Post Orgasmic Illness Syndrome (P.O.I.S.)

POIS Cause/Treatment Discussions => General Alternative Causes and Treatments of POIS => Topic started by: Clues on July 05, 2021, 06:26:28 AM

Title: Mastic Gum etc
Post by: Clues on July 05, 2021, 06:26:28 AM
Finally found a shop that sells mastic gum (supplement) in Norway. Will give it a try and report back.
Title: Re: Re: POIS is gone! (mastic)
Post by: John21 on July 05, 2021, 04:23:08 PM
Finally found a shop that sells mastic gum (supplement) in Norway. Will give it a try and report back.

I'm glad to hear it, hope it works!
Title: Mastic Gum etc
Post by: John21 on July 10, 2021, 04:51:30 AM
I thought I should repost the "POIS is gone" into a separate thread with a more appropriate title to make it better for any newcomers to discover what has worked for me. The following is an explanation of what has eliminated all POIS symptoms for me. It has been about 3 months since beginning this experiment.

From my experience I became convinced that the POIS problem directly involves the gut. Initially I benefited from consuming certain things like niacin, taruine, and then Pepto Bismol. Then, POIS went away entirely after I was sick with salmonella and was treated with antibiotics. But, then it came back. So, I then decided to have a trial of supplements to eradicate whatever bacteria or virus or whatever might be living in me. I went on the assumption that my POIS was a reaction to h pylori or something like it. So I started a 3 week trial of supplements that kill h pylori.

Here is what I took for 3 weeks:
Mastic gum 400mg  2x/day
L-Glutamine 5g  1x/day
Caprylic acid 525mg 2x/day
Oregeno oil 180mg 1x/day
probiotic 1x/day

On occasion I sometimes included one of these:
Pepto Bismol (262mg tablet x2)
NAC 800mg
Taurine 1000mg
Vitamin C

Since this trial I have had no POIS symptoms at all. I think that something worked and that it is gut related in my case. Perhaps my system will revert as it did previously, time will tell whether I have to continue to supplement. I suspect that the mastic gum is the most significant one. I originally started with 3/day mastic but backed off to 2/day because it constipated me somewhat. Other in this forum have reported gastrointestinal reactions to taking it. If you have any experience with it whether positive or negative please post it here.

Title: Re: Mastic Gum etc
Post by: Clues on July 10, 2021, 08:44:38 AM
Very interesting report!

A root cause in the gut seems pretty likely in my case as well. I'm working on my gut health in general, and have just started taking mastic gum (two days ago). I'm also taking L-Glutamine and I'm getting Caprylic acid from my diet, so I'm already not too far off what you've been doing. I'll add oregano oil as well.

Did you take your oregano oil in a capsule? What brand was it?

EDIT: Picked up Solaray Oregano Oil 150 mg capsules. Trying a similar regimen to John21's.
Title: Re: Mastic Gum etc
Post by: John21 on July 10, 2021, 12:57:31 PM
Did you take your oregano oil in a capsule? What brand was it?

I took this (https://holista.com/en-ca/product/oregano-oil-with-vitamin-e-extra-strength-80-carvacrol/). I think I bought it at Costco.
Title: Re: Mastic Gum etc
Post by: Journey on July 10, 2021, 01:59:19 PM
I can buy L-Glutamine/Caprylic acid/Oregano oil and some probiotics too from online stores here, lately been trying out Taurine, Glycine, Lysine, Tribulus Terrestris, Ashwagandha, Zinc Picolinate however idk if mastic gum is available on any online stores at here
Title: Re: Mastic Gum etc
Post by: mike_sweden on July 11, 2021, 09:50:23 AM
I thought I should repost the "POIS is gone" into a separate thread with a more appropriate title to make it better for any newcomers to discover what has worked for me. The following is an explanation of what has eliminated all POIS symptoms for me. It has been about 3 months since beginning this experiment.

From my experience I became convinced that the POIS problem directly involves the gut. Initially I benefited from consuming certain things like niacin, taruine, and then Pepto Bismol. Then, POIS went away entirely after I was sick with salmonella and was treated with antibiotics. But, then it came back. So, I then decided to have a trial of supplements to eradicate whatever bacteria or virus or whatever might be living in me. I went on the assumption that my POIS was a reaction to h pylori or something like it. So I started a 3 week trial of supplements that kill h pylori.

Here is what I took for 3 weeks:
Mastic gum 400mg  2x/day
L-Glutamine 5g  1x/day
Caprylic acid 525mg 2x/day
Oregeno oil 180mg 1x/day
probiotic 1x/day

On occasion I sometimes included one of these:
Pepto Bismol (262mg tablet x2)
NAC 800mg
Taurine 1000mg
Vitamin C

Since this trial I have had no POIS symptoms at all. I think that something worked and that it is gut related in my case. Perhaps my system will revert as it did previously, time will tell whether I have to continue to supplement. I suspect that the mastic gum is the most significant one. I originally started with 3/day mastic but backed off to 2/day because it constipated me somewhat. Other in this forum have reported gastrointestinal reactions to taking it. If you have any experience with it whether positive or negative please post it here.

dont you think it was the pepto bismol that healed you?
Title: Re: Mastic Gum etc
Post by: John21 on July 11, 2021, 05:26:04 PM
I thought I should repost the "POIS is gone" into a separate thread with a more appropriate title to make it better for any newcomers to discover what has worked for me. The following is an explanation of what has eliminated all POIS symptoms for me. It has been about 3 months since beginning this experiment.

From my experience I became convinced that the POIS problem directly involves the gut. Initially I benefited from consuming certain things like niacin, taruine, and then Pepto Bismol. Then, POIS went away entirely after I was sick with salmonella and was treated with antibiotics. But, then it came back. So, I then decided to have a trial of supplements to eradicate whatever bacteria or virus or whatever might be living in me. I went on the assumption that my POIS was a reaction to h pylori or something like it. So I started a 3 week trial of supplements that kill h pylori.

Here is what I took for 3 weeks:
Mastic gum 400mg  2x/day
L-Glutamine 5g  1x/day
Caprylic acid 525mg 2x/day
Oregeno oil 180mg 1x/day
probiotic 1x/day

On occasion I sometimes included one of these:
Pepto Bismol (262mg tablet x2)
NAC 800mg
Taurine 1000mg
Vitamin C

Since this trial I have had no POIS symptoms at all. I think that something worked and that it is gut related in my case. Perhaps my system will revert as it did previously, time will tell whether I have to continue to supplement. I suspect that the mastic gum is the most significant one. I originally started with 3/day mastic but backed off to 2/day because it constipated me somewhat. Other in this forum have reported gastrointestinal reactions to taking it. If you have any experience with it whether positive or negative please post it here.

dont you think it was the pepto bismol that healed you?

No I don't. During this trial I only took it a couple of times. It has never resoled POIS long term before why would that be the case now? Perhaps more than one of the supplements contributed but I currently believe that mastic gum is the all-star in the lineup.
Title: Re: Re: POIS is gone! (mastic)
Post by: Meshal on July 15, 2021, 12:44:25 PM
An update on my attempt from your success, John. I bought the mastic gum Monday at Vitamin Shoppe (due to delayed shipping on Amazon's part and my impatience).  It's been 3 days taking 500mg 3 times daily 30 minutes before meals.  You were right - the cramping/knots are real. This supplement is noticeably interacting with my stomach and intestines.   The feedback, while negatively feeling, is a positive sign that change could be taking place. However, from your timeline, it's far to early to confirm if the supplement is actually benefiting my body. The other supplements I'm taking as well, and have in the past (all except the mastic gum). These aren't and haven't provided any physical feedback. Perhaps they can support the mastic gum though. So just an update from your protocol.  Thanks

Hello there, Limejuice!

any updates on your trial? I sure do hope for a success.
Title: Re: Re: POIS is gone! (mastic)
Post by: Meshal on July 15, 2021, 12:48:07 PM
Mastic gum still going strong...
You're the second person after John21 who had success with it. Looks like I'll be hopping on that mastic gum train very soon!
Title: Re: Re: POIS is gone! (mastic)
Post by: Clues on July 16, 2021, 02:13:30 AM
I've been taking Mastic Gum for about a week. No change so far. Will keep you posted. Anyone else experimenting with this, let us know your dosage and what form you take it in. (Supplement or natural resin.)

I bought the supplement from Jarrow Formulas. Each capsule is 500 mg, but it says on the package a serving is two capsules. I've started taking only 500 mg, one capsule, daily, as John21 was taking 400 mg per day and having success with that I think. Just want to make it last a bit longer as it's fairly expensive.
Title: Re: Re: POIS is gone! (mastic)
Post by: John21 on July 16, 2021, 05:36:55 AM
I've been taking Mastic Gum for about a week. No change so far. Will keep you posted. Anyone else experimenting with this, let us know your dosage and what form you take it in. (Supplement or natural resin.)

I bought the supplement from Jarrow Formulas. Each capsule is 500 mg, but it says on the package a serving is two capsules. I've started taking only 500 mg, one capsule, daily, as John21 was taking 400 mg per day and having success with that I think. Just want to make it last a bit longer as it's fairly expensive.

The brand that I have are 400mg.  I started at 3x per day but backed off to 2x per day to rid myself of constipation. 
Title: Re: Re: POIS is gone! (mastic)
Post by: Clues on July 16, 2021, 05:48:33 AM
The brand that I have are 400mg.  I started at 3x per day but backed off to 2x per day to rid myself of constipation. 

Is that 400 mg per capsule, or 400 mg per serving? Assuming it's 400 mg per capsule, would you say you took 800 mg in total per day for most of those 3 weeks?
Title: Re: Re: POIS is gone! (mastic)
Post by: Mushnikk on July 16, 2021, 06:45:43 AM
There are reports that Mastic gum capsules work better than tablets. I take the capsules - lets see where I am at in two weeks.
Title: Re: Re: POIS is gone! (mastic)
Post by: fsol on July 16, 2021, 09:54:29 AM
I'm taking mastic gum capsules as well. Will try twice a day, but will combine them with pepto and a pre-pack before and after O.
Title: Re: Re: POIS is gone! (mastic)
Post by: John21 on July 16, 2021, 04:12:57 PM
The brand that I have are 400mg.  I started at 3x per day but backed off to 2x per day to rid myself of constipation. 

Is that 400 mg per capsule, or 400 mg per serving? Assuming it's 400 mg per capsule, would you say you took 800 mg in total per day for most of those 3 weeks?
400 per capsule, so 800mg/day for most of the time. I was on 1200mg/day for a few days only at the beginning.
Title: Re: Mastic Gum etc
Post by: Pontevin on July 18, 2021, 10:38:22 AM
Hey @John21

Could you post a link to the mastic gum brand you used?

I?ve found that gastrodenol which is chemically similar to Pepto has eliminated my anxiety completely. But it?s not for long-term use.

Thanks for posting!
Title: Re: Mastic Gum etc
Post by: John21 on July 18, 2021, 01:30:31 PM
Hey @John21

Could you post a link to the mastic gum brand you used?

I?ve found that gastrodenol which is chemically similar to Pepto has eliminated my anxiety completely. But it?s not for long-term use.

Thanks for posting!

Sure no problem here (https://aor.ca/product/mastica-chios/) it is.
Title: Re: Mastic Gum etc
Post by: Progecitor on July 19, 2021, 12:35:22 PM
Another theoretical possibility involves 11B-HSD1 inhibition.
Mastic gum inhibits 11B-HSD1 which converts the inactive cortisone to the active cortisol form. Others here had success with green tea that contains EGCG and this is another 11B-HSD1 inhibitor. Coumestrol (alfalfa) and glycyrrhetinic acid (liquorice) also inhibit 11B-HSD1, however they inhibit other 17B-HSD types as well, so they are not selective.
Besides E. japonica Banaba leaf extract also contains corosolic acid which is an 11B-HSD1 inhibitor and could be a good thing to investigate. Furthermore fenofibrate is a selective 11B-HSD1 inhibitor while ketoconazole is a selective 11B-HSD2 inhibitor. As a side note Banaba leaf and fenofibrate are PPARA agonists as well.
Although alfalfa and liquorice work for me, recently I have retested matcha tea and green tea and I had to realize that they don't work in my case. This makes it more likely that my case is connected to 17B-HSDs, but I am still going to test mastic gum if I have the opportunity.

The microsomal enzyme 11B-hydroxysteroid deydrogenase type 1 (11B-HSD1) catalyzes the interconversion of glucocorticoid receptor-inert cortisone to receptor-active cortisol, thereby acting as an intracellular switch for regulating the access of glucocorticoid hormones to the glucocorticoid receptor. There is strong evidence for an important aetiological role of 11B-HSD1 in various metabolic disorders including insulin resistance, diabetes type 2, hypertension, dyslipidemia and obesity. Hence, modulation of 11B-HSD1 activity with selective inhibitors is being pursued as a new therapeutic approach for the treatment of the metabolic syndrome.
Indeed we found that tea extracts inhibited 11B-HSD1 mediated cortisone reduction, where green tea exhibited the highest inhibitory potency with an IC50 value of 3.749 mg dried tea leaves per ml.
(?)-Epigallocatechin gallate (EGCG) revealed the highest inhibition of 11B-HSD1 activity (reduction: IC50?=?57.99 uM; oxidation: IC50?=?131.2 uM). Detailed kinetic studies indicate a direct competition mode of EGCG, with substrate and/or cofactor binding. Inhibition constants of EGCG on cortisone reduction were Ki?=?22.68 uM for microsomes and Ki?=?18.74 uM for purified 11B-HSD1.

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0084468

The short-chain dehydrogenase/reductase (SDR) enzyme family are nicotinamide adenine dinucleotide NAD (phosphate (P))-dependent enzymes.
The SDR family contains HSDs that play key roles in adrenal and gonadal steroidogenesis as well as in the metabolism of steroids in peripheral tissues. Some of these HSDs are considered as promising therapeutic targets for the treatment of estrogen- and androgen-dependent diseases such as osteoporosis, endometriosis, and breast and prostate cancer, and other enzymes gained interest regarding the treatment of corticosteroid-related diseases such as diabetes, visceral obesity and dyslipidemia, atherosclerosis, wound healing, glaucoma, neurodegenerative disease, and cognitive impairment.
The two isoenzymes of 11B-HSD catalyze the interconversion of the biologically inactive cortisone and the active cortisol. The 11B-HSD1 is ubiquitously expressed and mediates the regeneration of active glucocorticoids, whereas 11B-HSD2 catalyzes the inactivation of glucocorticoids mainly in the kidney, colon and placenta. There is evidence for beneficial effects of 11B-HSD1 inhibition in the metabolic syndrome, atherosclerosis, osteoporosis, glaucoma, cognitive functions, skin aging, and wound healing. Thus, inhibition of 11B-HSD1 has substantial therapeutic potential for glucocorticoid-related diseases. Numerous 11B-HSD1 inhibitors have already been identified and some have reached the clinical phase, but to date still no 11B-HSD1 inhibitor is on the market.
These models identified compounds resembling the structure of the known unselective 11B-HSD inhibitor glycyrrhetinic acid (GA), steroid-like compounds, and novel structural classes.
Earlier investigations led to the assumption that extracts from the anti-diabetic medical plant loquat (Eriobotrya japonica) dose-dependently and preferentially inhibit 11B-HSD1 over 11B-HSD2. Therefore, the virtual screening hit corosolic acid, a known constituent of E. japonica, was tested and identified as potent inhibitor of human 11B-HSD1 with an IC50 of 810 nM. Subsequent bioassay-guided phytochemical analyses revealed further secondary metabolites from the triterpenoid ursane type as 11B-HSD1 inhibitors with IC50 in the micromolar range. Importantly, a mixture of the constituents with moderate inhibitory activities displayed an additive effect. This is a common observation in phytotherapy, where a mixture of constituents is often responsible for the therapeutic effect.
Both the refined 11B-HSD1 (A) and 11B-HSD2 (B) model identified novel scaffolds. The inhibitor fenofibrate maps the 11B-HSD1 model (A) and ketoconazole matches the 11B-HSD2 model.
Using the refined 11B-HSD1 model, Vuorinen et al. applied a VS to filter a database consisting of constituents from medicinal plants to identify potential 11B-HSD1 inhibitors focusing on triterpenoids present in Pistacia lentiscus (P. lentiscus), so-called mastic gum that is used in traditional Greek medicine for the treatment of diabetes. The VS hit list contained eight hits of P. lentiscus constituents. The two main constituents of mastic gum, masticadienonic acid and isomasticadienonic acid, were chosen for further biological evaluation. Both compounds were shown to selectively inhibit 11B-HSD1 over 11B-HSD2 with IC50 values of 2.51 uM for masticadienonic acid and 1.94 uM for isomasticadienonic acid, respectively. Examination of the whole resin's activity revealed half the IC50 value of the single molecules, suggesting an additive inhibitory effect. Thus, the hypothesis of 11B-HSD1 involvement in the antidiabetic activity of mastic gum was supported.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332202/
Title: Re: Mastic Gum etc
Post by: Pontevin on July 20, 2021, 05:58:07 AM
Hey @John21

Could you post a link to the mastic gum brand you used?

I?ve found that gastrodenol which is chemically similar to Pepto has eliminated my anxiety completely. But it?s not for long-term use.

Thanks for posting!

Sure no problem here (https://aor.ca/product/mastica-chios/) it is.


Thanks @John21 !! ;D
Title: Re: Mastic Gum etc
Post by: berlin1984 on July 27, 2021, 03:10:04 AM
Some small data points from me.

* Trying it for 5 days now or so. Did not try to orgasm yet.
* Using the real mastic pieces delivered from Greece, not pills or tablets or pre-made chewing gums
* Chewing them for a while because I want to also fix my peridontal problems (https://poiscenter.com/forums/index.php?topic=2904)
* Then I swallom the gum when it lost the taste for a while. I make sure to stand and have a bottle/glass of water ready as it tends to get easily stuck in throat.
* I think (can be coincidence) I get some gut symptoms (diarrhea) from it ONLY if I take it away from food and/or when I combined it with NAC as biofilm buster.
* Oregano oil and Pepto Bismol I had tried some weeks ago and they did not change POIS.
* I never did a H.Pylori test and also don't have stomach pain. I only have bloating/gas issues which this hopefully can improve. I try nowadays to eat without milk products to avoid lactose and unfermented casein. Let's see.


Title: Re: Mastic Gum etc
Post by: berlin1984 on July 27, 2021, 02:25:45 PM
You all mentioned that you have the mastic gum capsules..

Could you describe or make a photo on how they look inside?
Is it powdered mastic gum or is it granular pieces..

Becasuse now I think maybe my way of using it as a real chewing gum might not work as well as yours.
Title: Re: Mastic Gum etc
Post by: John21 on July 27, 2021, 06:00:06 PM
You all mentioned that you have the mastic gum capsules..

Could you describe or make a photo on how they look inside?
Is it powdered mastic gum or is it granular pieces..

Becasuse now I think maybe my way of using it as a real chewing gum might not work as well as yours.
It is a powder inside the capsule. I doubt that the form matters whether powder or pieces.
Title: Re: Mastic Gum etc
Post by: fsol on July 27, 2021, 09:35:55 PM
Some initial impressions after 1-2 weeks of mastic gum:

I usually use Quantums prepack which gives me 75%-80% relief. I started with doing antibiotics + probiotics for two weeks, along with a low fodmap diet. After that I tried an O without the prepack and was immediately reminded of how terrible POIS is, without using the prepack.

I then started adding pepto bismol to the prepack and saw increasing relief. Then the mastic gum arrived and I started taking it twice a day. My initial impressions are that they provide relief overall. They also provide relief for NEs (nocturnal emissions), for which I cannot take the prepack, since they are unplanned. Another observation is that they make me bloated, like my stomach literally looks bigger, which of course isn't too great.

For now, I will continue with the mastic gum + the prepack and pepto plus a mostly low fodmap diet, as I see relief from this combination.

I'm wondering if the mastic gum has to be taken continously, or three weeks like John did will be enough..
Title: Re: Mastic Gum etc
Post by: berlin1984 on July 28, 2021, 09:00:25 AM
Did any of you get chills or sore throat when taking mastic hum?
Title: Re: Mastic Gum etc
Post by: Meshal on July 28, 2021, 11:15:30 AM
my mastic gum order will arrive next week, hopefully.(same brand john21 used). Will try it for three weeks and post the results.

I don't take any prepacks or supplements, and do not suffer any gut problems. Just hoping to get the best out of it because why not.
Title: Re: Mastic Gum etc
Post by: John21 on July 28, 2021, 04:51:40 PM
Did any of you get chills or sore throat when taking mastic hum?
No, nothing like that.
Title: Re: Mastic Gum etc
Post by: Iwillbeatthis on July 29, 2021, 06:04:17 AM
Did any of you get chills or sore throat when taking mastic hum?

It's most probably a die off reaction so its killing something bad, the same thing happened to me last week when I was eating lots of raw cilantro(corriander), which is good at killing salmonella (I tested positive for this). Cilantro is also a heavy metal chelator and I didn't realise it was so powerful until I tried eating lots of it raw recently.
Title: Re: Mastic Gum etc
Post by: Limejuice on July 29, 2021, 05:53:36 PM
Sorry for the tardy response. Management of my time is a challenging feat for me :)

Regarding my trials with mastic gum, I used 500 to 1000mg daily for 3 weeks (until the bottle was almost gone) and unfortunately saw little results. I suspect my inconsistency (empty stomach/full stomach, morning/night, dosage) may have effected the results, or duration may not have been long enough (some articles suggest use for up to several months). Sorry for the erratic application.

I intend on trying again with a more consistent and longer trial, and the bottle is in the mail now.

Thanks
Title: Re: Mastic Gum etc
Post by: demografx on July 29, 2021, 07:00:40 PM

Management of my time is a challenging feat for me :)


Limejuice, I gave up on that long ago.

Now I just let time manage me :)
Title: Re: Mastic Gum etc
Post by: Limejuice on July 29, 2021, 11:29:15 PM

Management of my time is a challenging feat for me :)


Limejuice, I gave up on that long ago.

Now I just let time manage me :)

 ;D ;D ;D
Title: Re: Mastic Gum etc
Post by: John21 on July 30, 2021, 03:39:32 AM
Sorry for the tardy response. Management of my time is a challenging feat for me :)

Regarding my trials with mastic gum, I used 500 to 1000mg daily for 3 weeks (until the bottle was almost gone) and unfortunately saw little results. I suspect my inconsistency (empty stomach/full stomach, morning/night, dosage) may have effected the results, or duration may not have been long enough (some articles suggest use for up to several months). Sorry for the erratic application.

I intend on trying again with a more consistent and longer trial, and the bottle is in the mail now.

Thanks

This is disappointing. I am emphatic that something I took in those 3 weeks resulted in eradication of all symptoms (so far). Maybe it wasn't mastic gum, or not entirely that. Maybe 2 or 3 or 4 things worked together. It will take some experimentation to get to the bottom of this but I hold out hope that this process can help many people with POIS.
Title: Re: Mastic Gum etc
Post by: Clues on August 01, 2021, 03:12:50 AM
This is disappointing. I am emphatic that something I took in those 3 weeks resulted in eradication of all symptoms (so far). Maybe it wasn't mastic gum, or not entirely that. Maybe 2 or 3 or 4 things worked together. It will take some experimentation to get to the bottom of this but I hold out hope that this process can help many people with POIS.

John21, it seems entirely possible that Mastic Gum works for you, but not for someone else. Maybe a bacterial infection is your root cause, but there may be any number of root causes that lead to POIS as far as we know. Just like many things can lead to depression for example.

Btw, I'm still taking Mastic Gum as well, plus Oregano Oil and a few more things. I'm past 3 weeks now. Haven't tried orgasm yet, but there's no change in exercise intolerance so far.
Title: Re: Mastic Gum etc
Post by: John21 on August 01, 2021, 05:53:35 AM
This is disappointing. I am emphatic that something I took in those 3 weeks resulted in eradication of all symptoms (so far). Maybe it wasn't mastic gum, or not entirely that. Maybe 2 or 3 or 4 things worked together. It will take some experimentation to get to the bottom of this but I hold out hope that this process can help many people with POIS.

John21, it seems entirely possible that Mastic Gum works for you, but not for someone else. Maybe a bacterial infection is your root cause, but there may be any number of root causes that lead to POIS as far as we know. Just like many things can lead to depression for example.

Btw, I'm still taking Mastic Gum as well, plus Oregano Oil and a few more things. I'm past 3 weeks now. Haven't tried orgasm yet, but there's no change in exercise intolerance so far.

I agree, there may be different "types" of POIS. This is perhaps shown in the variety of POIS symptoms. For example I have never experienced exercise intolerance. But I hold out hope that others can benefit as I have.
Title: Re: Mastic Gum etc
Post by: demografx on August 01, 2021, 10:18:08 AM

…I hold out hope that others can benefit as I have.


Modesty! :) Many POISers have benefitted from you since 2007!
Title: Re: Mastic Gum etc
Post by: John21 on August 01, 2021, 02:01:41 PM

…I hold out hope that others can benefit as I have.


Modesty! :) Many POISers have benefitted from you since 2007!

Thanks Demo, but I'm sure no one has done as much as you. You took the lead from the beginning and have been encouragement to many, including myself.  Thanks for all you do!   ;D ;D
Title: Re: Mastic Gum etc
Post by: berlin1984 on August 01, 2021, 02:03:17 PM
While I don't think it had an effect on my POIS (but that's hard to say because I also tested Quantum's pre-pack), I feel less bloated recently.
So it does _something_ that's for sure.
Title: Re: Mastic Gum etc
Post by: berlin1984 on August 01, 2021, 02:04:08 PM
Thanks Demo, but I'm sure no one has done as much as you. You took the lead from the beginning and have been encouragement to many, including myself.  Thanks for all you do!   ;D ;D

Agreed. This forum is great!
Title: Re: Mastic Gum etc
Post by: demografx on August 01, 2021, 02:08:21 PM

…I hold out hope that others can benefit as I have.


Modesty! :) Many POISers have benefitted from you since 2007!

Thanks Demo, but I'm sure no one has done as much as you. You took the lead from the beginning and have been encouragement to many, including myself.  Thanks for all you do!   ;D ;D

 :o :o
Title: Re: Mastic Gum etc
Post by: demografx on August 01, 2021, 02:09:14 PM
Thanks Demo, but I'm sure no one has done as much as you. You took the lead from the beginning and have been encouragement to many, including myself.  Thanks for all you do!   ;D ;D

Agreed. This forum is great!

Thanks, Berlin!!
Title: Re: Mastic Gum etc
Post by: Limejuice on August 04, 2021, 11:06:37 AM

…The new mastic bottle arrived so the trials with your success continues.


Exciting progress news, Limejuice!
Title: Re: Mastic Gum etc
Post by: Meshal on August 09, 2021, 12:59:17 PM
my AOR mastic gum bottle just arrived. Starting off with 1cap/400mg a day for three days, here's to eradicate pois from existence!!
Title: Re: Mastic Gum etc
Post by: Clues on August 09, 2021, 02:08:29 PM
Quick report on my mastic gum trial. I've used up one bottle of capsules, took roughly a month I believe. I haven't tried an orgasm yet due to life circumstances. However, my exercise intolerance seems completely unaffected, and I've felt no other notable changes, so I'm not very hopeful for my case. FWIW right now I'm kinda leaning against my gut issues being the root cause in my case, as I've managed to improve my gut function tremendously over the last year or two, but while lessened, my symptoms are far from gone.
Title: Re: Mastic Gum etc
Post by: Meshal on August 15, 2021, 02:34:22 AM
Well I'll be damned, *something* is actually working. Had two arousals so far and I can definitely tell there is something different about my pois physical symptoms.
Still early to tell, though. I'll give my full report in two weeks with definitive results.
Title: Re: Mastic Gum etc
Post by: drop247 on August 20, 2021, 02:08:14 PM
John21, sorry if you already answered this but did you take the mastic gum on an empty stomach, before meals, after meals? Same question for your other supplements.

How are you doing now? Still taking anything?
Title: Re: Mastic Gum etc
Post by: John21 on August 20, 2021, 05:01:28 PM
John21, sorry if you already answered this but did you take the mastic gum on an empty stomach, before meals, after meals? Same question for your other supplements.

How are you doing now? Still taking anything?

I don't remember taking any supplement on an empty stomach but rather with meals. I would often chew the mastic gum before swallowing. Currently I am not taking supplements. I presume that I am still out of the woods but am presently chaste.
Title: Re: Mastic Gum etc
Post by: Mr Raba on August 21, 2021, 10:08:50 AM
This is an excellent article on gut causes of  inflammatory conditions, what works according to research discussed (herbs ) and most importantly the mechanism that stars and perpetuates systemic inflammation that can be traced to gut. Excellent resource for this discussion.

https://www.healthrising.org/blog/2021/08/11/gulf-war-illness-herbs-gut-chronic-fatigue-fibromyalgia/

I just bought  Andrographis from amazon for about 14$.  The article presents it and the evidence is encouraging.
Title: Re: Mastic Gum etc
Post by: John21 on August 22, 2021, 05:10:28 AM
This is an excellent article on gut causes of  inflammatory conditions, what works according to research discussed (herbs ) and most importantly the mechanism that stars and perpetuates systemic inflammation that can be traced to gut. Excellent resource for this discussion.

https://www.healthrising.org/blog/2021/08/11/gulf-war-illness-herbs-gut-chronic-fatigue-fibromyalgia/

I just bought  Andrographis from amazon for about 14$.  The article presents it and the evidence is encouraging.

Interesting. I just ordered a bottle to try it (not for POIS but for general health).
Title: Re: Mastic Gum etc
Post by: Clues on August 23, 2021, 05:48:28 AM
Mastic gum update:

I took 1000 mg mastic gum per day for about a month, in the form of capsules from Jarrow Formulations brand. Tried an orgasm a few days after finishing the bottle, and symptoms were as usual. Mastic gum had no perceptible effect for me.

Note also that while I was taking the mastic gum, I speculated that a H. pylori infection might be the reason some people were seeing improvements from mastic gum, and took multiple other supplements that combat H. pylori:
I also took oregano oil capsules, which ostensibly combat a different set of pathogenic gut bacteria, just in case that might help.

Net result: No change whatsoever. To me this reinforces the idea that POIS can arise from multiple root causes. In my case, I doubt the root cause is a gut infection.
Title: Re: Mastic Gum etc
Post by: berlin1984 on August 23, 2021, 01:49:40 PM
For me it's similar no effect, although I did not follow the regime so closely as Clues and I did not use a powedered one.

Some time ago, I also did not have a change with Pepto Bismol.

I also think I never got improvements with methylation stacks (also as per my 23andme checks, my methylation seems not so bad?)

I agree that for me, the POIS is more dsyautonomia/disregulation + "bad" genes +  some other infection?
(And Quantum's stack plus herbs/adaptogens is more useful for me)
Title: Re: Mastic Gum etc
Post by: John21 on August 23, 2021, 04:44:13 PM
Well this is disappointing. Maybe there are different types of POIS, but maybe I guessed wrong, maybe mastic gum was not the key in the supplements that I took... something worked.
Title: Re: Mastic Gum etc
Post by: Clues on August 24, 2021, 02:53:07 AM
Well this is disappointing. Maybe there are different types of POIS, but maybe I guessed wrong, maybe mastic gum was not the key in the supplements that I took... something worked.

IMO it's totally plausible that it may have worked for you but not others. :)
Title: Re: Mastic Gum etc
Post by: Progecitor on September 06, 2021, 02:13:30 PM
Could anyone who had a positive experience with mastic gum report about when they first began to see any change in symptom intensity? Was it only a day or two or maybe a week or more?
Title: Re: Mastic Gum etc
Post by: elish2006 on January 25, 2022, 10:03:56 AM
Hey John21,

What were your POIS symptoms?
Title: Re: Mastic Gum etc
Post by: John21 on February 20, 2022, 08:26:27 AM
Cognitive issues: poor short term memory and unwell feeling. 
Title: Re: Mastic Gum etc
Post by: Disaster on March 10, 2022, 12:08:57 PM
I also believe there is a microbiome component to POIS. When I was very young I got a lot of strep throat so I was put on antibiotic every other week. I can remember having accidents when I was little up until maybe 12 years old because I could barely hold back pooping. Looking back I think the antibiotics were the cause. So it is quit possible there is a link since I had mild POIS from my 1st orgasm on. To this day I have major gastrointestinal problems and part of my POIS numbs my lower abdominals and then after 24 hours they get very inflamed and I could have the worst level 10 pain depending on what I eat. I learned that if I avoid dairy that helps some. Also less junk type of food help. So no fried foods, candy, soda, ect? all things I love.

Regarding Mastic Gum I have been using it for over a decade and I have used every form of it, chewing gum, mastic tears, tea, tooth paste, oil, baking with it and and capsules. I have seen no improvement of POIS symptoms with it. It?s more of a stomach and teeth medicine than a colon and intestinal medicine.

Most of the the digestive supplements I have tested over the years and there are so many you would not believe, have helped my gut but with no effect on my POIS.

The last 5 years I have focused on my microbiome and I suggest everyone get microbiome testing, it is the future of medicine. The Microbiome is extremely resilient, antibiotics can whip out healthy and harmful bacteria but they usually come back depending. But probiotics also only has a temporary change for it. The trick is adding on a consistent basis as much different fibers as possible. It?s not about quantity but variety. Also natural ferments, like sauerkraut, Kefir, Kombuchas, Natto, ect?
Title: Re: Mastic Gum etc
Post by: John21 on April 03, 2022, 04:03:24 AM
Interesting. It has been a year or so since I had the success and it now seems to have repeated. I once again had some minor POIS so I again tried supplements - glutamine, mastic gum and probiotics. And once again it worked. I am now doubting whether mastic gum plays any part. It may be that in my case probiotics are enough to correct an imbalance. Also of note, it seems that my mood has improved after starting the probiotics. I find this amazing and want to learn more about how to improve the gut health. The probiotic I have been taking says to take one a day but I have been taking one in the AM and one in the PM. Maybe the glutamine is helping out as well.  I know others have not been helped by this type of treatment and that sucks, but it does indeed seem that my POIS is related to the gut as I have also previously benefited from things like taurine and pepto bismol. I am also wondering if gut disbyosis could be responsible for my longstanding insomnia.

Interesting article (https://www.biocodexmicrobiotainstitute.com/en/pro/taurine-energizes-gut-microbiota-against-pathogens) on taurine. Maybe I'll try adding taurine to what I am currently taking. 

I remember that dandelion has helped me in the past for mental wellness (but didn't help POIS). If I understand what I have read today bitter herbs like that can help the liver produce bile which can fight invaders.  Perhaps I'll try a bitter herbs supplement.
Title: Re: Mastic Gum etc
Post by: Quantum on April 03, 2022, 08:13:45 AM
Interesting. It has been a year or so since I had the success and it now seems to have repeated. I once again had some minor POIS so I again tried supplements - glutamine, mastic gum and probiotics. And once again it worked. I am now doubting whether mastic gum plays any part. It may be that in my case probiotics are enough to correct an imbalance. Also of note, it seems that my mood has improved after starting the probiotics. I find this amazing and want to learn more about how to improve the gut health. The probiotic I have been taking says to take one a day but I have been taking one in the AM and one in the PM. Maybe the glutamine is helping out as well.  I know others have not been helped by this type of treatment and that sucks, but it does indeed seem that my POIS is related to the gut as I have also previously benefited from things like taurine and pepto bismol. I am also wondering if gut disbyosis could be responsible for my longstanding insomnia.

Hi John,
Alot of research has been done in recent years about the different roles of gut flora, and it is far more important than we thought.  Here is an article about its importance in relation to our mood:   https://www.psychologytoday.com/us/blog/neuroscience-in-everyday-life/201908/gut-bacteria-can-influence-your-mood-thoughts-and-brain


Title: Re: Mastic Gum etc
Post by: Hopeoneday on April 03, 2022, 01:40:22 PM
Interesting. It has been a year or so since I had the success and it now seems to have repeated. I once again had some minor POIS so I again tried supplements - glutamine, mastic gum and probiotics. And once again it worked. I am now doubting whether mastic gum plays any part. It may be that in my case probiotics are enough to correct an imbalance. Also of note, it seems that my mood has improved after starting the probiotics. I find this amazing and want to learn more about how to improve the gut health. The probiotic I have been taking says to take one a day but I have been taking one in the AM and one in the PM. Maybe the glutamine is helping out as well.  I know others have not been helped by this type of treatment and that sucks, but it does indeed seem that my POIS is related to the gut as I have also previously benefited from things like taurine and pepto bismol. I am also wondering if gut disbyosis could be responsible for my longstanding insomnia.

Interesting article (https://www.biocodexmicrobiotainstitute.com/en/pro/taurine-energizes-gut-microbiota-against-pathogens) on taurine. Maybe I'll try adding taurine to what I am currently taking. 

I remember that dandelion has helped me in the past for mental wellness (but didn't help POIS). If I understand what I have read today bitter herbs like that can help the liver produce bile which can fight invaders.  Perhaps I'll try a bitter herbs supplement.

Hi John, who knows, maybe l-glutamine repair yours leaky gut fast..
What brand of probiotics you taking?
Title: Re: Mastic Gum etc
Post by: John21 on April 03, 2022, 05:44:58 PM
Quote
Hi John, who knows, maybe l-glutamine repair yours leaky gut fast..
What brand of probiotics you taking?

Webber Naturals - Probiotic 30 Billion - 8 Probiotic Strains
Title: Re: Mastic Gum etc
Post by: Charles_b on April 03, 2022, 10:30:36 PM
Hi John, glad you are able to get relief again!  Just had a question about the probiotics: I thought you had previously mentioned taking Jamieson 10billion cfu probiotics.  Did you just recently switch to webber, or was Webber part of your original relief as well?

I ask because the one constant I keep seeing in microbiome research is that particular strains seem to make all the difference.
Title: Re: Mastic Gum etc
Post by: John21 on April 04, 2022, 04:51:59 PM
Quote
Did you just recently switch to webber, or was Webber part of your original relief as well?

Webber is just the one I happened to buy this time, that is what the store had. I selected the one with the highest number of strains.