A while ago I had a comprehensive checkup with an immunologist with no results. The immunologist then suggested to give diclofenac (Voltaren) a try - a suggestion based on
Ashby J, and Goldmeier D. Postorgasm illness syndrome: A spectrum of illnesses. J Sex Med 2010;7:1976-1981.
https://www.ncbi.nlm.nih.gov/pubmed/20214722I have now tried diclofenac for about 1.5 months and can report substantial improvement of symptoms. I have found a rhythm where I masturbate once a week, usually on a Friday or Saturday evening. I take 50 mg of diclofenac orally some time before orgasm. I then take three times 50 mg (morning, noon, evening) for the following two days. Previously, I would usually suffer from fatigue, lack of mental clarity, mood issues and physical weakness. The second morning after an orgasm would be the worst with extreme fatigue. Now, I can more or less function normally during the weekend. On the first day after orgasm, I still feel the need to take a nap in the afternoon and feel quite tired towards the evening. The second day is a big improvement to before. Where previously I would have often stayed home and rested and slept most of the day, I can now go out and do things. On day 3 when I stop taking diclofenac, I still feel the remains of POIS, but I can work more or less normally. I have also experimented with taking Benadryl in addition which has previously helped me, in particular with quality of sleep - so far the experiment is inconclusive.
Please note that diclofenac can have serious side effects and can be dangerous for the kidneys. Always consult with a physician first. In my case, I am a bit worried about kidney function, since in the past I have had elevated creatinine, but not lately. I will keep monitoring this. Of course, if there is a less problematic drug with the same effect, I'd be happy to hear about it.
I'd also be curious to hear about others' experiences with diclofenac. There are a few older posts on the forum, but overall not much.
