Post Orgasmic Illness Syndrome (P.O.I.S.)

General Category => Poll Center => Topic started by: b_jim on June 03, 2011, 04:08:23 AM

Title: Premature ejaculation
Post by: b_jim on June 03, 2011, 04:08:23 AM
I wanted to create it long time ago but I only remember today.
Title: Re: Premature ejaculation
Post by: Daveman on June 03, 2011, 09:58:00 AM
I put "normal", but it's more like "sometimes".

If I would put 100 events on a statistical curve, the curve would probably peak on slightly better than normal (40%), but with a range that varies from severe to not at all (P<2%).

Title: Re: Premature ejaculation
Post by: Starsky on June 03, 2011, 12:37:11 PM
How quick is Premature Ejakulation? 2 minutes? Davemen did you have that problem before POIS?
Title: Re: Premature ejaculation
Post by: Willem on June 03, 2011, 01:02:49 PM
I don't know about you guys, but for me, this is all a question of frequency.  When I was first married this wasn't an issue at all, and those times that I have an O too often it's also not an issue.  What do you guys think?  Is there some other correlation besides just having to hold off for so long? 
Title: Re: Premature ejaculation
Post by: Daveman on June 03, 2011, 01:30:22 PM
How quick is Premature Ejakulation? 2 minutes? Davemen did you have that problem before POIS?

No problem whatsoever before. I was even proud of my longevity!!

2 minutes inside would be pretty good I think, maybe my average. Sometimes I can go 5 to 7, sometimes barely scratch the surface!!

Strangely, when I tend to be most sensitive, I can't hardly even get it up, yet just about anything will set it off.

If I'm really "hot" and "hard" (excuse the graphic nature), I will usually last longer.

Weird huh?

Title: Re: Premature ejaculation
Post by: Daveman on June 03, 2011, 01:36:38 PM
I don't know about you guys, but for me, this is all a question of frequency.  When I was first married this wasn't an issue at all, and those times that I have an O too often it's also not an issue.  What do you guys think?  Is there some other correlation besides just having to hold off for so long? 

I've thought the same..... I think it has to have something to do with it.

I imagine if I was doing it every other day, it would be a different story.

There are things like in my last post here though that make me feel as though there is someting else involved too.... but can't really put my finger on it. (else it goes of heh, heh)

Title: Re: Premature ejaculation
Post by: Vandemolen on June 03, 2011, 06:11:31 PM
I am happy that I don't have PE. It must be hard for the guys who have PE.

I think there is a link between abstinence and PE. I also read it in an article about POIS.
Title: Re: Premature ejaculation
Post by: Daveman on July 20, 2011, 08:41:20 AM
Strange, isn't it, since PE is a particular interest of his!
Title: Re: Premature ejaculation
Post by: omen on July 20, 2011, 06:24:02 PM
I am happy that I don't have PE. It must be hard for the guys who have PE.

I think there is a link between abstinence and PE. I also read it in an article about POIS.
yeah cause when i am absistence from an O for a long time i tend to PE but if i have an O regularly then there is no PE....
Title: Re: Premature ejaculation
Post by: MrMoonJr on September 15, 2011, 01:13:14 PM
I have severe PE. It is hard, really it is. Im not sure how niacin will effect this... Now. Is it possible PE is caused by my subconcious anxiety over POIS? it would be something interesting to looking into... I may experiment with this to see if i Can discover something more about my PE and PE in general
Title: Re: Premature ejaculation
Post by: Daveman on September 15, 2011, 02:47:29 PM
I have severe PE. It is hard, really it is. Im not sure how niacin will effect this... Now. Is it possible PE is caused by my subconcious anxiety over POIS? it would be something interesting to looking into... I may experiment with this to see if i Can discover something more about my PE and PE in general

Yes, I think it has a lot to do with anxiety. There are a lot of factors.

Maybe the most important is that we don't have as much sex as we could. Before I had POIS, when I was about 35, my personal prime, I had three girlfriends at a time and usually had sex with them all regularly. So it wouldn't be unusual to be "doing it" A LOT. On weekends, I could hardly keep up. But when i was doing it a lot, I never had problems with PE, almost the opposite. It got sore from trying and trying, not able to have the orgasm. I guess they liked it!

But when you do it once every two weeks, just "getting it to the surface" is enough to set you off. Sometimes you are so worried about POIS that you can;t even get it up, but even then, the slightest stimulation and POW. Believe me, you don't need an erection to have an orgasm.

Somehow with masturbation there is less PE. I think that has to do with the less intimate character, les stimulation and less "responsibility".

The stress of responsibility seems to work against us, especially if we are "hot".

Sometimes, before POIS, if I wanted to be sure I could last for a new hottie, I'd masturbate beforehand, so that I could last longer. We can't do that now.  We'd be so POISed out afterwards!!

Title: Re: Premature ejaculation
Post by: Observer on September 17, 2011, 09:53:52 AM
I have found that garlic helps against PE.

My case is rare, because there are times that i control effectively the impulse of eyaculating and there are times that i just can´t. I remember that after 20 days without any ejaculation i was able to have sexual intercourse and not orgasm, and some days i don´t last enough.

Be relaxed, not tired, not eat heavy food, take garlic... are the best tips i could suggest. It seems that the niacin is helping too, but if i have an orgasm every day, that would take a toll on the quality of sexual intercourse the following days(erections, PE). I realized that it is better to have some day of rest following 3-4-5 days of daily intercourse to not have PE, because i have the feeling of being somewhat "sexually exhausted"(I feel great, but i just don´t want to have sex or masturbate). Maybe this is because i have never get used to have an O. so repeatedly. I am going to rest more than a week and i will report later with my next experiences.
Title: Re: Premature ejaculation
Post by: b_jim on September 20, 2011, 11:25:54 AM
If garlic help you I'm ok to test it but I'm sceptic  :) Why not.
Title: Re: Premature ejaculation
Post by: FloppyBanana on July 26, 2012, 12:42:53 PM
I know this is a pios from but I think this relevant, it has been of use for me. There are some delay creams out and some are fake however; there is one Chinese balm called Pau Yuen Tong. This helped because I could have a goos sex session without shooting the gun. Gun sometimes fired by mistake thuo. this is more likely to happen if I have not had sex for a month.
Title: Re: Premature ejaculation
Post by: slugishdragonn on January 22, 2014, 04:09:57 PM

well if you guys are still interested on the PE topic.
From my research, what I understand is following:
1. The allergen in the semen, causes the Mast cells to release histamine.
2. This histamine builds up over time in our body causing inflammations. I have gingivitis, sinusitis, UTI, Acne and nerves.
3. Histamine is also responsible for vasodilation of capillaries.
4. Histamine quickens ejaculation/reach orgasm. Some doctors prescribe histidile tablets to women who cant reach orgasm.
5. People with low histamine have difficulty reaching orgasm.

If that is true, than most likey people who have Positive skin prick test, must be experiencing PE.
For myself, I have positive and PE.. 5-10 strokes in and am set off :(

Any thoughts on this ?

Cheers,
slugishdragon

Title: Re: Premature ejaculation
Post by: b_jim on January 23, 2014, 07:43:06 AM
Yes, that's a good hypothesis.
Title: Re: Premature ejaculation
Post by: slugishdragonn on January 23, 2014, 04:50:50 PM

Further, we are most probably Histadials - Body with higher side of the regular histamine levels.
Do a research on this topic, it is pretty interesting.

MTFHR:
There are some people with Gene mutation (MTFHR, if am not wrong) who have problem with Histamine synthesis, because they cannot express Methyn, which is essential for synthesis of Histamine through the process called Methylation.

Under methylers
People with high histamine are ambitious, achievers, pushers, successful.. that explains why most of us are engineers and researchers :P

Anti histamines like citrizine blocks the H1 receptions, might be to an extent H2, out of (H1, H2, H3, H4 Receptors), but the histamine in body remains, and needs to be synthesized into something (Himocysteins) and excreted gradually. And only with Methyn could we synthesize histamine in brain... Anti-histamines either ways dont cross the blood brain barriers.

Recovery time:
I suspect the time we take to recover from the POIS (1-15 days roughly speaking), is directly proportional to Histamine released due to allergic reaction by the Mast cells, and inversely proportional to the Methylation ability of the person..

To test this hypothesis, I have started taking Methonine - 500 mg, Magnesium - 400 mg (Magnesium, Zince are essential in the Methylation process) to get rid of the excess Histamine in me. I might also start taking Vitamin B3 and B6 to prevent building excess Himocystines (which cause several cardiac diseases etc).

If I could delay my ejaculation in any measure or better see some improvements with Gingivitis/UTI/Acne , this hypothesis will be proved right ;)


Cheers,
slugishdragon
Title: Re: Premature ejaculation
Post by: Stef on January 24, 2014, 06:09:50 PM

Further, we are most probably Histadials - Body with higher side of the regular histamine levels.
Do a research on this topic, it is pretty interesting.

MTFHR:
There are some people with Gene mutation (MTFHR, if am not wrong) who have problem with Histamine synthesis, because they cannot express Methyn, which is essential for synthesis of Histamine through the process called Methylation.

Under methylers
People with high histamine are ambitious, achievers, pushers, successful.. that explains why most of us are engineers and researchers :P

Anti histamines like citrizine blocks the H1 receptions, might be to an extent H2, out of (H1, H2, H3, H4 Receptors), but the histamine in body remains, and needs to be synthesized into something (Himocysteins) and excreted gradually. And only with Methyn could we synthesize histamine in brain... Anti-histamines either ways dont cross the blood brain barriers.

Recovery time:
I suspect the time we take to recover from the POIS (1-15 days roughly speaking), is directly proportional to Histamine released due to allergic reaction by the Mast cells, and inversely proportional to the Methylation ability of the person..

To test this hypothesis, I have started taking Methonine - 500 mg, Magnesium - 400 mg (Magnesium, Zince are essential in the Methylation process) to get rid of the excess Histamine in me. I might also start taking Vitamin B3 and B6 to prevent building excess Himocystines (which cause several cardiac diseases etc).

If I could delay my ejaculation in any measure or better see some improvements with Gingivitis/UTI/Acne , this hypothesis will be proved right ;)


Cheers,
slugishdragon

Slugishdragonn,

How were you tested for excess histamine -- what lab tests were performed?

Stef

Title: Re: Premature ejaculation
Post by: FloppyBanana on January 25, 2014, 05:19:37 AM
... Anti-histamines either ways dont cross the blood brain barriers.
Hi Slugishdragonn,
This is not true. Some antihistamines cross the brain barrier and some do not. Some antihistamines which people use for POiS do cross the brain barrier.
FB
Title: Re: Premature ejaculation
Post by: slugishdragonn on February 28, 2014, 02:35:51 PM
@Stef
I havent tested histamine levels in my blood. The various inflammations (sinus, nerves, Gingivitis, UTI) goes to show that.
They worsen soon after ejaculation. I cant think of anything else which causes inflammations. In addition, antihistamines, quercetin seems to help a lot.

In my latest research, I tried taking Calcium (400mg). Calcium is supposed to release(eventually to excrete out of body) Histamine from the mast-cells into Blood.
And I could say that after 3-4 hours of taking calcium my Gingivitis gets bad, untill I take Methionine and Magnesium. BTW Magnesium (helps in mythlation) helps me a lot.


BTW, my doctor has prescribed me Mast-Cell Stabilisator Allegroval (Cromoglicic acid). 200mg 2 times a day.
Am taking this since a month, I feel very good. But not sure, if its this Mast-cell Stabilisator or my 4 times/per week Fitness studio + Magnesium supplements doing the trick :(
I will take the medicine another one month and report to the doctor. And a couple of weeks before that, stop taking any Magnesium and Neem (Quercitin) supplements.

I know am messing up with too many things (Neem, Mast-cell stabilisator, Work out, Magnesium, Zinc, Calcium supplements)
But hey I was diagnosed positive with POIS just a month ago after 15 years of suffering!! I am excited, happy, sad, impatient, stronger, hopeful, nervous all at once.

Title: Re: Premature ejaculation
Post by: Starsky on March 07, 2014, 03:43:54 PM
Check your copper levels. Most of POISers have low ceruloplasmin which is bioavaliable copper. Low copper=high histamine.  I am working to have more bioavailable copper and so far i have good results.

My ceruloplasmin levels were 0,13 Range 0,20-0,60.

I reached now 0,21.

I did not take copper. It seems that i had copper stored in tissues which is really disturbing on the body.

This is the histamine metabolism. You need copper to produce DAO. If you have good amounts of copper and still high histamine than its a methylation issue. But please check your copper in blood.

(https://ainotes.wikispaces.com/file/view/histamine_metabolism.png/204439802/720x315/histamine_metabolism.png)
Title: Re: Premature ejaculation
Post by: Stef on March 07, 2014, 10:13:22 PM
Hi, Slugishdragonn (and everyone else!),

It's great to hear that you're feeling better on your current regimen. POIS is such a miserable, awful condition. When something actually helps -- it's like a miracle has occurred! I don't say that lightly.

As you stated, you're doing several different things to find some relief -- neem (an herb -- I'm not clear about what it does), regular exercise, magnesium supplements, cromoglicic acid ("cromylyn" in the US --  an over-the-counter mast cell inhibitor that is used to treat allergies and asthma).

It could be that the combination of therapies -- or even just one -- is helping you. There's no way to know what's providing the relief.

The most important thing is that you're being followed by your physician...this can't be emphasized enough!!

We're all wishing you the best of luck!

As an aside, Starsky -- there's no research or documentation, anywhere, reflecting that men with POIS have low ceruloplasmin levels.  This is a theory that some forum members subscribe to -- but it is not fact. It might be worthy of formal scientific research at some point.

Stef   




Title: Re: Premature ejaculation
Post by: b_jim on March 10, 2014, 05:20:38 AM

My ceruloplasmin levels were 0,13 Range 0,20-0,60.

I reached now 0,21.



Does it really improve your pois symptoms ?
Title: Re: Premature ejaculation
Post by: slugishdragonn on March 10, 2014, 01:07:22 PM
Hi all,
thanks for your replies.

My entire regime seems to help just accelerate the Histamine excretion.
However, I still do feel POIS symptoms after Orgasm. I suspect the Auto Immune reaction still exist, whenever I ejaculate the body histamine level increases and after taking Magnesium, Methionine, Neem, Calcium, Vitamin C the Histamine level comes down waiting for the Orgasm to start it all over again !

By the way, I also feel pain in my Hands and Legs during sex (Even before ejaculation... when my Penis is erect and I get pleasure vibes).
I could imagine it to be my prostate, which is inflammed (due to exposure of semen all this long), and on erection/ejaculation, it is squeezed/tensed whatever, and the pain trickles all through the limbs.

Do you guys experience the same pain ?
I also have pain in mild pain in my lower back on the day of Orgasm.

Your expereinces/views are higly appreciated.

Thanks in advance.
slugishdragonn
Title: Re: Premature ejaculation
Post by: berlin1984 on May 24, 2020, 01:51:53 PM
Cross posting:

Premature ejaculation seems to be very common in the 'nofap' community, so it might be a general body (mal)adaption and not related exclusively to POIS.

Taking Tryptophan, 5HTP or Slow-Release 5HTP can help some people with premature ejaculation. It's also a side effect of SSRIs (anti depressants).

I've also seen that the above amino acids can help a bit with slow transit contipation (https://poiscenter.com/forums/index.php?topic=3293.0).
Title: Re: Premature ejaculation
Post by: berlin1984 on June 07, 2020, 10:20:05 AM
See also this thread:

* During an orgasm, histamine is released, and has been connected to the sex flush among women. However, men with high histamine levels may suffer from premature ejaculations.

And this one:
...
My thought: Person consumes too much histamine via food and also histamine liberators. Has problems with DAO (histamine intolerance (https://poiscenter.com/forums/index.php?topic=2061.0)). Has leaky gut (https://poiscenter.com/forums/index.php?topic=3098.0), making histamine passing through to bloodstream. Then: Histamine is released at orgasm. Virus is somehow re-activating and does it's thing, maybe involving more histamine.
All this histamine overload leads to problems.
...
Title: Re: Premature ejaculation
Post by: Muon on August 02, 2020, 10:19:39 AM
See also this thread:

* During an orgasm, histamine is released, and has been connected to the sex flush among women. However, men with high histamine levels may suffer from premature ejaculations.

Glans Penis Augmentation Using Hyaluronic Acid Gel for the Treatment of Premature Ejaculation (https://www.jsm.jsexmed.org/article/S1743-6095(20)30393-3/abstract)

Guess what, HA inhibits histamine (from mast cells)
https://sci-hub.se/https://www.sciencedirect.com/science/article/pii/S0161589008000151

Mast cell mediated premature ejaculation?

Association of NE, leptin, and 5‐HT with electrophysiological parameters in patients with primary premature ejaculation (https://poiscenter.com/forums/index.php?topic=139.msg34761#msg34761)
Title: Re: Premature ejaculation
Post by: Iwillbeatthis on February 16, 2021, 02:03:26 PM
When I last had sex a few years ago I had premature ejaculation before penetration even, I was also under the influence of alcohol. The times I've had sex since I devoloped POIS I've had premature ejaculation every time, apart from one time where I wasn't drinking alcohol - this time the first the first O was premature however the second O wasn't.

Before I had POIS my experience was that the more times I had sex the premature ejaculation got better every time which is the case with most men who have PE.

Now I can't tolerate alcohol at all so maybe I won't have PE the next time I have sex.

If you have PE issues cutting out Porn is probably the most helpful thing you can do. Porn is instant gratification which messes up the circuits in your brain causing PE.
Title: Re: Premature ejaculation
Post by: Cursed on February 17, 2021, 04:45:30 PM
How quick is Premature Ejakulation? 2 minutes? Davemen did you have that problem before POIS?

Strangely, when I tend to be most sensitive, I can't hardly even get it up, yet just about anything will set it off.

If I'm really "hot" and "hard" (excuse the graphic nature), I will usually last longer.

Weird huh?

I feel exactly the same. In fact, it's very strange that sometimes I feel that I just need to masturbate because I have this feeling of stimulation, even though I have no erection unless I actually start masturbating and then I would finish very quick. Also, this isn't really real horniness, I think it's more similar to what's called restless genital syndrome or something like that. I get this often the next day after ejaculation. Then it goes away.

At leaat for me, it is all depends very much on what I eat and how my GI tract is doing, but I haven't found anything that really works. I'm playing around with fecal transplants, hoping to fix the microbiome.

To add: these symptoms got better after I began using taurine, b2, b6, TMG, zinc,selenium and occasionally some methylfolate.
Title: Re: Premature ejaculation
Post by: VSmasher on July 15, 2021, 05:45:52 PM

well if you guys are still interested on the PE topic.
From my research, what I understand is following:
1. The allergen in the semen, causes the Mast cells to release histamine.
2. This histamine builds up over time in our body causing inflammations. I have gingivitis, sinusitis, UTI, Acne and nerves.
3. Histamine is also responsible for vasodilation of capillaries.
4. Histamine quickens ejaculation/reach orgasm. Some doctors prescribe histidile tablets to women who cant reach orgasm.
5. People with low histamine have difficulty reaching orgasm.

If that is true, than most likey people who have Positive skin prick test, must be experiencing PE.
For myself, I have positive and PE.. 5-10 strokes in and am set off :(

Any thoughts on this ?

Cheers,
slugishdragon

You can have high histamine WITHOUT having an allergic reaction. Histamine is used in your body for a ton of natural daily reactions. For instance, your body histamine increases in the morning to wake you up. (I think that's why I cum so quick with morning sex). Also, you don't need mast cells to release histamine. Your brain makes histamine inside the CNS as it acts as a neurotransmitter. You can have no mast cell release of histamine, and still have high brain histamine. I agree 100% that brain histamine may be our problem though.
Title: Re: Premature ejaculation
Post by: VSmasher on July 16, 2021, 02:14:42 PM

well if you guys are still interested on the PE topic.
From my research, what I understand is following:
1. The allergen in the semen, causes the Mast cells to release histamine.
2. This histamine builds up over time in our body causing inflammations. I have gingivitis, sinusitis, UTI, Acne and nerves.
3. Histamine is also responsible for vasodilation of capillaries.
4. Histamine quickens ejaculation/reach orgasm. Some doctors prescribe histidile tablets to women who cant reach orgasm.
5. People with low histamine have difficulty reaching orgasm.

If that is true, than most likey people who have Positive skin prick test, must be experiencing PE.
For myself, I have positive and PE.. 5-10 strokes in and am set off :(

Any thoughts on this ?

Cheers,
slugishdragon

Also, Opioids like oxycotin stop me from having an orgasm. Opioids release tons of histamine. Maybe our histamine is to low..?
Title: Re: Premature ejaculation
Post by: Muon on July 20, 2021, 06:52:12 AM
Note that a couple of women here with POIS suffer from premature orgasm.