Based on current data/similarities in POISers what you think causes it?

[Journey]

Based on current data/similarities in POISers what you think causes it? There are patterns POISers got in common-anyone has theory that's most fitting based on POISers patterns/treatments/experiences? What you think is mechanism of action of it-what exactly happens during O and how it leads to symptoms? What's the root cause that activated next steps resulting in it?