Summary of treatments to manage opioid receptors

[jamot]

Hello,

I am interested in testing the implication of different opioid receptors (right now Kappa-opioid) on my POIS and general health issues (generalized anxiety, OCD for context) but couldn't find much information on the available treatments (drugs or supplements) to increase/decrease activation of such. It is to note that, since for now I'm not seeing a specialist for my POIS, I can't access any drug for my tests.
Therefore, I'm gonna try (with your collaboration by any chance) to list possible adequate treatments hoping to speed up my trials and, hopefully, ones of others !

Don't hesitate to communicate on this topic and make this thread useful

Mu receptors :

Agonists :

- kanna**

Antagonists :

- LDN*

Kappa receptors :

Agonists :

- salvinorin A** (in Salvia divinorum)

Antagonists :

- amentoflavone** (in Ginkgo biloba, St. John's Wort.)
- apigenin** (in chamomile)

Delta receptors :

Agonists :

- kanna** : D2 opioid receptors.

Antagonists :

---------------------------------------

Controversial :

- sulforaphane** (cruciferous vegetables) : see this study.


* pharmaceutical, generally obtainable exclusively with a prescription.

** natural, generally buyable over the counter.

[Progecitor]

Welcome to the forum jamot!

I wouldn’t give kappa opioids too much thought. It was also one of my first idea here, if you have read that. Opioids really seem to be involved in POIS, but this could be also an indirect effect. You can do your own research, but I don’t think you will find many more legally available options to test.
Amentoflavone and apigenin are two kappa opioid receptor antagonists. I haven’t tried amentoflavone directly, but it can be found in Ginkgo biloba and St. John's Wort. Apigenin (e.g. chamomile) helps me a little, but other things are more beneficial without a relation to KOR.
Salvia divinorum is a KOR agonist that can induce psychosis. I wouldn’t actually recommend trying it of course.
https://en.wikipedia.org/wiki/Salvia_divinorum

Some less risky supplements with a connection to opioids (mostly MOR): Zembrin (kanna), Sulforaphane, LDN.

If you have anxiety issues you had better try some anxiolytics instead.
https://poiscenter.com/forums/index.php?topic=4111.msg43981#msg43981

Is there actually a reason you suspect opioids to be involved? Could you give us some more details about your symptoms and about anything that can change POIS?

[jamot]

Thank you for the answer Progecitor ! Yes, it also seemed to me that not much things without prescription are available to experiment on opioid receptors.
I hadn't heard about those 2 chemicals, that's super helpful to point them out. I'll for sure check in depth your summary since from your message I can tell it probably has tons of valuable information that could help me
I'm not looking for a Kappa agonist for now, neither a MOR agonist (immediately at least) but I'll take note of the Salvia divinorum option.
Thank you for your suggestion of alternative treatments for mental health.

I exposed to you in direct messages additional information about my case. I don't think it's needed to expose them here for the reasons I gave you (like the anxiety it would cause for me), and because the meaning of this thread is firstly to list medical information ; options for action on the opioid receptors - I'll set up a presentation of that in the next months, when I have time and energy for it.