Post Orgasmic Illness Syndrome (P.O.I.S.)

General Category => Poll Center => Topic started by: Muon on September 10, 2020, 05:06:45 PM

Title: Time of day and POIS
Post by: Muon on September 10, 2020, 05:06:45 PM
Even if it's temporary and the effect barely noticable. If more than one interval applies, select the one where you feel best.

https://en.m.wikipedia.org/wiki/24-hour_clock

Melatonin mediates mucosal immune cells, microbial metabolism, and rhythm crosstalk: A therapeutic target to reduce intestinal inflammation (https://sci-hub.se/https://onlinelibrary.wiley.com/doi/abs/10.1002/med.21628)

The role of melatonin in the cells of the innate immunity: a review (https://onlinelibrary.wiley.com/doi/full/10.1111/jpi.12075)

(https://www.mattressadvisor.com/wp-content/uploads/2019/05/melatonin.jpg)

(https://onlinelibrary.wiley.com/cms/asset/ca4da959-36ce-4c08-b508-43aa72898692/jpi12075-fig-0002-m.jpg)

(https://onlinelibrary.wiley.com/cms/asset/3a80a1c5-bff0-4e30-ab33-cac585bfcf21/med21628-fig-0004-m.jpg)

(https://onlinelibrary.wiley.com/cms/asset/a27b3d87-bc82-4ecb-92e3-de6405ec1a95/exd13288-fig-0001-m.jpg)
Title: Re: Time of day and POIS
Post by: Journey on September 14, 2020, 07:32:36 AM
I feel as POIS is less in night and Oing before sleep give bit less.
Title: Re: Time of day and POIS
Post by: Iwillbeatthis on September 14, 2020, 06:58:32 PM
Always feel best at 9pm-12am, like I mean really good its a shame I don't feel the same in the mornings. I have recently bought some blue light blocking glasses off amazon and they do seem to increase wellbeing quite a bit, also my face looks a lot better after wearing them and the skin on my face looks much more healthy and brighter, eye bags go away. Also wake up feeling more refreshed.
Title: Re: Time of day and POIS
Post by: Muon on September 15, 2020, 08:51:09 AM
I feel significantly better as a function of time (12 a.m - 3 a.m) when I'm approaching 3 a.m just like my brother. I get more energy, feel that I'm less inflamed and being less sensitive to triggers. I also get the impression that it (some circadian parameter) synergizes with a drop in ambient temperature at nightfall. I wish this effect was present during daytime rather than at night. There were some russians a while ago discussing about sleep deprivation being beneficial to their symptoms. I don't think it is that, it probably has to do with experiencing a rise in melatonin.
Title: Re: Time of day and POIS
Post by: certainlypois2 on September 15, 2020, 11:38:17 PM
I used to feel worse at night, but that doesn't happen anymore.
Title: Re: Time of day and POIS
Post by: Muon on September 25, 2020, 07:26:05 AM
Melatonin receptor agonists for POIS? It also affects ion channels and regulate ion flux inside the cell.

https://en.wikipedia.org/wiki/Melatonin_receptor_agonist

https://en.wikipedia.org/wiki/Melatonin_receptor

https://en.wikipedia.org/wiki/G_protein-coupled_receptor

(https://upload.wikimedia.org/wikipedia/commons/4/43/MT1_melatonin_receptor_signaling.jpg)

(https://upload.wikimedia.org/wikipedia/commons/5/53/MT2_melatonin_receptor_signaling.jpg)
Title: Re: Time of day and POIS
Post by: Muon on January 12, 2021, 11:22:44 PM
https://selfhacked.com/blog/th17/

Th17 cells seem to have a circadian rhythm. The amount of Th17 cells changes during the day-night cycle. Animal studies suggest that the production of Th17 is higher at midnight than at noon

Based mostly on animal findings, Th17 appears to have a protective role in combating fungi
Title: Re: Time of day and POIS
Post by: an-y-more on January 14, 2021, 06:58:27 PM
I'm not sure about better but I do enjoy nightitme more for some reason. And my daytime regime in these years was always slipping to night much easier than other way around.
 During a summer I used to stay up at night and sleep during a day usually and it was pretty common that in the morning (vaguely around 7 o clock) I would start to feel shaky like I had tremor or some tension problems. This wasn't fatigue or anything like that. Seems about a time melatonin drops at your graph..