Post Orgasmic Illness Syndrome (P.O.I.S.)

POIS Life Style => Lifestyle Diary and POIS Summaries => Topic started by: Prospero on January 05, 2021, 10:28:37 AM

Title: An introduction to Prospero's case
Post by: Prospero on January 05, 2021, 10:28:37 AM
Hi all,

I'm 23 years old, I have Pois since 2015 for sure, probably earlier. Here is a personal thread to sum up datas which may be relevant about my POIS.

Please forgive me my possible linguistic mistakes, I'm French and my English isn't perfect. I have no scientific training, so I'll try to be cautious when making comments but I can still say something silly !

Contents :
I/ Triggers
II/ Symptoms
III/ Health background and analyses
IV/ Chronological evolution of POIS
V/ Experiences with treatments


I/ Triggers :

There are several triggers to my POIS, each having slightly different consequences, which will be detailed in the 2nd section :

a. Orgasm/ejaculation, of course. As far as I know, stronger or repeated orgasms make POIS worse. As I'm abstinent since approximately one year and a half, nocturnal emissions are now my only source of O-related POIS apart from a few exceptions.

b. Arousal : several symptoms appear from the first seconds of arousal, as I'll explain later. However, the longer the arousal, the worse. The stronger the arousal, the worse. If the arousal is kindled by a sexually explicit image, video or text, symptoms are immediately more virulent than if I'm just thinking by my own about something exciting for a few seconds. Whether pre-ejaculate is dropped or not seems to decide whether other symptoms will appear and stay for days, but I'm not sure. If before arousal I'm perfectly POIS-free, just a few seconds of arousal can trigger a complete POIS episode, while if I'm already in some kind of POIS state, even if it's mild, things are not so clear.

c. Physical exercise, whether it be sport or any kind of sustained effort. When I'm enduring an acute POIS episode, I'm completely unable to do physical exercise so there is no question. Physical activity is possible under a milder POIS state, but then there are still problems : my respiration is bad, my heart rate at rest is too high (between 90 and 110 bpm) and intense or sustained effort makes me sick, I often feel a brief burning sensation around the heart, followed by an overwhelming fatigue/malaise that lasts maybe for 24 to 48 hours, during which I have to rest. It also seems that even under a very mild POIS condition, physical exercise can trigger some POIS symptoms. I'm not sure about physical exercise triggering symptoms when I'm completely POIS-free : in the beginning it wasn't the case for sure, but since the end of 2019 I have almost never been completely POIS-free, so exercise was always harmful. The only exception was when my POIS was temporarily neutralized by daily Omega-3 last September, I spent days cycling without any problem.
Some sports are more harmful : several years earlier, when I had my first symptoms caused by exercise, they were only triggered by abdominal exercises (originally I thought that it had something to do with my breathing in this specific case, as I felt that I was unwittingly 'holding my breath' in a way very similar to what I did during masturbations). Then push-ups, lifting weights, rowing began to make me sick as well, then running, cycling, etc. Still now, running and cycling do not necessarily generate symptoms, but they often do when exercise gain some intensity or duration.

Exceptions :
- Unconscious nocturnal ejaculations without wet dream : it happened rarely but I have experienced NE completely free of wet dream and orgasm, while I'm deeply asleep. I just wake up at some point to realize that my groin is wet. Usually this happens earlier in the night (2-3 a.m.) than typical wet dreams (from 5 to 9 a.m.), but it is not an inflexible law. No POIS or less POIS in these cases.
- "Romantic" wet dreams did not trigger POIS : it happened only one or two times, I'm not sure, so take it with caution but I had no POIS after a NE triggered not by a classical "masturbatory" wet dream (a "pornographic fantasy") but by a "romantic", non-sexual one (in which I was overwhelmed by the sweet presence of a beloved being). (Endorphins?)


II/ Symptoms :

After orgasm :
- Overwhelming fatigue, feeling "empty" (always)
- Muscular weakness (always)
- Nervousness (always)
- Depressed mood, anhedonia, lack of energy, motivation, social skills and creativity (always)
- Irritability, mainly in the first 24h (always)
- Social anxiety, feeling vulnerable, need to be alone (always)
- "Bad" breathing : not deep and "oxygenating" enough - it's a feeling (always)
- Tachycardia (90 to 110 bpm at rest) (always)
- When I awake (after a night or even just a few seconds of somnolence), my heart rhythm races unusually (always, linked to the previous one)
- Intolerance to physical effort (always)
- Reduced hunger (always)
- Lack of resistance to stress (always)
- Chest pain (a burning point near the heart), especially when an air bubble is going up from my belly to my mouth (often). Sometimes there is a pain a bit lower, which is not worsened by air bubbles.
- Diarrhea / sudden increase of gut motility in the following hours (sometimes), then constipation in the subsequent days (always)
- Nausea (often)
- Asthenia, impaired work capacity, slower thinking process, speech impairment (often, but decreased since abstinence)
- Dry mouth and throat after sleeping (often, by periods)
- Fasciculations and nervous spasms when I relax and lie down, or before falling asleep (often)
- Post-nasal drip (often)
- Acne pimples, or a unique big one (often)
- Appearance of a ganglion under the jaw, for 24/48h (sometimes)
- Lower back pain, disappearing after a few hours (sometimes)
- Nasal congestion (sometimes)
- Insomnia (sometimes)
- Shrill voice (sometimes)

After a sustained sexual arousal (more than a few minutes), without orgasm :
Most symptoms are similar but NO overwhelming fatigue, not such a feeling of emptiness / weakness / vulnerability. Other symptoms include :
- Big nausea (almost always)
- Unpleasant body odour (almost always)
- Muscular (?) pain, especially in all the thorax area (often)
- Need to urinate just after (always), sometimes for multiple times
- Shivering (often, but just in the minutes or hours following the end of arousal)
- Difficulty for breathing, which ? needs ? some conscious effort, and can be irregular (sometimes)
- Pelvic pain (sometimes)
- Pain near the jaw (sometimes)

After physical exercise (with some intensity) :
- General fatigue, of a different kind than post-orgasmic fatigue (often)
- Bad breathing (often)
- Muscular (?) pain, especially in all the thorax area (often)
- Difficulty for breathing, which "needs" some conscious effort, and can be irregular (often)
- Nervousness (sometimes)
- Tachycardia (sometimes)

After a few seconds of slight arousal if POIS-free, after the release of pre-ejaculate if already in POIS :
- Nervousness (always)
- Constipation (always)
- Bad breathing (always)
- Tachycardia (always)
- Depressed mood, lack of energy (always)
- Lack of social skills, self-confidence and creativity (always)
- Reduced hunger (always)
- Lack of resistance to stress (often)
- Fatigue and need to sleep (sometimes, IF completely POIS-free before)

Most of post-orgasmic, post-sustained arousal or post-exercise symptoms resorb after a period from 24h to a week. The last list of symptoms can last for weeks (it's more difficult to be precise because it can be difficult to avoid arousal completely for a long time).

It means that the signs of complete remission from POIS are the following :
- Breathing suddenly becomes normal, deeper, with a "fresh" feeling in the entire body at each breath
- Heart rhythm gets back to normal (60-70 bpm) and doesn't race when I awake
- General relaxation of my body, I feel calm
- No more constipation
- Hunger
- Joyfulness, humour, social skills, energy and self-confidence come back
- I feel more intelligent, sharp, creative, motivated, I wake up earlier, etc.
This happens at the same time, either when I wake up in the morning or suddenly in the middle of the day. The last time it happened was in May 2020. This state of "perfect health" lasted one day before POIS came back when I had a few seconds of slight arousal in the morning.
Most of the time my illness decreases progressively (with some symptoms like tachycardia finally disappearing) but not to the point of complete remission.

Miscellaneous :
- My orgasms are not as pleasant as they used to be before POIS. There is often a bittersweet feeling, evocative of a poisoning, during the orgasm and in the following seconds.
- My ejaculate became yellow, liquid and transparent since 2016.
- Usually, masturbating or being aroused will prompt some (apparently) stress-related symptoms starting from the very first seconds : anxiety spikes up, heart rhythm increases, my body get insanely tensed, my breath almost stops by moment, then all this vanishes and only some minutes after do the "post-arousal" symptoms manifest themselves.
- Repeated orgasms or masturbations without ejaculation, in the space of one or a few days, worsen my condition. The symptoms that worsen the most are nausea, fatigue, weakness, depression, shivers, body pain, social anxiety, anguish. If I were to speculate a little, I would say that these are the 'opioid withdrawal-like' symptoms.
- What I call my 'big POIS crises' have two possible causes : repeated orgasms/masturbations, or physical effort in the 24h following an orgasm or a prolonged arousal. In this second case, it can be a slight and temporary effort (vacuuming my room, for example). It would usually cause a one-time burn near the heart, then an overwhelming fatigue, nausea, and anguish, often leading to a crisis of tetany for a few moment. Tetany seems to be caused only by anxiety, because now that I have POIS for years and that I know somewhat that this a real disease, I don't have these attacks anymore in the same situation.
- I'm not 100% sure about this one, but it looks like my immune system is weakened after an orgasm, because I quite often fall sick (from a 'common' illness) in the 24 or 48h after it, mainly in autumn, winter and spring. Now that my orgasms are rare, and almost only from nocturnal ejaculations, it has become clearer. For example, last winter, I got the flu one day after a NE, probably in a cinema, while my mother who was with me didn't catch it. Then in March I got Covid-19, like all my colleagues : in the first days I had only a post-nasal drip (I'm young, after all), then I had two NE, two nights in a row, the usual symptoms lasted for a few hours only, and after less than 48h I became very ill, which lasted for 13 days. I have other cases in mind.
- Please also notice that I don't have POIS when I'm ill, like with the flu or Covid-19 (though some Covid symptoms were very evocative of POIS). It is also true, though, that I'm less prone to sexual arousal when I'm sick...
- I feel "less heterosexual", or "less manly", in a POIS state, and I experience a much stronger desire for females out of it, as well as a stronger "willingness to assume a manly role", sexually.
- In the "not sure about this one" category, I believe that my POIS is rather less powerful in winter.


III/ Other informations on my health :

- I am subject to cholinergic urticaria since 2012, ie when I suspect that POIS appeared. My mother had this when she was 14 to 18 years old, but then it disappeared (it did not for me).
- I have always been sensitive to constipation, but under POIS it has become systematic and almost a permanent state. My grand-mother also has a long history of chronic constipations.
- Since my teen years I have important bloating. I also have gastroesophageal reflux sometimes, which is quite common in my family (due to problems with a valve somewhere).
- I have haemorrhoid problems since the beginning of 2020, as I'm almost always constipated, but I also wonder if there's not a link with changes concerning blood vessels in POIS. I've noticed that leaving POIS state immediately stops haemorrhoids, while ending constipation alone doesn't seem to be as efficient. Not sure, though.
- Since my teen years, I'm vulnerable to stress : in the beginning, it was mainly when I had to speak in public that I had spikes of stress, then it extended to some situations when playing video games, and more recently to watching movies (when there is suspense). In this kind of situation, my heart rhythm increases importantly, I feel anguished even if I'm not, I sweat, I'm shaking,... I've noticed that I'm much more prone to this in a POIS state, and that Omega-3 are a great help for this problem, as they are for some other POIS symptoms.
- I have a lymph node behind the right ear since 2008. I was also tested for EBV this same year, but I don't remember if it was because of this or if I was also sick (the result of the test was negative).
- I have atopic dermatitis (eczema) on the face since 2007 (mainly around the eyes, but it spreads on the forehead and the cheeks when I wash my face). It was more virulent when I was younger, but I didn't succeed in erasing it completely.
- I had a skin mycosis on my arms in 2007-2009, but I got rid of it.
- I was tested positive for allergies against ? dust ? (acarids) and cypress pollen in 2007. No other allergy test was made, except against mimosa pollen (mild reaction, not very important).
- I had a surgery of the retina (with laser) in 2012, after a tennis accident.
- My weight remained between 51 and 54 kg (it varies) since 2012. As I am 178 cm tall, I'm underweight. My body appearance is skinny and it's very difficult for me to gain muscle, even with sustained physical exercise (which I can't do now that it gives me POIS symptoms, but I used to go to the gym for some periods before, though I was never good at sport).
- It seems that I have Gilbert's syndrome, according to my last analyses (my doctor said so).
- I'm beginning to have some gum problems, it's more easily irritated and bleeding than it used to, but I don't know if there's a link with POIS.
- I have been taking anti-histamines (desloratadine) very regularly for long periods of time when I was younger, before POIS onset (approximatively between 2008 and 2014, I'd say, and much less frequently until 2016), first because of my allergies which were thought to result in eczema, and then because of my cholinergic urticaria (which manifested only when I went bathing). At the time, desloratadine didn't trigger any special nervousness, which it now does, at least during POIS episodes (but they never really end). I report this because some people here seem to think that prolonged use of anti-histamines can in fact increase histamine production and allergic sensitivity.
- In 2019 I suddenly developed a mild phimosis and had an injury of the frenulum. I don't know which caused which: one day pulling back the foreskin became a bit more difficult and painful, notably in the frenulum, and a few months later, when I had a rare sexual intercourse with a woman, my frenulum was injured and bled. Since then, stretching the frenulum is very painful, pulling back the foreskin when I have an erection is impossible, the extremity of the glans seems permanently irritated (there is a point, just at the junction of the frenulum and the urethra, which is now abnormally red, like an inflammation or a little cut which doesn't heal), and having a coitus is impossible (too painful). "Fortunately" I don't have a girlfriend. When I saw a urologist recently, he estimated that the frenulum should be removed. As for the phimosis properly said, its intensity varies through time: most of the time it isn't really obvious, there is just the frenulum problem which prevents me from pulling the foreskin, but sometimes the foreskin is much more tight and adhesive, to the point that when I finally pull it, the glans is red and irritated.
Before 2019 I had never had any problem of phimosis or frenulum. It may be a pure coincidence if this happened but... well, no, I don't really believe in this kind of coincidence, I guess there is a link with POIS. Maybe a chronic inflammation of the genital tract which resulted in the weakening of the frenulum? A consequence of a general tension and stress in my body? I've also read that scleroderma (connective tissue autoimmune disease) can cause dyspareunia (my kind of problem), and scleroderma develops through Th1 & Th17, ROS, VEGF upregulation, etc., i.e. mechanisms which have been discussed for POIS.
- Someone recently mentioned hiatus hernia, it's a common problem in my family and it may cause my important bloating & digestive issues, I don't know.

Results of my blood and urinary analyses :
November 2020 : (https://poiscenter.com/forums/index.php?topic=2684.msg37565#msg37565)

Probably the most interesting anomaly is the presence of Anti-nuclear antibodies, of the ENA kind, which may be indicative of an auto-immune condition.

Other anomalies:
- total bilirubin: 23,9 umol/L (norm: 3.4 - 20.5)
- albumin: 49,1 g/L (norm: 40.2 - 47.6 g/L)
- proteinuria: 0,22 g/L (norm: < 0,14)
- red blood cells in urina: 9 090 (norm: < 5 000)

Normal values:
- blood counts
- CRP
- sodium / potassium / chloride / proteins / calcium / phosphorus
- uric acid: 370 umol/L (norm: 208 - 428)
- blood creatinin
- ASAT / ALAT / alkaline phosphatase / GGT
- conjugated bilirubin / free bilirubin
- cholesterol / triglycerids
- TSH
- testosteron / free testosteron
- vitamin D: 32 ng/mL (30 - 60) - I had taken a supplementation in september, as I had a deficiency in previous tests.
- prostate-specific antigen: 0,996 ug/l (<4)
- syphilis / HIV / hepatitis B and C: negative
- anti-dsDNA antibodies and anti-phospholipid antibodies: negative
- leukocytes in urina: 1 980 /mL (< 10 000)
- no urinary infection
- Chlamydia, gonorrhoeae, mycoplasma hominis, ureaplasma urealyticum (though only in first jet of urina, semen was not tested): negative
- C3, C4 and CH50 complements: normal
- ANCA specificities (MPO / PR3): negative

May (https://poiscenter.com/forums/index.php?topic=2684.msg40737#msg40737) and June 2021 (https://poiscenter.com/forums/index.php?topic=2684.msg41284#msg41284):
1/ May:
LH: 2,91 IU/l (RR: 0.57 to 12.07)
FSH: 1,39 IU/l (RR: 0.95 to 11.95)
Prolactine: 196,0 mIU/l (RR: 72.7 to 407.4)
LH and FSH are still in the reference range but seem pretty low.

2/ June:
Abnormal values:
Progesterone: <1.6 nmol/l (RR: <0.64)
Homocysteine: 12,73 micromol/l - Normal: <10 micromol/l ; Intermediary level: 10 to 15 micromol/l ; Superior level: 15 to 30 micromol/l

Normal values:
Estradiol: <88.1 pmol/l - RR: 40 to 161
Estrone: <0.04 nmol/l - RR: 0.03 to 0.22
DHEA-S: 6.6 micromol/l - RR: 5.7 to 13.4 micromol/l
Histamine: 392.2 nmol/l - RR: 200 to 2000
Tryptophan: 59 micromol/l - RR: 52 to 82
Adrenaline: <0.50 nmol/l - RR: < 1,00
Noradrenaline: 2.37 nmol/l - RR: < 4,00
Dopamine: <0.50 nmol/l - RR: < 1,00


Previous analyses :
Vitamin D3 deficiency (in 2016 and 2018, end of summer).
Iron, B9 and B12 values were normal.
In 2008, my ferritin was low, but it was never tested anew later.
EBV negative in 2008.
Normal cerebral MRI in 2016 and 2020.

Genetic profile for methylation and detox. (https://poiscenter.com/forums/index.php?topic=2684.msg38803#msg38803)


IV/ Chronological evolution of my POIS :

2012 : Suspected first POIS symptoms at age 14/15. I noticed that my breath was not always as good, deep and regular as it used to. I stopped to gain weight. In 2012/2013 I became much less social, joyful and energetic, had a more depressed general mood, lost progressively most of my friends and became completely solitary. At school, one of my friends noticed that I was depressed and silent in the morning, but that I was better after noon. I remarked that it was true when I masturbated in the morning, when I awake, and that I had a much better mood when I abstained. At the time though, I masturbated several days a week, if not every day. As I became solitary and depressed, I masturbated more often.

2014/2015 : Increased loneliness when I entered the university, increased masturbations. I slowly became consciously addicted to it. I started to have insomnias sometimes in 2015, linked to anxiety, nervousness, bad breathing and tachycardia in the night (probably after evenings when I had been aroused by some stuff). I realized that when I was aroused / masturbating, I had this rise of strange stress symptoms, and tried to be more relaxed when doing it, without success. At the time I only suspected problems of posture or breathing when masturbating.

2016 : First time I became really sick because of POIS, early in the year : I had made push-ups some time after a masturbation, if I remember well. Big nausea and anxiety, really bad. Then I noticed that after an orgasm I was tired and weak for hours (climbing up the stairs going to my appartment was difficult). I also became convinced that abstaining from masturbation for several days allowed me to regain an unsuspected level of energy, good mood, calm and sociability. I thought that I was masturbating too much, and tried to do it less... but it was difficult. The more I wanted to stop it, the more I felt that I was addicted. In November I had my second big POIS crisis, I believed that I was going to die and it lasted for almost a week, then it got back to normal. It became nightmarish : I tried to stop masturbation, but I was waking up in the morning while realizing that I had been unconsciously doing it. My general psychological well-being was, huh, not very good.

2017-2018 : The nadir of this period. Though I did succeed in slowing down the rhythm of my sexual stimulations, I became progressively more sensitive, all the other symptoms popped up and worsened, and they lasted longer. Social anxiety in particular was very hard to manage at the time. Still, POIS did not last for more than 1 week, and there were many periods of complete remission. In the summer 2018, I could do one month of daily exercise, while abstaining completely, and felt very healthy. However, at the end of 2018, I began to get symptoms even from sport.

2019-2020 : When I understood that even a few seconds of masturbation, without orgasm or anything, were sufficient to make me sick, I definitively stopped doing it. I'm still completely abstinent now, but since the beginning of 2020 my sensitivity to POIS and its duration increased ever more, and I'm no longer able to stay in a state of complete remission for more than 24h. Last winter, the maximum duration of POIS was 10 days, it went to 15 days in the spring, to 5 weeks until May, and since then it never really ended. However I discovered several useful supplements and drugs, and I keep being abstinent, so generally speaking I'm in a much better state than during the previous period.


V/ My experience with treatments, supplements, etc.

Spontaneous remission cases :
- After spending an evening with friends : I don't do that often because I have very few friends and almost no social life, but two years ago I was invited to an aperitif with work friends, while I was feeling sick (I had had a prolonged period of arousal earlier in the day). It began at 6 pm and ended at 1 am, and when going back home I suddenly realized that I was perfectly well, calm, no more tachycardia, etc. (Endorphins?).
- It also happened two times that a 'very long' night of good sleep ended a POIS episode suddenly. I mean going to bed at 7 pm and waking up at 12 am. I tried to repeat this solution but I didn't fall asleep before 2 am, so it didn't work... (POIS often causes insomnia and bad sleep.)
- Showers : they have sometimes stopped a mild-POIS onset after the "slight arousal" kind of trigger. Even if they do not, I usually feel better after a shower. Warm showers are especially welcome to end my nervousness.

Drugs :
- Paracetamol (500 mg, immediately after O) : 50 to 80% of symptoms reduction. Tired in the following evening but most symptoms are under control. Some of them can still be there but they are attenuated and resorb more quickly.
- Tramadol (37,5 mg + Paracetamol 325 mg, immediately after O) : no POIS, but I seemingly got a mild serotonin syndrome the second time I tried it. Other side effect : stronger constipation for 48h.
- Codeine (20 mg + Paracetamol 400 mg, immediately after O) : no POIS. Side effect : stronger constipation for 48h.
- Anti-histamines (ebastine, desloratadine) : I've noticed that ebastine seemed to help against nasal congestion, but I'm not sure that my nasal congestion is linked to POIS, I'm allergic to dust and some pollens, so it may be just this. I didn't carry on with anti-histamines because they stirred up important nervousness and insomnia every time I tried them (I don't know why). Update April 2021 : I also tried Cetirizine for a week, no side effect but no positive effect either.

Supplements :
- Omega-3 (EPA 400 mg, DHA 200 mg, daily) : most useful supplement so far. I tried it last September, together with Vitamin D3, and I experienced 2 or 3 very good weeks, all my physical problems vanished, my psychological state was better though it was not a complete remission with regard to this. I tried brief sexual stimulation without O in this period, it did gave me the usual symptoms but they disappeared after a few hours. However it ceased to be this efficient at the end of the month (but I had problems due to Vitamin D3, as I'll explain). I stopped, then tried Omega-3 anew in November, my remaining symptoms disappeared (especially tachycardia and constipation). It was also very efficient against problems of stress/anxiety management. However, once again my tachycardia & constipation came back after some time, while I was still taking the supplements. So I'll probably continue to take them and cycle-off regularly.

- Vitamin D3 (800 IU, daily) : as my blood tests show a deficiency since many years, my doctor used to prescribe monthly doses of 100.000 IU during winter. I never noticed any effect on my POIS. Then, last september I decided to take daily doses of 800 IU. I don't know if they had positive effects as I took them with Omega-3, but after maybe 3 weeks strange symptoms appeared : I felt like my brain was permanently intoxicated by a mild feeling of sexual pleasure or stimulation (without any related trigger or physical sign). As days passed, this feeling gained strength and worsened to the point that it became difficult to think about something else. I had a kind of pressure point somewhere near the center-back of my skull and a small area (near the center of the brain, but it would be difficult for me to be more precise) where this strange "pleasure" originated, generating waves of stimulation more and more intense and spreading in the rest of the head whenever I thought about it, thought about nothing, lied down, tried to sleep or changed my body posture (it seemed that when the higher part of the neck or the lower part of the skull was pressed on, the stimulation increased). The only way to keep this strange stimulation in check was to focus on doing or thinking about something precise, reading, speaking, etc. If you don't understand my explanations, you're not alone, doctors did not either. All this in turn generated big nauseas, anxiety crises, tachycardia, diarrhea. It was extremely frightening. After a few days I stopped vitamin D3 and Omega-3, and the symptoms vanished progressively. Two weeks later I tried to take vitamin D3 anew (without O-3) and symptoms re-appeared in several days. Then two weeks later again, I tried another brand of vitamin D3, from lichen, which seemed very safe, and took only 400 IU : the symptoms burst in, in the following hour. I stopped my experiences with D3.

- Quercetin (500 mg) : last summer, I tried quercetin and curcumin supplements after reading posts from Muon, Quantum & others about mast cells issues. In a short period of time after taking the pill (45 min to 3h, I'd say), quercetin seemed to allow me to be slightly aroused (and even to masturbate a bit) without having the immediate unpleasant symptoms (sweating, mood shift, tachycardia, anxiety, need to sleep just after). It was completely useless to prevent symptoms from orgasm, however, and I also got symptoms from prolonged arousal. Taking quercetin daily for one month was equally fruitless.

- Curcumin (Curcuma longa 500 mg + piperin) : as for curcumin, it seems to provide some help in order to recover after orgasm, though it is a partial help. Taken 1h before O: extremely similar to the effect of Paracetamol. I feel that I'm a bit "emptied", and I get out of breath quickly if I make a little physical effort (climbing up my stairs...), but I'm overall good.

- Flaxseed oil (500 mg, 2 times a day) : 1 g seemed to offer similar effects as quercetin when taken 1h before sexual arousal (but nothing more). As with quercetin also, orgasm after having taken flaxseed oil was a bit different (less powerful). Taking 1 g of flaxseed oil daily for a week helped to clear all my long-lasting symptoms for another week, then they returned and flaxseed oil wasn't useful anymore.

- L-theanin (100 mg) : I tried it when I was beginning to experience troubles with vitamin D3. Positive effect, it suppressed the awkward feeling of intoxication with pleasure/stimulation that I was enduring these days, and it seemed also to spare me the post-arousal symptoms, but after an hour I had what resembles a mild serotonergic syndrome (spike of anxiety, feeling cold, important tachycardia, fasciculations, nervous spasms, shivering, nausea), disappearing after a few hours. I had it each time I tried it (3 or 4 times), but the last time the side effects were really stronger so I stopped.

- Hawthorn (Crataegus) : a doctor gave it to me in order to alleviate my tachycardia and it's very efficient, although the effect doesn't last much. It's sold under the brand Cardiocalm in France (70 mg of hawthorn), and currently I take it in the brand Omezelis (50 mg of hawthorn + 45 mg of lemon balm). When I can't sleep because of tachycardia or anxiety it's a good help.
Title: Re: An introduction to Prospero's case
Post by: drop247 on January 05, 2021, 01:06:43 PM
Did you ever receive medical investigation into why you have a high amount of red blood cells in your urine? According to a quick Google:
"Depending on the condition causing your hematuria, treatment might involve taking antibiotics to clear a urinary tract infection, trying a prescription medication to shrink an enlarged prostate or having shock wave therapy to break up bladder or kidney stones. In some cases, no treatment is necessary."
Title: Re: An introduction to Prospero's case
Post by: Iwillbeatthis on January 05, 2021, 01:18:42 PM
https://poiscenter.com/forums/index.php?topic=2502.msg38616#msg38616

Have a look about what I wrote about pure epa oil, thats good that normal fish oil has helped you but I think this can help you even more
Title: Re: An introduction to Prospero's case
Post by: Journey on January 05, 2021, 02:40:56 PM
Interesting we have many similarities for example I too stopped gaining weight ever since 16 years and I weight like 64kgn at 190cm height. I too have a powerful decrease in anxiety/nervousness and overall more relaxation and parasympathetic system activation after takign warm baths/showers and this effect lasts for like 24 hours. I too when I had a cold in the 2020 February had a nocturnal emission without erotic dream as far as I remember during a deep sleep phase (I slept like 10 hours and woke up only once when I had that cold) and in the morning I realized I have had a nocturnal emission but I also noticed I felt different and that my mental processing speed had increased and then I orgasmed later and realized I had zero brain fog other than maybe from the cold itself but no POIS symptoms at all and my mental processing speed had stayed the same at it's highest and then I had another orgasm which again was POIS free but when I healed from that cold and had another orgasm it made POIS come back fully and WHAT IS INTERESTING IS THAT I felt an increased pleasure/sensitivity in the middle deeper area of my genitals and I have never had that specific type of sensitivity increase in that specific area when the POIS symptoms are triggerable I only felt it when I was sick with that cold and completely free of POIS symptoms even after those two orgasms and that one nocturnal emission which resulted in zero POIS and I felt great.
Title: Re: An introduction to Prospero's case
Post by: Mushnikk on January 05, 2021, 02:57:47 PM
Interesting we have many similarities for example I too stopped gaining weight ever since 16 years and I weight like 64kgn at 190cm height. I too have a powerful decrease in anxiety/nervousness and overall more relaxation and parasympathetic system activation after takign warm baths/showers and this effect lasts for like 24 hours. I too when I had a cold in the 2020 February had a nocturnal emission without erotic dream as far as I remember during a deep sleep phase (I slept like 10 hours and woke up only once when I had that cold) and in the morning I realized I have had a nocturnal emission but I also noticed I felt different and that my mental processing speed had increased and then I orgasmed later and realized I had zero brain fog other than maybe from the cold itself but no POIS symptoms at all and my mental processing speed had stayed the same at it's highest and then I had another orgasm which again was POIS free but when I healed from that cold and had another orgasm it made POIS come back fully and WHAT IS INTERESTING IS THAT I felt an increased pleasure/sensitivity in the middle deeper area of my genitals and I have never had that specific type of sensitivity increase in that specific area when the POIS symptoms are triggerable I only felt it when I was sick with that cold and completely free of POIS symptoms even after those two orgasms and that one nocturnal emission which resulted in zero POIS and I felt great.

Doesnt the fact that you are pois-free when being a ill pointing towards nanna1s theory of a viral infection/a transient immunsupression which did not happen when you were sick (immune system overactivated countering the immunsupression)
Title: Re: An introduction to Prospero's case
Post by: Muon on January 05, 2021, 04:16:17 PM
Regarding low body weight; Leptin could be explored.
Title: Re: An introduction to Prospero's case
Post by: Prospero on January 06, 2021, 02:55:50 PM
@Iwillbeatthis : yes, I saw it, thank you. It's interesting.

@Muon : yes, I saw that you posted something about it previously.
There's something else I would like to explore : many drugs (cocaine, ecstacy, etc.) cause weight loss, and drug addicts are usually very skinny. I don't know the mechanisms which explain this fact, but I wonder if they couldn't be similar for POIS.

@drop247 : no, but my doctor thought that there was no reason to worry about this, as the norm is sometimes held to be < 10.000. Moreover, I have a little irritation at the beginning of the genital tract, near the frenulum, which could be an explanation. I'll add more information about this point soon, and about other important elements which I realize are lacking.
Title: Re: An introduction to Prospero's case
Post by: quikot on January 06, 2021, 03:20:49 PM
Do you have any amalgam fillings, Prospero?
Title: Re: An introduction to Prospero's case
Post by: Prospero on January 06, 2021, 04:48:03 PM
No.
Title: Re: An introduction to Prospero's case
Post by: Prospero on January 07, 2021, 12:59:28 PM
I'm currently facing a resurgence of the very strange phenomenon described in the "Vitamin D3" section - but this time I didn't take vitamin D, nor anything special.

Fortuitously, I saw a photo of a young woman whom I found very hot (it was not my project to be aroused), and it kindled a strong feeling of pleasure in my brain, for a few seconds. The problem is that it didn't just vanish, it's like I was intoxicated within these few seconds and a phantom feeling of sexual pleasure remains in the background, which is re-activated whenever I think about it and can gain a great strength. It's not real sexual pleasure, just a part of the feeling, which reminds the kind of thing I experience during an orgasm in an attenuated and partial way, or when I'm on the edge of an orgasm and, huh, stimulate my penis mildly in order to have flashes of pleasure (sorry for the smutty details, but I guess it's difficult to understand what is going on so I'm doing my best). There isn't the "excitement" part, nor the "feel-good" part, just the "pleasure stimulation" part, though it's not pleasing at all. The area of the brain which is concerned is in the center, rather in the back, but it can "radiate" to the rest of the head.
It causes important anguish, I have a knot in my stomach, I have had two diarrheas, my head feels a bit heavy and I feel a bit cold and feverish. A night has passed, I have had a shower, a day passed and nothing has changed.

This is absolutely nightmarish, as avoiding sexual stimulation is my main option to fight POIS, if my brain acts by itself as if I was continually masturbating or aroused, it's really scary. I didn't read anyone with this kind of problem on the forum.
Title: Re: An introduction to Prospero's case
Post by: berlin1984 on January 07, 2021, 02:46:44 PM
I've read somewhere on the internet, that people sensitive might get less problem with vitamin D2.
D3 acts directly as hormone and D2 needs to be converted (in a rate limited step).
(or something like that)

Regarding your gum problems: I think you should get that checked and try to improve it.
In my theory, POIS is made worse by bad bacteria (https://poiscenter.com/forums/index.php?topic=2904.msg36479#msg36479).
Title: Re: An introduction to Prospero's case
Post by: CharlesB on January 07, 2021, 03:10:02 PM
I'm currently facing a resurgence of the very strange phenomenon described in the "Vitamin D3" section - but this time I didn't take vitamin D, nor anything special.

Fortuitously, I saw a photo of a young woman whom I found very hot (it was not my project to be aroused), and it kindled a strong feeling of pleasure in my brain, for a few seconds. The problem is that it didn't just vanish, it's like I was intoxicated within these few seconds and a phantom feeling of sexual pleasure remains in the background, which is re-activated whenever I think about it and can gain a great strength. It's not real sexual pleasure, just a part of the feeling, which reminds the kind of thing I experience during an orgasm in an attenuated and partial way, or when I'm on the edge of an orgasm and, huh, stimulate my penis mildly in order to have flashes of pleasure (sorry for the smutty details, but I guess it's difficult to understand what is going on so I'm doing my best). There isn't the "excitement" part, nor the "feel-good" part, just the "pleasure stimulation" part, though it's not pleasing at all. The area of the brain which is concerned is in the center, rather in the back, but it can "radiate" to the rest of the head.
It causes important anguish, I have a knot in my stomach, I have had two diarrheas, my head feels a bit heavy and I feel a bit cold and feverish. A night has passed, I have had a shower, a day passed and nothing has changed.

This is absolutely nightmarish, as avoiding sexual stimulation is my main option to fight POIS, if my brain acts by itself as if I was continually masturbating or aroused, it's really scary. I didn't read anyone with this kind of problem on the forum.

I have had similar symptoms, where if I get incidentally aroused by something (which happens unfortunately often during abstinence), the arousal chemicals seem to be stuck in my brain for many hours afterwards.  To your point this is not pleasurable at all and is frankly a gross feeling.  I haven?t figured out any way to get rid of it other than waiting it out and trying to distract myself.

I saw someone mentioned D3 and D2, just wanted to throw out there again that I am very sensitive to regular D3 (even 1000iu makes me very loopy and get POIS symptoms) - Vegan D3 from Lichen I can tolerate with minimal issues though, and take 5000 out per day.  Hopefully that is helpful to someone.
Title: Re: An introduction to Prospero's case
Post by: Prospero on January 07, 2021, 04:05:25 PM
Well, I'm somewhat relieved that someone else has this same problem, though it would probably not be fitting to say that I'm happy...
Could it be a problem with the transporter of a neurotransmittor? (dopamine? something else?) It's extremely strange and seemingly specific to POIS, I talked about this problem with two doctors and they were flabbergasted.

High-quality lichen D3 gave me the worst symptoms, while Solgar's bottom-of-the-range supplements needed some time to product symptoms (maybe because their D3 isn't so pure ^^)
I should try D2, perhaps.

Regarding the gum, I'll think about it, thank you Berlin for the link.
Title: Re: An introduction to Prospero's case
Post by: Muon on January 12, 2021, 03:19:00 PM
Are you going to make an appointment with Dr. Amarenco?
Title: Re: An introduction to Prospero's case
Post by: Prospero on January 12, 2021, 04:17:23 PM
Yes, soon.
Title: Re: An introduction to Prospero's case
Post by: Muon on January 27, 2021, 01:39:54 PM
Last months increased breathing problems. Low respiratory rate ~6 (once every 10 seconds) and sometimes it stalls and have to remind myself to breath, respiratory muscle are slightly weak (need force). This leads to Arrhythmia (not the other way around). One of these days I will get a heart attack. If I force myself to maintain a normal RR my body feels better instantly, brain and extremities ,especially the feet. Healtcare doesn't monitor these things, what a joke.

Hello,
It looks like I have a similar problem these days. Did you find a way to manage this? Thank you.

Not really, however, avoiding POIS attacks, (restraint/static) stress, high temperatures and bad posture decreases the risk of heavier episodes of these.

https://poiscenter.com/forums/index.php?topic=3591.0
Title: Re: An introduction to Prospero's case
Post by: Prospero on January 27, 2021, 05:49:16 PM
Thank you for your response.
As for my respiratory rate, I measured 15 breaths per minute, but I guess that it's not faithful to what happens, because my breathing is different if I focus on it or if I don't think of it.
My breathing problems seem to be related to a kind of irrepressible nervousness, though I'm not sure if nervousness causes bad breathing or the reverse. Also, I'm very constipated these days, I wonder if it could be linked.

Some additional information on my case:

- I have been taking anti-histamines (desloratadine) very regularly for long periods of time when I was younger, before POIS onset (approximatively between 2008 and 2014, I'd say, and much less frequently until 2016), first because of my allergies which were thought to result in eczema, and then because of my cholinergic urticaria (which manifested only when I went bathing). At the time, desloratadine didn't trigger any special nervousness, which it now does, at least during POIS episodes (but they never really end). I report this because some people here seem to think that prolonged use of anti-histamines can in fact increase histamine production and allergic sensitivity.

- In 2019 I suddenly developed a mild phimosis and had an injury of the frenulum. I don't know which caused which: one day pulling back the foreskin became a bit more difficult and painful, notably in the frenulum, and a few months later, when I had a rare sexual intercourse with a woman, my frenulum was injured and bled. Since then, stretching the frenulum is very painful, pulling back the foreskin when I have an erection is impossible, the extremity of the glans seems permanently irritated (there is a point, just at the junction of the frenulum and the urethra, which is now abnormally red, like an inflammation or a little cut which doesn't heal), and having a coitus is impossible (too painful). "Fortunately" I don't have a girlfriend. When I saw a urologist recently, he estimated that the frenulum should be removed. As for the phimosis properly said, its intensity varies through time: most of the time it isn't really obvious, there is just the frenulum problem which prevents me from pulling the foreskin, but sometimes the foreskin is much more tight and adhesive, to the point that when I finally pull it, the glans is red and irritated.
Before 2019 I had never had any problem of phimosis or frenulum. It may be a pure coincidence if this happened but... well, no, I don't really believe in this kind of coincidence, I guess there is a link with POIS. Maybe a chronic inflammation of the genital tract which resulted in the weakening of the frenulum? A consequence of a general tension and stress in my body? I've also read that scleroderma (connective tissue autoimmune disease) can cause dyspareunia (my kind of problem), and scleroderma develops through Th1 & Th17, ROS, VEGF upregulation, etc., i.e. mechanisms which have been discussed for POIS.

- Someone recently mentioned hiatus hernia, it's a common problem in my family and it may cause my important bloating & digestive issues, I don't know.

Also, an update about the strange problem I described on January 7 (feeling like I'm intoxicated with some chemicals of sexual pleasure): it finally disappeared, maybe 10 or 15 days ago. Before that, I tried to provoke an orgasm and didn't had POIS symptoms (this isn't the experience of CharlesB, as he told me), though it didn't put an end to the problem, either.

Are you going to make an appointment with Dr. Amarenco?
Finally, after many exchanges with the different secretaries of Pr. Amarenco and his service, he notified me that he doesn't see POIS patients anymore, and sent me to one of his colleagues. I'll have an appointment in the beginning of February.
Title: Re: An introduction to Prospero's case
Post by: Muon on February 06, 2021, 04:59:11 PM
How is your breathing rhythm while taking tramadol?
Title: Re: An introduction to Prospero's case
Post by: Prospero on February 06, 2021, 05:14:52 PM
It was rather normal when I took opioids, but I took opioids at times when my breathing rhythm was already normal. (I wouldn't try to take opioids when I have breathing difficulties.)
Title: Re: An introduction to Prospero's case
Post by: Muon on February 06, 2021, 05:35:33 PM
It was rather normal when I took opioids, but I took opioids at times when my breathing rhythm was already normal. (I wouldn't try to take opioids when I have breathing difficulties.)

How is your breathing rhythm post O when your breathing rhythm is normal pre O? The same?
Title: Re: An introduction to Prospero's case
Post by: Prospero on February 06, 2021, 06:18:14 PM
It depends. Generally speaking, in a POIS state my breathing is not as good as in a "perfect health" state : it is less deep in particular, but as I said I'm not sure the *rhythm* itself is changed. These changes happen not after an orgasm but before, as a consequence of arousal. This is very clear. The rhythm certainly changes when I'm sexually aroused : I believe that is slows down, sometimes I realize that I have been holding my breath for a few seconds. When arousal stops, I guess that my rhythm is normalized but my breathing remains weaker. It somewhat evokes the problems of tensed diaphragm which a recent post by "Freeman" mentioned.

That being said, there is another problem which I mentioned in the previous posts regarding breathing, which is a more advanced state of impaired breathing: I feel that my breathing is really slowed when I don't care about it, I feel like I have to "force" myself to breath, and it seems to provoke arrhythmia, as you described. This is not a common post-orgasmic symptom but something which appears either 1/ more or less spontaneously, when I'm in a POIS state (that is, almost always), without appearant reason, 2/ after a longer period of arousal and/or masturbation (ie more than a couple of minutes), or 3/ after sustained physical exercise.
It doesn't happen every time after those triggers, and in fact it is rather rare. I didn't notice that orgasm in particular would trigger this problem, but it may perfectly have been the case that it happened in the past.
Oh, and I'm not sure about this but I would also say that intense stress/anxiety can provoke similar breathing difficulties in the aftermath.

There may be a third aspect of breathing problems, which centers more on having difficulties to inhale fully. As I have noticed that, the last time I had this breathing problem, I was very constipated, and as I believe that it was also the case in the past, I wonder if there may not be a link with a Roemheld Syndrome (https://en.wikipedia.org/wiki/Roemheld_syndrome) (bloatings, constipated digestive system and maybe hiatal hernia or other stomach problems, which create a pressure on the lungs, heart and/or vagus nerve). A pain in the heart area, especially when air bubbles go up the oesophagus, is a very recurring symptom since my teen years, especially when I'm constipated and also especially after a sustained arousal since my POIS onset.

Edit : I just saw what you posted in your personal thread. These are interesting hypotheses indeed.
Title: Re: An introduction to Prospero's case
Post by: Prospero on February 12, 2021, 11:17:29 AM
Some experiments:

Recently, as I was feeling better than is usually the case (no ejaculation since a while, zero sexual arousal, omega-3 doing their job to prevent my now-chronic symptoms like tachycardia), I tried some immune supplements anew.

I began with low-dose vitamin D3 (400 IU), which I took for a few days. I remembered that when I took it during the fall, one of the first apparent benefits had been that my dry mouth & throat, which felt almost irritated, came back to normal very quickly. I didn't know if it was a coincidence, so as I had the same symptom of dry mouth & throat last week, I thought it would be useful to try and see. The result of the experiment was the same : the dryness disappeared in 24h after beginning daily vitamin D3, and came back only a few days after having stopped to take it. This time, vitamin D3 didn't cause me strange symptoms of "pleasure intoxication". I guess that it's because I didn't have any moment of arousal and POIS state was kept in check, as I also had this "pleasure intoxication" triggered out of D3 by arousal. Last september D3 didn't have bad effects either, before I began to have some arousal episodes. However, this time I took less D3 (400 IU rather than 800) and only for a week, maybe it would have been different otherwise.

Whatever it be, I stopped D3 after a week and began zinc instead, since the beginning of the week. I had also already tried zinc last October, but only a few times because I felt that it aggravated my tachycardia and general POIS condition. However, as I had many problems at the time related to POIS, vitamin D3, etc., and as I was more frequently aroused, I wasn't really sure that zinc had such an effect. This time also, I tried it at lower dose, 15 mg daily rather than 30 mg. I take it during lunch. I didn't feel any particular effect in the first days but now they appeared. Yesterday I was feeling great in the morning (I could climb quickly the six floors of my apartment block without shortness of breath, which *never* happens during POIS and with tachycardia), but some time after the lunch I was suddenly tired, needed to lie down, and finally began to feel that several classic symptoms of POIS were here again. I checked my heart rate which was 92 bpm, clear tachycardia. Nonetheless I was not sure it was zinc because just after the lunch I had played at a video game for some time, which generated stress, and I never feel very good after stress. In the evening I took a warm shower and felt good anew, symptoms being gone. Heart rate 64 bpm, normal. Today I wake up in the same healthy state, but this time I was very careful not to do anything stressful during the day. Same thing happened however, a few time after my lunch and the zinc pill, I suddenly perceived that "POIS" was coming back, breath being shortened and less deep, feeling more tired. Heart rhythm 94 bpm.

So I guess that there may be two main explanations : 1/ immune activation due to zinc, as expected by nanna1 (the idea of taking zinc came from his posts, of course) ; 2/ zinc is linked to some neurotransmittors so maybe something happens at this level. I'm more inclined to favor the immune activation explanation, but I find a bit odd that a warm shower is sufficient to put an end to the symptoms, if this is so. Or the scheme is something like Zinc -> immune activation -> triggering of nervous symptoms -> nervous symptoms can be removed while immune reaction continues without manifest symptoms.


Also, I had my appointment in Pr. Amarenco's service, at Hospital Tenon (not with him personally). Nothing notable, the doctor was not very talkative. "There is seemingly a dysfunction of the autonomous nervous system" was all that she said about POIS. She wants me to come back for complementary examinations and mentioned a MRI (I said that I had had a cerebral MRI, but I read elsewhere that Amarenco & alii had studied the spinal column of previous patients). I'll have a notification for the appointment, probably not very soon, apparently. Ah, and she gave me cetirizine, to try.
Title: Re: An introduction to Prospero's case
Post by: Muon on February 12, 2021, 11:44:38 AM
The ANS affects the immune system. Let me know when you have the MRI planned and of your MRI results. I can postpone my spinal MRI again and look at your results first. Not sure if I have asked this already but do you have premature ejaculation?
Title: Re: An introduction to Prospero's case
Post by: Prospero on February 12, 2021, 11:56:31 AM
No premature ejaculation. I guess that you shouldn't postpone anything, the doctor was quite clear in telling me that it should take a while.
Title: Re: An introduction to Prospero's case
Post by: Prospero on March 02, 2021, 05:24:00 PM
Curcumin & black pepper 1h before O: extremely similar to the effect of Paracetamol. I feel that I'm a bit "emptied", and I get out of breath quickly if I make a little physical effort (climbing up my stairs...), but I'm overall good.
Title: Re: An introduction to Prospero's case
Post by: BoneBroth on March 03, 2021, 06:09:10 AM
This is absolutely nightmarish, as avoiding sexual stimulation is my main option to fight POIS, if my brain acts by itself as if I was continually masturbating or aroused, it's really scary. I didn't read anyone with this kind of problem on the forum.

Same here, just a sexual arosal, if only for some seconds, will cause headache for hours to days. But sometimes it does not. I belive this happens when dopamin receptor cells are overstimulated, or over production of dopamin, or there is a temporary hormon deficiency. When I feel mentally stronger I build up a resistance against the effects of theese arousal. So its definitly possible to work with. Have a look at my story at the link below, its much the same as yours Prospero.

We must be aware of that the efficiency of absorption of nutrients (D3, Zink etc) varies greatly depending on where in the POIS cycle we are. After O the intake is probable very low and stays low for a week since the intestines are inflamed. Then the supplements might seem less efficient. The sexual arousal also has it cycles. I can stay "cold" about 20-30 days, but then the NE is more likely to appear again. So its more important to build up resistance between POIS periods, its important to take those supplements when they are doing the most work.
Title: Re: An introduction to Prospero's case
Post by: Muon on April 14, 2021, 10:28:57 AM
- I feel "less heterosexual", or "less manly", in a POIS state, and I experience a much stronger desire for females out of it, as well as a stronger "willingness to assume a manly role", sexually.

https://en.wikipedia.org/wiki/Progesterone
"Dr. Diana Fleischman, of the University of Portsmouth, and colleagues looked for a relationship between progesterone and sexual attitudes in 92 women. Their research, published in the Archives of Sexual Behavior found that women who had higher levels of progesterone scored higher on a questionnaire measuring homoerotic motivation. They also found that men who had high levels of progesterone were more likely to have higher homoerotic motivation scores after affiliative priming compared to men with low levels of progesterone."

https://poiscenter.com/forums/index.php?topic=2545.msg40271#msg40271
Title: Re: An introduction to Prospero's case
Post by: Prospero on April 14, 2021, 10:47:24 AM
This is extremely interesting, thank you. Your progesterone result is incredible. I want to do more hormonal blood tests too, I planned an appointment with my doctor at the end of the month to try to get a prescription.
Title: Re: An introduction to Prospero's case
Post by: Prospero on April 28, 2021, 04:10:24 PM
Had my exam at Pr. Amarenco's service of neuro-urology in Paris. Finally no MRI, only tests of the autonomous nervous system, which showed that there was no anomaly (I was unfortunately not in a full Pois state, I had provoked an orgasm the day before but it was not strong and I didn't feel very sick; I guess that the result is still valid though).
The neurologist suggested that I try alpha-blockers (silodosin) for one month and prescribed me blood tests for LH, FSH and prolactine but nothing else, although I asked her for more. She also mentioned that nervous stimulation therapy could be a possibility. She recognized that, as tests thus far weren't conclusive, she couldn't tell me anything about my Pois and she declined to make hypotheses regarding the reasons why opioids and omega-3 are beneficial in my case.

Today I had another appointment with my gp. I tried to get additional blood tests prescribed but he refused. As he couldn't find reasons for the success of codeine and omega-3, he concluded that it was placebo effect and that I should see a psychologist / sexologist.

I'm a bit tired of doctors, and their reluctance to investigate when there are no predefinite rules and when they're not sure to know what they will find.
Title: Re: An introduction to Prospero's case
Post by: BoneBroth on April 29, 2021, 02:28:31 AM
They have economical restrictions, tests costs. But the state funded doctors use to be more generous.
Title: Re: An introduction to Prospero's case
Post by: Prospero on June 23, 2021, 06:39:54 PM
LH: 2,91 IU/l (RR: 0.57 to 12.07)
FSH: 1,39 IU/l (RR: 0.95 to 11.95)
Prolactine: 196,0 mIU/l (RR: 72.7 to 407.4)

LH and FSH are still in the reference range but seem pretty low.

Last round of tests, on my own:

Abnormal values:
Progesterone: <1.6 nmol/l (RR: <0.64)
Homocysteine: 12,73 micromol/l - Normal: <10 micromol/l ; Intermediary level: 10 to 15 micromol/l ; Superior level: 15 to 30 micromol/l

Normal values:
Estradiol: <88.1 pmol/l - RR: 40 to 161
Estrone: <0.04 nmol/l - RR: 0.03 to 0.22
DHEA-S: 6.6 micromol/l - RR: 5.7 to 13.4 micromol/l
Histamine: 392.2 nmol/l - RR: 200 to 2000
Tryptophan: 59 micromol/l - RR: 52 to 82
Adrenaline: <0.50 nmol/l - RR: < 1,00
Noradrenaline: 2.37 nmol/l - RR: < 4,00
Dopamine: <0.50 nmol/l - RR: < 1,00
Title: Re: An introduction to Prospero's case
Post by: Muon on June 24, 2021, 08:00:01 AM
- I feel "less heterosexual", or "less manly", in a POIS state, and I experience a much stronger desire for females out of it, as well as a stronger "willingness to assume a manly role", sexually.

https://en.wikipedia.org/wiki/Progesterone
"Dr. Diana Fleischman, of the University of Portsmouth, and colleagues looked for a relationship between progesterone and sexual attitudes in 92 women. Their research, published in the Archives of Sexual Behavior found that women who had higher levels of progesterone scored higher on a questionnaire measuring homoerotic motivation. They also found that men who had high levels of progesterone were more likely to have higher homoerotic motivation scores after affiliative priming compared to men with low levels of progesterone."

https://poiscenter.com/forums/index.php?topic=2545.msg40271#msg40271

Good intuition. I have high progesterone like you. I'll post the results of my last tests soon.
Progesterone 1.6 nmol/l, RR: <0.64.

Ideas from someone I'm discussing with:
"High progesterone can be:
A) to retain potassium and waste sodium
B) problems with conversion into 5a-dhp and allopregnanolone
C) problems with liver (gilbert's, etc)

Usually high progesterone comes with normal results for other steroids.
"
Title: Re: An introduction to Prospero's case
Post by: Iwillbeatthis on June 24, 2021, 08:29:35 AM
- I feel "less heterosexual", or "less manly", in a POIS state, and I experience a much stronger desire for females out of it, as well as a stronger "willingness to assume a manly role", sexually.

https://en.wikipedia.org/wiki/Progesterone
"Dr. Diana Fleischman, of the University of Portsmouth, and colleagues looked for a relationship between progesterone and sexual attitudes in 92 women. Their research, published in the Archives of Sexual Behavior found that women who had higher levels of progesterone scored higher on a questionnaire measuring homoerotic motivation. They also found that men who had high levels of progesterone were more likely to have higher homoerotic motivation scores after affiliative priming compared to men with low levels of progesterone."

https://poiscenter.com/forums/index.php?topic=2545.msg40271#msg40271

Good intuition. I have high progesterone like you. I'll post the results of my last tests soon.
Progesterone 1.6 nmol/l, RR: <0.64.

Ideas from someone I'm discussing with:
"High progesterone can be:
A) to retain potassium and waste sodium
B) problems with conversion into 5a-dhp and allopregnanolone
C) problems with liver (gilbert's, etc)

Usually high progesterone comes with normal results for other steroids.
"

I'm sure it is because of A) to retain potassium and waste sodium
Title: Re: An introduction to Prospero's case
Post by: Muon on June 24, 2021, 05:27:21 PM
@prospero

About the bisexuality, i too notice that during POIS i lean more towards dating a girl (aka same sex) and be the leader/dominant one whereas in my ?normal? state i lean more towards dating a guy (thus opposite sex) & enjoy feeling more feminine. Its very weird.
Im a female so my progesterone naturally fluctates, but i notice during the 2 weeks that my progesterone rises i feel almost constant POIS with flu-like symptoms and fatigue. When my period starts and the 2 weeks before ovulation i feel pretty much normal with no flu symptoms and energy is pretty good most of the time.

Does anyone here know their progesterone levels? Are they high aswell?
https://poiscenter.com/forums/index.php?topic=3575.0
Title: Re: An introduction to Prospero's case
Post by: Muon on June 24, 2021, 06:00:28 PM
I'm sure it is because of A) to retain potassium and waste sodium
https://en.wikipedia.org/wiki/Progesterone
"Moreover, progesterone is also known to be an antagonist of the sigma 1 receptor"

https://www.reddit.com/r/POIS/comments/ninfii/i_could_potentially_have_this_but/

Quote from: brittneystaubin
For 24+ hours after masturbating (all external, not internal), I get very faint/lightheaded, as well as the symptoms of: fatigue, nausea, brain fog and inability to concentrate, low or no appetite, a small headache, and an intense bloating and tingling pressure in my uterus area. It gets worse immediately after eating anything (both the bloating and the weird pressure). But I am not able to drive the next day from this. I also have POTS and IBS-C.

I believe Voltage-gated sodium-selective ion channel NaV1.5 mutations can play a role in both syndromes.

Antagonist action of progesterone at sigma-receptors in the modulation of voltage-gated sodium channels (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043630/)

NaV1.5 channels...
Title: Re: An introduction to Prospero's case
Post by: Prospero on June 25, 2021, 04:47:55 AM
Yesterday, there were people saying they developed POIS after Finasteride use (see https://poiscenter.com/forums/index.php?topic=458.msg41283#msg41283 (https://poiscenter.com/forums/index.php?topic=458.msg41283#msg41283)). Finasteride is an inhibitor of 5alpha-reductase, which happens also to transform Progesterone in 5a-dhp and then allopregnanolone. It may be no coincidence. So low activity of 5a-reductase equal high progesterone, low allo and low dihydrotestosterone. I'm furious the lab didn't test DHT as I wanted them to do... The lab assistant didn't know what it was, while it was in their *** catalogue of exams.
Title: Re: An introduction to Prospero's case
Post by: Muon on June 25, 2021, 07:10:59 AM
https://en.wikipedia.org/wiki/5?-Reductase#List_of_conversions
Link doesnt work. Search manually.

The following reactions are known to be catalyzed by 5a-reductase:

Cholestenone > 5a-Cholestanone
Progesterone > 5a-Dihydroprogesterone
3a-Dihydroprogesterone  > Allopregnanolone
3b-Dihydroprogesterone > Isopregnanolone
Deoxycorticosterone > 5a-Dihydrodeoxycorticosterone
Corticosterone > 5a-Dihydrocorticosterone
Cortisol > 5a-Dihydrocortisol
Aldosterone > 5a-Dihydroaldosterone
Androstenedione > 5a-Androstanedione
Testosterone > 5a-Dihydrotestosterone
Nandrolone > 5a-Dihydronandrolone

Wiki uses this as source, figure 2:
 Steroid 5?-Reductase as a Novel Therapeutic Target for Schizophrenia and Other Neuropsychiatric Disorders (https://sci-hub.se/10.2174/138161211795049589)

This could be involved in my brother’s psychotic disorder which he developed last year.
Title: Re: An introduction to Prospero's case
Post by: Prospero on June 25, 2021, 07:54:56 AM
Hm. 3a-dihydroprogesterone, which is transformed in allo by 5a-reductase, "has also been found to inhibit the secretion of follicle-stimulating hormone (FSH)" (https://en.wikipedia.org/wiki/3%CE%B1-Dihydroprogesterone (https://en.wikipedia.org/wiki/3%CE%B1-Dihydroprogesterone)). I have very low FSH. Of course it could be caused by many things.

Wikipedia also mentions that 5a-reductase is involved in bile acid biosynthesis. Gut issues connection?
Title: Re: An introduction to Prospero's case
Post by: Muon on June 27, 2021, 12:39:18 PM
Wikipedia also mentions that 5a-reductase is involved in bile acid biosynthesis. Gut issues connection?
Progesterone is involved in sensory nerves as well. I have a suspicion that sensory pathways are involved in my symptomatology which seem to interact with low grade inflammation.

Persistent Genital Hyperinnervation Following Progesterone Administration to Adolescent Female Rats (https://academic.oup.com/biolreprod/article/91/6/144,%201-9/2434180?login=true)

"In this regard, it is noteworthy that inflammation also contributes to hyperinnervation [64, 65], raising the possibility that progesterone and inflammation could act synergistically to promote hyperinnervation and hypersensitivity."

Hypersensitivity in the sense that it lowers thresholds in combo with increased nerve fiber density, increasing susceptibility for neuropeptides/neuron interaction. IL-8+progesterone?

Substance P inhibits progesterone conversion to neuroactive metabolites in spinal sensory circuit: A potential component of nociception (https://www.pnas.org/content/102/25/9044.short)
Title: Re: An introduction to Prospero's case
Post by: Progecitor on July 07, 2021, 02:04:04 PM
I bought a red clover supplement to test and while reading about it I found some information that may be of interest to you as well. Although phytoprogestins bind to progesterone receptors (PR) some of them (not all!) may actually antagonize PR and down-regulate progesterone activity. So if you wanted to reduce your progesterone level or activity they could be beneficial. Of course you would have to be extremely careful as this may potentially backfire due to scarce scientific evidence.  I suspect that in my case ER is more likely to be involved, although I am not yet sure how.

The six highest ER-binding herbs that are commonly consumed were soy, licorice, red clover, thyme, tumeric, hops, and verbena. The six highest PR-binding herbs and spices commonly consumed were oregano, verbena, tumeric, thyme, red clover and damiana.
Induction of alkaline phosphatase is dose dependent, occurs over a physiological range of progesterone, and is highly progestin specific as no other steroids (estrogens, androgens, glucocorticoids), induce this enzyme at a physiologic dose. Alkaline phosphatase induction defines the PR-binding herb as an agonist, whereas no induction functionally defines the herb either as neutral or as an antagonist. If the herb blocks progesterone induction of alkaline phosphatase, it is defined as an antagonist.
In contrast, red clover, licorice, goldenseal, pennyroyal, and nutmeg all either completely or partially blocked enzyme induction by progesterone, tentatively defining them as antiprogestins.
One of the mechanisms by which progestins modulate estrogen action is by down regulating ER. Estrogens also down regulate ER, but the mechanism is different.
The mean progesterone levels (determined by RIA) in the saliva of MPA and diosgenin users was very low; respectively, 17 pg/ml (n = 7, range 10-27) and 19 pg/ml (n = 10, range 5-34).
These pilot results showing that MPA (pharmaceutical synthetic progestins like medroxyprogesterone acetate) and diosgenin (wild yam root) appear to suppress progesterone synthesis are very consistent with a much larger database from our laboratory.
Licorice and red clover, but not soy milk, also had high levels of a PR-binding component(s) which had potent progestin antagonist properties based on their ability to block progesterone induction of alkaline phosphatase, an end product of progestin action. Interestingly, all three herbs belong to the leguminosa family, yet the active phytoestrogen is derived from different parts of the plant-bean, root, and flower, respectively. Of further interest is that all three have been suggested to have cancer-preventive properties. We recently have reported on the biphasic actions of genistein on cell proliferation in ER(+) human breast cancer cells in vitro. Genistein is one of the principal phytoestrogens in soy and thought to be present in other legumes like licorice and red clover.

https://sci-hub.se/https://journals.sagepub.com/doi/abs/10.3181/00379727-217-44247
Title: Re: An introduction to Prospero's case
Post by: Prospero on July 07, 2021, 03:05:18 PM
Interesting, thank you.
Title: Re: An introduction to Prospero's case
Post by: Muon on July 19, 2021, 05:06:24 AM
I'm sure it is because of A) to retain potassium and waste sodium
https://en.wikipedia.org/wiki/Progesterone
"Moreover, progesterone is also known to be an antagonist of the sigma 1 receptor"

Yesterday, there were people saying they developed POIS after Finasteride use (see https://poiscenter.com/forums/index.php?topic=458.msg41283#msg41283 (https://poiscenter.com/forums/index.php?topic=458.msg41283#msg41283)). Finasteride is an inhibitor of 5alpha-reductase, which happens also to transform Progesterone in 5a-dhp and then allopregnanolone. It may be no coincidence. So low activity of 5a-reductase equal high progesterone, low allo and low dihydrotestosterone.

helllo,i sufferd from pois for 7 years,it was a nightmer my i had severe brain fog and itchy eyes,i lost a lot of opportunities because of brain fog,i tried a lot of doctors:urologist?Immunologist mostly,no results or little results
i thought it might be related to brain so i went to a neurosurgen and gave him the articles about pois he told me to visit his friend who was  on of the top Psychiatrist in the country,after some sessions with him,he told me that my pois is caused by imbalance in my brain biochemistry and its psychosomatic but "it has  physical roots in brain,he prescribed 80 miligrams of prozac and 20 miligram of bouspirion and after 3 months i had no brain fog or itchy eyes,i never felt this great in my life,guys find the best psychiatrist in your county and ask for his or her help,maybe your case is similar to mine or brain related

https://en.wikipedia.org/wiki/Fluoxetine#Pharmacodynamics

"Fluoxetine increases the concentration of circulating allopregnanolone, a potent GABAA receptor positive allosteric modulator, in the brain."

"In addition, fluoxetine has been found to act as an agonist of the sigma-1 receptor."
Title: Re: An introduction to Prospero's case
Post by: Prospero on July 19, 2021, 04:25:26 PM
Interesting findings, Muon, thanks.

As for sigma receptors, I'm a bit worried. When I read that "physiologic effects when the sigma-receptor is activated include hypertonia, tachycardia, tachypnea, antitussive effects, and mydriasis" (wiki (https://en.wikipedia.org/wiki/Sigma_receptor)), it resembles some of my symptoms. I also read that it increases glutamate release. But if I have high progesterone I would expect the opposite, excessive antagonism of sigma receptors. Or would extra progesterone be produced by the body to counter over-activation of sigma receptors?

I have new blood tests coming in a few days, I'll keep you updated.
Title: Re: An introduction to Prospero's case
Post by: Muon on July 20, 2021, 07:52:27 AM
Or would extra progesterone be produced by the body to counter over-activation of sigma receptors?

IDK. takedrugstoletgo said that her menstrual cycle induces POIS like symptoms when progesterone rises plus she becomes more attracted to same sex in POIS mode. So this could be pointing in the direction of progesterone. The latter could perturb some kind of balance. If the sigma's are overactive then, you would say, a rise in progesterone would decrease the POIS symptoms but the opposite is true in the example above, that is, if changes in progesterone affects POIS symptoms at all. So does progesterone rise upon orgasm?

I've tried medication that targets P4 receptors but without any noticable effect. Same dose as in the 2nd POIS paper. The sigma-1 receptor modulates calcium signaling through the IP3 receptor. I don't have knowledge about these mechanics. I already mentioned in my thread that decreases of intracellular calcium could play a role in lymphocytes regarding the lab data. There are other hormones that bind to sigma's as well. Sigma 2 is involved in mTOR which is linked to cancer (and mast cell activation). High levels in men: High progesterone levels are associated with family history of premature coronary artery disease in young healthy adult men (https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215302)

https://en.wikipedia.org/wiki/Sigma-1_receptor
Title: Re: An introduction to Prospero's case
Post by: Prospero on July 22, 2021, 03:28:32 PM
Some new blood tests.

DHT: 0.69 ng/ml (RR: 0.33-1.20)
Aldosterone: 312 pg/ml (RR: 67-335)
Renin: 12.60 pg/ml (RR: 5-40)
Vit. B6: 89 nmol/l (RR: 42-145)

So it seems normal, though Aldosterone is quite high. But what is puzzling is the result for amino acids. They're almost all under the reference range. Extremely strange.

Alanine: 182 micromol/l (RR: 286-416)
Arginine: 48 micromol/l (RR: 61-103)
Asparagine: 42 micromol/l (RR: 45-72)
Aspartic acid: 2 micromol/l (RR: ?)
Citrulline: 17 micromol/l (RR: 20-34)
Cystine: 9 micromol/l (RR: 65-109)
Glutamic acid: 14 micromol/l (RR: 9-107)
Glutamin: 263 micromol/l (RR: 432-706)
Glycine: 132 micromol/l (RR: 181-293)
Histidine: 48 micromol/l (RR: 73-97)
Hydroxyproline: 8 micromol/l (RR: <37)
Isoleucine: 46 micromol/l (RR: 54-78)
Leucine: 82 micromol/l (RR: 109-153)
Lysine: 119 micromol/l (RR: 157-231)
Methionine: 17 micromol/l (RR: 21-35)
Ornithine: 37 micromol/l (RR: 50-100)
Phenylalanine: 33 micromol/l (RR: 43-65)
Proline: 96 micromol/l (RR: 150-224)
Serine: 76 micromol/l (RR: 98-174)
Taurine: 35 micromol/l (RR: 30-116)
Threonine: 77 micromol/l (RR: 97-197)
Tryptophan: 43 micromol/l
Tyrosine: 27 micromol/l (RR: 50-76)
Valine: 167 micromol/l (RR: 213-283)
1-Methylhistidine: 4 micromol/l
3-Methylhistidine: <10 micromol/l
AABA: 14 micromol/l
Argininosuccinic acid: 6 micromol/l
Homocitrullin: 2 micromol/l
Pipecolic acid: 4 micromol/l
Beta-alanine: 4 micromol/l
Ethanolamine: 6 micromol/l
Hydroxylysin: 1 micromol/l
Phosphoethanolamine: 4 micromol/l
Saccharopine: 8 micromol/l
Sarcosine: 1 micromol/l
Title: Re: An introduction to Prospero's case
Post by: Muon on July 22, 2021, 03:41:10 PM
Aminos Acids (No GABA detected and low in GABA precursors like Leucine, Glutamine, Valine, Serine)
_URINE AMINO ACIDS QUANTITATION_
Ref Range:
AMINO ACID Result (uM/mM Crea) Reference Range (uM/mM Crea)
~
Phosphoserine 4 Not Detected
Taurine 58 16-180
Phosphoethanolamine 3 Not Detected
Aspartic Acid 2 2-7
Hydroxyproline 1 <13
Threonine *6 7-29
Serine *16 21-50
Asparagine 4 <23
Glutamic Acid 1 <12
Glutamine 20 20-76
Sarcosine 0 Not Detected
Alpha Aminoadipic acid 1 Not Detected
Proline 0 <9
Glycine 46 43-173
Alanine 21 16-68
Citrulline 1 <4
Alpha Aminobutyric 0 <4
Valine 3 3-13
Cystine 3 3-17
Methionine *1 2-16
Isoleucine 1 <4
Leucine *1 2-11
Tyrosine 3 2-23
Phenylalanine 3 2-19
Beta Alanine 2 Not Detected
Beta Aminoisobutyric 2 <91
GABA 0 Not Detected
Ethanolamine 17 Not Detected
Tryptophan 0 Not Detected
Hydroxylysine 0 Not Detected
Ornithine 2 <5
Lysine 7 7-58
1-Methylhistidine 59 Not Detected
Histidine *25 26-153
3-Methylhistidine *14 19-47
Anserine 1 Not Detected
Carnosine 5 Not Detected
Arginine 1 <5
-
Creatinine 1469 mg/l

Lab Interpretation:
Aminoacids (U): Essentially normal urinary excretion of
physiological aminoacids. Excluded are cystinuria, Hartnup
disease, and lysinuric protein intolerance. No generalised
hyperaminoaciduria.
Title: Re: An introduction to Prospero's case
Post by: Muon on July 22, 2021, 04:07:19 PM
But what is puzzling is the result for amino acids. They're almost all under the reference range. Extremely strange.
Malabsorption?
Title: Re: An introduction to Prospero's case
Post by: Prospero on July 22, 2021, 04:15:50 PM
It's the first explanation I can think of, given that I'm underweight and have chronic constipation problems. Still, I have no deficiency for the vitamins I tested, nor iron etc., so it seems strange.
The lab made a little comment suggesting that empty stomach when I did the test was a possible explanation for low values (the body used the amino acids) but I had normal meals the days before, and I guess that everyone does the blood tests in the morning with empty stomach, so I'm a bit skeptic.
Title: Re: An introduction to Prospero's case
Post by: Iwillbeatthis on July 22, 2021, 08:20:02 PM
https://feelgoodbiochem.com/chapter-5/

"For low overall amino acids, either you are not eating enough protein and/or your GI tract is not absorbing them well. Consider appropriate diet and supplements to address amino acid support. Consider a CSA test and GI Test to address digestive issues. You can also consider running an Intestinal Permeability test and a Celiac test. Also consider a MAP test to look for ketosis. For low overall amino acids, consider Egg Protein Powder, AminoAssist capsules, and AminoAssist spray for three routes of administration of amino acids. Also, consider Bowel Support nucleotide blend, VitaOrgan, and Royal Jelly, if you have no bee allergies. Ora-Placenta may also be a help to support amino acids."

Copied from Amy Yasko (methyl cycle expert) biochemical test guide website, the products and tests mentioned are on https://www.holisticheal.com/. You can find more info on each specific amino acid on the first link I provided. The AminoAssist, egg protien powder, vitaorgan bowel support rna would be most helpful.

If you are gonna get a test like this again eg: hair mineral, gut tests I would recommend getting it through her website so you can get her suggestions specific to your results. She's seen tens of thousands of the same tests so she knows exactly what to suggest based on the levels of each amino acid etc. Which is better than just doing a test yourself somewhere and then not knowing how to fix it.

Title: Re: An introduction to Prospero's case
Post by: Muon on July 23, 2021, 06:01:10 AM
https://en.wikipedia.org/wiki/Malabsorption#Causes
Title: Re: An introduction to Prospero's case
Post by: Muon on July 24, 2021, 01:21:21 PM
https://forums.phoenixrising.me/threads/channelopathy-in-cfs.84906/

@Prospero
Discussion about TRMP3, progesterone, pregnenolone, mu-opioid interaction. NK cells contain this channel as well. My IL-2 drops down and wonder whether it suppresses NK cell function which could tie into nanna's theory about viral replication (it sure affects Tregs). I haven't read everything.
Title: Re: An introduction to Prospero's case
Post by: Prospero on July 29, 2021, 03:51:13 PM
A quick update of my case: since approximately three months, the intensity of my POIS decreased significantly. Especially the permanent symptoms I was suffering from, which are much less violent and even perceptible (I had tachycardia absolutely all the time until April, in particular, and now much less and only in the hours following arousal). If I abstain from arousal for more than a day, I feel almost normal after the night, and showers systematically erase my post-arousal symptoms. As for the post-orgasmic symptoms, they're still there, but well controlled with Paracetamol, and they disappear after a day or two.
So this is for the "hard" symptoms, but I still do not feel like before my POIS become "permanent": I never feel perfectly healthy, physically or psychologically, and just a little arousal is enough to trigger the usual symptoms again. (There are often different symptoms according to the time, not the complete set each time: sometimes chills, sometimes pelvic pain, sometimes need to sleep, loss of appetite... though always nervousness, mood shift, weakness.)

What I've done concretely since April:
1/ stop taking Omega-3 (they were beneficial in the beginning, they calmed tachycardia, nervous and anxiety-related symptoms, but I felt that some other POIS problems were increased after a few months, like strange issues when falling asleep, and they ceased immediately after stopping Omega-3 ; and they were less efficient in the long run, tachycardia had returned after weeks or months and I was feeling generally unwell) ;
2/ taking artichoke+rosemary pills daily for 2 months, which are supposed to be good for the intestines and liver, and have choleretic properties: gut problems decreased markedly (no more constipation, although it returns if I stop the pills), I don't know if it's linked to the rest of the symptoms decrease ;
3/ eating more eggs, approximately every two days. (EDIT: + I also stopped milk and ate much less cheese.)
So I don't know precisely why, but after a few weeks, in May, I was really better and I still am. No change since then.

Next envisaged steps: I believe that I'll try a supplementation of amino acids to see if it changes anything, and I shall probably look for a few other blood tests (B1, B3, cortisol, ACTH come to my mind as for now). I may also see a gastroenterologist.