Post Orgasmic Illness Syndrome (P.O.I.S.)

POIS Cause/Treatment Discussions => Hormonal Causes and Treatments => Topic started by: Nas on January 25, 2019, 03:27:40 PM

Title: Catecholamines Depletion as a Possible Cause for Cognitive Symptoms
Post by: Nas on January 25, 2019, 03:27:40 PM
Since Waldinger's paper was ever published, POIS was associated with immune activity, and the side effects were seen as caused by inflammation. How ever no has consistently treated his POIS symptoms by taking NSAID's. NSAID's are the first method of reducing inflammation all over the body since it inhibits the expression of COX 1-2 which are the major enzymes the body uses for the formation of Prostaglandins, this should've made, at least, some remedy to the symptoms, but at least in my case, it didn't. I also investigated the role of histamine without any success. One other point is that many of us who did MRI's in the brain, did not find any observable swelling. Thus any approach is proposed, in that instead of looking at the cognitive symptoms as a result/symptom of POIS. We could perhaps consider it as the main issue around POIS. Or perhaps to be more precise, it is a type of POIS where they immune activity is instigated by hormone depletion instead of the other way around. Which makes more sense, since the brain is quite far from the genital region to be directly affected by it if you ask me.

This thread could be potentially be a deeper investigation to Catecholamines deficiency theory. 

I'll start the first topic with this article:  Are you suffering from The Blahs? (https://mindblowingwellness.com/catecholamines-are-you-suffering-from-the-blahs/)

This article is well written and articulates many observable phenomena that have been discovered in this forum.

"Dopamine, Epinephrine (adrenaline) and Norepinephrine (noradrenaline) are the primary catecholamines or ?cats?, as they are known. Catecholamines function both as hormones and neurotransmitters."

"If you have adequate cats, you feel energized, upbeat, alert and focused and you don?t crave caffeine or sugar for a pick-me-up.
If your cats are low, you may feel the kind of depression that lands you curled up in the bed all day with extremely low motivation."

If you ask me I have strong cravings for coffee and sugar when I'm in POIS which could be an indication of low dopamine, it can also explain what it actually helps with POIS.

"These are typical symptoms of people suffering from low cats:
- Trouble dragging yourself out of bed
- Inability to motivate yourself
- Feelings of worthlessness
- Feelings of hopelessness
- May lose temper for minor reasons
- Inability to handle stress
- Not enough focus or concentration
- Numb-feeling emotionally
- Lack of energy
- Craving carbs, alcohol, caffeine or drugs for energy
- Procrastination and indecisiveness
- Apathy
- Easily bored
- Attention Deficit Disorder diagnosis
- Reluctant to socialize, desire to be alone
- Lack of concern for family and friends"

I feel these are very accurate to what I feel right after orgasm, it does not mention difficulty speaking, trouble doing day to day jobs and bad short term memory. 

"What can Deplete Catecholamines?
- Chronic stress over time or acute stress during a crisis
- Genetic anomaly?some people have a genetic tendency toward low cats
- Chronic dieting with low calorie or high carb diets
- Low protein intake
- Sedentary lifestyle
- Low estrogen or testosterone
- Uncontrolled blood sugar
- Iron anemia"

Note Low estrogen or testosterone and Iron anemia these are two phenomena that have been discussed in this forum.

"These steps will allow your body and brain to receive the nutrients needed to make the neurotransmitters it needs to function optimally"
- Improve your stomach acid levels to properly digest and allow your body to use the nutrients you eat.
- Eat plenty of healthy fats and especially protein. Avoid these cooking oils and use plenty of these oils.
- Increase your Omega-3 essential fatty acid intake. A simple test can detect your current levels.
- Check your Vitamin D levels and supplement where needed. Vitamin D directs the conversion of tyrosine to cats.
- Ditch processed foods and enjoy lots of whole, organic food.
- Drink plenty of clean water.
- Eat fermented foods that are rich in probiotics.
- Good sources of catecholamine-rich foods are beef, fish and eggs. Americans who are not vegetarians/vegans typically consume plenty of these foods.
- Start slow with exercise. Try yoga, tai chi or meditation. Or simply take a walk.
- Consider amino acid and other supplements once your healthy nutrition is in place."

Again, these which are in bold, are all discussed in this forum in detail.

Now to the supplements part, the Article proposes the following supplements:
- Tyrosine
- Phenylalanine
- Beta-Phenylethylamine (PEA)
- SAMe
- mucuna pruriens
- Blueberry Extract
- Alpha Lipoic Acid, Selenium and N-acetyl-cysteine

Notable comments on these supplements:

Talking about Tyrosine: "These important nutrients are cofactors used in the conversion of tyrosine:  Folate, Niacin, Vitamin C, Copper and SAMe. In other words, you need these to make tyrosine convert into the catecholamines."
See Folate, Niacin and SAMe are the most successful remedies that have been tested in this forum.

Talking about Phenylalanine: "Phenylalanine metabolism requires the following cofactors: Vitamin B6 (P5P), Niacin, Vitamin C, Copper, SAMe, Iron and Folate."
Again these in bold were all discussed in this forum.
Title: Re: Catecholamines Depletion as a Possible Cause for Cognitive Symptoms
Post by: b_jim on January 25, 2019, 03:37:15 PM
Absolutely agree. The fact tyrosine is pumped by cathecolamines production and by thyroid is something i didn't think before.
Title: Re: Catecholamines Depletion as a Possible Cause for Cognitive Symptoms
Post by: Vandemolen on January 25, 2019, 04:05:30 PM
Sleep also plays an important role in catecholamines. Better sleep means a better gut. And in the gut is where a few hormones are produced. A healthy gut also means that you will sleep better. A bad sleep means high cortisol. Cortisol controls adrenaline and noradrenaline.
Title: Re: Catecholamines Depletion as a Possible Cause for Cognitive Symptoms
Post by: Nas on January 25, 2019, 06:20:41 PM
Sleep also plays an important role in catecholamines. Better sleep means a better gut. And in the gut is where a few hormones are produced. A healthy gut also means that you will sleep better. A bad sleep means high cortisol. Cortisol controls adrenaline and noradrenaline.
That's weird since the use of corticosteroids in my case is quite benefitial. I've read in an article somewhere that corticosteroids can potentially damage the brain and reduce Norepinephrine and dopamine production, quite paradoxical...
Title: Re: Catecholamines Depletion as a Possible Cause for Cognitive Symptoms
Post by: Hopeoneday on January 31, 2019, 08:41:56 AM
Guys... Nas , as i observing my self lately i can fell that my body cant metabolise
some chemicals normaly. Those test results (genetic) i posted recently from one poiser,
mean exsces cemicals not less,
so in certein situations like arosaul sex, "He hawe exsces cemicals" and cant degrade
naturaly in proper whey.
Check this out: My conection with trauma and hiperstress..

http://www.healing-arts.org/tir/n-r-diehl.htm


    Increased levels of catecholamines (chronic hyperstress)
    Decreased levels of glucocorticoids (poor immune functioning)
    Decreased alpha-2 Adrenergetic receptors (less regulation of catecholamines)
    Increased endogenous opioid levels during traumatic memory triggers (equivalent to the consumption of 8mg of morphine!)
    Acoustic startle response: (ACR) Survivors of trauma are easily trigger by loud noises or surprises sounds. While other's may "jump" only the first couple of times they hear a loud noise, trauma survivors often startle with each and every repeat of the noise.
   


Title: Re: Catecholamines Depletion as a Possible Cause for Cognitive Symptoms
Post by: Nas on January 31, 2019, 10:31:01 AM
HOP, maybe try adrenocepter antagonists and see if they work.
Title: Re: Catecholamines Depletion as a Possible Cause for Cognitive Symptoms
Post by: FernandoPOIS on February 05, 2019, 12:34:35 PM
I agree with you NAS.
Title: Re: Catecholamines Depletion as a Possible Cause for Cognitive Symptoms
Post by: Nas on February 05, 2019, 06:21:29 PM
So yesterday I tried a medication called Bromocriptine. It is supposed to lower prolactin levels and raise dopamine. I tried that right after orgasm ( I also did another round right after that cause I'm horny like that ). I also took all of this in a day where I worked my ass off for a house we're moving in to, and didn't get enough time to eat a lot, so my blood pressure and sugar levels were probably low.  So all of that culminated in my getting super dizzy and nauseous, and I threw up a lot. I had to take two bags of nutrients to re-up my blood pressure. Bromocriptine stimulates Dopamine receptor non-specifically so it can stimulate D2 receptors which induced my vomiting + low blood sugar dizziness. Suffice to say I don't recommend this. The medication had no immediate effect, however now I'm on my second day and I don't feel quite bad, maybe it was the vomiting or maybe it was the medication. I suspect that perhaps supplementing L-Dopa is a much better and safer way than to stimulate dopamine receptors, after all you can't stimulate what's already depleted. I'm obviously not taking the medication nor do I recommend it. The experiment was, interesting though, I guess...
Title: Re: Catecholamines Depletion as a Possible Cause for Cognitive Symptoms
Post by: FernandoPOIS on February 06, 2019, 06:24:40 AM
I'm laughing a lot here. Very cool these experiences. Cheers, my friend.
Title: Re: Catecholamines Depletion as a Possible Cause for Cognitive Symptoms
Post by: Nas on February 06, 2019, 08:42:55 AM
I'm laughing a lot here. Very cool these experiences. Cheers, my friend.
Why are you laughing at my misery ;D
Title: Re: Catecholamines Depletion as a Possible Cause for Cognitive Symptoms
Post by: demografx on February 06, 2019, 02:14:32 PM
Nas, can I laugh, too?

(https://cdn2.iconfinder.com/data/icons/facebook-ui-colored/48/JD-18-512.png)
(https://cdn2.iconfinder.com/data/icons/facebook-ui-colored/48/JD-18-512.png)
(https://cdn2.iconfinder.com/data/icons/facebook-ui-colored/48/JD-18-512.png)
Title: Re: Catecholamines Depletion as a Possible Cause for Cognitive Symptoms
Post by: Nas on February 06, 2019, 02:41:47 PM
Nas, can I laugh, too?

(https://cdn2.iconfinder.com/data/icons/facebook-ui-colored/48/JD-18-512.png)
(https://cdn2.iconfinder.com/data/icons/facebook-ui-colored/48/JD-18-512.png)
(https://cdn2.iconfinder.com/data/icons/facebook-ui-colored/48/JD-18-512.png)
Help your self :P
Title: Re: Catecholamines Depletion as a Possible Cause for Cognitive Symptoms
Post by: FernandoPOIS on February 07, 2019, 12:11:18 PM
I'm sorry, but I keep remembering my experiences with various products that unfortunately did not result in anything and some days I thought I would die due to side effects. Today I think funny but at the time it was haunting hahahaha
Title: Re: Catecholamines Depletion as a Possible Cause for Cognitive Symptoms
Post by: koko on February 09, 2019, 07:42:02 PM
I think the pois is due to depletion of dopamine in the brain after the orgasm. I convinced my doctor to prescribe a dopamine receptor drug, a drug given to Parkinson's disease and to restless leg syndrome.

I hope this medicine will improve my life.
Title: Re: Catecholamines Depletion as a Possible Cause for Cognitive Symptoms
Post by: Wolf berry on February 09, 2019, 08:49:22 PM
I think the pois is due to depletion of dopamine in the brain after the orgasm. I convinced my doctor to prescribe a dopamine receptor drug, a drug given to Parkinson's disease and to restless leg syndrome.
Qoute from hurray

I hope this medicine will improve my life.
I spent a while trying dopamine-related medications, hoping that they could alleviate my POIS:

piracetam
l-tyrosine
selegiline
wellbutrin
cabergoline
modafinil
Adderal
Caffeine

There's probably a bunch more that I can't remember right now, most were a number of years ago.

They didn't ultimately do much for me, although in some cases they gave my brain a boost when I was out of POIS.

I'm currently taking Ritalin, with the help of my psychiatrist (40mg/day). This has been the most useful medicine so far by some distance, but for me it doesn't prevent or cure POIS.

I'm not suggesting that there isn't a link between POIS and dopamine, but various dopaminergic drugs didn't feel like they were doing much to fight my POIS. I would be very interested to see somebody reporting long-term success with this class of drugs, I believed for years that dopamine was the key to the POIS mystery.

it can make you mania without cognitive improvement!

All the best, Wolf berry
Title: Re: Catecholamines Depletion as a Possible Cause for Cognitive Symptoms
Post by: Nas on February 09, 2019, 09:34:06 PM
I spent a while trying dopamine-related medications, hoping that they could alleviate my POIS:

piracetam
l-tyrosine
selegiline
wellbutrin
cabergoline
modafinil
Adderal
Caffeine

There's probably a bunch more that I can't remember right now, most were a number of years ago.

They didn't ultimately do much for me, although in some cases they gave my brain a boost when I was out of POIS.

I'm currently taking Ritalin, with the help of my psychiatrist (40mg/day). This has been the most useful medicine so far by some distance, but for me it doesn't prevent or cure POIS.

I'm not suggesting that there isn't a link between POIS and dopamine, but various dopaminergic drugs didn't feel like they were doing much to fight my POIS. I would be very interested to see somebody reporting long-term success with this class of drugs, I believed for years that dopamine was the key to the POIS mystery.

it can make you mania without cognitive improvement!

All the best, Wolf berry
Good to know, I haven't tried them yet and I feel pessimistic about their function. This is largely and indicator that it's not dopamine that is responsible, especially when it gives you mania without improving Cognitive symptoms. Any idea on what it could be otherwise? Something that could also potentially be involved in the HPA axis?
Title: Re: Catecholamines Depletion as a Possible Cause for Cognitive Symptoms
Post by: Nas on February 11, 2019, 02:01:39 PM
Took L-Dopa yesterday. Surprisingly, I also had an orgasm that day. I took L-Dopa the first time and it was a good experience, I recommend it if you're suffering from anxiety and trouble focusing. However, its effect was not fundamental. When I had orgasm that day the symptoms arose with the same intensity. I took L-Dopa again after that and it also didn't do much. I later took B-comlex (B1-B6-B12) and it seems to work well with L-Dopa to increase relaxation. Yet I also recommend to have an anti-emetic with L-Dopa or any non-specific dopamine booster to avoid nausea. Overall it doesn't seem very promising for the catecholamines theory. 
Title: Re: Catecholamines Depletion as a Possible Cause for Cognitive Symptoms
Post by: Wolf berry on February 11, 2019, 06:11:18 PM
Took L-Dopa yesterday. Surprisingly, I also had an orgasm that day. I took L-Dopa the first time and it was a good experience, I recommend it if you're suffering from anxiety and trouble focusing. However, its effect was not fundamental. When I had orgasm that day the symptoms arose with the same intensity. I took L-Dopa again after that and it also didn't do much. I later took B-comlex (B1-B6-B12) and it seems to work well with L-Dopa to increase relaxation. Yet I also recommend to have an anti-emetic with L-Dopa or any non-specific dopamine booster to avoid nausea. Overall it doesn't seem very promising for the catecholamines theory.

Vitamins B's play several role in the body including being important  to brain functions and energy.  It has been tried by several members with good results. Some of the theories behind the success of vitamin Bs are they help replenish brain neurotransmitters, they replace something lost after ejaculation and they help reduce excess histamine produced by the body.
 
quote by Edorgon
Yeah, I too have noticed that although B vitamins are really effective for getting my energy, blood flow and mental function up, after about a week they begin to cause an absolutely crushing fatigue. I don't know what to do about it. I'm thinking of just kind of scaling back how often i use them.

Has anyone else had this problem and, if so, how'd you fix it?

Quote by UnderstandingPois
he effects i get from taking a multivitamin is. Irritablness , feel crappy cant think at all or use personality trait thoughts. Severe depression. Everythings looks duller and is so bright and bothers me. No emotion . No energy . I noticed while taking it waayy harder to control urge of orgasm. Cause of all the awfullness and depression. Basically feel like hell. And i cannot believe one multivitamin does all that to me without adderall. And so much more horrible stuff like no socializing at all. Will stay away from people. Crushes personality completely. In every way it makes me sick and dead.  Cant proccess or understand things at all really very hard. Have to reread and reread to understand. My pois started when i hit puberty. And around the same time i started taking multivitamins and vitamins. So if that long i was taking them for and how i feel crappy just taking one multivitamin. Im so sure for me that thats what that chalky white stuff was , build up. First time my condition improved was when i was taking supplements and prozac n others and i had a orgasm and pop i felt in my head and all this chalky stuff came out for a long time in a big matter.  I cant ever imagine going thrue pois ever again. Its the definition of hell.  Im so glad those days are over. Yearsn years. Hope maybe this
 will benefit someone?

Qoute by Daveman
Hey UnderstandingPois,

Long time!

Glad you're feeling better. I agree about the multi-vitamins. At one point I started taking multi-vits and they made things WAY worse. Like maybe 5 times worse. I guess that's why I was surprised that just niacin, and/or the B vitamins worked so well. With niacin, I'm like you, no POIS!

Kurtosis said it not too long ago, POIS is a little different for each person, yet the "broken system" is the same for everybody. It's just what part of it is broken and how that makes the difference.

It seems to me for instance that Adderall doesn't work for many, nor does niacin work for all. So it's still vital to get to the bottom of all of this.

The important is that you are POIS free, and "chalky stuff free" too!

it?s been only 1 day and you say it help your pois symptoms

All the Best, Wolf Berry
Title: Re: Catecholamines Depletion as a Possible Cause for Cognitive Symptoms
Post by: Nas on February 11, 2019, 07:40:32 PM


The important is that you are POIS free, and "chalky stuff free" too!

it?s been only 1 day and you say it help your pois symptoms

All the Best, Wolf Berry
I don't think you understood what I said, it did not make me POIS free it only had minor relaxing effect, and taking Neurobine with it seems to make it better. But if we truly had catecholamines depletion I kind of expect a fundamental change, and it didn't bring me that change.
Title: Re: Catecholamines Depletion as a Possible Cause for Cognitive Symptoms
Post by: koko on February 14, 2019, 03:40:57 AM
A month later I took a dopamine agonist with a name drug is "Requip 2 mg". Unfortunately, the drug did not have any effect on the symptoms. I asked my doctor to try to increase the dosage of the agonist for dopamine but thought it unnecessary and prescribed more psychiatric drugs instead of dopamine. The agony is still in my life
Title: Re: Catecholamines Depletion as a Possible Cause for Cognitive Symptoms
Post by: Nas on February 14, 2019, 01:32:56 PM
A month later I took a dopamine agonist with a name drug is "Requip 2 mg". Unfortunately, the drug did not have any effect on the symptoms. I asked my doctor to try to increase the dosage of the agonist for dopamine but thought it unnecessary and prescribed more psychiatric drugs instead of dopamine. The agony is still in my life
I personally took an L-Dopa supplement plus vitamin B complex, this way you increase your base dopamine metabolism. If you're already depleted stimulating the receptors won't help. Plus always have an anti-emetic with you if you're messing with dopamine. Overall for me it does help, but it's not fundamental; it does not stop POIS.
Title: Re: Catecholamines Depletion as a Possible Cause for Cognitive Symptoms
Post by: hurray on March 16, 2019, 05:50:39 PM
I personally took an L-Dopa supplement plus vitamin B complex, this way you increase your base dopamine metabolism. If you're already depleted stimulating the receptors won't help. Plus always have an anti-emetic with you if you're messing with dopamine. Overall for me it does help, but it's not fundamental; it does not stop POIS.

An interesting article Nas. Some of the dopamine-related medication I have tried has had a useful stimulating effect outside of POIS. However, inside POIS they were ineffective at best, and they didn't do anything to prevent the onset of POIS.

I haven't tried L-DOPA, but it seems like an interesting supplement. The pharmaceutical L-DOPA that is prescribed to Parkinson's sufferers is usually combined with another drug such as carbidopa:

https://en.wikipedia.org/wiki/Carbidopa/levodopa

Quote
Levodopa is converted to dopamine via the action of a naturally occurring enzyme called DOPA decarboxylase. This occurs both in the peripheral circulation and in the central nervous system after levodopa has crossed the blood brain barrier. Activation of central dopamine receptors improves the symptoms of Parkinson's disease; however, activation of peripheral dopamine receptors causes nausea and vomiting. For this reason levodopa is usually administered in combination with a DOPA decarboxylase inhibitor (DDCI), in this case carbidopa, which is very polar (and charged at physiologic pH) and cannot cross the blood brain barrier, however prevents peripheral conversion of levodopa to dopamine and thereby reduces the unwanted peripheral side effects of levodopa. Use of carbidopa also increases the quantity of levodopa in the bloodstream that is available to enter the brain.

I wonder if this form of L-DOPA would be more effective for POIS sufferers than the supplements? Of course, carbidopa/levodopa could only be taken after a consultation with your doctor.

Title: Re: Catecholamines Depletion as a Possible Cause for Cognitive Symptoms
Post by: b_jim on March 17, 2019, 10:54:04 AM
You should have a look of definition of :
serotonin syndrome  (https://en.wikipedia.org/wiki/Serotonin_syndrome)
Symptoms match with my Pois symptoms.
I really wonder if a possible high level of serotonin/tryptophan could be the cause.

Anticholinergic symptom is another possible way to explore and it is linked itself to dopamine.

What science says ?
5gr of tryptophan can create "minor disorders" : drowness, headaches, acne, tachycardia, nausea. 5gr is huge much more what we found in a normal diet .

I will try again to take a source of tryptophan (pumpkin seeds) and sugar before orgasm.

 
Title: Re: Catecholamines Depletion as a Possible Cause for Cognitive Symptoms
Post by: Vandemolen on March 17, 2019, 11:12:17 AM
You should have a look of definition of :
serotonin syndrome  (https://en.wikipedia.org/wiki/Serotonin_syndrome)
Symptoms match with my Pois symptoms.
I really wonder if a possible high level of serotonin/tryptophan could be the cause.

Anticholinergic symptom is another possible way to explore and it is linked itself to dopamine.
A good way to check high serotonin is 5HIAA in 24 hours urine. High serotonine can be caused by a few things, including serotonin syndrom and carnoid tumors. Before this urine test you can not eat: bananas, tomatoes, avocado, nuts, kiwi, plums and old cheese.
Title: Re: Catecholamines Depletion as a Possible Cause for Cognitive Symptoms
Post by: b_jim on March 17, 2019, 11:46:50 AM
When I read this non-scientific article, it's a mirror of my personal situation...


Quote
According to Datis Kharrazian, PhD, DHSc, author of Why Isn’t My Brain Working?, mild symptoms of too much serotonin include:

    shyness
    feeling “not good enough”
    desiring, yet fearing, social interactions
    nervousness
    being easily upset by criticism
    lack of motivation (2)

More serious symptoms of too much serotonin include: (3, 4)

    feeling agitated or restless
    mental confusion or disorientation
    headache
    dizziness
    increased heart rate or blood pressure
    dilated pupils
    goose bumps, sweating, or shivering
    diarrhea, nausea, or vomiting
    tremors or twitchy muscles

The mild symptoms match with my symptoms out of Pois (anxiety)
And more serious symptom, in Pois...
Title: Re: Catecholamines Depletion as a Possible Cause for Cognitive Symptoms
Post by: b_jim on March 18, 2019, 12:54:44 PM
For 2019, my new strategy is to add 2 amino-acid 30 min before orgasm : Glycine + Taurine.
I hope to get an effect on serotonin/tryptophan and NMDA/glutamate receptor.
Title: Re: Catecholamines Depletion as a Possible Cause for Cognitive Symptoms
Post by: Nas on March 18, 2019, 12:58:51 PM
For 2019, my new strategy is to add 2 amino-acid 30 min before orgasm : Glycine + Taurine.
I hope to get an effect on serotonin/tryptophan and NMDA/glutamate receptor.
I'm also expecting Glycine soon, we'll see how that'll work out.
Title: Re: Catecholamines Depletion as a Possible Cause for Cognitive Symptoms
Post by: Unvers on August 15, 2020, 12:03:48 PM
The decrease in signaling of catecholamines is certainly a distinctive trait of cognitive POIS but I believe that it in turn is caused by something else, that is, it is something that in the cascade of events of POIS happens quite forward and can be considered more a symptom of events more subtle than a real cause of POIS, however, it is certainly something that is better to be treated by taking special supplements, I take 5HTP which is a precursor of serotonin and levodopa which is a precursor of dopamine, as regards norepinephrine the problem is not given to me that dopamine itself is a precursor of noradrenaline.
Title: Re: Catecholamines Depletion as a Possible Cause for Cognitive Symptoms
Post by: berlin1984 on August 15, 2020, 12:19:44 PM
- Low protein intake
...
- Consider amino acid and other supplements once your healthy nutrition is in place."

I was actually investigating this topic today.
Amino acid powders (e.g. hydrolysed protein from a complete form, e.g. dairy or meat or (insert vegetarian/vegan option here)) as a drink could be interesting (note: tastes awful, started today with it).
Especially given that certain illnesses seem to have a deficiency (serum) in certain amino acids. E.g. in CFS (https://www.google.com/search?client=firefox-b-d&q=amino+acids+cfs)

My strategy then would be a basic shake + additional amount of the amino acids that I think can help in my situation (spoiler: glutamine, taurine, ornithine, alanine, maybe citrulline and alcar but they're not mixing well, creatine, sometimes tryptophan or tyrosine)

Why a shake (on empty stomach, first thing in morning)?
Because then you (your body), not your gut bactieria, can absorb the amino acids.
Why amino acid shake instead of protein shake?
Because then you don't need to break it down first.

Also related (instead of shake): Use Glutamine to Heal the Gut and Hinder Your Gut Bacteria from Eating Away Your BCAA, Arginine and Other Aminos  (https://suppversity.blogspot.com/2012/04/use-glutamine-to-heal-gut-and-hinder.html)


(I'll move this message to a different thread if there is a better one).

Related: https://en.wikipedia.org/wiki/Orthomolecular_medicine