I have had positive skin reactions in a clinical setting from seminal dilutions of 1-80,000 up to 1-700 w/ resulting symptoms varying greatly. I have experienced systemic responses in all cases w/ a great amount of variation in intensity, yet my skin didn't react at the injection site until about 1-15,000 to 1-10,000. As dilutions have increased, so has my skin, neurological and flu-like reaction to them.
At this point in the experimental treatment I am debating moving forward w/ my desensitization treatment as I have seen new and increased neuropathy. In scaling back a recent dose of 1-700 to 1-000 I experienced immediate improvements. I had experienced minor improvements in the past (e.g. improvement in depressive symptoms) between the doses of 1-5000 and 1-2000 (there were extra doses between 5k and 2k), yet of recent of have only declined.
I have also rubbed my own undiluted semen on my arm multiple times (very primative
and found that I do break out in hives at the site.
I would warn against a skin prick test without the over-site of a doctor and I am not at all convinced of the benefits of a desensitization treatment at this point. For myself, I had to try to the treatment to see whether it is truly beneficial, yet the results are not outweighing benefits at this point and I may discontinue it altogether. It is your body and your choice to experiment w/ it if you choose to as I did and continue to do.
The bottom line is these tests are not truly indicative of POIS or not, yet in my experience they can have a very real positive and negative effect on your body in and out of the doctors office.