Post Orgasmic Illness Syndrome (P.O.I.S.)

General Category => Poll Center => Topic started by: Muon on July 27, 2020, 12:55:44 PM

Title: Varicocele
Post by: Muon on July 27, 2020, 12:55:44 PM
https://en.wikipedia.org/wiki/Varicocele
Vote can be changed.
(https://upload.wikimedia.org/wikipedia/commons/thumb/0/06/Varicocele.png/800px-Varicocele.png)
Title: Re: Varicocele
Post by: b_jim on July 28, 2020, 03:06:52 PM
Yes, left.
Title: Re: Varicocele
Post by: Muon on July 28, 2020, 03:20:23 PM
Yes, left.

Do you get problems in that area during POIS b_jim?
Title: Re: Varicocele
Post by: BoneBroth on November 17, 2020, 12:14:51 PM
It really feels like I have one on the left side. Never got it checked thought. Varicose veins on the blood vessels to the testes can supress testosterone according to christoffer Walker here: https://www.youtube.com/watch?v=hCfAZeCRpaI (https://www.youtube.com/watch?v=hCfAZeCRpaI)
Title: Re: Varicocele
Post by: Muon on November 17, 2020, 01:10:24 PM
I can have a sore left testis and left side of scrotum including sore surrounding soft tissues and becomes systemic when pre-ejaculate releases. Probably some inflammatory chain reaction. Left side of scrotum feels thick as well. Premature ejaculation is actually beneficial in my case because I will be exposed to seminal fluids for a short time.
Title: Re: Varicocele
Post by: BoneBroth on November 17, 2020, 03:00:25 PM
Dad and brother has one too, as long as they remember, but dont have POIS. How is your testosterone levels Muon?
Title: Re: Varicocele
Post by: Muon on November 17, 2020, 03:15:47 PM
How is your testosterone levels Muon?
No idea.
Title: Re: Varicocele
Post by: Iwillbeatthis on November 19, 2020, 06:26:09 PM
Have a big varicose on my left testicle I remember them on a scan. Feels like a lump on my epididymitis however doesn't cause any issues for me that I know of. I don't believe I had this before POIS.
Title: Re: Varicocele
Post by: Muon on November 19, 2020, 06:45:56 PM
I think POIS leads to ballooning of those blood vessels.
Title: Re: Varicocele
Post by: Hopeoneday on November 22, 2020, 06:47:46 PM
https://poiscenter.com/forums/index.php?topic=3028.msg37615#msg37615

Guys who hawe painfull testicle and all odhers members ,
could you do a litle tests for science  :) ?
Can you find painfull small node floating around testicles after eyculation?
Title: Re: Varicocele
Post by: Muon on December 05, 2020, 03:49:59 PM
Dad and brother has one too, as long as they remember, but dont have POIS. How is your testosterone levels Muon?

I forgot about this, never mentioned it on the forum I believe, but I had an enlarged left testicle when I was younger before POIS diagnosis was made. Scan revealed benign thickening.

I can have a sore left testis and left side of scrotum including sore surrounding soft tissues (hip/groin area) and becomes systemic when pre-ejaculate releases. Probably some inflammatory chain reaction. Left side of scrotum feels thick as well.

Scrotal edema?
Title: Re: Varicocele
Post by: LookingForACure on March 28, 2021, 10:45:33 PM
I have not been tested and do not have a varicocele that is easily detectable. However, I do have some symptoms of local venous hypertension on one side of my scrotum, which from the papers I read may be suggestive of sub-clinical varicocele. Whether or not this is related to POIS, I do not know. If it is, the mediating factor is unlikely to be testosterone because my levels are quite good.
Title: Re: Varicocele
Post by: Muon on May 25, 2021, 06:59:08 AM
I would not be surprised when blood vessels look like a varicocele in other parts of the body.

Edit: Dumping stuff here, maybe there is something useful to be found.

A global view of the pathophysiology of varicocele (https://onlinelibrary.wiley.com/doi/full/10.1111/andr.12511)

(https://onlinelibrary.wiley.com/cms/asset/4dc8c11d-bab4-46ec-af52-59433e87217d/andr12511-fig-0001-m.jpg)

Inflammatory and anti-inflammatory cytokines in the seminal plasma of infertile men suffering from varicocele (https://onlinelibrary.wiley.com/doi/abs/10.1111/and.12685)

Proteomic analysis of seminal plasma from bilateral varicocele patients indicates an oxidative state and increased inflammatory response (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859669/)

Changes in Inflammatory Cytokines Accompany Deregulation of Claudin-11, Resulting in Inter-Sertoli Tight Junctions in Varicocele Rat Testes (https://www.auajournals.org/doi/abs/10.1016/j.juro.2016.05.004)

Berberine ameliorates experimental varicocele-induced damages at testis and sperm levels; evidences for oxidative stress and inflammation (https://onlinelibrary.wiley.com/doi/abs/10.1111/and.13179)

Silymarin and celecoxib ameliorate experimental varicocele-induced pathogenesis: evidences for oxidative stress and inflammation inhibition (https://link.springer.com/article/10.1007/s11255-018-1862-5)

Sperm DNA damage and cytokines in varicocele: A case-control study (https://onlinelibrary.wiley.com/doi/abs/10.1111/and.14023)

Oxidative stress, nitric oxide and inflammation in the pathophysiology of varicocele and the effect of hydrogen sulfide as a potential treatment (https://www.researchgate.net/profile/Keivan-Lorian/publication/338645934_Oxidative_stress_nitric_oxide_and_inflammation_in_the_pathophysiology_of_varicocele_and_the_effect_of_hydrogen_sulfide_as_a_potential_treatment/links/5e241be6a6fdcc10157512bd/Oxidative-stress-nitric-oxide-and-inflammation-in-the-pathophysiology-of-varicocele-and-the-effect-of-hydrogen-sulfide-as-a-potential-treatment.pdf)

Presence of The NLRP3 Inflammasome Components in Semen of Varicocele Patients (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139229/)

The Association between Varicocele, Premature Ejaculation and Prostatitis Symptoms: Possible Mechanisms (https://www.sciencedirect.com/science/article/abs/pii/S1743609515322840)

Seminal inflammasome activity in the adult varicocele (https://www.tandfonline.com/doi/abs/10.1080/14647273.2020.1870756)

 Association of Seminal Plasma Total Antioxidant Capacity and Malondialdehyde Levels With Sperm Parameters in Infertile Men With Varicocele (http://ajmb.umsha.ac.ir/Article/e33540)
Title: Re: Varicocele
Post by: Rollo on May 25, 2021, 12:27:32 PM
This is actually interesting... i voted no but now that i have seen that picture i might indeed have one.
There are two oblong shaped hard and non painful "unidentified things" on the right side of my crotch.
There is a slight pain sensation in that area sometimes but not too heavy so i didn't have it checked out yet....i might now though.
Title: Re: Varicocele
Post by: Pontevin on June 06, 2021, 06:44:19 PM
I was diagnosed around the time of symptoms appearance many years ago but hadn?t even thought about it until I randomly came upon this poll. I had inguinal hernia surgery and they said I had varicocele. Are there any cases of varicocelectomies curing POIS?