Relora® (Magnolia officinalis bark extract / Phellodendron amurense bark extract

[berlin1984]

We had quite a few discussions about Relora @ thenakedscientists.com

Here’s one, a Relora POIS “cure” - -
https://www.thenakedscientists.com/forum/index.php?topic=6576.msg241729#msg241729

I was also surprised to find that this supplement (especially the magnolia part I guess?) was so popular in the old school POIS times but is barely mentioned in Poiscenter in the recent years.

You can find some Google hits including on this obscure google sites page: https://sites.google.com/site/poiswebsite/test-page/successful-methods/relora

It has a ton of effects on the body, the reason I'm trying to take it is for Cortisol balancing (I had some good experiences with other nootropic or adaptogenic herbs)...

Nootropicsexpert on magnolia: https://nootropicsexpert.com/magnolia-bark/
Main components in mangolia: Honokiol and Magnolol
You see it's supposed to have a ton of effects.

Phellodendron amurense wikipedia says it has effects on urological/prostate things.

Relora® is a patented extract of two plant components so you have a kind of quality guarantee, but it's also possibly to experiment with other supplements standardized for a certain percentage of Honokiol.


Found this thing here from b_jim in the old forum:

Results with Relora :
 You should ask your doctor before taking Relora

1/ Tarkington (p72) 3 caps a day, (reduce all symptoms anxiety, brainfog...) Tarkington confirm Relora is a real cure for his Pois Symptoms (p172). 9 months later, Tarkington is 100% healed even if 1 orgasm or more a day ! Congratulation Tarkington ! Thanks ! (p193)
2/ Limjuice (P75, p76) 50% Healed, 3x250 mg of Relora a day. Headaches ?
3/ Pyropeach (p83,p81) 65% healed
4/ Pantaloon (p156) 80% healed with relora  but some side effects (p195)
5/ goingcrazy (p174) Relaxed, rested, better focus out-of-Pois. Wait for testing effect in-Pois.
6/ nTonic (p176) After such a long story, I found that Relora was kinda useful in lessening my symptoms.
7/ John21 (p191) No symptoms Relora + Garlic
8/ tazzy (p258) Relora helps with anxiety behaviour but don't supress all Pois symptoms for the moment.
9/ ad75 (p295) "Relora is helping me enormously"

[drop247]

Isn't it basically a herbal benzo? Benzos are mast cell stabilizing but are physically addictive.

[berlin1984]

According to the nootropicsexpert it's not:

First, you should not develop dependence when using Magnolia Bark. Even though it is as potent as some benzos it is NOT a benzodiazepine

Also found this interesting:

Magnolia Bark interacts is an antagonist of the dopamine transporter and dopamine D5 receptor. Which means Magnolia Bark is forcing the transporter and receptor to release that dopamine for reuse in your brain. So it is NOT depleting dopamine but rather helping your brain to use it more efficiently.

[demografx]

[Relora] was so popular in the old school POIS times but is barely mentioned in Poiscenter in the recent years.

Hi, Berlin,

I prefer “POISCenter’s predecessor forum”
to          “the old school POIS times”


As moderator/admin at our predecessor forum for 5+ years, I feel we set the pace for modern research into the agonizing malady called POIS - -
as well as to initiate the very beginnings (including Research Study funding)  of POISCenter.com


From Google search:
What is another word for old-school?

quaint                          antique
old-fashioned                  old-time
old-world                          old-timey
outmoded                          outdated
dated                             out-of-date

Sorry if I’m overly sensitive:)

[berlin1984]

As I'm not a native speaker so the following is the definition I adhere to (from terms like "old school hip hop"  )

"Anything that is from an earlier era and looked upon with high regard or respect. Can be used to refer to music, clothing, language, or anything really."
https://www.urbandictionary.com/define.php?term=old%20school

So no offense at all 

[demografx]

So no offense at all 

And I’m sorry again for my oversensitivity

[drop247]

According to the nootropicsexpert it's not:

First, you should not develop dependence when using Magnolia Bark. Even though it is as potent as some benzos it is NOT a benzodiazepine

Also found this interesting:

Magnolia Bark interacts is an antagonist of the dopamine transporter and dopamine D5 receptor. Which means Magnolia Bark is forcing the transporter and receptor to release that dopamine for reuse in your brain. So it is NOT depleting dopamine but rather helping your brain to use it more efficiently.

Don't forget this is coming from the guy selling Magnolia Bark extract. I've read elsewhere that it is a benzo.


"Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, induces sleep via the benzodiazepine site of GABA(A) receptor in mice"
https://pubmed.ncbi.nlm.nih.gov/22771461/

[Progecitor]

Magnolia bark doesn't have the best immediate effect for me, but its possible long-term benefit surely sounds promising. I will also try to get Relora to compare them.

In the meanwhile I tested a Magnolia bark supplement and it provided a moderate benefit for me.
Honokiol is a phytochemical that can be found in Magnolia species. Honokiol could prevent tumorigenesis. Honokiol could significantly inhibit DNMT activity and reduced Dnmt1, Dnmt3a and Dnmt3b proteins expression. Honokiol could also reactivate and restore the levels of TET proteins suppressed by UVB radiation. Indomethacin can also inhibit DNA methylation. Honokiol application induced persisting effects.
Honokiol application also inhibited UVB-induced DNA hypermethylation and its elevation of the levels of TET enzyme, which is responsible for DNA demethylation in UVB-exposed skin.
Collectively, these data suggest that PGE2 promotes UVB-induced immunosuppression and that the PGE2 may act to suppress the immune reactivity by promoting DNA methylation in UVB-exposed skin.
It has been shown that the ten eleven translocation (TET) enzymes that catalyze demethylation of 5-methyl cytosine (5-mC) and promote locus-specific reversal of DNA hypermethylation.
Furthermore, honokiol inhibits the transcription regulators of Dnmt activity, Sp1 and Sp3, which have been implicated in DNA demethylation. In addition to blocking the addition of extra methyl groups to the 5th position of cytosine through inhibiting Dnmt activity, honokiol treatment also promotes DNA demethylation of existing DNA hypermethylation through activation of the TET enzyme and expression of TET proteins. Active DNA demethylation by TET proteins has been shown to play critical roles in T cell functions and particularly cytokine expression. This is consistent with the literature indicating that epigenetic modifications in general, and especially aberrant DNA methylation, play important role in the regulation of cytokines in malignancies.
https://www.nature.com/articles/s41598-017-01774-5

[demografx]

I will also try to get Relora to compare them.

Bold emphasis on Relora mine - Demo

A lot of discussion of Relora at our predecessor forum:
https://tinyurl.com/2p9b6462

[berlin1984]

My experiences: It works fine for calming down (agression, anxiety, feeling of too much going on)...
I still stopped with it as it does not influence my POIS greatly, it's just one toolbox item I could use for day-after-orgasm.

I found something more promising, will experiment more:

(...), by sipping Yakult or Actimel with meals. 1 to 1.5 bottles (they are small!) per day.

Takes a few days to get accustomed to (initial flatulence, better don't take it in evening..).

Makes my mood during the day much calmer than before, less agression and MORE ENERGY. I'm really surprised it has such a big effect!

https://cfsremission.com/2015/11/29/yakult-l-casei-shirota/