No Solution)

[jonny88]

Hi

It's just a Information to understand POIS, do not try this. Its not legal, makes you addicted and can ruin your life!

Somebody with POIS did a Experiment with low dose Cocaine. So he had a Orgasm (without sex) while on it.
Results: On the next day, he had no POIS (0%), he felt the opposite of it, he felt good & happy. It's not the effect of the drug.
His second try: 1h after C* comedown, he had 100% POIS on the next day.

Wikipedia:

"Cocaine acts by inhibiting the reuptake of serotonin, norepinephrine, and dopamine. This results in greater concentrations of these three neurotransmitters in the brain."

So the receptors were blocked by C* that's why he didn't had POIS next day.

He tried "Ritalin" too wich got the similar effect like C* and hat 30% less POIS.

Maybe we can build on it and find another legal solution that works that way healthy.

He tried "Omega 3 fats" / "fish oil" before sex, results: He was very horny, he came very fast and had no control about it and: The POIS 30 minutes after O were much much stronger than usually. He was very depressed felt a lil bit schizophrenic.

He tried alcohol before O: 60-70% less pois next day.

[demografx]

...Maybe we can build on it and find another legal solution that works that way healthy...

Excellent idea

Welcome to POISCenter, jonny88.

[Going less Crazy]

Yes.  I can see cocaine blocking POIS symptoms as the high dopamine and especially epinephrine will cause inflammation to drastically lower.

I've experienced the same results with claritin D.  The pseudoephedrine seemed to block the inflammation attributing to pois by increasing epinephrine and dopamine.  So cocaines POIS diminishing effect is probably highly related to my claritin D experience.

[portuguese_poiser]

Alcohol is also famous for "curing" POIS . Maybe the idea of "it's all in your head" isn't wrong at all . It's just not in the way docs sell it. It's well known the relationship between alcohol and dopamine . I think the trauma and the stress i had in my childhood originated/induced some type of "deficiency" on the brain . This post deserves more attention , i'm not an expert on drugs but we should give this "cocaine" thing more attention , maybe our answer is here (just the answer for a real cure , cause coke is out of question ). It's well known that dopamine deficiency provoques a big range of symptoms . In my opinion , most of our "treatments" consist in things that have a relation with our neurology .

[Scrub]

Wow, very interesting, illegal and risky, but is clear that POIS is related to some neurotransmitter dysfunction. I'd bet on acetylcholine/dopamine disorder which causes POIS.

Drugs, diet or supplementation involving dopamine and acetylcholine boosters seems to prevent or fix POIS.

[Hopeoneday]

Yes , it did discussed alredy about that.
I got this effect from coffeine-cofee
(but unfortinatly i am intolerant on cofee).
I am "complitly different" person after cofee ingestion, helping for  MG
symptomes , my body posture became normal because nervoz system work...
We must not forget prolactin role here, when dopamine go high then
prolactine get lower.
Prolactine hawe good benefits,
but it can couse inflamation proceses
acording my resarch.

[Hopeoneday]

Wow, very interesting, illegal and risky, but is clear that POIS is related to some neurotransmitter dysfunction. I'd bet on acetylcholine/dopamine disorder which causes POIS.

Drugs, diet or supplementation involving dopamine and acetylcholine boosters seems to prevent or fix POIS.

Yes you are wright here, intresting disccusion is mentioned on russian forum, about
upregulated or downregulated receptors.

[swell]

O well, I have been taking low-dose synthetic cocaine since a decade (for my Attention deficit) with only in-direct effect on POIS.  Cocaine or amphetamines give you a euphoria (short-lived) which can "mask" POIS symptoms "temporarily" but it is no lasting solution.  Euphoria is that "very strong motivating feeling", a temporary, you gain muscle strength also, you feel like a god but long-term it retards protein synthesis and growth, which is why I have to take drug holidays. 

The most healthy solution I have found so far is T3 hormone.

Hi

It's just a Information to understand POIS, do not try this. Its not legal, makes you addicted and can ruin your life!

Somebody with POIS did a Experiment with low dose Cocaine. So he had a Orgasm (without sex) while on it.
Results: On the next day, he had no POIS (0%), he felt the opposite of it, he felt good & happy. It's not the effect of the drug.
His second try: 1h after C* comedown, he had 100% POIS on the next day.

Wikipedia:

"Cocaine acts by inhibiting the reuptake of serotonin, norepinephrine, and dopamine. This results in greater concentrations of these three neurotransmitters in the brain."

So the receptors were blocked by C* that's why he didn't had POIS next day.

He tried "Ritalin" too wich got the similar effect like C* and hat 30% less POIS.

Maybe we can build on it and find another legal solution that works that way healthy.

He tried "Omega 3 fats" / "fish oil" before sex, results: He was very horny, he came very fast and had no control about it and: The POIS 30 minutes after O were much much stronger than usually. He was very depressed felt a lil bit schizophrenic.

He tried alcohol before O: 60-70% less pois next day.

[swell]

sorry I didn't mean to undermine scope of cocaine , it could be relevant.  Now that I think of it, I do like my Adderall A LOT.  Just read that (as Going less crazy pointed out) it is a clinically significant anti-inflammatory through dopamine agonism, controls:   
NLRP3 inflammasome-dependent inflammation
neurotoxin-induced neuroinflammation
LPS-induced systemic inflammation
monosodium urate crystal (MSU)induced peritoneal inflammation.

[berlin1984]

Wikipedia:
"Cocaine acts by inhibiting the reuptake of serotonin, norepinephrine, and dopamine. This results in greater concentrations of these three neurotransmitters in the brain."

Wikipedia:
"Hyperforin may be a constituent responsible for the antidepressant and anxiolytic properties of the extracts of St. John's wort.In vitro, it acted as a reuptake inhibitor of monoamines (MRI), including serotonin, norepinephrine, dopamine, and of GABA and glutamate"
https://en.wikipedia.org/wiki/Hyperforin

Just to give people an idea to experiment with..

[demografx]

My psychiatrist years ago, when I reported to him dopamine/POIS theories (from b_jim), thought POIS could be countered by cocaine.

He added that it would be irresponsible for him to suggest experiments

[berlin1984]

He tried alcohol before O: 60-70% less pois next day.

https://poiscenter.com/forums/index.php?topic=555.0

[Muon]

NLRP3 inflammasome-dependent inflammation

Also a nice parameter to investigate for POIS research. Isn't this intracellular inflammation?

From tuning the brain:
"Androgens such as testosterone increase the secretion of dopamine, probably by decreasing the activity of the dopamine transporter. Ritalin and cocaine also have this action. Androgens also increase DA by interacting with NO"

"Adderall works both by inhibition of dopamine reuptake and by increasing secretion of norepinephrine and dopamine. Inhibition of dopamine reuptake by blocking the plasma membrane dopamine transporter is the primary mechanism of action of methylphenidate (MPH, Ritalin) and cocaine."

Nitroglycerin may work as well. I bet this is one of the possible pathophysiologies of POIS. Hmm medical cocaine is available in The Netherlands, nitroglycerin is much cheaper though.

[Muon]

I wonder if someone with premature ejaculation has tried ecstacy. It increases serotonin in the synapses.

[Muon]

The sigma-1 receptor as key common factor in cocaine and food-seeking behaviors

Some POISers mention food seeking behaviour in POIS mode especially junk food. Cocaine shuts this Ghrelin(?) mediated behaviour down via Sigma-1 receptor agonism. POIS itself could be an antagonist of Sigma-1 receptor.