Hi Buckaroo,
There is some isolated reports of success with prednisone, but there is no one that have reported the effectiveness of it over a long period of time on a as needed basis ( like taking it before or after O, for a period of 3 months). So, there are no clear data about prednisone or dexamethasone.
Humire/adalimumab is a very potent drug, and has also many potentially severe side effects. And, POIS being almost totally unknown to the medical world, it is far from becoming a legitimate illness, so there would be no insurance coverage by any health insurance company. This is not a detail, when talking about a drug treatment which cost more than $50 000 a year.
It is well known that I am fond of natural products. Research have been done on many natural compound showing TNF alpha inhibitory properties. Some of the well-known and easily accessible ones are curcumin ( from turmeric), and catechins from green tea. You can find an extensive list of natural TNF-alpha inhibitors in this scientific article:
https://www.ncbi.nlm.nih.gov/pubmed/22650373 ( the full text is available for free dowload at
http://www.eurekaselect.com/100651/article . In table 1 of the article, there is a long list of natural TNF-alpha inhibitors, along with their IC50 value, so you can see their relative potency). Any TNF-alpha inhibitor will show anti-inflammatory effects, so it is not surprising that many of these compounds have been helpful for members here. Fish oils, curcuma, green tea, milk thistle, garlic, and so on, have been reported to be beneficial, at least for some, against POIS.
It is clear, however, that those natural products do not have the potency of Humira. But they are way more safer, and much less expensive. A stack of natural TNF inhibitors can surely be helpful.
Looking at the list, I see that there are many TNF inhibitors in my pre-pack: magnesium, fish oils, curcuma, green tea (
http://poiscenter.com/forums/index.php?topic=2090.msg16604#msg16604 ). That surevaccounst for a part of why they are beneficial for me.
