Quantum/Romies- what do you think about taking your prepacks in addition to my prepack just once to determine whether your prepack works for me also? I get about 70-80% reduction with mine but I wonder if taking your prepack additionally would produce even better results and thus enable me to determine whether I may be able to switch to your prepack alone in future. Is that a bad idea in your view? Can taking your prepack or a compressed version of it (eg. Quercetin-curcumin-5htp) interfere with or reduce the effectiveness of my (rather large) prepack? Any thoughts?
Hi Michael,
Here is my understanding of your regimen before. correct me if I am wrong.
Prepack: Vitamin's B1 (250mg), B6(200mg), B12 (1000mcg), B3 (500 mg, niacinamide), Vitamin C (1000 mg), Vitamin E (500IU), Fenugreek (1000 mg), Alfalfa (2 capsules).
Post pack:Zinc (40mg) and Mg(400mg)
I did have these POIS symptoms similar to yours before my current prepack regimen: brain fog, anxiety, depression, low energy, no motivation. I also had other allergy-like symptoms and upper-respiratory symptoms.
My analysis:
1. If Nurofen does not seem to work, stop taking it. Nurofen alone can activate mast cell for some people and cause more cognitive problems.
2. I might need to take a 2nd/3rd dose of 5htp (12 hrs apart) for a really bad POIS (rarely happens). 5htp is the main ingredient for me to alleviate anxiety (I become content and not caring much about all the worries).
3. I don't know much about Fenugreek or Alfalfa. But the other ingredients do not conflict with Quercetin-curcumin-5htp, because I take daily supplements of B6(morning), B12(morning), Vitamin C(before sleep) too.
Fenugreek and Alfalfa are not MAOI, so the risk of serotonin syndrome is low. However, if Alfalfa is mostly a tryptophan source for you, then you don't need it when you take 5-htp.
the last 2 times I had POIS because of an NE or missing taking the prepack, taking B3 afterwards made it really bad. Increased anxiety and symptoms lasted an extra 1-2 days! So no more B3 afterwards for me. I took it once after a NE and it made it worse, and also took it with the other B's (1,6,12) and it also made it much worse. So, no B's for me during POIS.
B3 (niacin or niacinamide) consumes a lot of methyl group during metabolism. I personally cannot tolerate them in large dose. Taking 500mg niacinimide alone will give me 6-10 hrs brainfog, even longer after exercise or an O.
Niacinamide effects on me: (my best guestimate)
1. reduced methyl group availability --> BH4 deficiency --> Dopamine, Serotonin deficiency
2. reduced methyl group availability --> unable to metabolize NorEpinephrine --> anxiety.
See
https://www.ncbi.nlm.nih.gov/pubmed/21918528BTW, Niacin flushing never worked for me.
Potential solutions:
1. I take a daily low dose (400mcg each) Methylfolate, and methyl-B12 for this methylation issue. I suspect you may also need extra methyl group.
2. Take some SAMe as part of your post-NE pack. If it makes your anxiety worse, then you are likely to have over-methylation. But I suspect you have undermethylation. and SAMe will alleviate your symptoms. See recent posts from nanna1 about SAMe
You can find some references about the effect of niacinamide here:
http://forums.phoenixrising.me/index.php?threads/nicotinamide-nad-p-h-and-methyl-group-homeostasis.18026/and earlier (2012-2013) posts by Kurtosis are very informative on this topic.
http://poiscenter.com/forums/index.php?action=profile;area=showposts;u=5614