Monoclonal Antibody Therapy

[biocentric]

From: http://www.bbc.co.uk/health/physical_health/conditions/in_depth/allergies/allergicmedical_treatments.shtml

Treating allergies:
1) Desensitisation immunotherapy
2) Effective symptom relief
3) Treating inflammation
4) Monoclonal antibodies
5) DNA vaccines

One of the most exciting developments in medical science this century is the so-called biological agents, or monoclonal antibodies.
Patients with allergies have increased blood levels of the antibody IgE, which triggers mast cells to release histamine and other inflammatory mediators. If the effect of IgE is blocked, the allergic reaction is stopped in its tracks.
Humanised monoclonal antibody proteins cling to free immunoglobulin IgE in the bloodstream and render it inactive, preventing allergies from developing.
They also stick to the activation areas on mast cells preventing IgE from attaching, as well as reducing the overall manufacture of IgE in the body.
The monoclonal antibody omalizumab is available as a treatment for asthma and rhinitis. Similar monoclonal antibodies can be used to prevent food allergic reactions by blocking the effect of IgE.
These wonder proteins have a general 'calming' effect on many forms of inflammation, including arthritis, colitis and skin diseases.
As with any new drug, they're expensive. They also have to be given by injection - being proteins, they'd be digested and rendered inactive if taken orally.

http://en.wikipedia.org/wiki/Monoclonal_antibody_therapy

[Daveman]

Good Find!

If I find time I'll try to put the the reference in one of the databases, maybe lab reference for now.

I wonder how specific the monoclonal antibody is. If one would have to be developed, extracted for POIS.

We're going to have to try to contect them.

[biocentric]

Might worth writing to Dr.Waldinger about...

or even might be an option for Vande, and also Limejuice with Dr.Bernstein?....

This could well be the only quick fix cure for POIS out there at the moment
what a shame its injection only

[Habibou]

This is a website about the link between inflammation and the brain fog by Monocytes trade : http://www.natap.org/2009/HIV/031009_07.htm

"How Inflammatory Disease Causes Fatigue: chronic inflammation infiltrates the brain but can be blocked"

example : The researchers found that in mice with inflamed livers, white blood cells called monocytes infiltrated the brain...

a possible link ?

[Daveman]

We are going to be beginning the task of defining an investigation route for the future of POIS, which will be undertaken by very well trained and experienced researchers. But we need to have our route defined and know what we want before we enter the process. We will need to present a united front

I'm going to open another Board under "POIS Cause/Treatment Discussions"->"Investigation Areas"

It will have 4 main threads (topiscs).

• New Concepts for Discussion
• Approved for Investigation
• Further Discussion for Approval
• Disapproved for Investigation

This topic we are discussing above is an excellent candidate for Investigations. We should move or copy the principal posts to the "New Concepts for Discussion" thread.

Once we have a concensis we will enter the principal information for the topic to the corresponding thread below.

This information will be available both for us and any investigator who may be interested in seeing what is going on with POIS.

[Ccconfucius]

This is a website about the link between inflammation and the brain fog by Monocytes trade : http://www.natap.org/2009/HIV/031009_07.htm

"How Inflammatory Disease Causes Fatigue: chronic inflammation infiltrates the brain but can be blocked"

example : The researchers found that in mice with inflamed livers, white blood cells called monocytes infiltrated the brain...

a possible link ?

niceeeeeeeeeee

[Vandemolen]

The monoclonal antibody omalizumab is available as a treatment for asthma and rhinitis. Similar monoclonal antibodies can be used to prevent food allergic reactions by blocking the effect of IgE.
These wonder proteins have a general 'calming' effect on many forms of inflammation, including arthritis, colitis and skin diseases.

I was looking for a medication against urticaria and I discovered omalizumab (Xolair). Did anyone tried this? Offcourse under supervision of a doctor. omalizumab is an injection, so you will need a doctor. It might also help against POIS.