Completely cured of POIS for 2 years

[Iwillbeatthis]

Do you think this Ox (animal) bile supplement could help?! https://nutriest.eu/products/ox-bile-supplement/?_kx=nrNXUZlcnLnTPRIkqkH9HUDEYcPUviWAP16ZL2Ahr1EMNsl7mq1wWQVjGkPnHFox.WNJbcj

Be careful

Ox Bile 500 mg from Nutricology gave me GI distress. Had some kind of pulsating cramps at the height of the stomach for at least 30 min. The dose is probably too high for me or I just cannot tolerate the stuff. I have only used it once.

I was not aware of this:
Activation of mast cells by bile acids:
https://www.sciencedirect.com/science/article/abs/pii/001650859190024F

Basically means your bile is toxic if you can't tolerate them, bile supplements used to cause me major issues too but not anymore. They cause your liver to release more bile.

[marrtintintin]

confirmed, the bile supplement doesn't seem to do me good. It triggers my symptoms

[benoluxuryrentals]

This is motivating. I work in helicopter tours company and my work is sometimes stressful and dealing with POIS is not good. I hope I will follow your experience and get rid of it. Thanks

[marrtintintin]

some poiser have low or high testosterone -> testicular glands
(and some with low testosterone seems to have  some results  reducing POIS symtoms with testosterone replacement therapy.)

some poiser have low or high cortisol -> adrenal glands (this is my case)

some poiser have low or high t3 / t4 -> thyroid glands ( Iwillbeatthis's and marrtintintin's case)
Iwillbeatthis seems to have some result  reducing POIS symtoms treating  thyroid

but what do all these glands have in common ?
answer : hypothalamus/pituary

hypothalamus gives orders to other glands with -> acth, tsh, gh, etc ...
then the differents glands produce testosterone, thyroid hormones, cortisol, etc ...

so all those hormonal problems (that seem common to a lot of poiser and maybe the origin of POIS) could come from a specific gland but maybe our gland is ok and the problem could come from the hypothalamus on a higher level or maybe both.
thats why sometimes treat the gland gives some result reducing POIS symptoms but not always 100%

there could be many reason why our glands or hypothalamus would be defective but the main reason would be chronic/traumatic stress (a lot of poiser seems sensitiv to stress) or intoxication that tires or disrupts the glands.

but before focus on why we need to know which.

so for any new poiser my suggestion would be to do a blood test to check all this hormones before and after an orgasm to identify which hormones/ glands seems to be defective.
blood test : acth, tsh, gh, somatomedins, prl, fsh, lh, msh, oxytocin, adh, epinephrine, norepinephrine, cortisol, corticosterone, t3, t4, inhibin, testosterone,

note that as i tried to explain in my case (https://poiscenter.com/forums/index.php?topic=4556.msg48987#msg48987)
there could be many reasons why some of us could still have normal level for a hormone.
that's why doing a blood test after an orgasm even if it would be such a pain could be really helpfull to see clearer.
since an orgasm seems to break everything, a blood test after orgasm could  reveal more thing.

Hey largoo, thank you so much for your interesting post. It does make a lot of sense—the hypothalamus and "traumatic stress". What you describe makes a lot of sense for me. I wonder what to do with this informaiton, and what would help curing the hypothalamous and not reacting to stress like this.

[marrtintintin]

Do you think this Ox (animal) bile supplement could help?! https://nutriest.eu/products/ox-bile-supplement/?_kx=nrNXUZlcnLnTPRIkqkH9HUDEYcPUviWAP16ZL2Ahr1EMNsl7mq1wWQVjGkPnHFox.WNJbcj

Be careful

Ox Bile 500 mg from Nutricology gave me GI distress. Had some kind of pulsating cramps at the height of the stomach for at least 30 min. The dose is probably too high for me or I just cannot tolerate the stuff. I have only used it once.

I was not aware of this:
Activation of mast cells by bile acids:
https://www.sciencedirect.com/science/article/abs/pii/001650859190024F

Basically means your bile is toxic if you can't tolerate them, bile supplements used to cause me major issues too but not anymore. They cause your liver to release more bile.

I thought that if the problem was bile liquid, maybe it would be good to supplement it. I don' fullyt understand why it increases my pois. I mean, I will beat this, you did mention that our bile is toxic, I just don't fully understand how our bile is toxic. 

[marrtintintin]

Tonight, I was feeling a bit of pain in my left lower back, and I had two wet dreams in one night! and every time I had wet dreams, I felt this pain in my left lower back.
I know that I will beat this realise that probably it is not the kidneys causing the problem and that it is rather the liver, bile ducts and gall bladder. And it makes sense. I have also always thought that it was the kidneys who were responsible, but since tonight having this pain on the left side, I am reconsidering that kidneys still play a part in this. I mean, I think the right side was also hurting a little bit, but mostly I was feeling the right side.
also, usually, I have these pains when digestion doesn't work well. when the stomach feels stuck and there is this lower back pain. then I get a wet dream, dk why...

[largooo]

do you have lower back pain also when you are stress or only when pois/wet dream/bad digestion ?