Regulatory T Cell investigation in POIS

[nanna1]

Hey Muon, You might find this interesting. I assume these are healthy non-POIS men.

"the orgasm induced a moderate but statistically significant transient elevation of the cytotoxic/suppressor T cell (CD3+CD8+) numbers (Fig. 2). In contrast, the absolute numbers of T cells (CD3+), T helper cells (CD3+CD4+), and B cells (CD3-CD20+) were not affected by sexual stimulation...the levels of LPS-induced proinflammatory cytokines (IL-6, TNF-alpha) remained unaffected by masturbation-induced orgasm...The effects of orgasm on peripheral lymphocyte subsets were restricted to NK cells and had minor or no effects on T or B cell subsets and showed no effects on (IL-6, TNF-alpha) cytokine production, indicating limited and selective effects of orgasm on immune system functions in parallel with its selective and short-lived neuroendocrine effects." -Effects of Sexual Arousal on Lymphocyte Subset Circulation and Cytokine Production in Man (P Haake, U Hartmann, et al., 2004)

[Muon]

I don't have any ideas concerning NK cells. It seems from that paper it rises quickly after orgasm before reaching base values again for healthy people. Don't know what to think of that. IL-6 and TNF-alpha don't change which I have measured as well.

I'm actually quite disturbed what the reason is behind my mother's intravaginal reaction upon contact with sperm. It sounds like immune tolerance in the female reproductive tract is failing. What mechanism is playing/failing here and does this have a genetic cause which has been transferred to me and my brother? Does this create POIS in males?

Here is a paper I'm interested in but that is too technical for me: Manifestations of immune tolerance in the human female reproductive tract

Don't think the next one is relevant but still posting: Etiology of sperm immunity in women

[Nas]

I wonder if somehow the auto-immune reaction prevents the replenishment of neurotransmitters for what ever reason. Just a thought.

[Vandemolen]

I'm actually quite disturbed what the reason is behind my mother's intravaginal reaction upon contact with sperm. It sounds like immune tolerance in the female reproductive tract is failing. What mechanism is playing/failing here and does this have a genetic cause which has been transferred to me and my brother? Does this create POIS in males?

3 people in 1 family with POIS-like symptoms: that is interesting. I wonder if any other members have family with POIS. In my family not. But I do have 2 brothers with Crohn’s disease.

[Hopeoneday]

Genetic factor play a big role here.