My tools for treatment-resistant POIS and pyroluria

[poison]

I'm a longtime suffer from terrible POIS, I didn't know about POIS until recently but I've had the symptoms since teenage years.

The symptoms I suffer from are:
? Sneezing
? Brain fog
? Generalised pain
? Depression/anxiety
? Testicular pain/coldness
? Digestion problems
? Muscle twitching
? Suicidality
? Stiffness
? Lack of energy/restful sleep

I do suffer from some of the above in general, but after O everything is 100 times worse. The symptoms remain in an elevated state for 3-4 days and calm down by around 7 days.

Recently I was diagnosed with Pyroluria, a dual deficiency of zinc and vitamin B6. I found that sticking to the supplement regimen for this has helped me, I could manage 1 or 2 O's per week. 3 is definitely stretching it. The supplement regimen is as below.

75mg zinc (as picolinate)
200mg B6 (as pyridoxine hydrochloride)
50mg pyridoxal-5-phosphate (activated B6)
10mg manganese (as gluconate)

The zinc and manganese I take as powders with a glass of effervescent vitamin (has more vitamin B's and extra zinc and magnesium in it) first thing in the morning. The B6 and P5P I take with lunch. I suffered from digestion problems for a long time before this and had to work on optimising how/when to take them to avoid feeling stomach sick.

I find the above supplements help reduce the intensity of around 50-70% of my symptoms.

To help smooth things out, I take:
? 100mg aspirin (1 in the morning after digesting breakfast, 1 before sleep)
? 1 can of red bull (thanks b_jim)
? curcumin if I have any lying around (thanks nightingale)


I've tried a lot of other supplements, too many to remember/list:


Limited help (mostly surpassed by pyroluria protocol above)
? 5-htp
? D-phenylalanine
? L-tyrosine
? Fish oil

No help:
? Olive leaf extract
? Niacin
? Niacinamide
? Saw palmetto
? Anti-histamines
? GABA

If you suspect you have pyroluria too, please see a doctor who specialises in functional medicine or orthomolecular medicine. They will ask you to submit a sample for urinary pyrrole testing and work out a treatment plan for you if the diagnosis is confirmed.
The protocol is specific for each person and varies according to body weight/copper toxicity etc.

Good luck

[sameer7777]

Amazing information you posted bro I will must try some of the active one
Thanks a lot

Do they have test of zinc and b6 ?

Thanks again

[poison]

The doctor will probably test for plasma zinc as well as plasma copper and ceruloplasmin. If you have a zinc deficiency, the body will often substitute with other metal ions such as copper, i.e. you may have accumulated copper toxicity as well.

I don't think there is a B6 test. Its generally taken in proportion with the zinc, although some increase the dosage until particular symptoms are treated. For some people, P5P appears to work better, I think most take a combination of both.

[sameer7777]

id p5p and vitamin b 6 is same , or both different , do i have to take both tablets , and how much you think i should start with ......??
sorry you have described that already , lol !!
thanks

[sameer7777]

sorry again can u please tell me the medicine or brand name you taking pls guide , any pictures pls thanks alot

[sameer7777]

75mg zinc (as picolinate)

you wrote the above , i think i have developed insulin resistance , i read this can help is it true ?? pls guide

[poison]

Yes you can start with half the above dose. The actual dose depends on you body weight and urine/blood results.

For P5P I use 300mg tablet from Source Naturals brand and cut with pill cutter.
For zinc picolinate and manganese gluconate I take Thorne Research brand and empty the capsules into a vitamin drink.
B6 I take Country Life 100mg tablets.

I don't know if Zinc helps with insulin resistance... it helps a lot with digestion. I also have more energy and smooths out the mid-afternoon lull. Thats probably due to the B vitamins though.

[sameer7777]

which urine blood test