Post Orgasmic Illness Syndrome (P.O.I.S.)

POIS Cause/Treatment Discussions => Hormonal Causes and Treatments => Topic started by: Vandemolen on May 18, 2011, 05:07:02 PM

Title: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: Vandemolen on May 18, 2011, 05:07:02 PM
Did someone of you used Roaccutane/Accutane against acne? It also know as Isotretinoin? I had that 10 years ago against acne. It is a very heavy medicine and doctors warned me. But I asked and asked for it, because it was the only medicine which could get the acne get away. It is bad for the liver. It could be that my hormones were messed up by this medicine and caused POIS.
Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: nyan on May 18, 2011, 07:08:50 PM
No.
Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: hurray on May 19, 2011, 08:18:58 AM
Not me. Although I enjoy drinking alcohol and was drinking heavily around the time when POIS started to happen. So there could be some kind of link to liver damage and POIS.
Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: bruxe on May 19, 2011, 03:51:16 PM
not me
Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: Ccconfucius on May 19, 2011, 09:06:50 PM
Not me. Although I enjoy drinking alcohol and was drinking heavily around the time when POIS started to happen. So there could be some kind of link to liver damage and POIS.
me too started having pois in college when i started drinking. but my roommate drinks every day, lots and lots but dosent have pois so i never thought that has anything to do with it.

never used accutane.
Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: Hoping on May 21, 2011, 03:08:46 PM
Did someone of you used Roaccutane/Accutane against acne? It also know as Isotretinoin? I had that 10 years ago against acne. It is a very heavy medicine and doctors warned me. But I asked and asked for it, because it was the only medicine which could get the acne get away. It is bad for the liver. It could be that my hormones were messed up by this medicine and caused POIS.

I used accutane for a year or so in high school. i was also wondering if there might be some connection to POIS.
Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: Vandemolen on May 22, 2011, 05:04:30 AM
There are a few others on TNC forum who used it. In MY OPINION our immune system is messed up. And for some of us Accutane is the reason.
Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: fidalgo on June 20, 2012, 08:27:38 AM
I used Roaccutane and, for some reason, I always think that my have some relations with POIS. But I used Roaccutane when I was 14-15 years old and my POIS started when I was 20.
Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: Nightingale on June 20, 2012, 11:30:07 AM
I'm worried about where this thread is going.  What is the evidence to back up the claim that accutane interferes with the immune system?  Would hope to have seen a discussion about that here.  Just because a lot of people with POIS took accutane (a very common drug to be taking during the years of puberty when you first get semen in your body) doesn't necessarily mean it caused or contributed to it.  If you have evidence for otherwise, then that would be worth posting. Again, I'm worried that the speculation here isn't adding to anything and at worst sending people down the wrong path.

Don't take this as me saying accutane is not the cause of your POIS, I don't know that.  But do you know?  Post evidence please!

I have not used accutane, but I had serious acne as a kid.  
Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: Daveman on June 20, 2012, 02:43:38 PM
Besides, it would seem that there would be a lot more people in the world with POIS if that were true.

Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: fsol on July 10, 2012, 09:44:47 AM
I used it when I was younger as well.
Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: Ccconfucius on July 10, 2012, 02:05:18 PM
never used it.
Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: Going less Crazy on August 06, 2012, 11:45:21 PM
Never used accutane, but did have acne at the time I developed POIS.  I also thought there was some correlation between me drinking coffee and POIS.  But it seems that mostly everyone who drinks coffee doesn't have pois.  Sooo I don't think really that there is a "causative" factor to this disease.

Or maybe something put our body in stress and than POIS came out.
Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: Porke on August 22, 2012, 04:15:21 PM
Yup, I did! I asked about it on the naked scientist forums, but the reactions were mixed. My POIS started about 6-12 months after a heavy course of accutane. My health was also never the same (I now suffer with CFS as well)

Ofcourse its difficult to prove any sort of cause and effect, but I also follow these mega threads about accutane users who suffered alot of health issues after this terrible drug.

http://www.acne.org/messageboard/index.php/topic/295030-repairing-the-long-term-damage-from-accutane/ (http://www.acne.org/messageboard/index.php/topic/295030-repairing-the-long-term-damage-from-accutane/)

http://www.musclechatroom.com/forum/showthread.php?20097-Official-Accutane-Thread (http://www.musclechatroom.com/forum/showthread.php?20097-Official-Accutane-Thread)

There are many pseudo links and testimonials between accutane and it somehow messing with the immune system.

Many people have taken the drug without any adverse side effects, but a portion have suffered long term side effects. Remember, we all have genetic variations, and poison for one person is medicine for another.

Accutane might not be the cause, but could rather be a contributing factor or a triggering mechanism

For me, POIS and CFS are terrible diseases, battling them and living with them are extremely difficult, but the hardest part is that you don't know the cause, and cant see what your fighting. I would give anything to atleast know what was making me ill. CFS and POIS are phantoms.

Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: kurtosis on August 22, 2012, 05:23:31 PM
I took it for a month. It worsened my acne and made me feel awful so I stopped it.
I had POIS before I took it, while taking it and POIS after it. No difference so far as I could tell.
Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: BoneBroth on October 31, 2020, 06:52:48 PM
I also took Roaccutan for acne when I was about 14-16 years old. It seems to be a pure poison.

Reported side effect of Roaccutan:
Kills cells
Dry skin
Severe birth defects
Muscle and joint pain
Headaches
Liver damage
Depression
Elevated blood sugar

Much the same as for POIS! My girlfriend also took it. Her vision got so bad right after so she had to get glasses, never improved since.
Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: mike_sweden on November 03, 2020, 10:01:44 AM
I did use strong acne solution too!!

Maybe we got something very interesting here!!
Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: Journey on November 03, 2020, 10:55:13 AM
I did use strong acne solution too!!

Maybe we got something very interesting here!!
What acne solution you used?
Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: Journey on November 03, 2020, 11:00:29 AM
I personally haven't used any acne stuff all medicines I recall are-antibiotic at ag 7 for stopping near-pneumonia, anti-epileptics since I was a kid till 15 when I took light SSRI for 1 year to transition to a medicine-free state once EEG showed lack of epileptic activity (I had sleeptime cramp seizures shortly after falling asleep as a toddler as confirmed by eeg) that's all medicines I recall ever taken.
Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: Clues on November 06, 2020, 03:30:09 AM
I took Roaccutane in my early twenties, around 20 years ago. Truly evil stuff. I have no idea whether that's when my POIS started, as it's so long ago, but I'm not ruling it out. I certainly did get some severe skin symptoms. Pretty severe inflammation and flaking/shedding skin in the face especially. My dermatologist at the time also gave me a Tetracycline, a heavy antibiotic I believe.
Title: Acne accutane antibiotics
Post by: Hopeoneday on January 14, 2022, 07:06:32 AM
From this angle it seams that peoples who took accutane
could be the couse of theirs pois...

Me, after severe preumona as a teeneger i was treated with
antibiotics, after that i got severe cystic acne wich last for 6
years.. acne was a nightmare for me.. i do not remeber what i did
not taking i thouse time to get rid of acne, but i clearly remeber
that i order and drink  (set medication for acne, wich did conteined
red pils,, i am 100% sure it was accutane )

I noticed that thigs like acne, antibiotics gut problems
are randomly repeates by poisers... that leed to warisos
disorders.. lipids, fat suliable vitamines(eg D), liver problems etc

This man is man is "damaged by accutane" eg antibiotics..
https://inews.co.uk/news/health/roaccutane-acne-drug-poisoned-fitness-fan-228884

https://poiscenter.com/forums
/index.php?topic=107.msg37379#msg37379

https://poiscenter.com/forums/index.php?topic=2081.msg16476#msg16476

https://poiscenter.com/forums/index.php?topic=3713.msg40812#msg40812

https://poiscenter.com/forums/index.php?topic=3799.msg40406#msg40406

https://poiscenter.com/forums/index.php?topic=3799.msg40406#msg40406

https://www.reddit.com/r/POIS/comments/rzonck/woman_with_pois_symptoms/ (a woman probbly damaged
by accutane and antibiotics combo)
Title: Re: Acne accutane antibiotics
Post by: BoneBroth on January 14, 2022, 08:03:57 AM
I also had Acne accutane in my teens (maybe for some months), so did my gf. She dont have POIS now but shares many other synptoms, most distinctly low blood pressure. She also said her vision was harmed directly following the accutane treatment. After that she had to wear glasses and had since. I dont remember if I developed POIS before or after the accutane though, but yeah, it could be a contributing factor.
Title: Re: Acne accutane antibiotics
Post by: Hopeoneday on January 14, 2022, 02:57:26 PM
The size of potential damage form accutane is fascinating.

I now remebered that i losted my hair from it...

Internal organs damaged, panceras, liver, gut, pitury gland
increasing brain pressure, reduced blod flowe...

https://www.healthline.com/health/accutane-side-effects-on-the-body

https://www.medicalnewstoday.com/articles/accutane-side-effects
Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: berlin1984 on January 14, 2022, 03:21:28 PM
I had skin issues and I remember using some topical products that all didn't help so much.
I (or my mother) don't remember if I took any pills or which one it was.

Journey, interested in making a poll on Reddit? Seems that's an easy way to get a lot of replies.
[ ] Yes oral
[ ] Yes topical
[ ] I don't remember if I took it (oral, topical)
[ ] No and I had acne skin issues
[ ] No and I never had acne skin issues
Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: BoneBroth on January 14, 2022, 03:42:44 PM
Perhaps my pancreas took a hit on the accutane, thats why I have symptoms like yellow stools, bloating etcetera. Check out this poll (https://poiscenter.com/forums/index.php?topic=4092.msg43446#msg43446). Accutane is just a syntetic form of Vitamin A that is extremely potent and potential toxic (not to compare with Vitamin A pills you buy at the healthshop with natural betacarotene or retinyl palmitate).
Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: Progecitor on January 14, 2022, 04:49:05 PM
Well, we may have fewer POISers here than we thought. :)
Objective: To investigate clinical reports of post-SSRI sexual dysfunction (PSSD), post-finasteride syndrome (PFS) and enduring sexual dysfunction following isotretinoin.
Serotonin reuptake inhibiting medications, including the selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and the serotonin reuptake inhibiting tricyclic antidepressants, as outlined in their datasheets, almost invariably affect sexual functioning and do so after a first dose. The 5a-reductase inhibitors, finasteride and dutasteride, according to their labels, commonly (5–9%) have acute effects on sexual functioning. Isotretinoin also has acute effects on sexual functioning, but the frequency of this change is unknown and is not mentioned in the medicine’s label.
While PSSD and PFS have been named in the clinical literature, post-retinoid sexual dysfunction (PRSD) has not.
Table 1 Treatments linked to enduring sexual dysfunction
The mean causality scores were 8.9 for serotonin reuptake inhibitors, 8.8 for 5a-reductase inhibitors and 8.5 for isotretinoin.
In many instances the sexual dysfunction only appeared or became significantly worse when treatment was stopped. There were 41 (18.6%) reports for serotonin reuptake inhibitors, 9 (16.7%) for isotretinoin, and 7 (28.0%) for 5a-reductase inhibitors. Three subjects on SSRIs reported an increasing loss of sexual function as the dose was tapered. For all three drug groups there were reports of profound dysfunction appearing within days of stopping. This has similarities to antipsychotic-induced tardive dyskinesia which can appear on treatment and remain afterwards, or only appear when the drug is stopped.
Finasteride and isotretinoin are usually stopped abruptly whereas antidepressants are often tapered over weeks or months due to a withdrawal syndrome. At present, it appears that PSSD is equally likely following abrupt or gradual discontinuation of an SSRI or SNRI.
Seventeen subjects reported having the syndrome for at least 10 years since stopping treatment with isotretinoin (n ?= ?8 ), serotonin reuptake inhibitors (n? = ?8 ) or finasteride (n?=?1). Of these, five subjects reported that it had been over 20 years since stopping isotretinoin (n?=?4) or fluoxetine (n?=?1). Subjects also reported fatigue (9%), muscle weakness (3%), and cognitive problems including brain fog (19%) and memory impairment (11%). These were worse on finasteride. The cognitive symptoms appear to be a meta-cognitive problem in that testing rarely reveals deficits on what are tests of higher order cognitive function. Other drugs such as statins are linked to comparable difficulties.
In cases of enduring dysfunction, finasteride and isotretinoin appear to induce genital effects comparable to those found with serotonin reuptake inhibitors. However, finasteride and isotretinoin do not routinely cause acute onset genital anaesthesia that patients we have questioned are aware of. In this series, the numbness sometimes developed while on finasteride or isotretinoin, and occasionally appears to have done so shortly after commencement, but more often this feature became apparent during later treatment or after stopping the drug.
Pleasureless or weak orgasm is also common to the three treatment groups. This is experienced as a reduction or loss of pleasurable feeling, so that orgasm becomes a set of rhythmic muscle contractions with little accompanying sensation. These muscle contractions can also be weaker than normal, and may be noticed in male subjects as reduced ejaculatory force.
Rodents given fluoxetine were found to have sustained desensitisation of 5-HT1A receptors after removal of the drug. In another study, a 5-HT1A antagonist was shown to reverse and prevent sexual dysfunction in rodents that were being administered with fluoxetine. However, PSSD sufferers through online support forums have tried and reported on the effects of all combinations of medicines acting on serotonin and dopamine systems, and medicines known to enhance function such as sildenafil, but without benefit. The problem is again similar to tardive dyskinesia in this respect, in that counter manipulations of systems on which triggering agents work do not seem to remedy the problem.
It was hypothesised that SSRIs may induce disturbances of transient receptor potential (TRP) ion channels. The serotonin reuptake inhibiting antidepressants all have effects on sodium currents and other ion channels, raising the possibility that enduring effects arise from this source rather than at conventional receptor sites.
In addition to clinical need and research opportunities, these syndromes raise philosophical questions. The most common initial clinical and research response is to think about brain function. It is equally possible the problems arise peripherally, consistent with the James–Lange theory of the emotions which sees affective states arising from the periphery and more of our cognitive functioning as stemming from the body than is ordinarily supposed.

https://content.iospress.com/articles/international-journal-of-risk-and-safety-in-medicine/jrs744

So just add some poison to the venom and everything will be alright.
In order to convey as many targets as possible to stop Covid-19, it is possible to use combinations of molecules and some are currently being studied. The first combination that we will spell out is the association of isotretinoin with tamoxifen. Isotretinoin is a drug that is currently used to treat acne because of its antiandrogenic effect. Indeed, isotretinoin diminishes the serum levels of dihydrotestosterone, which is an androgen that promotes the transcription of TMPRSS2. The effect of androgens on regulating the expression of TMPRSS2 was previously reported on lungs. For this reason, it is tempting to speculate that suppressing the activity of androgens (including testosterone and dihydrotestosterone) will lead to the reduction of the expression of TMPRSS2, which results in less viral infection and this suppression may be induced by isotretinoin. Beyond its antiandrogenic activity, Sinha et al. have found out recently that isotretinoin is a strong downregulator of ACE2 receptors, being the strongest one out of over 20000 molecules tested in vitro. Taken together, isotretinoin may have a protective role due to suppression of TMPRSS2 and ACE2 expression.
https://onlinelibrary.wiley.com/doi/full/10.1002/rmv.2290

3 a-diol G was also reported to be low in post-finasteride syndrome!
Serum samples were obtained at baseline, 8, 16, and 24 weeks, and assayed for precursor androgens -total testosterone (TT), free testosterone (free T), dehydroepiandrosterone (DHEA), dehydroepiandrosterone-sulfate (DHEA-S); and tissue androgens - dihydrotestosterone (DHT), and its metabolite, 3 a-androstanediol glucuronide (3 a-diol G). Isotretinoin had no meaningful effects on precursor androgens, except for producing an elevation of free T in women. In contrast, isotretinoin produced depressions in the serum levels of DHT and 3 a-diol G in women and in 3 a-diol G in men. These decreases are believed to be the result, rather than the cause, of a reduction in the size of the sebaceous glands: The magnitude of the observed decreases may represent the amount of tissue-derived androgens that sebaceous glands normally contribute to the circulating pool.
https://jamanetwork.com/journals/jamadermatology/article-abstract/549304

It could be worth mentioning that alfalfa may increase 3a-HSD activity.
13-cis-retinoic acid (isotretinoin), 3,4-didehydroretinoic acid, and 3,4-didehydroretinol, but not all-trans-retinoic acid or the synthetic retinoids acitretin and adapalene, were potent competitive inhibitors of the oxidative 3a-HSD activity of RoDH-4, i.e., reduced the formation of dihydrotestosterone and androstandione in vitro. Extrapolated to the in vivo situation, this effect might explain the unique sebosuppressive effect of isotretinoin when treating acne.
https://www.sciencedirect.com/science/article/abs/pii/S0006291X03003322

There was a significant fall in testosterone during treatment and a significant reduction in the 24 h urinary excretion of androsterone, tetrahydrocortisone (THE) and tetrahydrocortisol (THF) from week 8 onwards and for aetiocholanolone and allo-THF from week 12. Although pretreatment levels of urinary steroid metabolites were not abnormal, the ratios of the 5a/5B metabolites (androsterone:aetiocholanolone and allo-THF:THF) were at the upper limit of the reference range and were lowered after treatment, suggesting that 5a-reductase activity is sensitive to isotretinoin.
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2133.1991.tb00598.x

In vitro studies of testosterone metabolism in hamster flank organ showed lack of inhibition of 5a-reductase by isotretinoin, but in female rats isotretinoin treatment caused a decrease in steroid 5a-reductase activity in both skin and liver. In cultured human prostatic cells 5a-reductase can be inhibited by retinoic acid through competitive inhibition of cofactor action (NADPH) yet in men circulating dihydrotestosterone is unchanged throughout isotretinoin therapy. In the present study marked reductions in the major androgen and glucocorticoid metabolites were found at the same time as decreased levels of 5a-reduction. 5a-reduction of androgens occurs in the peripheral tissues as well as the liver while glucocorticoids are mainly 5a-reduced in liver. It is therefore unlikely that these changes can be accounted for solely by drug-induced reduction in the size of the sebaceous gland and a direct effect on liver 5a-reduction is postulated.
https://scholar.google.com/scholar?hl=hu&as_sdt=0%2C5&q=Isotretinoin+treatment+alters+steroid+metabolism+in+women+with+acne&btnG=
Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: Hopeoneday on January 14, 2022, 05:27:29 PM
My first intention is ruined now...
I did made a new topic acne-accutane-antibiotics on porpes...
and i think it shouldnt been deleted(it is important i think) , and his
place is not in hormonal but in generall section.
Old topics "are dead", antibitocis-acuttane topic is ipmortant as new !
Antibiotics-accutane combo are making
general body damage not yust hormonall.

Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: Progecitor on January 15, 2022, 01:27:20 AM
My first intention is ruined now...
I did made a new topic acne-accutane-antibiotics on porpes...
and i think it shouldnt been deleted(it is important i think) , and his
place is not in hormonal but in generall section.
Old topics "are dead", antibitocis-acuttane topic is ipmortant as new !
Antibiotics-accutane combo are making
general body damage not yust hormonall.

I am sorry if you feel so, however these changes usually go hand-in-hand and one can't really exclude the other. Dysbiosis apparently plays a part in practically all cases of POIS, however it can't be easily ascertained whether it is the source or the result of the disease. There is at least indication for both as far as studies count.

Propionibacterium acnes (PA) is frequently involved in acne and can be detected by PCR in 82.8% of lesions. Propionibacterium species may adhere to intestinal mucosa. They secrete hyaluronidase and can alter intestinal mucosa. Microbiomes may associate several aggressive bacteria such as PA or Acinetobacter species and lead to synergic destructive and atrophic effect on mucosa. Patients with acne may receive isotretinoin which mucosal side-effects profile is well documented.
Isotretinoin affects also stem-cells renewal. May an isotretinoin-induced mucosal atrophy occur, a long-term or even a permanent effect could be expected; leading to severe consequences, repeated consultations and explorations in gastroenterology, and therefore to health expenditures.
Group 2 (Isotretinoin-treated) presents with dysbiosis: higher levels of H2 (7.3 ppm +/- 7 versus 4.6 +/- 6.9) and methylacetate (5.4 +/- 2.6 versus 3.9 +/- 4.4) than in the control group. The difference was also significant between group 1 (antibiotic-treated) and group 2: 7.3 ppm +/- 7 versus 4.3 +/- 4.7. for H2 and 5.4 +/- 2.6 versus 3.9 +/- 2.4 for methylacetate.
Group 2 also presents more frequently with oral herpes simplex (30.4% versus 21.4%) or allergy (34.6% versus 15.7%) than the control group; which suggests dysimmunity.
Propionibacterium acnes (PA) is frequently involved in acne. Human enterotypes have been classified into three groups. PA belongs to the Prevotella-enterotype. PA secretes hyaluronidase and can alter intestinal mucosa. However, PA has not been associated with dysbiosis, malabsorption or colitis. The Prevotella-enterotype also includes Helicobacter pylori and Desulfovibrio species as well as Acinetobacter species. HP favours gastric mucosal atrophy without any jejunal involvement. Desulfovibrio favours ulcerative colitis.
Acinetobacter favours mucosal atrophy. Therefore, although PA cannot directly favour colitis, other associated bacteria belonging to the Prevotella-enterotype may induce mucosal inflammation. However, there is no argument for any jejunal adverse effect of PA or of any associated bacteria from the Prevotella-enterotype.
In addition, isotretinoin normalizes (lowers!) exaggerated TLR-2- mediated responses in acne patients. TLR2 regulates the production of neurotrophic factors in intestinal smooth muscle cells and promotes survival of enteric neurons and glial cells. TLR2 controls mucosal renewal. TLR2 enables local tolerance via Bacteroides fragilis. It discriminates between pathogens and symbiotic bacterial molecules in a process that engenders commensal beneficial colonization. TLR2 controls indigenous bacteria proliferation in the upper alimentary tract. Lack of TLR-2 contribute to the settlement of undesirable bacteria, especially Gram-positive, or candida.
Isotretinoin is known to impair stem cells renewal and TLR2 expression in the mucosa of the small gut. These pharmacological effects, explaining the efficacy of the medication on acne ("the metabolic syndrome of the pilosebaceous gland") may induce the progressive atrophy of the jejunal mucosa and its long-lasting consequences.

https://pdfs.semanticscholar.org/aa42/f3e7260c399337f8e74faac8f8899ccce5ee.pdf

As a comparison to finasteride-induced changes:
Indeed, immediately after drug treatment an increase in Bacteroidetes phylum as well as in Prevotellaceae family was reported; after discontinuation of the finasteride, a decrease in Ruminococcaceae family, Oscillospira and Lachnospira genus was observed. Changes in gut microbiota could be ascribed to different factors, such as changes induced by finasteride in plasma and/or brain neuroactive steroid levels.
For instance, rats with depressive-like behavior show an increase in Bacteroidetes.

https://www.sciencedirect.com/science/article/pii/S235228951930061X
Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: Hopeoneday on January 15, 2022, 04:09:09 AM
Somebody gaslighting us  ;D
Somebody sticked 11 year old topic, and glued my new topic on that topic..
My new topic isnt attention to question - "did someone use accutane"
Topics like that existed, one of them is 11 years old..
Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: berlin1984 on January 15, 2022, 04:52:48 AM
Nothing was deleted.
It was me who merged the topic and also made it sticky so more people would notice it when browsing the forum :)

It's no use if one topic (accutante) has 5 threads with the same topic. Poiscenter has already too many threads, if we reddit-style open new posts for everything there won't be any cohesive threads..

Maybe I misunderstood your intention of making a new thread?
Can you explain?

I see it positive that an idea that came 11 years ago is getting some fresh air by you collecting links to other threads with same topic.
I also proposed for Journey to make a poll on Reddit so we can get more data. So I fully support your idea.
Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: Hopeoneday on January 18, 2022, 12:29:35 PM
Berlin.. you killed my modjo  ;D
Topic like this questionare should be pull??
I agree with you, but on the odher side we are tini mini comunity..
a micron. So.. i do not think that we hawe to much post here..
And sometimes new topic is needed to spin the wheels, ewen this
forum sugesting that for you when you replay on old topic..
i using a search on this forum wery suscesifully. Reddit is different
platform. But more on the other side i agree that we need tickened plot
with toppics. My inetention is Acne-ucuutane-antibiotcs-sibo and
tematic what can be damaged by tat...
Ok but i will write here my findings as it is pinned toppic...
Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: Hopeoneday on January 18, 2022, 12:32:29 PM
Poisers coud hawe mucosal membrane damaged (a leaking)..
https://pubmed.ncbi.nlm.nih.gov/19492487/

Isotretinoin can affect all mucous membranes, causing multiple disorders of varying severity, affecting: the eyes (conjunctivitis); ear, nose and throat (epistaxis); respiratory tract; gastrointestinal tract (colitis); and urinary tract; (4)


Isotretinoin-induced inflammatory bowel disease
https://pubmed.ncbi.nlm.nih.gov/16517990/

Arthritis precipitated by isotretinoin treatment for acne vulgaris
https://pubmed.ncbi.nlm.nih.gov/8371229/

Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: Journey on January 19, 2022, 04:56:51 PM
Never
Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: Hopeoneday on January 20, 2022, 07:14:57 AM
Severe acne-antibiotics-havy metals exposure?
Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: Hopeoneday on February 03, 2022, 12:05:53 PM
NEUTROPENIA AND THROMBOCYTOPENIA IN A PATIENT USED
ISOTRETINOIN FOR ACNE VULGARIS

https://dergipark.org.tr/tr/download/article-file/521027
Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: Hopeoneday on February 03, 2022, 02:58:46 PM
https://www.reddit.com/r/SIBO/comments/pwgov5/new_study_accutane_causes_abdominal_adhesions/
Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: Progecitor on February 16, 2022, 04:06:57 PM
Accutane and antibiotics really do have a connection.

A vitamin A derivate used in acne therapy (isotretinoin) has been inconsistently associated with the onset of IBD. However, what needs to be considered is the previous treatment of acne patients with antibiotics that are also associated with the development of IBD, thus representing a crucial confounding factor. Here, we studied whether doxycycline (acne therapy), metronidazole (IBD therapy) or isotretinoin are able to induce alterations in DNA methylation and microRNA expression patterns in murine colonic intestinal epithelial cells (IECs).
As for changes in DNA methylation, we found isotretinoin to have strong demethylating effects, while antibiotic treatment had only a moderate impact.
Regarding microRNA and mRNA expression, isotretinoin and doxycycline, but not metronidazole, potentially induce long-term changes in microRNA/mRNA expression profiles towards the down-regulation of immune responses.
In contrast, isotretinoin had a strong impact on DNA methylation with 234 hypomethylated targets compared to the vehicle. Previous treatment with isotretinoin resulted in eight hypermethylated targets, indicating a resolution of the direct effect on demethylation, and thereby pointing to a short-term effect of isotretinoin on DNA methylation. In total, 308 mRNAs were up-regulated and 136 mRNAs down-regulated after isotretinoin-washout, while treatment with metronidazole and doxycycline up-regulated the expression of 23 and 59 mRNAs, respectively, and down-regulated the expression of 59 and 91 mRNAs, respectively. These results point to possible long-term changes on mRNA expression levels after isotretinoin treatment in murine colonic IECs.
Treatment with the vitamin A derivate isotretinoin led to the demethylation of targets that were involved in IL-12 signaling and developmental processes, including the hypomethylated target IL-12rb1 and the corresponding up-regulated IL-12-dependent pathway in the transcriptome analysis directly after isotretinoin treatment in IECs. Although epigenetic marks such as DNA methylation are long-lasting and inheritable modifications, isotretinoin-induced demethylation was resolved after the washout phase of 4 weeks, indicating short-term effects on IL-12rb1. Furthermore, isotretinoin did not affect IBD-associated microRNAs in IECs neither directly after treatment cessation nor after the washout phase.

https://www.mdpi.com/2075-4655/1/3/24/htm

HDAC1 is overexpressed in prostate, gastric, colon, and breast cancers, and HDAC2 is overexpressed in colorectal, cervical, and gastric cancers.
Direct effects may be caused by drugs that affect chromatin architecture or DNA methylation, whereas indirect effects may be caused by drugs that affect transcription. For example, hydralazine directly affects the epigenome by inhibiting DNA methylation, and isotretinoin indirectly affects the epigenome by altering transcription factor activity. Drugs that indirectly affect the epigenome initially influence signaling pathways, thereby altering transcription factor activity at gene promoters and subsequently altering expression of receptors, signaling molecules, and other proteins. One study postulated that cells will ultimately adopt more permanent modifications to DNA methylation and chromatin structure, leading to enduring epigenetic changes. Thus these effects could persist after the drug is discontinued.

https://sci-hub.se/https://accpjournals.onlinelibrary.wiley.com/doi/abs/10.1002/phar.1408
Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: Vandemolen on February 18, 2022, 10:55:42 PM
Did someone of you used Roaccutane/Accutane against acne? It also know as Isotretinoin? I had that 10 years ago against acne. It is a very heavy medicine and doctors warned me. But I asked and asked for it, because it was the only medicine which could get the acne get away. It is bad for the liver. It could be that my hormones were messed up by this medicine and caused POIS.
This will sound a bit weird for you but I am using Roaccutane right now. My POIS doctor desrcribed it to me. But in a very low dose (10 mg a day). If I have side effects I have to skip it taking it for a day. I have less acne now. I take it since almost 3 months. Because I only take a very low dose it is ok to take it even more than a year. The key is taking a low dose. Because of that if will take a longer time before the acne goes away for good.
Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: Hopeoneday on February 25, 2022, 07:40:06 AM
Vander, i wouldnt recomended this medicine to my worst enemy!
Who hawe no luck in life, it would be damaged permanently from this medicine...

(https://i0.wp.com/images-prod.healthline.com/hlcmsresource/images/Effects_of_Accutane_1/Isotretinoin_Effects_Infographic_Interactive_crop.png?w=1155&h=2614)
Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: Vandemolen on March 02, 2022, 10:33:00 PM
I only use 10 mg a day. So I do not have any side effects.
Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: Hopeoneday on March 03, 2022, 04:52:13 AM
That is still 10000mcg of accutane, evan 10000mcg of naturall vit a is toxic .. still you can be "damaged" if you hawe no luck, i think that
some people here did got pois from this drug
eg specualy (antibiotics-accutane combo)...

This was TV comercial drug, (someone needs to earn mony),
for that mony you will be free from acne.
Now i do not think that this drug is TV comercilal eny more
, becuse of suing (side efffects, peoples ged badly dammaged)..

From numerous side effects i hawe from accutane one of them is
is incriesed presure in brain... we diccused here about (vascular, endothelial)
m,brain aneurism(Muon, Nana1)...
Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: Hopeoneday on March 21, 2022, 06:07:09 PM
https://www.reddit.com/r/SIBO/comments/tfgiky/did_anyone_else_trace_back_their_sibo_to_taking/
Title: Re: Did someone of you used Roaccutane/Accutane? Cause of POIS?
Post by: Hopeoneday on June 08, 2022, 08:02:58 AM
https://www.researchgate.net/publication/330086516_Severe_Acne_in_Female_Patients_Treated_with_Isotretinoin_is_associated_with_Dysbiosis_and_its_Consequences