Post Orgasmic Illness Syndrome (P.O.I.S.)

POIS Life Style => Lifestyle Diary and POIS Summaries => Topic started by: etcosp on January 29, 2022, 05:47:25 PM

Title: Etcosp's case - discussion
Post by: etcosp on January 29, 2022, 05:47:25 PM
This thread (in progress) is meant to summarize my POIS case and related information, and allow people to discuss them.
Title: Re: Etcosp's case - discussion
Post by: etcosp on January 29, 2022, 05:48:42 PM
Index :
- Presentation (https://poiscenter.com/forums/index.php?topic=4114.msg43703#msg43703)
- Triggers and symptoms (https://poiscenter.com/forums/index.php?topic=4114.msg43704#msg43704)
- Medical analysis results (https://poiscenter.com/forums/index.php?topic=4114.msg43705#msg43705)
- Trials to reduce the symptoms (https://poiscenter.com/forums/index.php?topic=4114.msg43706#msg43706)
- Others (https://poiscenter.com/forums/index.php?topic=4114.msg43707#msg43707)
- Discussion (page 2) (https://poiscenter.com/forums/index.php?topic=4114.20)
Title: Re: Etcosp's case - discussion
Post by: etcosp on January 29, 2022, 05:50:07 PM
Presentation :


I have had my first sexual experience in 2014/2015, but was never really active so I can't tell if I've had POIS since the beginning of puberty. I first made the link between rampant fatigue and O in 2017. At that time, most of my symptoms weren't very present and the strong fatigue was going away after a night of sleep. I'm now (in January 2022) 18, with a normal BMI, and my symptoms stay strong for about 2 days.


Global notes:

Trait characters :

Additional information about me may help understanding my case. Read them in the extended presentation, in the "Others" category (https://poiscenter.com/forums/index.php?topic=4114.msg43707#msg43707).


Due to the particularity of my profile, I believe that likely my POIS is linked to my other particularities.
Title: Re: Etcosp's case - discussion
Post by: etcosp on January 29, 2022, 05:52:29 PM
Triggers and symptoms :


Triggers of abnormal symptoms:


Symptoms - very strong for 2-3 days - after orgasm/ejaculation (POIS symptoms) :


Notes clearly related to orgasm/ejaculation (possibly linked with POIS) :


Symptoms - for 2 to 4 hours - after sexual stimulation, even really short and involuntary like repeated contact with clothes while being locally sensitive :


Symptoms - for a few hours or until the end of the day - after strong emotions (strong sadness/strong stress) :


Symptoms - for 2 to 4 hours - after naps during the day sometimes :
Title: Re: Etcosp's case - discussion
Post by: etcosp on January 29, 2022, 05:58:10 PM
Medical analysis results :


Global helpful notes when looking at the medical results :

All blood test results can be found here (https://docs.google.com/document/d/1BtjhtMNRwKrMBKcshEBRoKWQKx8nRfQbLvJkO2XijQQ/edit?usp=sharing).
Following, the anomalies shown in most blood tests/checked once, and analysis of them :


Immune system components :

Leukocytes : 4.0 < 4.2 < 11.0 Giga/L
   Chronically low (with one exception) : the reference range in other countries is often ~5 - 11 so I wouldn't be considered in the norm everywhere. Such results can be seen for example in autoimmune disorders sufferers. The 3 results seem to be coherent with the intensity of my symptoms during the periods of the analysis ?

Vitamins :

25-Hydroxyvitamin D : 54.3 < 75 < 150 nmol/L
   Not a really rare result in healthy people.
B9 Vitamin : 9.4 < 11.3 < 61.6 nmol/L
   To be checked again. This single result isn't significant because not necessarily a thing over a long period.

Diverse :

Transferrin saturation coefficient : 20 < 40 < 41.2%
   ?
Magnesium : 0.70 < 0.91 < 0.94 mmol/L
   ?


Note : Some of the anomalies I indicated are in the reference range (but close to its limit). I found them interesting because important results that can be related to some health conditions.



Specific genetic results from my 23andme test (important genes, notable mutations already noticed) can be found here (https://docs.google.com/document/d/1kd8-hjLVX0s639PaTeGAgUMZSy4b-3xXalaLCJeGM4U/edit).


Mutations I have I found interesting :

- rs361525 : ~6% (AG) - associated with a much greater TNF-a plasma level. Mutation far more frequent in people with psoriasis (~16%) and OCD, which I both have.
Title: Re: Etcosp's case - discussion
Post by: etcosp on January 29, 2022, 06:00:36 PM
Trials to reduce the symptoms :


Medications taken before strong POIS developed :

2006 :



2014 - 2017 :



Trials (supplements, medications, environment changes) and how they affected me and my POIS (over whole POIS days, except if mentioned otherwise) :

March 2019 - November 2019 :



2021 :


July :

August :

September :

October :

November :

December :
     Special note :
     2 POIS periods temporarily relieved by L-dopa end up resolving faster (in 1 day instead of 2) but are directly followed :
     * by urinary infection symptoms for 2 days after the 1st POIS period.
     * by fatigue and a strong headache for a day, which isn't one of my usual symptoms, after the 2nd POIS period.



2022 :
Title: Re: Etcosp's case - discussion
Post by: etcosp on January 29, 2022, 06:02:12 PM
Others :


Extended presentation :


Diverse events :


Unrelated to my POIS trials :

2003 :
2006 :
2011 :
2013 :
2013 - 2017 :
2017 :
September 2018 - March 2019 :
March 2019 (PTSD) :
March 2019 - November 2019 (PTSD) :
December 2019 - March 2021 :


Related to my POIS trials :

Mid 2021 - October 2021 :
October 2021 - ? :
~January 2022 :


Hypothesis :

1/ Immune system hypothesis :
For some reason an immune system global reaction is triggered after O/E. That's why I have symptoms of inflammation (including swelling). That could be due to a latent pathogen reactivation. My organism having constantly to deal with an immune reaction (which could explain OCD and recurring psoriasis), with one gene specifically that is associated with 2x the normal TNF-a levels, has a neurotransmitters depletion. This neurotransmitter depletion is maybe for something in the too strongly perceived immune reaction.
Else, since ways of stimulation of the vagus nerve (cold water immersion, relaxation maybe ?) and supplementation with its mediator of immunity (dopamine) help a lot, I suspect it's implicated. I have yet to test the way any other stimulation of it affects my symptoms (already had good results with gargling, to be confirmed).[/list]
Title: Re: Etcosp's case - discussion
Post by: etcosp on January 29, 2022, 06:03:23 PM
For convenience, I will reserve the next messages and leave space for discussion in page 2.

Don't hesitate to suggest edits and of course discuss my case. I answer all messages, sometimes after a few days, but my answers can be very unclear at first (most of the time due to POIS symptoms or similar symptoms, that happen very often).
Title: Re: Etcosp's case - discussion
Post by: etcosp on January 29, 2022, 06:09:56 PM
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Title: Re: Etcosp's case - discussion
Post by: etcosp on January 29, 2022, 06:10:38 PM
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Title: Re: Etcosp's case - discussion
Post by: etcosp on January 29, 2022, 06:11:12 PM
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Title: Re: Etcosp's case - discussion
Post by: etcosp on January 29, 2022, 06:14:48 PM
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Title: Re: Etcosp's case - discussion
Post by: etcosp on January 29, 2022, 06:15:48 PM
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Title: Re: Etcosp's case - discussion
Post by: etcosp on January 29, 2022, 06:16:33 PM
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Title: Re: Etcosp's case - discussion
Post by: etcosp on January 29, 2022, 06:18:28 PM
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Title: Re: Etcosp's case - discussion
Post by: etcosp on January 29, 2022, 06:19:09 PM
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Title: Re: Etcosp's case - discussion
Post by: etcosp on January 29, 2022, 06:20:06 PM
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Title: Re: Etcosp's case - discussion
Post by: etcosp on January 29, 2022, 06:20:40 PM
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Title: Re: Etcosp's case - discussion
Post by: etcosp on January 29, 2022, 06:21:17 PM
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Title: Re: Etcosp's case - discussion
Post by: etcosp on January 29, 2022, 06:21:57 PM
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Title: Re: Etcosp's case - discussion
Post by: Progecitor on March 10, 2022, 09:30:43 AM
Global notes:
  • I have respiratory allergies for part of the year and asthma (including exercise-induced).
  • I have recurring psoriasis.
  • I often have very dry skin which makes it irritated.
  • use of any of my hands for a mid amount of time. (10+ min) often makes them super cold. This can happen to a single hand (vasoconstriction : sympathetic system activation ?).
  • I always have a dry mouth in the morning (but I snore), often partially dry at other times of the day (especially in the evening - linked to anxiety periods ?).

Increased DNMT1 expression was observed in blood DNA from patients with psoriasis.
Hypermethylation of the Dnmt1 promoter was also responsible for reduced gene expression levels in various tissues of animal models of asthma.

https://www.mdpi.com/2218-1989/9/12/298/htm

You said that you have both psoriasis and asthmatic symptoms besides POIS, so I thought this would interest you. I don’t have either, but still many of the supplements that benefit asthmatics (e.g. saffron) also work in my case. Resveratrol and Relora are two supplements that could potentially reverse DNA hypermethylation as they inhibit DNMT1.
Title: Re: Etcosp's case - discussion
Post by: etcosp on March 19, 2022, 02:04:37 PM
Wow, I would never have heard of this. I'll keep searching extensively about this topic and look at options for experimenting on this, tho I'm probably not gonna be able to do so before months. But since you said it has to do with hypermethylation, I wanted to point out that my homocysteine level (indicated among my blood tests results (https://docs.google.com/document/d/1BtjhtMNRwKrMBKcshEBRoKWQKx8nRfQbLvJkO2XijQQ/edit?usp=sharing)) is normal. Not sure it's related to DNMT1 from what I read. Your post is very informative anyway, thank you for that !