Post Orgasmic Illness Syndrome (P.O.I.S.)

General Category => Articles, References and Links => Topic started by: Muon on November 02, 2019, 04:32:34 PM

Title: POIS Paper Archive - a list of scientific articles about POIS
Post by: Muon on November 02, 2019, 04:32:34 PM
People may post new papers in the comments instead of making new threads, these threads tend to scatter all over the forum. Use CTRL + F on this page and search for title or author keywords when you want to check if a specific paper is present on this list.

How to bypass paywalls of scientific papers in general:

Copy one of the following:

1) The URL of a website showing a paper (yes the entire http:// webbrowser link).
2) DOI number (shown by abstract/paper or it's oftentimes shown at the end of an URL).
3) Title of paper (less chance paper shows up than method 1 and 2).

And paste it into the search bar of https://sci-hub.se/ or https://sci-hub.tw/

Sometimes you will be prompted to type in a word (bot prevention). And sometimes the site doesn't show the paper but you can still retrieve it by using the save button at the left side.

Find the latest (POIS) papers by using:

https://scholar.google.com

https://www.ncbi.nlm.nih.gov/pubmed/


2002


1. Waldinger, M. D., & Schweitzer, D. H. (2002). Postorgasmic illness syndrome: Two cases. Journal of Sex & Marital Therapy, 28(3), 251-255. (https://sci-hub.tw/10.1080/009262302760328280)


2010


2. Ashby, J., & Goldmeier, D. (2010). Postorgasm illness syndrome - a spectrum of illnesses. The Journal of Sexual Medicine, 7(5), 1976-1978. (https://sci-hub.tw/10.1111/j.1743-6109.2010.01707.x)


2011

3. Waldinger, M. D., Meinardi, M. M. H. M., Zwinderman, A. H., & Schweitzer, D. H. (2011). Postorgasmic illness syndrome (POIS) in 45 Dutch caucasian males: Clinical characteristics and evidence for an immunogenic pathogenesis (Part 1). The Journal of Sexual Medicine, 8(4), 1164-1170. (https://sci-hub.tw/10.1111/j.1743-6109.2010.02166.x)


4. Waldinger, M. D., Meinardi, M. M., & Schweitzer, D. H. (2011). Hyposensitization therapy with autologous semen in two Dutch Caucasian males: Beneficial effects in postorgasmic illness syndrome (POIS; Part 2). The Journal of Sexual Medicine, 8(4), 1171-1176. (https://sci-hub.tw/10.1111/j.1743-6109.2010.02167.x)


5. Farley, S. J. (2011). Postorgasmic illness syndrome. Nat Rev Urol, 8(3), 121. (https://sci-hub.tw/10.1038/nrurol.2011.17)


6. Nguyen, T., Dimov, V., & Bewtra, A. (2011). Seminal fluid hypersensitivity in a man with postorgasmic illness syndrome (POIS). Annals of Allergy Asthma & Immunology, 107, A48-A48. (https://sci-hub.tw/10.1016/j.anai.2011.09.019)


2013


7. Desai, G., Sharma, M., & Chaturvedi, S. K. (2013). Medically unexplained symptoms explained! A case of post orgasmic illness syndrome. Indian Journal of Medical Case Reports, 2(1), 18-20. (https://pdfs.semanticscholar.org/1eb8/93056353f17057297c1e3beba3f928381971.pdf)


8. Attia AM, Yasien HA and Al-Ziny MH. Post-orgasmic illness syndrome: a case report [version 1; peer review: 3 approved with reservations, 1 not approved]. F1000Research 2013, 2:113. (https://f1000research.com/articles/2-113)


9. Puerta, S. J., & Cardona, M. W. (2013). Postorgasmic illness syndrome: semen allergy in men. Actas urologicas espanolas, 37(9), 593. (https://sci-hub.tw/10.1016/j.acuro.2013.03.002)


10. Shigeta K, Kikuchi E, Matsushima M, Daimon T, Yazawa S, Ando T, et al. A clinical case of suspected postorgasmic illness
syndrome
. J Sex Med. 2013;10 Supp 3:220. (https://sci-hub.se/https://doi.org/10.1111/jsm.12182_3)


11. Крижановський, І. Д. (2013). Postorgasmic illness syndrome: випадок із практики. Медико-соціальні проблеми сім'ї, (18,№ 4), 107-111. (http://www.irbis-nbuv.gov.ua/cgi-bin/irbis_nbuv/cgiirbis_64.exe?C21COM=2&I21DBN=UJRN&P21DBN=UJRN&IMAGE_FILE_DOWNLOAD=1&Image_file_name=PDF/Msps_2013_18_4_21.pdf)


2015


12. Jiang, N., Xi, G., Li, H., & Yin, J. (2015). Postorgasmic illness syndrome (POIS) in a Chinese man: No proof for IgE-mediated allergy to semen. The Journal of Sexual Medicine, 12(3), 840-845. (https://sci-hub.tw/10.1111/jsm.12813)


2016


13. Mashal, A. Beer, S. (2016). Post orgasmic illness. The Journal of Sexual Medicine, 13(5), S199. (https://sci-hub.tw/10.1016/j.jsxm.2016.03.271)


14. Waldinger, M. D. (2016). Post orgasmic illness syndrome (POIS). Translational andrology and urology, 5(4), 602. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001999/)


2017


15. Gerber, D. (2017). Flooding as A Treatment for Post Orgasmic Illness Syndrome. The Journal of Sexual Medicine, 14(1), S84. (https://sci-hub.tw/10.1016/j.jsxm.2016.11.189)


16. Serefoglu, E. C. (2017). Post-orgasmic illness syndrome: Where are we? The Journal of Sexual Medicine, 14(5), 641-642. (https://sci-hub.tw/10.1016/j.jsxm.2017.03.250)


17. Bignami, B., Honore, T., Turmel, N., Haddad, R., Weglinski, L., Le Breton, F., & Amarenco, G. (2017). Post-orgasmic illness syndrome. Progres en urologie: journal de l'Association francaise d'urologie et de la Societe francaise d'urologie, 27(7), 446. (https://sci-hub.tw/10.1016/j.purol.2017.03.007)


2018


18. Nguyen, H. M. T., Bala, A., Gabrielson, A. T., & Hellstrom, W. J. G. (2018). Post-orgasmic illness syndrome: A review. Sexual Medicine Reviews, 6(1), 11-15. (https://www.sciencedirect.com/science/article/pii/S2050052117301166?via%3Dihub)


19. Depreux, N., Basagana, M., & Pascal, M. (2018). Negative allergy study in a case of postorgasmic illness syndrome (POIS). Revista Internacional de Andrologıa, 16(1), 42-44. (https://sci-hub.tw/10.1016/j.androl.2017.06.002)


20. Kim, T. B., Shim, Y. S., Lee, S. M., Son, E. S., Shim, J. W., & Lee, S. P. (2018). Intralymphatic immunotherapy with autologous semen in a Korean man with post-orgasmic illness syndrome. Sexual Medicine, 6(2), 174-179. (https://www.smoa.jsexmed.org/article/S2050-1161(18)30019-9/fulltext)


2019


21. Strashny, A. First assessment of the validity of the only diagnostic criteria for postorgasmic illness syndrome (POIS). Int J Impot Res 31, 369-373 (2019). (https://sci-hub.tw/10.1038/s41443-019-0154-7)


22. Abdessater, M., Elias, S., Mikhael, E. et al. Post orgasmic illness syndrome: what do we know till now?. Basic Clin. Androl. 29, 13 (2019). (https://bacandrology.biomedcentral.com/articles/10.1186/s12610-019-0093-7)


23. Stafie, C. S., & Stafie, I. I. (2019). Post coital allergy - A case report of post orgasmic illness syndrome. The Medical-Surgical Journal, 123(2), 258-261. (https://www.revmedchir.ro/index.php/revmedchir/article/view/1798/1449)


24. De Amicis, K., Costa, P. R., Figo, D. D., De Lima, C. M. F., Castro, F. F. M., Kalil, J., Santos, K. S., Galvao, C. E. S. (2019). Immunophenotypical Characterization of a Brazilian POIS (Post-Orgasmic Illness Syndrome) Patient: Adding More Pieces to Puzzle. Journal of Sex & Marital Therapy, 1-7. (https://sci-hub.tw/10.1080/0092623x.2019.1677835)


25. Bolanos, J., & Morgentaler, A. (2019). Successful treatment of Post-orgasmic illness syndrome with human chorionic gonadotropin. Urology Case Reports, 101078. (https://www.sciencedirect.com/science/article/pii/S221444201930453X)


26. Pierce, H., Fainberg, J., Gaffney, C., Aboukhashaba, A., Khan, A., & Kashanian, J. (2019). Postorgasmic illness syndrome: potential new treatment options for a rare disorder. Scandinavian Journal of Urology, 1-3. (https://sci-hub.tw/10.1080/21681805.2019.1704861)


2020


27. Natale, C., Gabrielson, A., Nguyen, H. M. T., & Hellstrom, W. J. (2020). 139 Characterizing the Epidemiological Landscape of Post-Orgasmic Illness Syndrome. The Journal of Sexual Medicine, 17(1), S40. (https://sci-hub.tw/10.1016/j.jsxm.2019.11.085)


28. Paulos, M. R., & Avelliino, G. J. (2020). Post-orgasmic illness syndrome: history and current perspectives. Fertility and Sterility, 113(1), 13-15. (https://www.sciencedirect.com/science/article/pii/S0015028219325609)


29. Natale*, C., Gabrielson, A., Tue Nguyen, H. M., & Hellstrom, W. (2020). MP84-19 Characterizing the disease course and current treatment practices of Post-Orgasmic  Illness Syndrome in a large sample of patients. The Journal of Urology, 203(Supplement 4),e1271-e1272. (https://www.auajournals.org/doi/abs/10.1097/JU.0000000000000976.019)


30. Reisman, Y. (2020). Clinical experience with post-orgasmic illness syndrome (POIS) patients-characteristics and possible treatment modality. International Journal of Impotence Research, 1-7. (https://sci-hub.se/10.1038/s41443-020-0314-9)


31. Arata, K., Tamagawa‐Mineoka, R., Ohshita, A., Masuda, K., & Katoh, N. (2020). Nonsteroidal anti‐inflammatory drugs are effective against postorgasmic illness syndrome: A case report. Journal of Cutaneous Immunology and Allergy. (https://onlinelibrary.wiley.com/doi/full/10.1002/cia2.12123)


32. Takeshima, T., Kuroda, S., & Yumura, Y. (2020). Case of post‐orgasmic illness syndrome associated with hypogonadism. IJU Case Reports. (https://onlinelibrary.wiley.com/doi/full/10.1002/iju5.12184)


POIS related media articles

What It's Like to Be Allergic to Your Own Orgasms (https://www.menshealth.com/health/a19543976/inside-post-orgasmic-illness-syndrome/)

Does my boyfriend have post-orgasmic illness syndrome? (https://www.rappler.com/life-and-style/relationships/240195-two-pronged-post-orgasmic-illness-syndrome)

Post-Ejaculation Illness: Not So Rare After All? (https://www.medpagetoday.com/meetingcoverage/smsna/82964)

Man's 'debilitating' orgasm allergy left him with flu-like symptoms when he climaxed (https://www.newshub.co.nz/home/lifestyle/2020/01/man-s-debilitating-orgasm-allergy-left-him-with-flu-like-symptoms-when-he-climaxed.html)
Title: Re: POIS Paper/Journal Archive
Post by: Muon on November 02, 2019, 04:35:47 PM
Other papers worth a mention


Goldstein, I., & Komisaruk, B. R. (2018). Pathophysiology and Medical Management of Female Orgasmic Illness Syndrome. Textbook of Female Sexual Function and Dysfunction, 239-243. doi:10.1002/9781119266136.ch17 (https://sci-hub.tw/10.1002/9781119266136.ch17)


Kounis, N. G., Ren, H. L., Kavalioti, M., Koniari, I., & Theoharides, T. C. (2019). Intimate Contact Could Be Dangerous for Your Health. Clinical therapeutics. (https://sci-hub.se/10.1016/j.clinthera.2019.04.010)


Theoharides, T. C., & Stewart, J. M. (2015). Genitourinary mast cells and survival. Translational andrology and urology, 4(5), 579. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708553/)


Theoharides, T. C. (2017). Neuroendocrinology of mast cells: Challenges and controversies. Experimental dermatology, 26(9), 751-759. (https://onlinelibrary.wiley.com/doi/full/10.1111/exd.13288)


Bianchi, V. E. (2019). The Anti-Inflammatory Effects of Testosterone. Journal of the Endocrine Society, 3(1), 91-107. (https://academic.oup.com/jes/article/3/1/91/5137187)


Walecki, M., Eisel, F., Klug, J., Baal, N., Paradowska-Dogan, A., Wahle, E., ... & Fijak, M. (2015). Androgen receptor modulates Foxp3 expression in CD4+ CD25+ Foxp3+ regulatory T-cells. Molecular biology of the cell, 26(15), 2845-2857. (https://www.molbiolcell.org/doi/full/10.1091/mbc.E14-08-1323)
Title: Re: POIS Paper/Journal Archive
Post by: Muon on November 02, 2019, 04:38:08 PM
reserved 2
Title: Re: POIS Paper/Journal Archive
Post by: Muon on November 02, 2019, 04:39:29 PM
reserved 3
Title: Re: POIS Paper/Journal Archive
Post by: Muon on November 02, 2019, 04:41:14 PM
reserved 4
Title: Re: POIS Paper/Journal Archive
Post by: Muon on November 02, 2019, 04:46:02 PM
reserved 5
Title: Re: POIS Paper/Journal Archive
Post by: Muon on November 02, 2019, 04:49:10 PM
reserved final
Title: Re: POIS Paper/Journal Archive
Post by: Muon on November 02, 2019, 04:57:03 PM
New paper:
A New Exploration of the Combined Treatment of Symptoms and Social Work Psychology in Male Sexual Addiction Patients (https://www.atlantis-press.com/proceedings/cesses-19/125920296)

Stopped reading, I couldn't take it anymore. They are trying to couple masturbation addiction to POIS...nice try.

So much BS in this paper unbelievable.
Title: Re: POIS Paper Archive
Post by: demografx on November 04, 2019, 12:58:51 PM

Thread sent to our NORD researchers.
Title: Re: POIS Paper/Journal Archive
Post by: demografx on November 04, 2019, 05:01:06 PM
New paper:
A New Exploration of the Combined Treatment of Symptoms and Social Work Psychology in Male Sexual Addiction Patients (https://www.atlantis-press.com/proceedings/cesses-19/125920296)

Stopped reading, I couldn't take it anymore. They are trying to couple masturbation addiction to POIS...nice try.

So much BS in this paper unbelievable.

;D ;D
Title: Re: POIS Paper Archive
Post by: demografx on November 04, 2019, 05:01:43 PM


Thread sent to our NORD researchers.



What a great resource, Demo, thanks for sending!

TKL


Thank you, Muon!
Demo
Title: Re: POIS Paper Archive
Post by: Quantum on November 20, 2019, 10:20:38 PM
Hi Muon, I suggest you had this case report form 2017.  It back up the Chinese study about the fact that skin prick test are not valuable on POIS, among other things:

https://www.sciencedirect.com/science/article/abs/pii/S1698031X1730064X?via%3Dihub
Title: Re: POIS Paper Archive
Post by: Muon on November 21, 2019, 08:11:33 AM
Hi Muon, I suggest you had this case report form 2017.  It back up the Chinese study about the fact that skin prick test are not valuable on POIS, among other things:

https://www.sciencedirect.com/science/article/abs/pii/S1698031X1730064X?via%3Dihub
I don't understand your comment, do you mean this one is absent from the list? It's not, it's under 2018. As far as I know that paper was published in 2018. I checked it again via autociting to be sure and it gives me 2018.
Title: Re: POIS Paper Archive
Post by: Quantum on November 21, 2019, 10:53:53 PM
Hi Muon, I suggest you had this case report form 2017.  It back up the Chinese study about the fact that skin prick test are not valuable on POIS, among other things:

https://www.sciencedirect.com/science/article/abs/pii/S1698031X1730064X?via%3Dihub
I don't understand your comment, do you mean this one is absent from the list? It's not, it's under 2018. As far as I know that paper was published in 2018. I checked it again via autociting to be sure and it gives me 2018.

Sorry I had the publication year wrong, so I did not see it in your list.
Title: Re: POIS Paper Archive
Post by: Muon on November 22, 2019, 06:47:21 AM
Just use CTRL + F on this page and search for title or author keywords.
Title: Re: POIS Paper Archive
Post by: demografx on November 22, 2019, 08:13:05 AM
Thanks, Muon, didn’t know we could do that. You should give us an SMF tutorial! :)
Title: Re: POIS Paper Archive
Post by: Muon on November 22, 2019, 08:22:00 AM
Thanks, Muon, didn’t know we could do that. You should give us an SMF tutorial! :)
You can do that for almost every software out there, it's almost a universal command, thus not bound to SMF. PDF readers, internet browsers, windows etcetera are making use of it.
Title: Re: POIS Paper Archive
Post by: Muon on November 28, 2019, 05:42:27 AM
New paper:

Successful treatment of Post-orgasmic illness syndrome with human chorionic gonadotropin (https://www.sciencedirect.com/science/article/pii/S221444201930453X)
Title: Re: POIS Paper Archive
Post by: demografx on November 28, 2019, 06:47:37 AM
Thanks, Muon, sent to our POIS Research Team.
Title: Re: POIS Paper Archive
Post by: Nas on November 28, 2019, 07:09:50 AM
Good news I guess?
The problem is that my serum testosterone is actually normal high
So I don't know how to feel about testosterone treatment :/
Can we know exactly the guy's symptoms? The description doesn't sound sufficient for a POIS diagnoses.
Title: Re: POIS Paper Archive
Post by: demografx on November 28, 2019, 07:30:56 AM
Nas, I’ve had a theory, THAT I DON’T RECOMMEND TESTING WITHOUT CLOSE MEDICAL SUPERVISION, that TRT can also benefit some POISers with normal Free-T values. Not scientific. Call it a hunch. A POISer friend tried it and it didn’t help.
Title: Re: POIS Paper Archive
Post by: Eliasjoelrivera on November 28, 2019, 07:35:23 AM
New paper:

Successful treatment of Post-orgasmic illness syndrome with human chorionic gonadotropin (https://www.sciencedirect.com/science/article/pii/S221444201930453X)

interesting article. I think I will be happy to seek treatment to put it into practice. At some point I thought about using testosterone patches. But this method seems more effective. I will start consulting an endocrinologist. thanks for the info.
Title: Re: POIS Paper Archive
Post by: demografx on November 28, 2019, 07:35:58 AM
Can we know exactly the guy's symptoms?
Email the author?
Title: Re: POIS Paper Archive
Post by: demografx on November 28, 2019, 07:40:19 AM
I will start consulting an endocrinologist.
An endocrinologist is the *only* physician/medical specialist I consulted who actually helped me.

Ten years ago, I was advised by a Harvard biophysicist friend who pioneered & then developed some successful AIDS treatment, to seek out a *university* based endocrinologist because they are more research-oriented and thus likely to be more open to POIS evaluation & treatment. So I did.
Title: Re: POIS Paper Archive
Post by: Nas on November 28, 2019, 07:43:22 AM
Can we know exactly the guy's symptoms?
Email the author?
Sorry I didn't read the full article, yes the patient seems to be suffering from POIS evident by his social withdrawal.
Title: Re: POIS Paper Archive
Post by: demografx on November 28, 2019, 07:52:36 AM
Thanks, Nas
Title: Re: POIS Paper Archive
Post by: Nas on November 28, 2019, 08:02:49 AM
So can we suppose that gonadotropin treatment is similar to TRT or should we consider it as a novel treatment with a different mechanism of action?
Title: Re: POIS Paper Archive
Post by: demografx on November 28, 2019, 08:02:56 AM
Keep in mind that Dr. Waldinger’s first co-author is an endocrinologist. Even 10 years ago, I was successful in persuading my endocrinologist to take me seriously by pointing this out.

As Quantum often suggests, I showed him the Waldinger+endocrinologist article from 2002.
Title: Re: POIS Paper Archive
Post by: demografx on November 28, 2019, 08:04:03 AM
So can we suppose that gonadotropin treatment is similar to TRT or should we consider it as a novel treatment with a different mechanism of action?
I would ask an endocrinologist.
Title: Re: POIS Paper Archive
Post by: demografx on November 28, 2019, 08:10:36 AM
I don’t know anything about them (NYU docs sound promising), but I considered a similar online chat with an endocrinologist:
Chat with an endocrinologist:
https://tinyurl.com/rq28vrt
Title: Re: POIS Paper Archive
Post by: Muon on November 28, 2019, 04:08:45 PM
My mother, her sister and my grandmother who got health problems all felt better during pregnancy. Take a look at this:
https://en.wikipedia.org/wiki/Human_chorionic_gonadotropin#Reference_levels_in_normal_pregnancy

Theoretically, both desensitization and TRT are able to stabilize mast cells:
https://poiscenter.com/forums/index.php?topic=2301.msg31643#msg31643

By applying hCG they could have expanded his Treg pool by stimulation of androgen receptors. See links about androgens and Tregs inside this thread: https://poiscenter.com/forums/index.php?topic=2891.0

It would be of interest to know what his FOXP3+Treg numbers were before and after hCG treatment. The outcome of this 'treatment' is very encouraging but don't forget that this is only a case report so far and his POIS has not been completely reversed from what I understand despite having a high T level after application.

Some other papers which might be of interest:

Serotonin secretion from rat Leydig cells (https://academic.oup.com/endo/article-abstract/133/6/3026/3036095)

Human adrenal cortex hyperfunction due to LH/hCG (https://www.sciencedirect.com/science/article/abs/pii/S0303720707000469)
Title: Re: POIS Paper Archive
Post by: Nas on November 28, 2019, 04:37:27 PM
I just want to know what's the difference between hCG and TRT. Because the former is very rare and difficult to obtain and the other is easier but potentially more dangerous for cardiac issues.
Title: Re: POIS Paper Archive
Post by: Muon on November 28, 2019, 04:47:50 PM
I just want to know what's the difference between hCG and TRT. Because the former is very rare and difficult to obtain and the other is easier but potentially more dangerous for cardiac issues.
In addition to that, what else did it do besides cranking up T?
Title: Re: POIS Paper Archive
Post by: Nas on November 28, 2019, 05:04:38 PM
I just want to know what's the difference between hCG and TRT. Because the former is very rare and difficult to obtain and the other is easier but potentially more dangerous for cardiac issues.
In addition to that, what else did it do besides cranking up T?
I suspect the mechanism of POIS lies somewhere in their. For example there are many people who suffer from low testosterone but they don't have POIS. So it must be that in the mechanism of testosterone regeneration POIS occurs. Maybe androgen receptors in the brain or the testies.
Title: Re: POIS Paper Archive
Post by: Eliasjoelrivera on November 28, 2019, 05:24:29 PM
I just took a turn with an endocrinologist, I will present my case with documents taken from poiscenter. I hope to get a successful response and possible treatment. I'm sure he'll send me studies and so on.
Title: Re: POIS Paper Archive
Post by: demografx on November 28, 2019, 05:26:54 PM
TRT...is...potentially more dangerous for cardiac issues.
Depressing! I had 5-way bypass, open heart surgery...but I won’t blame you for ruining my Thanksgiving, my previous doctor agrees with you. No, that’s not why I fired him ;D
Title: Re: POIS Paper Archive
Post by: demografx on November 28, 2019, 05:28:00 PM
I just took a turn with an endocrinologist, I will present my case with documents taken from poiscenter. I hope to get a successful response and possible treatment. I'm sure he'll send me studies and so on.
Elias, excellent! Best wishes!
Title: Re: POIS Paper Archive
Post by: Nas on November 28, 2019, 05:36:31 PM
TRT...is...potentially more dangerous for cardiac issues.
Depressing! I had 5-way bypass, open heart surgery...but I won’t blame you for ruining my Thanksgiving, my previous doctor agrees with you. No, that’s not why I fired him ;D
You would love my Egyptian doctor he doesn't seem to think that TRT is bad for you ;D
Title: Re: POIS Paper Archive
Post by: Muon on November 28, 2019, 05:48:34 PM
I had 5-way bypass, open heart surgery...
What kind of cardiac symptom(s) led up to this surgery? 
Title: Re: POIS Paper Archive
Post by: demografx on November 28, 2019, 05:57:34 PM
Clogged arteries, arrhythmia, chest pain.
Title: Re: POIS Paper Archive
Post by: demografx on November 28, 2019, 05:58:37 PM
TRT...is...potentially more dangerous for cardiac issues.
Depressing! I had 5-way bypass, open heart surgery...but I won’t blame you for ruining my Thanksgiving, my previous doctor agrees with you. No, that’s not why I fired him ;D
You would love my Egyptian doctor he doesn't seem to think that TRT is bad for you ;D
Yes!!!! What’s his phone number? Hurry!!!!!            ;D
Title: Re: POIS Paper Archive
Post by: Muon on November 28, 2019, 06:06:40 PM
Clogged arteries, arrhythmia, chest pain.
I'm asking this because I developed cardiac issues over the years like arrythmia, POIS is making this worse.
Title: Re: POIS Paper Archive
Post by: demografx on November 28, 2019, 06:41:00 PM
Muon, I wouldn’t be surprised if years of POIS agony drove me to the ER (actually my wife drove me
:) )

I also suspect entrepreneurial-business pressure + poor diet + alcohol. Plus my father died of BP complications, so much of my condition I suspect is hereditary. Thankfully, my BP meds work wonderfully, even on this caffeine-addicted body of mine :)
Title: Re: POIS Paper Archive
Post by: Muon on November 29, 2019, 06:32:27 AM
''Treatment was initiated with hCG 1500IU injected subcutaneously three times per week. At six-week follow-up his symptoms had resolved completely, and he had discontinued use of alprazolam. He ejaculated more frequently, and experienced no weakness, anxiety, brain fog, or malaise afterwards. He noted improved mood, overall energy, and libido. Blood tests showed robust levels of total testosterone at 952 ng/dl and free T (direct) at 2.8 ng/dl. LH and FSH were below threshold limits. He reported this was the first time since he was 16y that he could experience orgasm without negative physical or emotional consequences afterwards. At six months of follow-up he continued hCG treatment, was happy, and masturbated several times per month. He still described mild POIS symptoms immediately following orgasm, but these resolved within 12 h and were not bothersome. Importantly, he no longer experienced dread with anticipated sexual activity.''

At six-week follow up his symptoms had resolved completely.
At six months of follow up he described mild POIS symptoms.

Did he stop doing hCG injections after the six-week follow up and continued after the 6-month follow up or did he use it all the time during these 6 months?
Title: Re: POIS Paper Archive
Post by: Eliasjoelrivera on November 29, 2019, 06:55:15 AM
Muon communicate with me. I was consulting with an endocrinologist and he told me that hcg medication is very expensive and is only prescribed on the basis of hypogonadism or infertility problems. In my case the testorene is within the normal ranges. Somewhat low, but normal. I am 382 ng / dl. It does not justify the treatment.
Will there be a way to go to the research team nord or pois to perform tests ?.
Next week I have another shift with an endocrinol, hopefully it will be positive to give me the medication and be able to experiment with me.
Title: Re: POIS Paper Archive
Post by: Eliasjoelrivera on November 29, 2019, 07:02:05 AM
We have a degree of hope. I will try by all means to apply the treatment, under medical prescription. In Argentina the treatment is very expensive. That is why it is very difficult to access it. I will keep you informed about everything.
Title: Re: POIS Paper Archive
Post by: demografx on November 29, 2019, 05:44:42 PM
Just use CTRL + F on this page and search for title or author keywords.
Is there an equivalent to CTRL-F on a mobile device?
Title: Re: POIS Paper Archive
Post by: Muon on November 29, 2019, 05:53:09 PM
Just use CTRL + F on this page and search for title or author keywords.
Is there an equivalent to CTRL-F on a mobile device?
Dunno I rarely use my mobile device.
Title: Re: POIS Paper Archive
Post by: Nas on November 29, 2019, 06:02:40 PM
Just use CTRL + F on this page and search for title or author keywords.
Is there an equivalent to CTRL-F on a mobile device?

On browser look for options and look for "find" or "find in page". I use this method all the time on my phone.
Title: Re: POIS Paper Archive
Post by: Muon on November 29, 2019, 06:04:05 PM
Ok I have compiled full versions of all papers in PDF format here:

https://www.dropbox.com/sh/i4ploderhgty86o/AAABk_eHd89Af66YjyGLZa7Ta?dl=0

Some titles have been slightly adjusted because they gave me (syntax) errors. You can also find this link on page 1 of this thread.

Have fun reading!
Title: Re: POIS Paper Archive
Post by: demografx on November 29, 2019, 06:34:02 PM
Just use CTRL + F on this page and search for title or author keywords.
Is there an equivalent to CTRL-F on a mobile device?

On browser look for options and look for "find" or "find in page". I use this method all the time on my phone.

Thanks, Nas!
Title: Re: POIS Paper Archive
Post by: demografx on November 29, 2019, 06:34:36 PM
Muon, splendid effort!
Title: Re: POIS Paper Archive
Post by: demografx on November 29, 2019, 07:06:33 PM
Ok I have compiled full versions of all papers in PDF format here:

https://www.dropbox.com/sh/i4ploderhgty86o/AAABk_eHd89Af66YjyGLZa7Ta?dl=0

Some titles have been slightly adjusted because they gave me (syntax) errors. You can also find this link on page 1 of this thread.

Have fun reading!
Sent to our POIS Research Team
Title: Re: POIS Paper Archive
Post by: demografx on November 30, 2019, 07:54:06 PM
''Treatment was initiated with hCG 1500IU injected subcutaneously three times per week. At six-week follow-up his symptoms had resolved completely, and he had discontinued use of alprazolam. He ejaculated more frequently, and experienced no weakness, anxiety, brain fog, or malaise afterwards. He noted improved mood, overall energy, and libido. Blood tests showed robust levels of total testosterone at 952 ng/dl and free T (direct) at 2.8 ng/dl. LH and FSH were below threshold limits. He reported this was the first time since he was 16y that he could experience orgasm without negative physical or emotional consequences afterwards. At six months of follow-up he continued hCG treatment, was happy, and masturbated several times per month. He still described mild POIS symptoms immediately following orgasm, but these resolved within 12 h and were not bothersome. Importantly, he no longer experienced dread with anticipated sexual activity.''

At six-week follow up his symptoms had resolved completely.
At six months of follow up he described mild POIS symptoms.

Did he stop doing hCG injections after the six-week follow up and continued after the 6-month follow up or did he use it all the time during these 6 months?

At age 25, I worry about his fertility! After TRT, my sperm count went to 0.00, presumably because of my TRT.

I’m not familiar with hCG, if it has the same downside risk.

I already had grown adult children. But this guy has his whole life ahead of him!
Title: Re: POIS Paper Archive
Post by: Nas on November 30, 2019, 08:35:10 PM

At age 25, I worry about his fertility! After TRT, my sperm count went to 0.00, presumably because of my TRT.

I’m not familiar with hCG, if it has the same downside risk.

I already had grown adult children. But this guy has his whole life ahead of him!

They mentioned in the paper that they decided to use hCG instead of TRT because the patient wished to keep his fertility and keep his testicular size.
Title: Re: POIS Paper Archive
Post by: demografx on November 30, 2019, 10:33:12 PM
Thanks again, Nas.
Title: Re: POIS Paper Archive
Post by: Muon on December 01, 2019, 08:16:01 AM
Muon, I wouldn’t be surprised if years of POIS agony drove me to the ER (actually my wife drove me
:) )

I also suspect entrepreneurial-business pressure + poor diet + alcohol. Plus my father died of BP complications, so much of my condition I suspect is hereditary. Thankfully, my BP meds work wonderfully, even on this caffeine-addicted body of mine :)

I'm wondering whether the POIS reaction dumps molecules into circulation increasing the risk of Atherosclerosis. I often get the impression circulation slowing down or at some spots feeling a local flow. Inflammation?--->Increased vascular resistance--->increased friction--->flow + friction = resonance/turbulence (less laminar flow)--->sense of flow. Also sometimes it feels just locally instable at spot X for a few seconds it disappears quick and soon after the same dynamic pops up somewhere else at spot Y.
Title: Re: POIS Paper Archive
Post by: demografx on December 01, 2019, 11:52:54 PM
Makes sense!
Title: Re: POIS Paper Archive
Post by: Muon on December 02, 2019, 07:15:18 AM
I wonder if BDNF is involved in poisers with relatively low levels of testosterone. Some POIS case reports state patients were stressed or having IBD prior to developing POIS aside from other things like allergies. PE and stress could be related to low levels of BDNF. I wouldn't be surprised when hCG upregulates BDNF. POIS is rare and you may ask yourself what the frequency is of non-poisers with low levels of testosterone. People don't completely recover from POIS by androgen treatment, which can be another indication you are modifying something else via T indirectly.

Brain‐derived neurotrophic factor: A steroidogenic regulator of Leydig cells (https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.28095)
Title: Re: POIS Paper Archive
Post by: Nas on December 02, 2019, 07:33:46 AM
I agree Muon. Testosterone, or whatever hCG does else, seems to regulate the mechanism POISers suffer from.
We should never look at what's common as indicator to the cause rather we need to look towards something equally as rare as POIS.
Title: Re: POIS Paper Archive
Post by: Muon on December 02, 2019, 08:21:17 AM
The change in testosterone per unit time could be responsible for positive effects rather than the higher absolute T levels...or both. It would not surprise me when the POIS symptoms returned and T levels remain normally high after the patient stopped hCG treatment.
Title: Re: POIS Paper Archive
Post by: Muon on December 08, 2019, 02:36:47 PM
Sex hormones and ANS: https://poiscenter.com/forums/index.php?topic=2695.msg32116#msg32116

Another idea: ANS activity could have been modulated indirectly by applying hCG.
Title: Re: POIS Paper Archive
Post by: Vandemolen on December 13, 2019, 09:58:49 PM
Did he stop doing hCG injections after the six-week follow up and continued after the 6-month follow up or did he use it all the time during these 6 months?
Yes I have the same question. I would be very expensive if he has to get HCG injections his whole life.

I mailed the link to the paper to my POIS-doctor and my urologist who knew prof. Waldinger and he is also seeing a few POIS patients at the moment.
Title: Re: POIS Paper Archive
Post by: Muon on December 14, 2019, 06:58:41 AM
I did send this question to the authors but got no response. You should give your doctors the link to this thread as well so they can stay up-to-date.
Title: Re: POIS Paper Archive
Post by: Vandemolen on December 14, 2019, 11:31:07 AM
Read this from the paper:

Quote
At six months of follow-up he continued hCG treatment
I think he had treatment of 6 weeks. After 4,5 months he had a follow-up and then continued the hCG treatment. But for how long? His whole life? 3 injections in a week....
Title: Re: POIS Paper Archive
Post by: Muon on December 14, 2019, 02:50:30 PM
This treatment isn't feasible. Poisers who are using TRT must keep using it to keep POIS at bay which is in line with this paper. Probably androgen receptors on unknown cell types that needs to be stimulated at a regular basis, but this is wild speculation on my part. You will need large scale group studies in case you are dealing with POIS being a spectrum of illnesses.
Title: Re: POIS Paper Archive
Post by: Nas on December 14, 2019, 03:52:51 PM
This treatment isn't feasible. Poisers who are using TRT must keep using it to keep POIS at bay which is in line with this paper. Probably androgen receptors on unknown cell types that needs to be stimulated at a regular basis, but this is wild speculation on my part. You will need large scale group studies in case you are dealing with POIS being a spectrum of illnesses.
Aren't their medications that just stimulate the androgen receptors?
Title: Re: POIS Paper Archive
Post by: Muon on December 16, 2019, 04:34:14 PM
Aren't their medications that just stimulate the androgen receptors?
No idea.
Title: Re: POIS Paper Archive
Post by: OpiesDad on January 02, 2020, 06:04:41 PM
New article behind a pay wall....

https://www.tandfonline.com/doi/full/10.1080/21681805.2019.1704861
Title: Re: POIS Paper Archive
Post by: Nas on January 02, 2020, 06:26:40 PM
New article behind a pay wall....

https://www.tandfonline.com/doi/full/10.1080/21681805.2019.1704861
Wow not even an abstract.
Title: Re: POIS Paper Archive
Post by: Quantum on January 02, 2020, 06:50:48 PM
New article behind a pay wall....

https://www.tandfonline.com/doi/full/10.1080/21681805.2019.1704861
Wow not even an abstract.

Here is the link for a free access to the full article :

https://sci-hub.se/10.1080/21681805.2019.1704861

:)

Thanks OpiesDad for making us aware fo this new article !



P.S.  The article presents, among other things, the use of alpha-blochers as a possible treatment for POIS.  It may be interesting for those presenting high blood pressure during POIS, but for someone like me, having low blood pressure during POIS ( hypotension), alpha-blockers would make things worst ( because they lower the blood pressure).  However, I am glad that another medical team is interested in POIS research :)
Title: Re: POIS Paper Archive
Post by: marrtintintin on February 02, 2020, 02:39:43 PM
New paper:

Successful treatment of Post-orgasmic illness syndrome with human chorionic gonadotropin (https://www.sciencedirect.com/science/article/pii/S221444201930453X)

interesting article. I think I will be happy to seek treatment to put it into practice. At some point I thought about using testosterone patches. But this method seems more effective. I will start consulting an endocrinologist. thanks for the info.


Has anyone contacted their endocrinologist? Any advise to give? I am very excited about this paper, but then I hope I can get this treatment in the UK with the NHS.
This treatment does not threat fertility, does it?
Also, the point the article makes on low testosterone is interesting. I am actually low in testosterone, but I always thought it was particular to me.
Title: Re: POIS Paper Archive
Post by: marrtintintin on February 02, 2020, 03:46:48 PM
New article behind a pay wall....

https://www.tandfonline.com/doi/full/10.1080/21681805.2019.1704861

Hi everyone,

just a question. The patient in the article suffers from Irritable bowel syndrome (IBS)*
And actually, I have recently noticed that my digestion is not ?normal?.
If I look back, my bad digestion started when I became a teenager?at the same time as POIS. I have finally realised that my digestion is far from normal: I don?t go to the toilet like people normally? do (every second or third day). And this might be related to POIS.
My digestion symptoms are quite similar to IBS: I usually go to the toilet every 4 days, sometimes less (but then I would poo not even a whole ?sausage?); other times it takes me 6 days or more. Then, once every two months or so, I suddenly spend one hour in the toilet, and maybe the following days as well. Because of this, I try to eat lots of fiber, such as flaxseeds and prunes.
Does this happen to anyone else? The thing is that, like pois, you might dismiss IBS as a ?normal? thing. Just some months ago, I thought that POIs symptoms were normal, and now, looking at my digestion, I realise that it is far normal.
I remember when I used to look surprised at my step-brother bcs he goes to the toilet every day?and other ppl go every second day?but I don?t. And I also have to be very careful with not to eat much if I am going going to bed soon. And after two months of pooing very little, I start losing my appetite, and start eating (considerably) less than usual, until I poo madly; and after that, back to start.

Let me know your thoughts....

do you think IBS and POIS could be related?
Do you go to the toilet every three-plus days? Could it be IBS?


Lastly: I feel so grateful to the people that decided to create this marvellous forum, and all those who have contributed. It definitely feels like we are much closer than ever, with the growing research and community.. I have also become more open about talking POIs, so that it might help others who might have it and don?t know it. This is a proper  Hybrid research collective, similar the Association Fran?aise contra les Myopathies (AFM) explained by Michel Callon. Let?s keep going!

(This is probably one of these optimistic posts when you think that you are about to Eureka! POIS)

*IBS: ?causes symptoms like stomach cramps, bloating, diarrhoea and constipation. These tend to come and go over time, and can last for days, weeks or months at a time.? (Source: NHS)j
Title: Re: POIS Paper Archive
Post by: Muon on February 02, 2020, 10:01:42 PM
Do you think IBS and POIS could be related?

https://poiscenter.com/forums/index.php?topic=3188.0
Title: Re: POIS Paper Archive
Post by: Muon on February 08, 2020, 07:45:21 AM
Got some new POIS paper hits. Haven't read them yet. Will update the entire thread later.

Post-orgasmic illness syndrome: history and current perspectives (https://www.sciencedirect.com/science/article/pii/S0015028219325609#!)

Introduction: Rare and unusual andrologic syndromes that clinicians should be aware of (https://sci-hub.se/https://www.sciencedirect.com/science/article/pii/S0015028219326007)
Title: Re: POIS Paper Archive
Post by: demografx on February 08, 2020, 03:44:24 PM
Got some new POIS paper hits. Haven't read them yet. Will update the entire thread later.

Post-orgasmic illness syndrome: history and current perspectives (https://www.sciencedirect.com/science/article/pii/S0015028219325609#!)

Introduction: Rare and unusual andrologic syndromes that clinicians should be aware of (https://sci-hub.se/https://www.sciencedirect.com/science/article/pii/S0015028219326007)
Thanks, Muon! Forwarded to POIS Research Team
Title: Re: POIS Paper Archive
Post by: Muon on February 10, 2020, 09:50:37 PM
Post-orgasmic illness syndrome: history and current perspectives (https://www.sciencedirect.com/science/article/pii/S0015028219325609#!)

Pointless and useless paper.
Title: Re: POIS Paper Archive
Post by: Quantum on February 11, 2020, 10:20:24 AM
Post-orgasmic illness syndrome: history and current perspectives (https://www.sciencedirect.com/science/article/pii/S0015028219325609#!)

Pointless and useless paper.

I dare to disagree, even if its content brings nothing new on the table.

This article may be the first article that many doctors will stumble upon, about POIS.  In this sense, it is valuable.

Moreover, this is how medical science works.   On topic that are popular, like diabetes, you may have dozens of similar articles on a very precise topic, or a very specific treatment approach or specific medicaiton, and just a few of them have something new and valuable to offer.  But this is how it goes, and these numerous "clones" on the same subject is a sign that there is interest from the medical research community about this topic.

So, no problem for me, bring in a dozen generic, repetitive POIS review articles in 2020 and each year after that, in different scientific magazines, it would be a good sign !
Title: Re: POIS Paper Archive
Post by: demografx on February 11, 2020, 07:53:24 PM
The more the better!
Title: Re: POIS Paper Archive
Post by: Muon on February 25, 2020, 07:15:35 AM
The list of papers has been updated.
Title: Re: POIS Paper Archive
Post by: demografx on February 26, 2020, 08:48:06 PM
Muon, where is the appropriate place for this POIS article?
https://www.medpagetoday.com/meetingcoverage/smsna/82964
Title: Re: POIS Paper Archive
Post by: Muon on February 27, 2020, 07:19:19 AM
That is media coverage based on paper #26. I can create a new header with media articles on page 1 and put it there. You have posted media articles througout the years on this forum. If you can find more of them I will copy paste them to the front page. Just place them in this comment section.
Title: Re: POIS Paper Archive
Post by: demografx on February 27, 2020, 07:38:43 AM
Thank you, Muon!
Title: Re: POIS Paper Archive
Post by: Quantum on February 27, 2020, 07:28:34 PM
A short case-report, not sure we have it yet in the archive:

https://sci-hub.se/10.1016/j.jsxm.2019.11.089
Title: Re: POIS Paper Archive
Post by: Quantum on February 27, 2020, 07:40:51 PM
And Here is the first results I see from the Tulane Survey that had been advertize on our home page for many months last year:

https://sci-hub.se/10.1016/j.jsxm.2019.11.085


This is the abstract of a conference ( 2019-11) by the Tulane team at an Urology congress.
Title: Re: POIS Paper Archive
Post by: demografx on February 27, 2020, 09:15:58 PM
Quantum, Great Work you did with Tulane!
Title: Re: POIS Paper Archive
Post by: Muon on February 28, 2020, 11:05:13 AM
A short case-report, not sure we have it yet in the archive:

https://sci-hub.se/10.1016/j.jsxm.2019.11.089

I think this one is the shorter version of #25. I will replace the hyperlinks by sci-hub links for convenience.
Title: Re: POIS Paper Archive
Post by: Mushnikk on February 28, 2020, 11:09:37 AM
A short case-report, not sure we have it yet in the archive:

https://sci-hub.se/10.1016/j.jsxm.2019.11.089

I think this one is the shorter version of #25. I will replace the hyperlinks by sci-hub links for convenience.

Interestingly the short summary mentions a complete remission following probiotic treatment, whereas the actual paper is less specific: "The patient subsequently self-started a probiotic containing Bacillus coagulans and fructooligosaccharide, which he reported improved his symptoms further." Perhaps the later published short summary includes a follow-up check with the patient underscoring the effectiveness of the probiotic.
Title: Re: POIS Paper Archive
Post by: Muon on February 28, 2020, 11:14:56 AM
They should do a lactulose (not to be confused with lactose) hydrogen+methane breath test in these patients.

Small Intestinal Bacterial Overgrowth Is Common in Mast Cell Activation Syndrome (https://journals.lww.com/ajg/Fulltext/2019/10001/Small_Intestinal_Bacterial_Overgrowth_Is_Common_in.1194.aspx)
Title: Re: POIS Paper Archive
Post by: Muon on March 30, 2020, 10:26:51 AM
Sci-hub.se appears to be down. Anyone else got this problem or is it me?
Title: Re: POIS Paper Archive
Post by: Mushnikk on March 30, 2020, 10:34:46 AM
Sci-hub.se appears to be down. Anyone else got this problem or is it me?

Up and working for me, they often change their domain though.
Title: Re: POIS Paper Archive
Post by: Journey on March 30, 2020, 02:25:27 PM
Sci-hub.se appears to be down. Anyone else got this problem or is it me?

Error 504 for me
Title: Re: POIS Paper Archive
Post by: Muon on March 30, 2020, 03:11:35 PM
Sci-hub.se appears to be down. Anyone else got this problem or is it me?

Error 504 for me

Error 502 for me. That means many articles posted on this forum are inaccessible. Replace .se by .tw in the URL and it will work again. I have changed the hyperlinks on page 1.
Title: Re: POIS Paper Archive
Post by: Muon on April 11, 2020, 04:33:45 PM
Almost 30 POIS papers exist at this point and not a single one discusses mast cell activation disease theory...mind blowing!
Title: Re: POIS Paper Archive
Post by: demografx on April 12, 2020, 02:43:07 AM

Almost 30 POIS papers exist at this point and not a single one discusses mast cell activation disease theory...mind blowing!

It’s just your own personal, unproven theory. Why should they study it?

But don’t get me wrong. I admire your exhaustive investigation.

Title: Re: POIS Paper Archive
Post by: demografx on April 12, 2020, 11:25:13 AM

Almost 30 POIS papers exist at this point and not a single one discusses mast cell activation disease theory...mind blowing!

Why should they study it?

Because it is capable of generating the same type of symptoms seen in POIS patients. Why would they study allergic activation of the mast cell but don't even mention antibody indepedent activation of the mast cell aside from mastocytosis? They ignore it or they lack knowledge. I think it's the latter.


Then go convince someone to study it!! Thats where I put my energy these last 13 years. Writing only  to forum members - - as much as I love them - - got us nowhere.

Title: Re: POIS Paper Archive
Post by: Muon on April 12, 2020, 11:56:21 AM
Hmm you are right this quite pointless. I have spoken to a dozen of researchers and specialists behind the scenes but to no avail. Time to hang up the gloves.
Title: Re: POIS Paper Archive
Post by: demografx on April 12, 2020, 12:00:27 PM

Time to hang up the gloves.


I hope not.

Over my last 13 years,  I wanted to quit - - a million times - - just to get POIS on a tiny medical map. But I persevered and we now have a shot at it!

Rare disorder medical research is not for the faint hearted!
Title: Re: POIS Paper Archive
Post by: Nas on April 12, 2020, 02:42:09 PM
Almost 30 POIS papers exist at this point and not a single one discusses mast cell activation disease theory...mind blowing!
It's just the reality of the situation; research is painstakingly slow, and for such a rare disease? You're lucky we even have 30 papers. Expect perhaps 15 more years of stumbling in the dark until we can have a better understanding of what POIS is.
Speaking of your theory though, have you tried Chormolyn Sodium yet? I heard it's pretty cheap in Germany.
Title: Re: POIS Paper Archive
Post by: demografx on April 12, 2020, 05:22:57 PM

Expect perhaps 15 more years of stumbling in the dark until we can have a better understanding of what POIS is.


I totally reject this incredibly pessimistic notion.
Title: Re: POIS Paper Archive
Post by: Limejuice on April 12, 2020, 09:00:38 PM
I agree that research on some diseases has appeared slow, like cancer, which is an extremely complex disease. But that's one end of the spectrum that not many diseases fall into. The other end are new diseases that haven't been researched properly, which root causes could be quickly determined by professionals. And even more exciting is the potential for existing therapies/drugs not originally designed for the new disease, to actually treat it! For example, think about the possible drugs available to treat the NEW corona virus.

The special sauce in speeding up the operation is having professionals work on it. It's so much slower (10x slower) having us generate theories without proper testing, etc.
Title: Re: POIS Paper Archive
Post by: demografx on April 12, 2020, 09:15:57 PM
Many thanks, Limejuice
Title: Re: POIS Paper Archive
Post by: hurray on April 14, 2020, 11:16:35 AM
Almost 30 POIS papers exist at this point and not a single one discusses mast cell activation disease theory...mind blowing!

Scientists don't operate in a vacuum - they are part of a community, submitting papers to scientific journals for peer review and publication.

There is usually no formal barrier to publication. You probably have more knowledge than any other person about mast cell activation disease theory with respect to POIS.

Why not write and submit a paper of your own? If published, it would certainly get the attention and interest of other scientists, and perhaps lead to further research along similar lines.
Title: Re: POIS Paper Archive
Post by: demografx on April 14, 2020, 11:36:06 AM
hurray, very nice idea!
Title: Re: POIS Paper Archive
Post by: demografx on April 14, 2020, 12:32:16 PM

You probably have more knowledge than any other person about mast cell activation disease theory with respect to POIS.


Unquestionably!
Title: Re: POIS Paper Archive
Post by: hurray on April 14, 2020, 12:38:48 PM
hurray, very nice idea!

If we want the scientific community to take our ideas seriously, we need to speak their language. A scientific paper would be a great way for Muon to condense and formalize his research, and allow him to reach out to other scientists.
Title: Re: POIS Paper Archive
Post by: demografx on April 14, 2020, 01:14:22 PM
Totally agreed!
Title: Re: POIS Paper Archive
Post by: Hopeoneday on April 14, 2020, 05:32:04 PM
It is been dicovered what is discovered till this day, numerous studies are vriten about complex body pathways, ewrything in the body depend on something else in body. It would be greath  that exist a device in medicine today, that can measure every single proces in body in real time, like cytokines, molecular DNA levels, neurotransmiters , hormones, imune ractions, receptor regulation... buttt... unfortunatly we live in times that is only on begining to discovering such a devices.
Thats been said, that medicine  today is  wery limited, espheshuly in some parts of medicine.
Knowing this, me personaly hawe no big expe from medicine in this times...
Title: Re: POIS Paper Archive
Post by: demografx on April 14, 2020, 09:56:02 PM
hurray, very nice idea!

If we want the scientific community to take our ideas seriously, we need to speak their language. A scientific paper would be a great way for Muon to condense and formalize his research, and allow him to reach out to other scientists.

And Muon indeed speaks scientific-ese!
Title: Re: POIS Paper Archive
Post by: Muon on May 17, 2020, 05:32:22 AM
Got a new hit related to POIS, regarding a female case:

Clinical Conundrum: A 33-Year-Old With Pain Post-Orgasm and a History of Endometriosis (https://www.sciencedirect.com/science/article/abs/pii/S1701216320300682)

Sci-hub doesn't seem to unlock this one in contrary to the article in French:

Raisonnement clinique : Une femme de 33 ans avec ant?c?dents d'endom?triose ?prouvant des douleurs apr?s l'orgasme (https://sci-hub.se/https://www.jogc.com/article/S1701-2163(20)30259-0/abstract)

Copying text from the article and putting them into a translator doesn't work well, punctuation marks aren't properly depicted when pasting.

Can someone get a hold on the full english version of the article or wanting to translate it to english?
Title: Re: POIS Paper Archive
Post by: demografx on May 17, 2020, 03:24:32 PM
Thanks, Muon, sent 1st link to POIS researchers.
Title: Re: POIS Paper Archive
Post by: Quantum on May 17, 2020, 07:05:01 PM
Got a new hit related to POIS, regarding a female case:

Clinical Conundrum: A 33-Year-Old With Pain Post-Orgasm and a History of Endometriosis (https://www.sciencedirect.com/science/article/abs/pii/S1701216320300682)

Sci-hub doesn't seem to unlock this one in contrary to the article in French:

Raisonnement clinique : Une femme de 33 ans avec ant?c?dents d'endom?triose ?prouvant des douleurs apr?s l'orgasme (https://sci-hub.se/https://www.jogc.com/article/S1701-2163(20)30259-0/abstract)

Copying text from the article and putting them into a translator doesn't work well, punctuation marks aren't properly depicted when pasting.

Can someone get a hold on the full english version of the article or wanting to translate it to english?


Hi Muon, I suggest you use a newer online translator which is far better than any others:   DeepL   ( https://www.deepl.com/translator ).   Almost no punctuation problems with DeepL ( they are managed before translation, by erasing them automatically).  Here is the first 5000 characters with DeepL ( free online DeepL works with 5000 max at a time), with no correction :

"THE CLINICAL PICTURE
Referred by a tertiary care centre in
sexual medicine, a 33 year old woman
presented with post-orgasm pain.
She had a history of dysmenorrhea and had
underwent laparoscopy about ten years ago plus t^ot for
treat probable endometriosis that was likely to be affected by
minimal to light. Thereafter, she remained under
continuous treatment with oral contraceptives and was
amenorrheic. She didn't present any history.
of dyspareunia. The patient was reaching orgasm,
which was pleasant and painless in itself, through the stimulation
of the clitoris and/or penetration with a partner
male. However, immediately after orgasm..,
she was suffering from cramps similar to dysmia.
enorrhea for approximately 30 minutes; these cramps
were also sometimes accompanied by vaginal bleeding.
Other symptoms included sweating,
occasional nausea and exhaustion. His
medical histories included a
resection at the diathermic loop to treat CIN1;
subsequent Pap test results were normal.
The patient reported a history of anxiety,
but she scored low on the questionnaire
on Generalized Anxiety Disorder GAD-7 (Generalized
Anxiety Disorder-7).
Clinician's comment: Pelvic pain after orgasm
are a little-studied phenomenon1. It would be important
to perform a speculum examination of the cervix, being
gives antecedents of post-coital bleeding and
treatment of CIN1 by diathermy loop resection.
Pelvic examination and imaging to detect the
the presence of endometriotic lesions, in particular of an endometriotic
deep endometriosis or ovarian endometriomas, would be
also instructive. It would also be useful to
imaging exams of the uterus itself to detect
the presence of adenomyosis, since the pain was similar to
is dysmenorrhea. The pelvic floor should also be examined, as pelvic floor dysfunction is a common cause of
pelvic floor would be a potential cause of pelvic floor pain.
moment of arousal, penetration or orgasm.
Finally, an examination of the vulva is recommended.
in all patients who experience pain during the course of
sexual intercourse.
THE DIAGNOSTIC PROCESS
On examination, the vulval skin and anatomy were
and palpation of the vulvar vestibule at the
with a cotton swab caused no pain.
Speculum examination revealed a cervix of the uterus.
appearance and the presence of a very good looking
small polyp on the external os. The results of
pelvic floor examination proved to be very helpful.
normal events and did not indicate any pain or
no sign of vaginismus. Pelvic exam, palpation...
of the uterus has allowed us to observe
a sensitivity, which was not the case with the bladder,
the pelvic floor, appendages or cul-de-sac, and
uterosacral ligaments. No nodularity was observed.
Detective. The endovaginal ultrasound revealed an
sensitivity to the cul-de-sac, both ligaments...
uterosacral and right ovary. On ultrasound, the uterus
showed a decrease in the demarcation
between the myometrium and endometrium, but otherwise, he's
was normal. The endometrial layer measured 5 mm.
and both ovaries were normal. A sign of the
positive slip between the uterus (cervix) and the c^olon a
e été observé, mais aucun signe echographique n'a pu
confirm the presence of nodules in the compartment
posterior.
Clinician's commentary: Given the sensitivity of the uterus
on bimanual palpation, it was issued as hypoth--
The uterus could be a factor in the origin of the
pain after orgasm. The elements that support this
are post-coital bleeding, which is diagnosed as post-coital bleeding.
could indicate a metrorrorror from the uterus,
and the ultrasound signs of adenomyosis (even though the
diagnosis cannot be confirmed due to the absence of
other echographic signs)2. However, the patient
was amenorrheic while she was using birth control.
oral, suggesting sufficient inhibition of
Uterine activity. The differential diagnosis includes the
recurrence of endometriosis; no sign of endometrioma
ovarian or deep endometriosis has been observed, but the
sensitivity to endovaginal ultrasound may be observed.
It is indicative of superficial peritoneal endometriosis3.
It is plausible that superficial endometriosis
may contribute to the post-orgasm pain, but it
would not be the direct cause of the bleeding, which indicates
a uterine cause. The differential diagnosis always holds
pelvic floor account, since the results of the
clinical examinations do not always correspond to the dysfunction.
of the pelvic floor in a sexual context.
We've considered increasing inhibition of the activity
uterine by administration of a progestin superimposed on the
oral contraceptive. A huddle... "


Sorry but due to the work overload linked to the pandemia  I do not have time to do the rest for now, or to edit this first part, but it is already very good as it is.

I am sure some dedicated member could do the rest !


( However - and there is a "spoiler" ahead - I have done a very rapid survey of the article, since I am French speaking, and the solution found in this case study is centered on controlling the endometriosis and the pain associated with it, so this will not apply to men, as I understand it after my very partial reading ).
Title: Re: POIS Paper Archive
Post by: Muon on May 31, 2020, 06:04:20 PM
hurray, very nice idea!

If we want the scientific community to take our ideas seriously, we need to speak their language. A scientific paper would be a great way for Muon to condense and formalize his research, and allow him to reach out to other scientists.

I have no experience in writing papers or how to publish one. I'm not affiliated to any institute and you will have to pay a fee for publishing open acces if I'm not mistaken. If someone could guide me through all the steps that are necessary to publish a paper I might consider to write one. Plus a mast cell disorder expert in the field should review the paper.
Title: Re: POIS Paper Archive
Post by: hurray on June 01, 2020, 11:59:03 AM
hurray, very nice idea!

If we want the scientific community to take our ideas seriously, we need to speak their language. A scientific paper would be a great way for Muon to condense and formalize his research, and allow him to reach out to other scientists.

I have no experience in writing papers or how to publish one. I'm not affiliated to any institute and you will have to pay a fee for publishing open acces if I'm not mistaken. If someone could guide me through all the steps that are necessary to publish a paper I might consider to write one. Plus a mast cell disorder expert in the field should review the paper.

One place to start could be checking to see which journals have published POIS-related papers in the past. The list you have helpfully made at the start of this thread lists a few different journals.  :)

The Journal of Sexual Medicine seems like a good candidate - it is an Elsevier publication. They give a lot of information about what they expect from a submission here (under "Resources" at the bottom of the page):

https://mc.manuscriptcentral.com/jsm

They also have a very comprehensive guide for authors here:

https://www.elsevier.com/journals/the-journal-of-sexual-medicine/1743-6095/guide-for-authors#91001'_new'
Title: Re: POIS Paper Archive
Post by: Muon on June 02, 2020, 09:25:09 AM
The fee is just too much for the journal of sexual medicine.

I have added a new paper to the list. It's from Amstelveen the Netherlands, same residential area as Waldinger. Must be a colleague of his.

There is a reference in that paper I'm unfamiliar with, slipped under the radar I guess. Does anyone have full working link to this article:
https://www.researchgate.net/publication/297569313_A_clinical_case_of_suspected_postorgasmic_illness_syndrome
Title: Re: POIS Paper Archive
Post by: demografx on June 02, 2020, 12:17:27 PM
Thanks, Muon, sent to POIS Research Team.
Title: Re: POIS Paper Archive
Post by: Mushnikk on June 02, 2020, 12:42:33 PM
A new paper has been published: 29 May 2020 /
Clinical experience with post-orgasmic illness syndrome (POIS) patients?characteristics and possible treatment / https://www.nature.com/articles/s41443-020-0314-9

Abstract: Post-orgasmic illness syndrome (POIS) is a rare condition that includes a cluster of post-ejaculatory symptoms with debilitating physical and psychological consequences. The prevalence and incidence of POIS remain unknown as well as the pathophysiology of the syndrome, and there are no well-studied recognized treatment modalities. The current retrospective observational study describes a series of 14 highly selected patients who were actively looking for medical help as POIS has a significant effect on patients and their partners. The aim is to increase knowledge about this syndrome and possible treatment modality. According to a standard protocol, patients have been systematically interviewed, had a physical examination, laboratory blood tests, and treatments. Mean age was 34.07 ? 6.65 years. The majority of patients had only one symptom in common?extreme fatigue. The most prevalent complaints were head pressure/heaviness, nose congestion and muscle tension; all patients suffered from more than 1 symptom. POIS started on average within 30 min of ejaculation and lasted for 3.5 days. The patients reported emotional and psychosocial burden of their symptoms, which also influence their partner and relationships. Immunoglobulin-E measurements did not show elevated levels and/or significant increase within 24 h after ejaculation. Silodosin, a highly selective alpha1A-blocker, which actually causes anejaculation, was effective treatment in 57% of the patients.
Title: Re: POIS Paper Archive
Post by: demografx on June 02, 2020, 01:07:22 PM
Thanks, Mushnikk!
Title: Re: POIS Paper Archive
Post by: demografx on June 02, 2020, 01:23:40 PM
Sent to POIS Research Team.
Title: Re: POIS Paper Archive
Post by: Muon on June 02, 2020, 02:27:22 PM
"Silodosin, which considered to cause anejaculation [15], was chosen as the first-line therapy. Eight patients (57%) were able to be effectively treated with this approach."

No ejaculation = no contact between UT mast cells and the ejaculate.

"Eleven (78.5%) patients had slightly elevated total IgE with a mean of 40.5 ? 24.7 kU/l (normal range <35)."

Cyokines can induce IgE in B-cells.

"Furthermore, the indicated level of IgE may not correlate with the extent or severity of symptoms when exposed to the allergen."

Eosinophil cationic protein correlates to allergic disease activity.

"There are no recognized treatment modalities. POIS patients have been treated with antihistamines, selective
serotonin reuptake inhibitors, nonsteroidal antiinflammatory medication, analgesics, benzodiazepines, and hyposensitization therapy.
"

In bold are the ones being used in MCAD. Steroids as well.

Title: Re: POIS Paper Archive
Post by: demografx on June 02, 2020, 03:41:53 PM

A new paper has been published: 29 May 2020 / ...


The POIS Research Team appreciated receiving!
Title: Re: POIS Paper Archive
Post by: hurray on June 02, 2020, 04:27:06 PM
"Silodosin, which considered to cause anejaculation [15], was chosen as the first-line therapy. Eight patients (57%) were able to be effectively treated with this approach."

No ejaculation = no contact between UT mast cells and the ejaculate.

"Eleven (78.5%) patients had slightly elevated total IgE with a mean of 40.5 ? 24.7 kU/l (normal range <35)."

Cyokines can induce IgE in B-cells.

"Furthermore, the indicated level of IgE may not correlate with the extent or severity of symptoms when exposed to the allergen."

Eosinophil cationic protein correlates to allergic disease activity.

"There are no recognized treatment modalities. POIS patients have been treated with antihistamines, selective
serotonin reuptake inhibitors, nonsteroidal antiinflammatory medication, analgesics, benzodiazepines, and hyposensitization therapy.
"

In bold are the ones being used in MCAD. Steroids as well.

That's interesting, thank you.

I tried silodosin myself several years ago to see if it would help with my POIS brain fog. I made a number of posts about it on the Naked Scientists Forum, if anybody is interested in the results that me and Habibou had, have a look at the thread:

https://www.thenakedscientists.com/forum/index.php?topic=6576.11660

It's fascinating to see the quality of discussion and the camaraderie back in 2011. People were encouraging each other, discussing new theories and trying new things.
Title: Re: POIS Paper Archive
Post by: demografx on June 02, 2020, 06:47:20 PM

It's fascinating to see the quality of discussion and the camaraderie back in 2011. People were encouraging each other, discussing new theories and trying new things.


hurray: 100% agreed!

Let’s all try to get some more of that old spark back!
Title: Re: POIS Paper Archive
Post by: Nas on June 03, 2020, 03:46:16 AM
"Silodosin, which considered to cause anejaculation [15], was chosen as the first-line therapy. Eight patients (57%) were able to be effectively treated with this approach."

No ejaculation = no contact between UT mast cells and the ejaculate.

I tried that, I had a dry ejaculation, still had POIS.
Title: Re: POIS Paper Archive
Post by: Muon on June 03, 2020, 07:13:59 AM
Got a working link now. A new article has been placed at #10. Scroll to page 220. (how do I filter out one specific page?)

He got atopic dermatitis which is associated with mast cells.
Title: Re: POIS Paper Archive
Post by: hurray on June 03, 2020, 02:51:56 PM
The fee is just too much for the journal of sexual medicine.

I have added a new paper to the list. It's from Amstelveen the Netherlands, same residential area as Waldinger. Must be a colleague of his.

There is a reference in that paper I'm unfamiliar with, slipped under the radar I guess. Does anyone have full working link to this article:
https://www.researchgate.net/publication/297569313_A_clinical_case_of_suspected_postorgasmic_illness_syndrome

I looked into it, and The Journal of Sexual Medicine doesn't charge any fees for publishing a paper in the traditional way. Open access publishing costs $2500 - if it were my paper, I would go down the free route.

Of course, getting published in a prestigious journal isn't easy, so you would have to be strongly motivated to succeed.  :)
Title: Re: POIS Paper Archive
Post by: cyberguy137 on June 04, 2020, 01:02:49 PM
Hi

Thanks Muon!! This latest paper by Y. Reisman, "Clinical experience with post-orgasmic illness syndrome (POIS)
patients?characteristics and possible treatment modality" , is one of the best I have seen. I think I'd like to try prednisone , and maybe silodosin.

I am working on a review of the literature. Right now it's a mess. However, if people would like to see it, they can take a look at it here:
https://www.overleaf.com/read/hstsyfsjpnrk

I'm doing it in LaTex, a markup language for technical documents.

I don't think I found anything that Muon hasn't already found.

Title: Re: POIS Paper Archive
Post by: Hopeoneday on June 04, 2020, 06:03:36 PM
A new paper has been published: 29 May 2020 /
Clinical experience with post-orgasmic illness syndrome (POIS) patients?characteristics and possible treatment / https://www.nature.com/articles/s41443-020-0314-9

Abstract: Post-orgasmic illness syndrome (POIS) is a rare condition that includes a cluster of post-ejaculatory symptoms with debilitating physical and psychological consequences. The prevalence and incidence of POIS remain unknown as well as the pathophysiology of the syndrome, and there are no well-studied recognized treatment modalities. The current retrospective observational study describes a series of 14 highly selected patients who were actively looking for medical help as POIS has a significant effect on patients and their partners. The aim is to increase knowledge about this syndrome and possible treatment modality. According to a standard protocol, patients have been systematically interviewed, had a physical examination, laboratory blood tests, and treatments. Mean age was 34.07???6.65 years. The majority of patients had only one symptom in common?extreme fatigue. The most prevalent complaints were head pressure/heaviness, nose congestion and muscle tension; all patients suffered from more than 1 symptom. POIS started on average within 30?min of ejaculation and lasted for 3.5 days. The patients reported emotional and psychosocial burden of their symptoms, which also influence their partner and relationships. Immunoglobulin-E measurements did not show elevated levels and/or significant increase within 24?h after ejaculation. Silodosin, a highly selective alpha1A-blocker, which actually causes anejaculation, was effective treatment in 57% of the patients.

60% benefit from uneyaculation  :o , a big percentage.
In wich contry is thouse chosen 14? Do they know about us?
Title: Re: POIS Paper Archive
Post by: hurray on June 04, 2020, 06:13:49 PM
A new paper has been published: 29 May 2020 /
Clinical experience with post-orgasmic illness syndrome (POIS) patients?characteristics and possible treatment / https://www.nature.com/articles/s41443-020-0314-9

Abstract: Post-orgasmic illness syndrome (POIS) is a rare condition that includes a cluster of post-ejaculatory symptoms with debilitating physical and psychological consequences. The prevalence and incidence of POIS remain unknown as well as the pathophysiology of the syndrome, and there are no well-studied recognized treatment modalities. The current retrospective observational study describes a series of 14 highly selected patients who were actively looking for medical help as POIS has a significant effect on patients and their partners. The aim is to increase knowledge about this syndrome and possible treatment modality. According to a standard protocol, patients have been systematically interviewed, had a physical examination, laboratory blood tests, and treatments. Mean age was 34.07???6.65 years. The majority of patients had only one symptom in common?extreme fatigue. The most prevalent complaints were head pressure/heaviness, nose congestion and muscle tension; all patients suffered from more than 1 symptom. POIS started on average within 30?min of ejaculation and lasted for 3.5 days. The patients reported emotional and psychosocial burden of their symptoms, which also influence their partner and relationships. Immunoglobulin-E measurements did not show elevated levels and/or significant increase within 24?h after ejaculation. Silodosin, a highly selective alpha1A-blocker, which actually causes anejaculation, was effective treatment in 57% of the patients.

60% benefit from uneyaculation  :o , a big percentage.
In wich contry is thouse chosen 14? Do they know about us?

Silodosin worked to a certain extent with me, but the side-effects of extreme fatigue were worse than the POIS, so I reluctantly had to stop using it. It may well be more useful for other people.
Title: Re: POIS Paper Archive
Post by: Hopeoneday on June 04, 2020, 06:19:51 PM
Intresting, i hawe permanent CFG/ME and when pois hit me it is party.
Title: Re: POIS Paper Archive
Post by: Muon on June 04, 2020, 06:22:38 PM
Intresting, i hawe permanent CFG/ME and when pois hit me it is party.
Changes in cytokine levels.
Title: Re: POIS Paper Archive
Post by: kingfisher on June 14, 2020, 01:08:56 AM
Hurray/Nas, did you try timing Silodosin couple hours before the O? Thanks.
As far as I could make out the Amstelveen study mentions a single dose rather than a continuous supplementation of Silodosin.
Title: Re: POIS Paper Archive
Post by: hurray on June 14, 2020, 03:51:26 AM
Hurray/Nas, did you try timing Silodosin couple hours before the O? Thanks.
As far as I could make out the Amstelveen study mentions a single dose rather than a continuous supplementation of Silodosin.

That's a good question, kingfisher.

I tried silodosin both as a single dose and continuously. When I took it as a single dose, it was often effective, but sometimes a small amount of ejaculate would come out, triggering full-blown POIS. I can't remember whether or not I waited 2 hours before O though, perhaps waiting for that long would make single dose silodosin more effective.
Title: Re: POIS Paper Archive
Post by: quikot on June 19, 2020, 11:17:23 PM
Hey. Not sure if this has been posted. There is a study published on 15/06/20 by Japanese researchers. Conclusion is that NSAIDs are 'effective' in managing POIS.

https://onlinelibrary.wiley.com/doi/full/10.1002/cia2.12123
Title: Re: POIS Paper Archive
Post by: demografx on June 19, 2020, 11:52:43 PM
Thanks, quikot, sent to POIS Research Team.
Title: Re: POIS Paper Archive - a list of scientific articles about POIS
Post by: Muon on June 20, 2020, 04:05:47 AM
Thanks quikot, added to page 1. Atopic dermatitis again: https://en.wikipedia.org/wiki/Atopic_dermatitis
Title: Re: POIS Paper Archive
Post by: drop247 on June 20, 2020, 01:19:48 PM
Hey. Not sure if this has been posted. There is a study published on 15/06/20 by Japanese researchers. Conclusion is that NSAIDs are 'effective' in managing POIS.

https://onlinelibrary.wiley.com/doi/full/10.1002/cia2.12123

What is AD? Autoimmune disorder?
Title: Re: POIS Paper Archive - a list of scientific articles about POIS
Post by: berlin1984 on June 20, 2020, 03:21:40 PM
If there is acronyms, they are usually explained at first usage. In this case:

Quote
In addition, he had suffered from moderate atopic dermatitis (AD)

Another trick for glimpsing studies: Read the last few sentences of an abstract for a conclusion:

Quote
Most of POIS patients had suffered from AD.1 COX pathways were reported to be regulated differently in AD patients than in healthy volunteers.5 It is suggested that the systemic regulation of COX responses causes the symptoms of POIS, especially in AD patients.

Title: Re: POIS Paper Archive - a list of scientific articles about POIS
Post by: Muon on June 20, 2020, 03:50:47 PM
They are refering to this paper: https://www.sciencedirect.com/science/article/abs/pii/S109888231300021X

"We conclude from this study, that in PBMCs from AD-patients in comparison to healthy volunteers, a systemic down-regulation of LOX- and COX-responses occurs to generally reduce eicosanoid/docosanoid synthesis during the current allergic inflammatory status."

From POIS paper: "Most of POIS patients had suffered from AD.1 COX pathways were reported to be regulated differently in AD patients than in healthy volunteers.5 It is suggested that the systemic regulation of COX responses causes the symptoms of POIS, especially in AD patients."

So the body downregulates COX in AD? Why do POIS symptoms decrease when you downregulate it even further? Doesn't make sense. Release of cytokines, which are able to upregulate COX, in combination with lipid production/release sounds more logical to me for this POISer.
Title: Re: POIS Paper Archive - a list of scientific articles about POIS
Post by: hurray on June 20, 2020, 04:34:34 PM
I'm a bit sceptical that an NSAID would have such a major effect on POIS symptoms.

https://www.thenakedscientists.com/forum/index.php?topic=6576.8900

That's the only mention of Diclofenac I could find, and Green claimed it only reduced his POIS symptoms by 20% or so. It's great to see new POIS research, but we should bear in mind that this paper only deals with one patient.
Title: Re: POIS Paper Archive - a list of scientific articles about POIS
Post by: demografx on June 20, 2020, 11:39:21 PM
hurray, exactly, a sample size of one is hardly convincing!
Title: Re: POIS Paper Archive - a list of scientific articles about POIS
Post by: berlin1984 on June 21, 2020, 01:57:50 AM
I'm a bit sceptical that an NSAID would have such a major effect on POIS symptoms.

And IMHO that's only working around the cause, not curing it (whatever the cause might be).

From Wikipedia:
"It is believed to work by decreasing the production of prostaglandin.It blocks both cycloxygenase-1 (COX-1) and cycloxygenase-2 (COX-2)." https://en.wikipedia.org/wiki/Diclofenac


From Wikipedia about Sexual Headache:
"Case series have found indomethacin and beta blockers to be successful in treating these headaches. Propranolol, Bellergal, and triptans have also been used with success. Anecdotal and indirect evidence suggests a trial of magnesium supplementation may improve symptoms (in subjects with known or suspected low Mg levels)."
https://en.wikipedia.org/wiki/Sexual_headache

In our forum Indomethacin is proposed (see search function), which is has a more "pronounced selectivity towards COX-1"
https://www.emedexpert.com/compare/nsaids.shtml

But according to the POIS study Celecoxib (more COX-2) was also effective. So maybe it doesn't matter.


About the AD, nanna1 writes:
5. You wrote that you were hoping to resolve your neutropenia by following the immune competence therapy. Have you had any tests done afterwards? Has there been any change in your neutrophil count?
  The neutrophil count is a test that I should do. During the time I was boosting the immune system with supplements, I was monitoring my acne (face) and eczema (foot). Acne usually occurs when bacteria enters the skin. Then white blood cells (neutrophils) leave the blood vessels and invade the skin to attack the infection. The white blood cells are part of what give pimple their white color. I used to get acne/pimples in the days following orgasm as one of my POIS symptoms. As my acne cleared up, that gave me evidence that my neutrophil function had normalized. Certain foods (chocolate, dairy, high-sugar) that used to give me acne, no longer do.

  I also used to have eczema on the heel of my foot. This was not associated with orgasm or any related activity. Both the acne and eczema that I have dealt with since I was a teenager have cleared up. And I never get acne now, no matter what junk-food I eat :). Side note: I did use tea tree oil on the eczema also.

  These are indirect (and free) measures of neutrophil activity. But I've mainly been avoiding spending money on more medical test.
Title: Re: POIS Paper Archive - a list of scientific articles about POIS
Post by: Clues on June 21, 2020, 03:04:14 AM
I'm a bit sceptical that an NSAID would have such a major effect on POIS symptoms.

Same here, hurray. Be careful everyone! I personally believe that I and most likely many other POISers have some form of mast cell activation disorder, which is intimately tied to gut health. Long-term use of NSAIDs can mess with your gut, so you may be trading away your long-term gut health for some quick relief if you go heavy on the NSAIDs. Some research here (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473116/#:~:text=About%2060%25%2D70%25%20of,obstruction%2C%20diverticulitis%2C%20ileal%20dysfunction%20and) and here (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754147/).
Title: Re: POIS Paper Archive
Post by: Nas on June 21, 2020, 04:17:15 AM
Hey. Not sure if this has been posted. There is a study published on 15/06/20 by Japanese researchers. Conclusion is that NSAIDs are 'effective' in managing POIS.

https://onlinelibrary.wiley.com/doi/full/10.1002/cia2.12123

Haha, I really like how Waldinger's (RIP) first paper set the criteria for testing, and when ever researchers try to build on it they instantly find that there is no detectable IgE for semen in patent's blood.
Also, since many of us don't really have physical symptoms, it's most likely the reason why NSAID's don't work for us. NSAID's only mask the inflammatory symptoms without addressing the underlying source.
Title: Re: POIS Paper Archive - a list of scientific articles about POIS
Post by: Muon on June 21, 2020, 09:19:39 AM
I'm a bit sceptical that an NSAID would have such a major effect on POIS symptoms.

https://www.thenakedscientists.com/forum/index.php?topic=6576.8900

That's the only mention of Diclofenac I could find, and Green claimed it only reduced his POIS symptoms by 20% or so. It's great to see new POIS research, but we should bear in mind that this paper only deals with one patient.

I have seen more POISers over the years reacting positive to NSAIDs, also seen a few that got adverse reactions from it. I don't consider this paper research though, it's not that they investigate the underlying cause. It's more like a clinical report plus. NSAIDs are often used when one suspects inflammation. Conclusion states that it's effective, how effective (% of POISers)? The latter is impossible to know based on case reports.

I get the impression people are waiting for something that works for most POISers. If a mast cell disorder is at the root of POIS you probably won't find any since the cell behaves in diverse ways. Many of the 'treatments' which were succesful for people have in common that they are able to interact with mast cells directly and/or suppress downstream mediator effects.

Also, since many of us don't really have physical symptoms, it's most likely the reason why NSAID's don't work for us.

I suspect NSAIDs don't work for most, because of the variety of pro-inflammatory profiles in POISers. But this argumentation could be applied to other medication as well. Multiple inflammatory mediators might be involved in people that react partially to meds.

https://scholar.google.com/scholar?hl=nl&as_sdt=0%2C5&q=atopic+dermatitis+mast+cell+&btnG=
Title: Re: POIS Paper Archive
Post by: Quantum on June 21, 2020, 05:33:10 PM
Hey. Not sure if this has been posted. There is a study published on 15/06/20 by Japanese researchers. Conclusion is that NSAIDs are 'effective' in managing POIS.

https://onlinelibrary.wiley.com/doi/full/10.1002/cia2.12123 (https://onlinelibrary.wiley.com/doi/full/10.1002/cia2.12123)

What is AD? Autoimmune disorder?
AD, in the article referred to, =  Atopic dermatitis    see https://en.wikipedia.org/wiki/Atopic_dermatitis (https://en.wikipedia.org/wiki/Atopic_dermatitis)
Title: Re: POIS Paper Archive - a list of scientific articles about POIS
Post by: Muon on June 22, 2020, 04:38:22 AM
Where are the patients with GI tract complaints in Reisman's paper? It doesn't appear in table 2, why?
Title: Re: POIS Paper Archive
Post by: demografx on June 22, 2020, 03:06:23 PM
Hey. Not sure if this has been posted. There is a study published on 15/06/20 by Japanese researchers. Conclusion is that NSAIDs are 'effective' in managing POIS.

https://onlinelibrary.wiley.com/doi/full/10.1002/cia2.12123

Thanks, quikot, sent to POIS Research Team.

quikot, I sent your post above to the POIS Research Team. They appreciated it: “ Interesting – and good to keep on track of the newest work. Thanks Demo!”

And thanks to everyone else (Quantum, Muon et al) who posted about it!
Title: Re: POIS Paper Archive - a list of scientific articles about POIS
Post by: drop247 on June 22, 2020, 09:28:07 PM
Thanks Quantum.
Title: Re: POIS Paper Archive
Post by: quikot on June 23, 2020, 05:51:55 AM
quikot, I sent your post above to the POIS Research Team. They appreciated it: “ Interesting – and good to keep on track of the newest work.

Glad to be of help!
Title: Re: POIS Paper Archive
Post by: demografx on June 24, 2020, 10:29:26 AM
quikot, I sent your post above to the POIS Research Team. They appreciated it: “ Interesting – and good to keep on track of the newest work.

Glad to be of help!

quikot, really appreciated!
Demo
Title: Re: POIS Paper Archive - a list of scientific articles about POIS
Post by: Muon on July 07, 2020, 06:10:39 AM
New paper: Case of post‐orgasmic illness syndrome associated with hypogonadism (https://onlinelibrary.wiley.com/doi/full/10.1002/iju5.12184)

The Anti-Inflammatory Effects of Testosterone (https://academic.oup.com/jes/article/3/1/91/5137187)

Table 1, significantly elevated levels of the proinflammatory cytokines in hypogonadism:

TNF-α (https://en.wikipedia.org/wiki/Tumor_necrosis_factor_alpha)
MIP-1α (https://en.wikipedia.org/wiki/CCL3) (CCL3)
MIP-1β (https://en.wikipedia.org/wiki/CCL4) (CCL4)

Table 2, Therapy:

T enanthate: Adiponectin (https://en.wikipedia.org/wiki/Adiponectin) and leptin (https://en.wikipedia.org/wiki/Leptin) level decreased.

DHT + hCG: Significant changes in CRP (https://en.wikipedia.org/wiki/C-reactive_protein), sVCAM-1 (https://en.wikipedia.org/wiki/VCAM-1), or sICAM-1 (https://en.wikipedia.org/wiki/ICAM-1).

Edit: Scroll down to the TRT & Tregs header.
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