Post Orgasmic Illness Syndrome (P.O.I.S.)

General Category => Poll Center => Topic started by: biocentric on August 30, 2011, 01:04:22 PM

Title: Niacin poll
Post by: biocentric on August 30, 2011, 01:04:22 PM
For only thoses who have tried Niacin prior to orgasm...
thanks
i havent been in a position to test it as yet.
Title: Re: Niacin poll
Post by: b_jim on September 01, 2011, 01:39:27 AM
I will give my answer later.
For the moment I have only took low dose (10-20mg). I can't say if it helped me.

Update : sept. 20th :
I have took 40 mg before orgasm and 20 the day before. I was suprised to have no flu-like symptoms and muscle pains dispite I had bad diet and some stress.
I will continue to test it. It seems it improves cognitive symptomes. Or it was placebo.
Title: Re: Niacin poll
Post by: Samir on September 29, 2011, 11:55:05 PM
I need to try this for sure.
Title: Re: Niacin poll
Post by: b_jim on January 05, 2012, 03:20:34 PM
I voted 0-40% because I'm not sure it helps. It seems to improve my cognitive symptoms but I'm sure it CANT block the inflammation  process. At least at my maximum dose (150mg).
Title: Re: Niacin poll
Post by: Vandemolen on January 05, 2012, 06:59:34 PM
Maybe 10 to 20 % relief.
Title: Re: Niacin poll
Post by: pep on June 24, 2012, 05:17:52 AM
Yes, 0-40% POIS relief

But i'm studying differents situations: a higher dosis, before/after go to the bed, healthy diet...

Nowadays i'm a observer like the user Observer! ;)
Title: Re: Niacin poll
Post by: Daveman on June 24, 2012, 10:02:12 AM
I'm 90 to 100.

I still get light physical symptoms, but have realized that most of those are more from age and weather than from POIS.

Title: Re: Niacin poll
Post by: kurtosis on August 18, 2012, 06:47:48 PM
About 50% relief from cognitive symptoms from niacin.
That's why I started researching all the other stuff. Having said, after tyrosine, niacin was one of the few things that gave me any relief. That first hit of niacin was very important to me and gave me the belief that this POIS thing was beatable.
Title: Re: Niacin poll
Post by: Egordon on August 18, 2012, 08:19:30 PM
Niacin is very effective for me. But since I began taking NSAIDs i've noticed that it probably only eliminates about 75% of my symptoms. Without additional intervention, I don't feel completely sharp until a few days later.
Title: Re: Niacin poll
Post by: Daveman on August 19, 2012, 07:17:00 AM
It's really hard to put a number on it. For instance I still have most of the inflammatory and join problems, although a little shorter, but the rest is gone. My overall sensation is like 90% relief.

It's really strange, because I always thought my POIS was mostly physical. But when niacin works, you come back to feeling what's normal and realize that (in my case) the cognitive effects were much more than I thought.

The same cognitive effects made the physical effects seem a lot worse too.

It's winter here and even with niacin and when I haven't had sex in 2 or 3 weeks, my joints and muscles hurt anyways... also I'm no young puppy! So I think that a lot of my
physical POIS sensations are actually more cognitive amplifcations of the physical problems that I already have and have always (well moreso in winter).

All the flu-like symptoms and the POIS BLAH UGH sensation which is also physical and not normal out of POIS is wiped out though. And of course ALL of the conginitive gone!


Title: Re: Niacin poll
Post by: Andy451 on January 21, 2013, 02:24:58 AM
I haven't had any marked improvement w/ niacin. While attempting to take just 50mgs per day I was spacy, experienced dizziness, uncontrollable vasco-dilation at times and a very low heart rate. These symptoms may be attributed to the combination psychotropics (e.g. 2grams Depakote ER and 1mg of Lorazepam), ingesting foods high in niacin already (e.g. peanut-butter), extreme neurological symptoms or attempting to maintain a high fitness level w/ consistent and intense cardiovascular exercise.

As a result, I do not think I am good measure or the effectiveness of niacin in myself or others because of numerous extraneous hypersensitivities and symptoms accumulated over years of exposure to POIS.   
Title: Re: Niacin poll
Post by: LAPOISSE on January 21, 2013, 04:40:46 AM
I take 500mg of Niacin everynight...I dont get a big flush anymore...Its probably prevent from brain vasoconstriction during the night. I feel much better.
Title: Re: Niacin poll
Post by: Andy451 on January 21, 2013, 05:39:50 PM
That's great LAPOISSE, I am happy niacin works so well for you!

 I will surely consider more extensive testing w/ the vitamin when I have weaned off of Lorazepam and tested it's effectiveness w/ depakote independently. Yet, the depakote I take has properties that cause vascular dilation and regulates the GABA receptor having an overall calming and balancing effect. I do not doubt the benefits of niacin, yet negative side-effects can be exaggerated in myself as a result of the depakote, hence replacing it w/ niacin is tricky and risky, especially at higher doses because there is a lower threshold for error.   
Title: Re: Niacin poll
Post by: Chris on March 28, 2013, 02:58:47 PM
Still most of us havent find relief from niacin..
Title: Re: Niacin poll
Post by: vonstermommy on April 07, 2013, 02:53:30 AM
My husband takes Niacin 24 hours ahead on an empty stomach.

Then he takes it again about 2 hours before on and empty or light stomach. After he flushes is the time to do the deed.  It was definitely a relief.  Recently he added a Benedryl pill and he was the best ever!  Nausea (which was the most annoying) never came, brain fog gone.  The headache remains.

Daveman suggested have sex again in a couple days.  Apparently it helps with POIS symptoms (from the last time).

Title: Re: Niacin poll
Post by: Daveman on April 07, 2013, 10:04:06 AM
My husband takes Niacin 24 hours ahead on an empty stomach.

Then he takes it again about 2 hours before on and empty or light stomach. After he flushes is the time to do the deed.  It was definitely a relief.  Recently he added a Benedryl pill and he was the best ever!  Nausea (which was the most annoying) never came, brain fog gone.  The headache remains.

Daveman suggested have sex again in a couple days.  Apparently it helps with POIS symptoms (from the last time).




If somehow you end up with POIS, or maybe the niacin was taken without much of a flush or something, you can have sex again in a day or two, taking niacin of course, and it should clear up all the POIS.

When does he take the Benedryl pill? Before, after?

Title: Re: Niacin poll
Post by: Clycos on April 07, 2013, 05:17:52 PM
Hey guys I tried niacin today for the first time and its been pretty effective!

This is exactly what I did I would be happy to hear your thoughts:

Day 1:

2x100mg niacin an hour before O
1x100mg niacin middle of the night
2x500mg tyrosine in the morning + 2000UI Vitamin D
1x100mg niacin 2 hours later
2x500mg tyrosine 2 hours later

and so on.

I am alternating between tyrosine and niacin because I know tyrosine can raise blood pressure a bit and I am afraid that niacin might do the same so thats why I chose to spread them out in approximately 2 hour intervals so that they don't have an interactions between them, let me know what you think. All this I would say has given me 80% relief so far, I feel almost the same way I felt yesterday (before O) and this is the first time I experience such relief.

I am convinced that POIS cause inflammation and therefore with inflammation comes inflation in the brain, hence the cognitive symptoms. You guys have to understand that brain inflammation affects the amygdala, which means it messes with our emotional system. This is why anti-inflammatory medication such as non-steroidical-anti-inflammatory-drugs AKA Advil (for beginners) AKA NSAIDS work well. My assumption is that niacin works similar to NSAIDS. Something I noticed when I started taking niacin a few days before my O that I had last night is that when I took niacin, of course I had mild flush symptoms but I also "felt my brain more" and actually experienced a feeling of more blood flow going to my brain which is a really good sign.

The only thing that truly troubles me until this point is that so far, taking either Advil or Celebrex (200mg) have only been effective on day 1 of orgasm. Day 2, and Day 3, whether I took NSAIDS or not I experience no relief.. I don't know what to say to this; if someone can enlighten me with this phenomena I would be really glad.


Good day gentlemen, keep your heads up :)
Title: Re: Niacin poll
Post by: Daveman on April 07, 2013, 06:24:23 PM
In my experience, niacin doesn't really do much [u[after[/u] O. The positive effect of the niacin is probably all from the pre "O" niacin.
The other problem with taking "ongoing niacin", is that it will tend to lower your threshold. If you have one "O a week, with your
program you'd be taking niacin almost continually. The effect would start to wear off in a few weeks and you would have to take more
to have the same effect, etc. etc.

Don't know about the tyrosine...haven't tried it myself, so don't know much about it.

Some have taken the pre-O niacin, and then if they still get light POIS, take an NSAID or two and/or a Benedryl after.

Title: Re: Niacin poll
Post by: Clycos on April 07, 2013, 06:40:26 PM
Hey daveman, thanks for your reply.

About tyrosine, I think its an excellent supplement as it is good for dopamine deficiency. What I really think is that we are not necessarily dopamine deficient however having a little extra dopamine while sick from POIS would make us feel a little better since a lot of good benefits come with dopamine such as lack of concentration, motivation, feeling good, energy, etc. Therefore as for tyrosine, I would say it doesnt really treat POIS but it does help alleviate some of the bad symtoms we experience from POIS.

Title: Re: Niacin poll
Post by: Clycos on April 08, 2013, 12:39:27 AM
Hey guys please read!: I strongly believe that POIS is an autoimmune response like Dr. Waldinger believes and that what we experience as cognitive symptoms that is BRAIN INFLAMMATION!

Our symptoms are IDENTICAL to gluten allergy!

I came accross this article about brain inflamation and how it can be reduced feel free to tell me what you guys think!
I have not tried any of these methods but I am strongly considering it.

Here is the link:

http://brain-dr.com/taming-brain-inflammation/
Title: Re: Niacin poll
Post by: vonstermommy on April 08, 2013, 10:48:00 PM
Hi Dave,

Fortunately my husband keeps a log of what he takes and the symptoms.  He states:

4am 300mg No Flush
noon - 200mg mild flush
8:30PM 300mg Strong Flush
9:00 2 Benadryl
10:00  Tylenol PM
There is always some light eating of fasting before taking Niacin. No Taurine this time.

Nausea, Brain Fog, Feeling Hot, Itchy Eyes, Soft Stool relieved!
Headache remained - 8 pain pills the day after, then 6, then 4...

Because we have sex so little - it was quite painful on this end - so that is why we have not tried the 2 Os within a couple days of each other.

How do we let other know to try Niacin?  Maybe it should be its own topic on the homepage. It is worth a try!
Title: Re: Niacin poll
Post by: Daveman on April 09, 2013, 06:42:31 AM
Hi Dave,

Fortunately my husband keeps a log of what he takes and the symptoms.  He states:

4am 300mg No Flush
noon - 200mg mild flush
8:30PM 300mg Strong Flush
9:00 2 Benadryl
10:00  Tylenol PM
There is always some light eating of fasting before taking Niacin. No Taurine this time.

Nausea, Brain Fog, Feeling Hot, Itchy Eyes, Soft Stool relieved!
Headache remained - 8 pain pills the day after, then 6, then 4...

Because we have sex so little - it was quite painful on this end - so that is why we have not tried the 2 Os within a couple days of each other.

How do we let other know to try Niacin?  Maybe it should be its own topic on the homepage. It is worth a try!


That's a lot of niacin.... but if it works!

Is that what he takes ONLY on days of sex? Or does he take that daily.

If I took 300mg in the morning I'd ignite the bed I'd flush so hard. Intersting how the flush build throughout the day, as though the niacin was accumulating.

My suggestion is that he reduce the amount of niacin to see if he can get away with less. It would be better in the long run.
Focus on a good flush an hour prior to sex.

For me at least, that gives me almost complete relief. More niacin isnĀ“t neccesary. But then it seems I react differently.

And yes, I've wanted to organize the niacin information! I'll see what I can do.

Title: Re: Niacin poll
Post by: vonstermommy on April 09, 2013, 12:47:42 PM

Is that what he takes ONLY on days of sex? Or does he take that daily.

---------------------------------------------------

He only takes it the day of and/or day before.  Yes, getting on the lowest dosage would be best!  Good advice.
Title: Re: Niacin poll
Post by: Vincent M on April 09, 2013, 12:56:41 PM
vonstermommy, tylenol pm is just tylenol mixed with benadryl. It'd probably be cheaper to buy the generic versions of both(diphenhydramine and acetaminophen).
Title: Re: Niacin poll
Post by: vonstermommy on April 09, 2013, 01:07:11 PM
Thank you Vincent.  I will do just that as we want him to have a good sleep (part of his proven healing of POIS) but dont want him to oversose on Benedryl!
Title: Re: Niacin poll
Post by: Chris on April 09, 2013, 05:34:17 PM
Careful with the niacin doses as 100mg is the 625 % daily amount that a human needs..It may damage the liver or cause some adverse symptoms..Taking 300mg or 400mg a day is approximately 2000% of daily need..I think thats a lot..
Title: Re: Niacin poll
Post by: vonstermommy on April 09, 2013, 06:44:27 PM
Careful with the niacin doses as 100mg is the 625 % daily amount that a human needs..It may damage the liver or cause some adverse symptoms..Taking 300mg or 400mg a day is approximately 2000% of daily need..I think thats a lot..

---------------------


That is huge - Ill tell him right away.  I dont know how to reply to you using your quote (Chris)
Title: Re: Niacin poll
Post by: Chris on April 10, 2013, 03:23:49 AM
Careful with the niacin doses as 100mg is the 625 % daily amount that a human needs..It may damage the liver or cause some adverse symptoms..Taking 300mg or 400mg a day is approximately 2000% of daily need..I think thats a lot..

---------------------


That is huge - Ill tell him right away.  I dont know how to reply to you using your quote (Chris)

You just press quote above,post the message and i 'll be sent a notification..Most people from this forum take bigger doses cause their body has get used to it and need more in order to have a flush.There is also the case that if you dont seal and protect the content good enough then it gets weaken as other members on this forum refer and you 'll have to take more in order to have the flush..If your husband has a flush with 100mg then he is fine and shouldn't take more..But if he needs 300mg or more in order to have the flush then gradually this big doses will cause him problems..Not only in the liver but in the brain nerves as well as i have read cause B complex vitamins are all associated with the brain and the nervous system..I suggest slowing down..He could stop taking niacin for a few days and then start again with smaller doses.
Title: Re: Niacin poll
Post by: Daveman on April 10, 2013, 01:16:13 PM
Careful with the niacin doses as 100mg is the 625 % daily amount that a human needs..It may damage the liver or cause some adverse symptoms..Taking 300mg or 400mg a day is approximately 2000% of daily need..I think thats a lot..

---------------------


That is huge - Ill tell him right away.  I dont know how to reply to you using your quote (Chris)

Not to minimize the potential for problems, but at least to put it more into context:

For a normal person, the MDR is only 16.5mg. It is a Minimum Daily requirement, not maximum daily requirement.

Most studies indicate that liver damage is not a real threat under 1000mg per day. After that they suggest that
one should have regular liver exams.

We suggest that anyone taking niacin for POIS should have liver tests done maybe twice or more a year anyway.

One should always take their own situation into account. We have had some with niacin allergies, and cannot
take ANY niacin. In some situations it can be dangerous. The doctors would know.

That said, most doctors would probably point blank, without really understanding the mechanisms say, "Why should
you exceed the MDR?", and may suggest not taking it without really taking your case into full consideration.

We suggest not taking more than required, trying to find a minimum dose that gives you optimum relief and have a
regular checkup to make sure everythings fine.

I've been taking niacin now for at least a year (as required... always trying to keep doses as close to the 100mg
as I can), and have had no ill effects to the liver, which I check twice a year, or skin or any other functions of
my body. Others have taken it for POIS for 3 or 4 years with no adverse effects. A few have taken it once with
scary problems, so take it responsibly.

Title: Re: Niacin poll
Post by: David Vee on April 13, 2013, 05:52:06 AM
I too am inclined to believe I have POIS. After a year of experiencing most of the symptoms and a dramatic negative change in the overall quality of life I started searching for diagnose. While my annual physical with the standard associated tests indicated a clean bill of health I was left with a disturbing reality. I am suspect many of you will relate. You know... "You say I'm healthy, but I don't feel healthy." My uncertainty was compounded by dismissing my lethargy to age (will turn 65 in a few months) and some of the meds I am taking for cardiomyopathy. It was only after my researching that I connected my malaise and other symptoms to post orgasm.
 
Perhaps I should add I am very physically active and work part time as a Nordic ski and Mountain bike coach. Consequently a good energy level is critical for my lifestyle.

While I do have some erectile dysfunction given my age, my libido is still strong. I am married and let's just say my reluctance to experience POIS symptoms has significantly affected my "night life".

I have subsequently experimented with abstinence (both masturbation and intercourse) for 1 week, 2 week and recently a 3 week interval. While the longer interval seemed to mitigate the symptoms, I still felt pretty lousy for 48 hours afterwards and would feel progressively better as time went on.

I now want to try the niacin treatment since, at first glance anyway, to be a conservative approach with little risk. While I have read the different protocols for taking the niacin in terms of dosage and times I would be grateful if someone felt comfortable in letting me know specifically what might be a good starting point for me.

Thanking all respondents in advance I shall remain hopeful for both a positive outcome and contributing some relevant info from my  experiences.

Respectfully,

David Vee
Title: Re: Niacin poll
Post by: Vincent M on April 13, 2013, 10:45:44 AM
David, a good starting point is 100mg on an empty stomach(6-10 hour fast). Make sure the bottle doesn't say "slow-release" or "no-flush" or "niacinamide". It should just say niacin and might say nicotinic acid, which is what you want.
Title: Re: Niacin poll
Post by: Daveman on June 01, 2013, 06:33:12 PM
Hi Dave, Dave here!

You probably already know, that the flush is important. This means niacin nicacin. Not delayed release or non-flush formulas. Some have said that niacinamid works wel,, which is no.flush, but if we are talking "starting point", start with regular niacin first.

To achieve the flush, an empty stomach is necessary. 4 to 6 hrs. of fasting. THe difference between 4 hrs and 6 hrs is great. With 6 hrs or more you shouldn't need more than about 100mg. With 4 hrs, you may need up to 400mg.

Personally, I have better results after 4 hrs of fasting and taking larger amounts of niacin.

I use capsules (Nature's Way). They offer greater freedom in dosing. Open them up and take what you want. 123 mg if you want.

The powder under the tongue also enters the system more quickly. I take the first dosage, 100 or 200 depending on the amount of previous fasting,
and then take increments under the tongue at 5 to 10 minute intervals until the flush starts to happen.

I am 64 y/o. We are very similar in that respect. niacin has changed my life.

Good luck.

Title: Re: Niacin poll
Post by: erik on August 17, 2013, 03:02:07 PM
After 25 years of trying almost everything with different but no everlasting results I tried Niacin 100 mg last Thursday night,
I hesitated for some time because of the flush, and the possible damage to the liver.
The flush was indeed scary and intense,
but it was worth the result.
Normally next day after orgasm I?m very depressive, tired , moody, no concentration, avoid social interactions etc.
But WOW, now I even felt better than I can remember for a long time.
I know from all the other stuff I tried this can only be a temporary result,
but with all the other stuff I always had side effects and now none. !

I am very curious about how this is working, is there any information about this ?

Thanks for this forum , and thanks to Daveman for this great discovery.
Title: Re: Niacin poll
Post by: Daveman on August 18, 2013, 06:58:18 AM
After 25 years of trying almost everything with different but no everlasting results I tried Niacin 100 mg last Thursday night,
I hesitated for some time because of the flush, and the possible damage to the liver.
The flush was indeed scary and intense,
but it was worth the result.
Normally next day after orgasm I?m very depressive, tired , moody, no concentration, avoid social interactions etc.
But WOW, now I even felt better than I can remember for a long time.
I know from all the other stuff I tried this can only be a temporary result,
but with all the other stuff I always had side effects and now none. !

I am very curious about how this is working, is there any information about this ?

Thanks for this forum , and thanks to Daveman for this great discovery.


I expected niacin to be temprary too, but I'm near two years now, and after tweaking the process, it's better than ever.

We always said the the flush is very importatnt, and to some extent it is...

I have found that if you eat light food before (like a small sandwich 1 hr before taking the niacin), you may need more niacin, and you may not hardly feel the flush, but it seems that taking a little more (300 say, buffered by that bit of food), the flush is quite small but the effects are much better.

NEVER take 300 in one dose, you never know if you'll react strongly or not. If I know I have eaten a fair bit, i MAY take 200 for the first dose. then after the initial 15/20 min take increments  in 50mg evey 10 minutes until I get flush or reach 400 (MAX). This way POIS (for me) is practially zero.

If you take 300 on an empty stomach, the flush is VERY strong, and it really doesn't work as well for some reason. So if you are going to take smaller doses on an empty stomach, then a medium flush is best, and let the flush pass (30 to 40 min) after peak, before "digging in".

Title: Re: Niacin poll
Post by: b_jim on August 21, 2013, 08:56:21 AM
And what happen if you takes 10 x 30mg of niacine (30 mg each hour), no flush then ?
Is it as effective without flush?
Title: Re: Niacin poll
Post by: Daveman on August 21, 2013, 01:23:02 PM
And what happen if you takes 10 x 30mg of niacine (30 mg each hour), no flush then ?
Is it as effective without flush?

It's only effective in your body for about 2 hrs. So after the first 2 hrs, the original 30mg would be almost gone.

So I don't know, it might work 30mg every 12 min.

Usually what I do is take some initial dose, that I know to be safe... 100mg on an empty stomach or 200 after eating a bit.

Then I take about 50mg under the tongue every 10 minutes. Under the tongue, the effect is felt within those 10 minutes. So if you take one "hit" of 50mg and nothing happens after 10 min, it's safe to take another 50mg.

I've never gone over 400mg total. and at times, haven't even gotten the flush (if the fast was short). But it seems that if you've taken 400mg, it doesn't seem to matter if you get the flush or not, and as a matter of fact, the effect is often better.

Of course if you have just finished a pork rib barbeque with wine and beer, it won't matter how much niacin you take, no flush NOR any reduction of POIS, so it's a balance.

It doesn't take much food to kill the flush, so too much and it kills the effect too.

I usually find that the best is when you take around 300 to 400 of niacin and just barely get the flush. That gives me about 95% to 100% relief.
Taking 100mg on completely empty stomach and strong flush gives me about 85% relief.

I know you are afraid of the flush. If you take it easy, it's really not all that bad, and WELL worth it.


Title: Re: Niacin poll
Post by: MrVat7 on December 20, 2013, 03:34:54 PM
I feel better with Niacin, notice some degree of Cognitive impairment though, Flu seems to have completely gone. Feel warm after niacin.
Title: NowFoods Sustained Release 1g (2 caps) Niacin flush reduced POIS by 80%
Post by: Journey on July 14, 2021, 08:09:08 AM
Yesterday I took in middle of day 2 caps of 500mg (1g in total) NowFoods sustained-release Niacin flush and had an orgasm in the evening around 7-8 hours later (probably had I done it earlier it would be even more noticeable, will try next time to orgasm 1-2 hours after taking it)

ZERO muscle/diapraghmal tightness/weird nausea/bloating/appetite issues in gut, brain fog, and voice weakness was slightly present in morning now today but towards afternoon it reduced

Overall Niacin flush seems to target something, I didn't get the flush visibly as it's sustained release

Also seems like putting something similar to cock ring and such and trapping a bit more blood in the penis results in a more "proper orgasm/ejaculation" giving less POIS as well, stimulation with hand alone seems to not result in fully "proper erection" leading to suboptimal orgasm/ejaculation which releases imbalanced neurochemicals leading to POIS

ALSO my stool was a lot more solid, very little looseness this morning despite bad sleep/stress yesterday - usually bad sleep+stress makes my stools extremely loose and wrecks my digestion but Niacin flush has improved my digestion greatly it seems

AND I do not have that pose-peeing dribble "not fully cleaned out bladder" feeling that I usually have, as if there is more pee left - so maybe Niacin interacts with noradrenaline and some organ systems
Title: Re: NowFoods Sustained Release 1g (2 caps) Niacin flush reduced POIS by 80%
Post by: cn7 on July 14, 2021, 02:56:09 PM
Good for you! Too bad niacin makes me feel weird ...  :(