I think everyone is different, but I don't feel that way personally. I usually feel really good afterward - better than usual. Then not too bad the next morning, and then in the following afternoon I get a migraine starting, body temperature issues, eye fatigue and blurry vision, digestive issues, etc. That continues for 1-3 days.
So for me, I think it could be norepinephrine involvement, but it's almost like the reverse that after a good experience that raises those levels, when they crash back down, my body can't replenish it. Or that's my vague theory. I also get the same POIS type feeling after other exertions, with the same delayed reaction.