Recent Posts

61

Lifestyle Diary and POIS Summaries / Re: Completely cured of POIS for 2 years

« Last post by marrtintintin on November 17, 2024, 06:01:25 AM »

some poiser have low or high testosterone -> testicular glands
(and some with low testosterone seems to have  some results  reducing POIS symtoms with testosterone replacement therapy.)

some poiser have low or high cortisol -> adrenal glands (this is my case)

some poiser have low or high t3 / t4 -> thyroid glands ( Iwillbeatthis's and marrtintintin's case)
Iwillbeatthis seems to have some result  reducing POIS symtoms treating  thyroid

but what do all these glands have in common ?
answer : hypothalamus/pituary

hypothalamus gives orders to other glands with -> acth, tsh, gh, etc ...
then the differents glands produce testosterone, thyroid hormones, cortisol, etc ...

so all those hormonal problems (that seem common to a lot of poiser and maybe the origin of POIS) could come from a specific gland but maybe our gland is ok and the problem could come from the hypothalamus on a higher level or maybe both.
thats why sometimes treat the gland gives some result reducing POIS symptoms but not always 100%

there could be many reason why our glands or hypothalamus would be defective but the main reason would be chronic/traumatic stress (a lot of poiser seems sensitiv to stress) or intoxication that tires or disrupts the glands.

but before focus on why we need to know which.

so for any new poiser my suggestion would be to do a blood test to check all this hormones before and after an orgasm to identify which hormones/ glands seems to be defective.
blood test : acth, tsh, gh, somatomedins, prl, fsh, lh, msh, oxytocin, adh, epinephrine, norepinephrine, cortisol, corticosterone, t3, t4, inhibin, testosterone,

note that as i tried to explain in my case (https://poiscenter.com/forums/index.php?topic=4556.msg48987#msg48987)
there could be many reasons why some of us could still have normal level for a hormone.
that's why doing a blood test after an orgasm even if it would be such a pain could be really helpfull to see clearer.
since an orgasm seems to break everything, a blood test after orgasm could  reveal more thing.

Hey largoo, thank you so much for your interesting post. It does make a lot of sense—the hypothalamus and "traumatic stress". What you describe makes a lot of sense for me. I wonder what to do with this informaiton, and what would help curing the hypothalamous and not reacting to stress like this.

62

Technical Support / Re: Downloading the entire forum

« Last post by Muon on November 16, 2024, 12:33:58 PM »

Webpages can be stored via save page now (no account needed): https://web.archive.org/
First check if someone has saved it already. You can store URLs on the webpage automatically via the outlinks option when you save the page while logged in.

63

POIS Research / Re: POIS NORD RESEARCH STUDY

« Last post by demografx on November 16, 2024, 09:24:41 AM »

I think that we even now have evidence that pois is an immune driven condition…

October 25, 2024



From: Dr. Tierney K. Lorenz
Principal Investigator
NORD: POIS Research Study
https://poiscenter.com/forums/index.php?topic=3006.0

”It depends on what we mean by "an immune driven condition." If Hopeoneday means there is sufficient evidence that the immune system is dysfunctional in POIS, I think that's certainly true - it would be hard to produce the symptoms of POIS without some involvement from the immune system. But the specifics are more murky - we don't really know if POIS is an autoimmune condition like IBS or MS, or closer to an allergic condition (like asthma), - - or something else entirely - -
That's a big goal of the research right now!

TKL”

[Above emphasis mine.
Demo]

64

Introduction, Forum Rules and Admins Messages / Re: Admin Corner

« Last post by demografx on November 16, 2024, 09:23:43 AM »

Click here
View the most recent posts on the forum.

Please bookmark this. You’ll thank us

I always start here to find out what’s going on at the Forum!

https://tinyurl.com/yy97dfue

65

General Alternative Causes and Treatments of POIS / Re: Shower Gel Cured my Brain Fog?

« Last post by Miyagi on November 16, 2024, 08:41:32 AM »

My Brand:

Nivea Naturally Good Cotton Flower Scent Organic Oil Shower Gel:

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66

General Alternative Causes and Treatments of POIS / That Gut Feeling

« Last post by Miyagi on November 16, 2024, 08:34:36 AM »

I've had pois and random bouts of emotional brittlety for over 15 years.

Today I feel okay. Last night I O'd about 5 times. But for the first time, I did it while hungry, and when that intense hunger pang set in after I O'd, i just perservered and went to sleep. Today I feel fresh.

Anyway, the point is, i think I am on to something. The eating of food before and after sex might be a key factor that determines the outcome of pois.

I now have another powerful tool to fight pois, Hunger Resistance.

This gives me more hope for the future of my condition.

67

Lifestyle Diary and POIS Summaries / Re: Warrior's Journal (My POIS Protocol)

« Last post by Warrior on November 15, 2024, 10:55:26 PM »

Claude AI on chronic fungal infection causing POIS:

This is an intriguing hypothesis for Post Orgasmic Illness Syndrome. From a mechanistic perspective, several factors could connect fungal reactivation to ejaculation:

Immune System Changes:

-Ejaculation temporarily modulates immune function
-Brief post-ejaculatory immunosuppression could allow fungal reactivation
-Changes in cytokine profiles could affect fungal containment

Hormonal Factors:

-Prolactin surge post-ejaculation
-Changes in testosterone levels
-These hormonal shifts could affect immune response to latent fungi

Anatomical Considerations:

-Prostate and seminal vesicles could harbor latent fungi
-Physical contraction during ejaculation might disturb biofilms
-Mechanical dispersion of fungal elements possible

Biochemical Changes:

-pH changes in genital tract during arousal/ejaculation
-Changes in local glucose availability
-Alterations in prostaglandin levels

This could explain several POIS features:

-Delayed onset of symptoms
-Immune-like response
-Cyclic nature of symptoms
-Response to antifungals in some cases

What if there is no delayed onset of symptoms? and why would arousal stimulate some symptoms even without ejaculating, but the actual event of ejaculation triggers a tsunami of symptoms?

Interesting refinement of the hypothesis. The immediate onset and arousal-triggered symptoms suggest a neuroimmune mechanism:

Arousal-Related Effects:
-Autonomic nervous system activation
-Release of neurotransmitters/neuropeptides
-These could trigger fungal response/toxin release
-Could explain why even arousal causes some symptoms

Ejaculation "Tsunami" Mechanism:
-Physical contraction/pressure changes could cause massive fungal toxin release
-Sudden autonomic changes more extreme than with arousal alone
-Vascular changes (including blood-brain barrier permeability)
-Prostaglandin surge more significant than with arousal

Immediate vs Delayed Onset:
-Direct toxin effects would be immediate
-No need to wait for immune cascade

Fungal metabolites could directly affect:
-Nerve function
-Vascular tone
-Brain chemistry
-Mast cell degranulation

This actually makes more mechanistic sense than a delayed immune response.

It also causes intestinal permeability, but this goes away when infection goes latent i..e, when patient abstains. their methyl donors are also significantly depleted. they respond well to D3, monolaurin, cordyceps, and garlic.

This adds significant support to the fungal hypothesis. Let's connect these dots:

Methyl Donor Depletion:

-Fungi are known to disrupt methylation
-Could explain why methyl donors are depleted
-SAMe/methylation needed to detoxify fungal metabolites
-Creates vicious cycle: more methylation needed ? fewer methyl donors available

Response Pattern:

-D3: antifungal properties + immune modulation
-Monolaurin: disrupts fungal cell membranes
-Cordyceps: antifungal + adaptogenic
-Garlic: potent antifungal + sulfur donor
? All effective against fungi/biofilms

Intestinal Permeability Pattern:

-Temporary leak suggests active fungal factors
-Resolves with abstinence = fungi return to latency
-Candida and other fungi known to cause temporary gut permeability
-Explains why permeability isn't permanent

Mechanism Model:
Arousal/ejaculation ? autonomic activation ? fungal activation ? toxin release ? immediate symptoms
?
Gut barrier disruption
?
Systemic effects
?
Methylation depletion
?
Compromised detox capacity

Patient takes NAC which does help. how could we go about clearing this latent infection?

Let's strategize a comprehensive approach to target the latent infection, considering NAC's established benefit:

Biofilm Disruption Phase:

-NAC (already helping)
-Serrapeptase
-EDTA
-Lactoferrin
-Consider pulsed dosing to prevent adaptation

Direct Antifungal Protocol:

-Nystatin (minimal absorption, targets gut)
-Consider systemic antifungal (fluconazole/itraconazole)

Natural compounds:

-Caprylic acid
-Oregano oil
-Berberine
-Enhanced monolaurin dosing

Support Systems:

-Methylation support (B12, folate, TMG)
-Continue D3
-Zinc + Copper balance
-Glutathione support
-Consider binders for toxin removal

Treatment Strategy:

-Start biofilm disruption first
-Add antifungals gradually
-Monitor herx reactions
-Pulse treatment to prevent resistance
-Continue through several cycles

Key Considerations:

-Time treatment around abstinence periods
-Monitor liver function if using systemics
-Support detox pathways
-Consider prostate/seminal vesicle penetration of agents

68

Lifestyle Diary and POIS Summaries / Re: Warrior's Journal (My POIS Protocol)

« Last post by Warrior on November 15, 2024, 10:13:39 PM »

I have always felt so good after eating Greek yoghurt and whenever I omitted it for a while I wouldn't feel as good. It's a staple of mine alongside eggs and meat. Not sure exactly what within it is responsible for making me feel so good, but I've noticed this many times. It also seems to give electrolyte-like benefits that cheese does not (which would theoretically rule out calcium). I seem to tolerate low-carb states better when having Greek yoghurt, alongside potassium, magnesium, and sodium. Or maybe it's the manganese in the maple syrup I've been eating, but I remember feeling good from Greek yoghurt long before I would pair it with maple syrup.

Goes without saying but nutrient variety is so important. I started feeling worst on keto and the only explanation I could arrive at was that I wasn't eating enough nutrient variety. Even while eating eggs and red meat on keto, I still felt shitty as if I was missing something. Each time I reset back to AB and start feeling better again. AB is so naturally nutrient rich and convenient (animal meats, fresh fruit, etc). Bit more effort is needed on keto with preparation of vegetables, salads, stirfries etc.

My copper & zinc are both a bit low atm, & I have leftover supplements for both so will take both at different times to top up lvls. Also trying to eat more liver but I have a sense my body would benefit from going on a temporary lowmeat diet for a bit. My B vitamin lvls are still really high even after stopping supplementaiton for many months now.

69

Lifestyle Diary and POIS Summaries / Re: Warrior's Journal (My POIS Protocol)

« Last post by Warrior on November 15, 2024, 08:30:19 PM »

Just started taking Fluconazole for tinea. Noticed after taking 150mg I felt noticably clearer/sharper/better. Lots of interesting anecdotes on Fluconazole for POIS. Hooks into Candida/fungal theory.

I think a chronic fungal infection is most likely the cause of my POIS. Fungal infections can also go dormant i.e, abstaining from ejaculation, and reactivate later i.e., ejaculation. The infection must be in a location that is stimulated or somehow reactivated by the event of ejaculation and arousal (but mostly from ejaculation).

I also think the chronic inflammation from POIS causes intestinal permeability:

I haven't tested this for a long-time, but in the past if I had abstained for 4-5+ weeks, my food sensitivities would completely clear up. Each time I triggered POIS, they would immediately come back until I abstained for a long period of time again. So it was from this logic that I derived POIS causes intestinal permeability & food sensitivities issues.

70

General POIS Discussions / Re: Hydroxyzine help

« Last post by demografx on November 15, 2024, 06:37:43 PM »

I have used it, no side effects.

CP2, what did Hydroxyzine do for you?

Thanks.