Post Orgasmic Illness Syndrome (P.O.I.S.)

POIS Cause/Treatment Discussions => Hormonal Causes and Treatments => Topic started by: nanna1 on January 19, 2019, 09:10:59 PM

Title: Neuroendocrine responses to arousal and orgasm
Post by: nanna1 on January 19, 2019, 09:10:59 PM
  The time course for various neuroendocrine hormones, neurotransmitters and heart parameters are shown below. Including prolactin, testosterone, follicle stimulating hormone (FSH), Luteinizing hormone (LH), cortisol, growth hormone (GH), dopamine, DOPAC, HVA, 3,4-MHPG, 5-HIAA, histamine, adrenaline (epinephrine), noradrenaline (norepinephrine), glutamate, GABA, aspartate, taurine, oxytocin, vasopressin, beta-endorphin, melatonin, blood pressure (systolic, diastolic), heart rate, natural killer cells, and cytokines (IL-6 and TNF-alpha). The below graphs show that dopamine, epinephrine, norepinephrine (noradrenaline), oxytocin, prolactin, heart rate, blood pressure and natural killer cell activity are highly correlated with the sexual response.

"Indeed, it is notable that different neuropharmacological factors impact thresholds for seizures and sexual climax in similar ways, likely reflecting overall propensity for activation cascades to spread through neuronal networks: thresholds increase with elevated GABA receptor stimulation, but decrease with elevated glutamate receptor stimulation, dopamine agonists, and dopamine/norepinephrine reuptake inhibitors"
-What is orgasm? A model of sexual trance and climax via rhythmic entrainment (2016) (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087698/)

(https://i.imgur.com/43RWkMg.png)
Figure from: Specificity of the neuroendocrine response to orgasm during sexual arousal in men. (THC Kruger, U Hartmann, et al, 2003) (http://joe.endocrinology-journals.org/content/177/1/57.full.pdf)

(https://i.imgur.com/A0gEDDw.png)
Neuroendocrine and cardiovascular response to sexual arousal and orgasm in men (THC Kruger, U Hartmann, et al., 1998) (https://www.ncbi.nlm.nih.gov/pubmed/9695139)

(https://i.imgur.com/z9pBMNj.png)
Figure from: Endocrine response to masturbation-induced orgasm in healthy men following a 3-week sexual abstinence (MS Exton, U Hartmann, et al., 2001) (https://www.ncbi.nlm.nih.gov/pubmed/11760788)

(https://i.imgur.com/jZIwDqR.png)
Figure from: Endocrine response to masturbation-induced orgasm in healthy men following a 3-week sexual abstinence (MS Exton, U Hartmann, et al., 2001) (https://www.ncbi.nlm.nih.gov/pubmed/11760788)

(https://i.imgur.com/E6uUA2W.png)
Figure from: Endocrine response to masturbation-induced orgasm in healthy men following a 3-week sexual abstinence (MS Exton, U Hartmann, et al., 2001) (https://www.ncbi.nlm.nih.gov/pubmed/11760788)

(https://i.imgur.com/HYQl1Fg.png)
Neuroendocrine response to film-induced sexual arousal in men and women (NG Exton, U Hartmann, et al., 2000) (https://www.ncbi.nlm.nih.gov/pubmed/10674282)

(https://i.imgur.com/mqX9qJj.png)
(https://i.imgur.com/5y2mwPV.png)
Orgasm-induced prolactin secretion: feedback control of sexual drive? (THC Kruger, U Hartmann, et al., 2002) (https://www.ncbi.nlm.nih.gov/pubmed/11835982)

Dopamine inhibits prolactin through the D2-dopamine receptor (Ref (https://en.wikipedia.org/wiki/Prolactin)).
(https://i.imgur.com/IgsOqT2.jpg)

(https://sites.tufts.edu/emotiononthebrain/files/2014/11/prolactin.jpg)

(https://i.imgur.com/6u2i9Sq.png)
"the orgasm induced a moderate but statistically significant transient elevation of the cytotoxic/suppressor T cell (CD3+CD8+) numbers (Fig. 2). In contrast, the absolute numbers of T cells (CD3+), T helper cells (CD3+CD4+), and B cells (CD3-CD20+) were not affected by sexual stimulation...the levels of LPS-induced proinflammatory cytokines (IL-6, TNF-alpha) remained unaffected by masturbation-induced orgasm...The effects of orgasm on peripheral lymphocyte subsets were restricted to NK cells and had minor or no effects on T or B cell subsets and showed no effects on (IL-6, TNF-alpha) cytokine production, indicating limited and selective effects of orgasm on immune system functions in parallel with its selective and short-lived neuroendocrine effects." -Effects of Sexual Arousal on Lymphocyte Subset Circulation and Cytokine Production in Man (P Haake, U Hartmann, et al., 2004) (https://www.researchgate.net/profile/Uwe_Hartmann/publication/8395744_Effects_of_Sexual_Arousal_on_Lymphocyte_Subset_Circulation_and_Cytokine_Production_in_Man/links/00b7d52f8e1b80712a000000.pdf)

(https://i.imgur.com/UJ5hfcM.png)
Effects of Sexual Arousal on Lymphocyte Subset Circulation and Cytokine Production in Man (P Haake, U Hartmann, et al., 2004) (https://www.researchgate.net/profile/Uwe_Hartmann/publication/8395744_Effects_of_Sexual_Arousal_on_Lymphocyte_Subset_Circulation_and_Cytokine_Production_in_Man/links/00b7d52f8e1b80712a000000.pdf)




(https://i.imgur.com/xOkczC0.png)
Melatonin Plasma Levels during Sexual Arousal and Orgasm in Males (THC Kruger, 2010) (https://www.ncbi.nlm.nih.gov/pubmed/20946177)

(https://i.imgur.com/UDA3DUO.png)
Is there a significance of histamine in the control of the human male sexual response? (A Becker, et al., 2011) (https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1439-0272.2011.01222.x)

(https://i.imgur.com/kCQTUHh.png)
Serial neurochemical measurement of cerebrospinal fluid during the human sexual response cycle (THC Kruger, et al., 2006) (https://doi.org/10.1111/j.1460-9568.2006.05215.x)

(https://i.imgur.com/IiFUnZk.png)
Serial neurochemical measurement of cerebrospinal fluid during the human sexual response cycle (THC Kruger, et al., 2006) (https://doi.org/10.1111/j.1460-9568.2006.05215.x)

(https://media.springernature.com/original/springer-static/image/art%3A10.1186%2F1741-7015-11-79/MediaObjects/12916_2012_Article_744_Fig3_HTML.jpg)
Manipulating the sleep-wake cycle and circadian rhythms to improve clinical management of major depression (2013) (https://www.ncbi.nlm.nih.gov/pubmed/23521808)

(http://brainimmune.com/wp-content/uploads/2011/07/T-Cell-During-Sleep-Fig2.jpg)
Figure 2 T Cell and Antigen Presenting Cell Activity During Sleep (http://www.brainimmune.com/t-cell-and-antigen-presenting-cell-activity-during-sleep/)

(http://www.brainimmune.com/wp-content/uploads/2011/07/T-Cell-During-Sleep-Fig-5.jpg)
Figure 5 T Cell and Antigen Presenting Cell Activity During Sleep (http://www.brainimmune.com/t-cell-and-antigen-presenting-cell-activity-during-sleep/)

(https://i.imgur.com/HzZX1b4.png)
(https://i.imgur.com/BwWIslE.png)
(https://i.imgur.com/FzLyQcN.png)
White circles: 24 hour sleep deprivation, Black circles: 24 hour normal sleep. Gray region (23:00 - 7:30): sleeping period
-Number and Function of Circulating Human Antigen Presenting Cells Regulated by Sleep (https://www.ncbi.nlm.nih.gov/pubmed/17520784)

(https://i.imgur.com/TWl4Eys.png)
Effects of sleep and circadian rhythm on the human immune system (https://www.ncbi.nlm.nih.gov/pubmed/20398008)

Title: Re: Neuroendocrine responses to arousal and orgasm
Post by: demografx on January 19, 2019, 10:36:13 PM
Amazing, nanna1!
Title: Re: Neuroendocrine responses to arousal and orgasm
Post by: Hopeoneday on January 20, 2019, 05:59:00 AM
This is all posted long time ago on the nakedscient... this is all normall proceses in
response to sexual stimuly, arosaul.
Those days i try to resarch and test on perpes why my body react hipersenzibile on sex
and film induced(ewan abstinence for years from film arosaul) nothing change.
So i try to resarch whot cemicals in exes couse all this reaction in my body, and cant
figureout yet.

Cofee help after pois hit me, my body is like shutted dow all
endocrine functions properly(cofee help because supose cortisol lift and help fight inflamation)
and probbly adrenaline raise help to when body is shutedd down.
But what intriguted me that when i recower, i cant drink cofe because make me sick,
i crashed from small amount of cofee when i recowered from pois.

That lead me to thik that in recowered fase, contsant and enormes amount of cronic
stress, play big part in pois, always in inflamatory state.

So,when i look in edocrine , for exemple adrenals , also doesnt lead me enywhere
by symptomes, nigdher adison cant fit in me here
https://pituitary.org/knowledge-base/disorders/adrenal-insuffieciency-addison-s-disease
https://www.hormone.org/diseases-and-conditions/adrenal/adrenal-incidentaloma

On odher side, nidher cushing disiese cant fit here(bisase my resarches that big
mayority of poisers hawe hi cortisol)
https://www.mayoclinic.org/diseases-conditions/cushing-syndrome/symptoms-causes/syc-20351310

Then, my resarching lead me to adiction part and witdrawls symptomes and i
wonder is my brain loook like this
https://upliftconnect.com/your-addiction-makes-perfect-sense/
https://imagenesmi.com/im%C3%A1genes/addicted-brain-9b.html

And again it doesnt fit in my case, because i hawe strong will power, i can cut eny
adictive behawior in "shor"t periods of time.
For exemple, film(porn) abstinence for seweral years dosnt get rid of me from pois,
and in my testing on masturbation,  if i masturbate i can watch pornography but i
radher masturbate on my natural womans who i know or meet in real life
(you know, naturall in 100%).
So, adiction part dosnt fit also....




Title: Re: Neuroendocrine responses to arousal and orgasm
Post by: Nas on January 20, 2019, 09:54:41 AM
This is all posted long time ago ond the nakedscient... this is all normall proceses in
response to sexual stimuly, arosaul.
Those days i try to resarch ant test on perpes why my body react hipersenzibile on sex
and film induced(ewan abstinence for years from film arosaul) nothing change.
So i try to resarch whot cemicals in exes couse all this reaction in my body, and cant
figureout yet.

Cofee help after pois hit me, my body is like shutted dow all
endocrine functions properly(cofee help because supose cortisol lift and help fight inflamation)
and probbly adrenaline raise help to when body is shutedd down.
But what intriguted me that when i recower, i cant drink cofe because make me sick,
i crashed from small amount of cofee when i recowered from pois.

That lead me to thik that in recowered fase, contsant and enormes amount of cronic
stress, play big part in pois, always in inflamatory state.

So,when i look in edocrine , for exemple adrenals , also doesnt lead me enywhere
by smptomes, nigdher adison cant fit in me here
https://pituitary.org/knowledge-base/disorders/adrenal-insuffieciency-addison-s-disease
https://www.hormone.org/diseases-and-conditions/adrenal/adrenal-incidentaloma

On odher side, nider cushing disiese cant fit here(bisase my resarches that big
mayority of poisers hawe hi cortisol)
https://www.mayoclinic.org/diseases-conditions/cushing-syndrome/symptoms-causes/syc-20351310

Then, my resarching lead me to adiction part and witdrawls symptomes and i
wonder is my brain loook like this
https://upliftconnect.com/your-addiction-makes-perfect-sense/
https://imagenesmi.com/im%C3%A1genes/addicted-brain-9b.html

And again it doesnt fit in my case, because i hawe strong will power, i can cut eny
aditiwe behawior in "shor"t periods of time.
For exemple, film(porn) abstinence for seweral years dosnt get rid of me from pois,
and in my testing on masturbation,  if i masturbate i can watch pornography but i
radher masturbate on mynatural womans who i know or meet in real life
(you know, naturall in 100%).
So, adiction part dosnt fit also....
Well HOP it can also be low Catecholamines, I don't know why or how but a test should be done after orgasm to be sure.
Title: Re: Neuroendocrine responses to arousal and orgasm
Post by: Vandemolen on January 20, 2019, 01:09:39 PM
Nanna, so porn is worse for you than cocaine because you lose more dopamine for a long time? Or is that the wrong conclusion of your shared pic?
Title: Re: Neuroendocrine responses to arousal and orgasm
Post by: b_jim on January 20, 2019, 03:23:54 PM
When you have 18 old year, I agree watchin a porn will make you release a lot of dopamine. But when you will be as old as me it will make release no more than a silent film of 1950 :D
Title: Re: Neuroendocrine responses to arousal and orgasm
Post by: demografx on January 20, 2019, 03:50:54 PM
When you have 18 old year, I agree watchin a porn will make you release a lot of dopamine. But when you will be as old as me it will make release no more than a silent film of 1950 :D

(https://cdn2.iconfinder.com/data/icons/facebook-ui-colored/48/JD-18-512.png)
Title: Re: Neuroendocrine responses to arousal and orgasm
Post by: Hopeoneday on January 20, 2019, 04:47:12 PM
When you have 18 old year, I agree watchin a porn will make you release a lot of dopamine. But when you will be as old as me it will make release no more than a silent film of 1950 :D

Aaahahah, B -jim, my sugestion is that you find 18 year old girl to boost your dopamine levels.
Tested 100% , and its legal to.

Warning, this solution rise only dopamine , nothing else!
Title: Re: Neuroendocrine responses to arousal and orgasm
Post by: demografx on January 20, 2019, 06:08:04 PM
Aaahahah, B -jim, my sugestion is that you find 18 year old girl to boost your dopamine levels.
Tested 100% , and its legal too.

Warning, this solution rise only dopamine , nothing else!
(https://cdn2.iconfinder.com/data/icons/facebook-ui-colored/48/JD-18-512.png)
Title: Re: Neuroendocrine responses to arousal and orgasm
Post by: Hopeoneday on January 20, 2019, 06:29:57 PM
I imagine all poisers togedher hawe a trip to Tyland !
Title: Re: Neuroendocrine responses to arousal and orgasm
Post by: nanna1 on January 21, 2019, 02:04:50 AM
Nanna, so porn is worse for you than cocaine because you lose more dopamine for a long time? Or is that the wrong conclusion of your shared pic?
This is what porn does to your dopamine levels.
(https://steemitimages.com/DQmeFcNBbBHXLGSmCDM8HndYj4j33DKKtojvrYnrCsyQ4UC/DopamineSurges.jpeg)

While porn is being viewed, dopamine levels remain elevated. But when the porn goes off, dopamine tanks. It's called the Coolidge effect (http://www.heretical.com/wilson/coolidge.html).
(https://oceanrecoverycentre.com/wp-content/uploads/2016/07/9.-Reward.png)
So if someone views porn for more than 3 hours it will become more addictive than doing cocaine.

Here is the full explanation:
http://www.best-infographics.com/porn-addiction-dopamine/
(http://www.best-infographics.com/wp-content/uploads/2018/07/06/Porn-Addiction-Dopamine.jpg)
Title: Re: Neuroendocrine responses to arousal and orgasm
Post by: Hopeoneday on January 21, 2019, 06:56:19 AM
Yes, this is well  known, but how this fit in pois?
Ewry click wich exite you on net act the same like this.
Some pois symptomes is similar like withdrawls from drugs, but it doesnt fit there
if you look diper.

Recently i write about this, and do some test on perpes, and obserwe
how weving explicit video for 20 min hit my body in pois state,
After long period of abstinence from arosaul. Ayes and
facilall change, sagy face pois state but not full blown, because no O, E.
So i can feel that my budy is filled with enosrmes amount of chemicals
wich cant be procesed properly.

So question? Is this all pois couse is dopamine receptors in brain downregulated?
And itspermanent damge, not inwersable?


For exemple, cut adiction in longer periodof time, you should feel beter from pois
and owerall health, but in practice this doesnt hapening.
You again hawe a pois tha damage your body.
Title: Re: Neuroendocrine responses to arousal and orgasm
Post by: Wolf berry on January 21, 2019, 01:02:24 PM
I used to believe Hardcore Porn or Masturnation before puberty it the cause of it. I don't think im addict to porn tho. I think pois suffered only watch porn skip all the part to best scenario then ejaculate very fast. Yourbrainonporn.com anti porn site. i think most of them are pseudoscience. Porn is healthy tho. i think pois suffered can't watch porn for a long time cause of premature ejaculation.
Title: Re: Neuroendocrine responses to arousal and orgasm
Post by: Muon on January 26, 2019, 10:05:04 AM
I'm adding this review paper to this thread. It gives a very basic overview but is well readable: Biology of Sexual Dysfunction (https://www.researchgate.net/publication/237119490_Peer_Reviewed_Open_Access_Free)
Title: Re: Neuroendocrine responses to arousal and orgasm
Post by: Nas on February 07, 2019, 03:50:45 PM
I wonder if I take an L-Dopa supplement, will that also increase Norepinephrine and Epinephrine levels, since the former are made from dopamine?
Title: Re: Neuroendocrine responses to arousal and orgasm
Post by: david on February 09, 2019, 09:25:23 AM
that is why i tried cabergolin 3 years ago and now i'm constantly on it
prolactin is the anti libido definitely
so keep your prolactin at lower reference
me personally can feel it very sharp
if my prolactin more then 250 i feel like crap especially after big O
if my prolactin is less then 80 i feel much better, much stable and can have several big O a day

and i totally agree that there is a dophamine depletion after big O for sure and i guess not only dopa very much probably some more substances depleted including hormones
and its not so easy to restore them
so far i tried L-tyrosin, DMAE, N-acetyl-tyrosin, noopept no luck :(
but i tried sulbutiamin recently and it gave me a good energy and mood boost
Title: Re: Neuroendocrine responses to arousal and orgasm
Post by: Nas on February 09, 2019, 10:17:53 AM
and i totally agree that there is a dophamine depletion after big O for sure and i guess not only dopa very much probably some more substances depleted including hormones
and its not so easy to restore them
so far i tried L-tyrosin, DMAE, N-acetyl-tyrosin, noopept no luck :(
but i tried sulbutiamin recently and it gave me a good energy and mood boost
Maybe taking both L-Tyrosin and Sulbutaimine or anyother vitamine B like Niacin or Folate might help? Maybe you have an issue with L-Tyrosin metabolism.
Title: Re: Neuroendocrine responses to arousal and orgasm
Post by: Wolf berry on February 09, 2019, 08:21:17 PM
this forum isn?t  a medical forum. Are you a doctor??
Title: Re: Neuroendocrine responses to arousal and orgasm
Post by: demografx on February 09, 2019, 11:47:18 PM
Wolf berry makes a point: we all need to be more careful about recommending any form of treatment here, from POISer to POISer.
Title: Re: Neuroendocrine responses to arousal and orgasm
Post by: Nas on February 10, 2019, 08:47:33 AM
Wolf berry makes a point: we all need to be more careful about recommending any form of treatment here, from POISer to POISer.
Just re-worded my reply, sorry.
Title: Re: Neuroendocrine responses to arousal and orgasm
Post by: demografx on February 10, 2019, 09:26:51 PM
Many thanks, Nas! Hopefully, others will follow suit.
Best,
Demo
Title: Re: Neuroendocrine responses to arousal and orgasm
Post by: romies on February 27, 2019, 11:18:29 PM
I wonder if I take an L-Dopa supplement, will that also increase Norepinephrine and Epinephrine levels, since the former are made from dopamine?

direct supplement with L-DOPA is bad. one of its metabolite in blood shuts down tyrosine transport through BBB, and causing paradoxically low dopamine level in CNS over longer terms.

That's why Parkinson patients have to increasing their L-DOPA dosage very quickly and the whole thing stops working after 1 year or two. 
Title: Re: Neuroendocrine responses to arousal and orgasm
Post by: Nas on February 28, 2019, 12:39:45 AM
I wonder if I take an L-Dopa supplement, will that also increase Norepinephrine and Epinephrine levels, since the former are made from dopamine?

direct supplement with L-DOPA is bad. one of its metabolite in blood shuts down tyrosine transport through BBB, and causing paradoxically low dopamine level in CNS over longer terms.

That's why Parkinson patients have to increasing their L-DOPA dosage very quickly and the whole thing stops working after 1 year or two.
Is it direct if I take Mucuna Pruriens 20% L-Dopa?
Title: Re: Neuroendocrine responses to arousal and orgasm
Post by: Unvers on August 15, 2020, 10:53:45 AM
I wonder if I take an L-Dopa supplement, will that also increase Norepinephrine and Epinephrine levels, since the former are made from dopamine?

I take levodopa 52mg and I think it increases as well as those are metabolites of dopamine as well as dopamine is of levodopa.