POISCENTER

General Category => POIS Research => Topic started by: mineral on June 24, 2024, 11:56:44 AM

Title: Meta analysis on poiscenter.com & research papers
Post by: mineral on June 24, 2024, 11:56:44 AM

poiscenter.com has been accumulating valuable data regarding POIS (i.e symptoms, medications experiences...), By using machine learning techniques to classify and summarize tens of thousands of messages, I've managed to generate the following article. The generative model is not perfect so it did miss some stuff but overall I think it did a nice job. I'm open to suggestions and ideas about further progress, especially if your are currently researching POIS.  :)

Meta-Analysis of POIS Treatment Experiences from POISCenter Forum Data

This comprehensive meta-analysis examines user-reported experiences with various medications and treatments for Post-Orgasmic Illness Syndrome (POIS) based on data extracted from the POISCenter forum. The analysis identifies prevalent themes, patterns, and findings, highlighting significant correlations, discrepancies, and insights derived from the collective data.

1. Individual Variability and the Need for Personalized Treatment

The most striking theme emerging from the data is the high variability in individual responses to treatments. What works for one person may have no effect or even worsen symptoms for another. This underscores the need for personalized approaches to managing POIS.

Examples:

Niacin: Some users report dramatic relief from POIS symptoms using niacin, particularly when experiencing a flush https://poiscenter.com/forums/index.php?topic=174.540 (https://poiscenter.com/forums/index.php?topic=174.540), https://poiscenter.com/forums/index.php?topic=200.20 (https://poiscenter.com/forums/index.php?topic=200.20), https://poiscenter.com/forums/index.php?topic=277.0 (https://poiscenter.com/forums/index.php?topic=277.0), while others find it ineffective or experience adverse reactions https://poiscenter.com/forums/index.php?topic=319.40 (https://poiscenter.com/forums/index.php?topic=319.40), https://poiscenter.com/forums/index.php?topic=1004.0 (https://poiscenter.com/forums/index.php?topic=1004.0).

Fenugreek: While many users experience significant symptom reduction with fenugreek https://poiscenter.com/forums/index.php?topic=27.180 (https://poiscenter.com/forums/index.php?topic=27.180), https://poiscenter.com/forums/index.php?topic=1057.20 (https://poiscenter.com/forums/index.php?topic=1057.20), others report no effect or even worsened symptoms https://poiscenter.com/forums/index.php?topic=292.0 (https://poiscenter.com/forums/index.php?topic=292.0).

Antihistamines: Some users find antihistamines, particularly loratadine and cetirizine, effective in managing POIS symptoms https://poiscenter.com/forums/index.php?topic=31.80 (https://poiscenter.com/forums/index.php?topic=31.80), https://poiscenter.com/forums/index.php?topic=1060.0 (https://poiscenter.com/forums/index.php?topic=1060.0), while others experience no benefit or even negative side effects like drowsiness and dry mouth https://poiscenter.com/forums/index.php?topic=308.0 (https://poiscenter.com/forums/index.php?topic=308.0), https://poiscenter.com/forums/index.php?topic=2289.100 (https://poiscenter.com/forums/index.php?topic=2289.100).

This variability suggests that POIS may have different subtypes or underlying mechanisms that are yet to be fully understood. Users often experiment with multiple treatments and dosages, adjusting their regimens based on individual responses and observed side effects.

2. Promising Treatments: Omalizumab and Ketotifen

Two medications, Omalizumab and Ketotifen, emerge as potentially significant treatments for POIS, with strong indications that they work by targeting the immune system.

Omalizumab (Xolair):

Reported Effects: Complete or near-complete remission of POIS symptoms, rapid onset of action, reduced intensity and duration of episodes. https://poiscenter.com/forums/index.php?topic=137.0 (https://poiscenter.com/forums/index.php?topic=137.0), https://poiscenter.com/forums/index.php?topic=244.0 (https://poiscenter.com/forums/index.php?topic=244.0), https://poiscenter.com/forums/index.php?topic=3127.20 (https://poiscenter.com/forums/index.php?topic=3127.20), https://poiscenter.com/forums/index.php?topic=4412.0 (https://poiscenter.com/forums/index.php?topic=4412.0)
Sentiment: Overwhelmingly positive, with users describing it as "life-changing."
Mechanism of Action: Anti-IgE monoclonal antibody; blocks allergic reactions and reduces inflammation.
Challenges: High cost, requires injection, limited availability.

Ketotifen:

Reported Effects: Reduction in POIS symptoms, stabilization of mast cells, improvement in allergy symptoms. https://poiscenter.com/forums/index.php?topic=504.0 (https://poiscenter.com/forums/index.php?topic=504.0), https://poiscenter.com/forums/index.php?topic=2372.0 (https://poiscenter.com/forums/index.php?topic=2372.0)
Sentiment: Cautiously optimistic, with users acknowledging individual responses and the need for further research.
Mechanism of Action: Mast cell stabilizer and antihistamine properties.
Challenges: Availability, delayed onset of action, potential side effects (drowsiness).

3. The Role of Inflammation and Immune System Dysregulation

A recurring theme is the potential role of inflammation and immune system dysregulation in POIS. This is reflected in the use of anti-inflammatory medications, mast cell stabilizers, and supplements aimed at modulating immune responses.

Examples:

NSAIDs (Non-Steroidal Anti-Inflammatory Drugs): Some users report relief from POIS symptoms using NSAIDs like ibuprofen and celecoxib https://poiscenter.com/forums/index.php?topic=54.0 (https://poiscenter.com/forums/index.php?topic=54.0), https://poiscenter.com/forums/index.php?topic=524.20 (https://poiscenter.com/forums/index.php?topic=524.20), https://poiscenter.com/forums/index.php?topic=2335.20 (https://poiscenter.com/forums/index.php?topic=2335.20).

Mast Cell Stabilizers: Quercetin, cromolyn sodium, and luteolin are frequently mentioned for their potential to stabilize mast cells and reduce histamine release https://poiscenter.com/forums/index.php?topic=384.0 (https://poiscenter.com/forums/index.php?topic=384.0), https://poiscenter.com/forums/index.php?topic=1328.0 (https://poiscenter.com/forums/index.php?topic=1328.0), https://poiscenter.com/forums/index.php?topic=2301.400 (https://poiscenter.com/forums/index.php?topic=2301.400).

Immunomodulatory Supplements: Vitamin D, zinc, and curcumin are often used for their potential to modulate immune responses and reduce inflammation https://poiscenter.com/forums/index.php?topic=257.80 (https://poiscenter.com/forums/index.php?topic=257.80), https://poiscenter.com/forums/index.php?topic=165.0 (https://poiscenter.com/forums/index.php?topic=165.0), https://poiscenter.com/forums/index.php?topic=1426.60 (https://poiscenter.com/forums/index.php?topic=1426.60).

The effectiveness of these treatments suggests that inflammation and immune system dysregulation play a role in POIS. However, the exact mechanisms and triggers for this dysregulation remain unclear.

4. The Gut-Brain Connection and POIS

Users frequently discuss the connection between gut health and POIS symptoms. Many report experiencing digestive issues alongside POIS, suggesting a potential role of the gut microbiome in symptom manifestation.

Examples:

Probiotics: Some users find relief from POIS symptoms using probiotics, particularly those targeting specific bacterial strains https://poiscenter.com/forums/index.php?topic=341.20 (https://poiscenter.com/forums/index.php?topic=341.20), https://poiscenter.com/forums/index.php?topic=807.0 (https://poiscenter.com/forums/index.php?topic=807.0), https://poiscenter.com/forums/index.php?topic=1193.20 (https://poiscenter.com/forums/index.php?topic=1193.20).

Dietary Changes: Eliminating gluten, dairy, and other potential food sensitivities is often mentioned as helpful in managing POIS symptoms https://poiscenter.com/forums/index.php?topic=14.60 (https://poiscenter.com/forums/index.php?topic=14.60), https://poiscenter.com/forums/index.php?topic=104.0 (https://poiscenter.com/forums/index.php?topic=104.0), https://poiscenter.com/forums/index.php?topic=820.40 (https://poiscenter.com/forums/index.php?topic=820.40).

Leaky Gut: Users often discuss the concept of "leaky gut" and its potential role in allowing inflammatory substances to enter the bloodstream, exacerbating POIS symptoms https://poiscenter.com/forums/index.php?topic=108.0 (https://poiscenter.com/forums/index.php?topic=108.0), https://poiscenter.com/forums/index.php?topic=480.0 (https://poiscenter.com/forums/index.php?topic=480.0), https://poiscenter.com/forums/index.php?topic=2851.0 (https://poiscenter.com/forums/index.php?topic=2851.0).

The anecdotal evidence suggests a strong connection between gut health and POIS. However, further research is needed to confirm this link and understand the specific mechanisms involved.

5. Hormonal Imbalances and POIS

Hormonal imbalances, particularly low testosterone levels, are frequently mentioned as a potential contributing factor to POIS. Some users report success with hormone replacement therapy, although the long-term effects and risks are debated.

Examples:

Testosterone Replacement Therapy (TRT): Several users report significant improvement in POIS symptoms using TRT, particularly those with diagnosed hypogonadism https://poiscenter.com/forums/index.php?topic=17.860 (https://poiscenter.com/forums/index.php?topic=17.860), https://poiscenter.com/forums/index.php?topic=74.0 (https://poiscenter.com/forums/index.php?topic=74.0), https://poiscenter.com/forums/index.php?topic=460.0 (https://poiscenter.com/forums/index.php?topic=460.0).

Progesterone: Some users find relief from POIS symptoms using progesterone, which can temporarily lower testosterone levels https://poiscenter.com/forums/index.php?topic=16.20 (https://poiscenter.com/forums/index.php?topic=16.20), https://poiscenter.com/forums/index.php?topic=74.0 (https://poiscenter.com/forums/index.php?topic=74.0), https://poiscenter.com/forums/index.php?topic=1178.20 (https://poiscenter.com/forums/index.php?topic=1178.20).

Other Hormonal Therapies: Users discuss the use of HCG, Clomid, and other medications that affect hormone levels, with varying degrees of success https://poiscenter.com/forums/index.php?topic=19.60 (https://poiscenter.com/forums/index.php?topic=19.60), https://poiscenter.com/forums/index.php?topic=146.40 (https://poiscenter.com/forums/index.php?topic=146.40), https://poiscenter.com/forums/index.php?topic=429.0 (https://poiscenter.com/forums/index.php?topic=429.0).

The effectiveness of hormonal therapies in some cases suggests that hormonal imbalances may contribute to POIS. However, further research is needed to confirm the specific role of hormones and develop safe and effective treatment strategies.

6. Prolactin and POIS: A Complex Relationship

The role of prolactin in POIS is a recurring theme in the POISCenter forum discussions. Users frequently speculate about the implications of high prolactin levels and experiment with medications and supplements that affect prolactin, seeking to understand its contribution to POIS symptoms.

Potential Role of Prolactin in POIS:

Hormonal Imbalance: Users frequently mention elevated prolactin levels post-orgasm, suggesting a disruption in hormonal balance as a potential trigger for POIS symptoms. https://poiscenter.com/forums/index.php?topic=849.0 (https://poiscenter.com/forums/index.php?topic=849.0), https://poiscenter.com/forums/index.php?topic=953.20 (https://poiscenter.com/forums/index.php?topic=953.20), https://poiscenter.com/forums/index.php?topic=1265.0 (https://poiscenter.com/forums/index.php?topic=1265.0)

Immune System Modulation: Prolactin is known to have immunomodulatory effects, and some users believe that high prolactin levels could contribute to the immune system dysregulation observed in POIS. https://poiscenter.com/forums/index.php?topic=1445.0 (https://poiscenter.com/forums/index.php?topic=1445.0), https://poiscenter.com/forums/index.php?topic=2745.40 (https://poiscenter.com/forums/index.php?topic=2745.40), https://poiscenter.com/forums/index.php?topic=2913.20 (https://poiscenter.com/forums/index.php?topic=2913.20)

Neurotransmitter Interactions: Users discuss the potential interplay between prolactin and neurotransmitters like dopamine, speculating that high prolactin levels might disrupt dopamine signaling and contribute to cognitive and emotional symptoms of POIS. https://poiscenter.com/forums/index.php?topic=612.0 (https://poiscenter.com/forums/index.php?topic=612.0), https://poiscenter.com/forums/index.php?topic=689.80 (https://poiscenter.com/forums/index.php?topic=689.80), https://poiscenter.com/forums/index.php?topic=2900.20 (https://poiscenter.com/forums/index.php?topic=2900.20)

Medications and Supplements Targeting Prolactin:

Cabergoline (Dostinex): This dopamine agonist is frequently mentioned as a treatment for high prolactin levels. Users report varied experiences, with some experiencing significant improvement in POIS symptoms and others seeing minimal or no effect. https://poiscenter.com/forums/index.php?topic=429.0 (https://poiscenter.com/forums/index.php?topic=429.0), https://poiscenter.com/forums/index.php?topic=849.0 (https://poiscenter.com/forums/index.php?topic=849.0), https://poiscenter.com/forums/index.php?topic=953.20 (https://poiscenter.com/forums/index.php?topic=953.20)

Bromocriptine: Another dopamine agonist that is occasionally mentioned as a potential treatment for high prolactin, but with fewer user reports compared to Cabergoline. https://poiscenter.com/forums/index.php?topic=849.0 (https://poiscenter.com/forums/index.php?topic=849.0), https://poiscenter.com/forums/index.php?topic=2745.40 (https://poiscenter.com/forums/index.php?topic=2745.40)

Vitamin B6 (P-5-P): Some users report success in reducing prolactin levels and POIS symptoms with high doses of vitamin B6, particularly the active P5P form. https://poiscenter.com/forums/index.php?topic=2767.0 (https://poiscenter.com/forums/index.php?topic=2767.0)

Other Supplements: Users discuss various supplements for potentially lowering prolactin, including zinc, magnesium, and chasteberry, with mixed results.

7. The Role of Neurotransmitters

Discussions about the role of neurotransmitters, particularly dopamine, serotonin, and GABA, are prevalent. Users speculate about neurotransmitter imbalances contributing to POIS symptoms and experiment with various supplements and medications that affect neurotransmitter levels.

Examples:

Mucuna Pruriens (L-Dopa): Used by some users to increase dopamine levels, with reports of both positive effects and adverse reactions like increased heart rate https://poiscenter.com/forums/index.php?topic=1071.0 (https://poiscenter.com/forums/index.php?topic=1071.0), https://poiscenter.com/forums/index.php?topic=2264.0 (https://poiscenter.com/forums/index.php?topic=2264.0), https://poiscenter.com/forums/index.php?topic=2899.0 (https://poiscenter.com/forums/index.php?topic=2899.0).

5-HTP: Taken by some users to increase serotonin levels, with mixed results and warnings about potential serotonin syndrome https://poiscenter.com/forums/index.php?topic=126.0 (https://poiscenter.com/forums/index.php?topic=126.0), https://poiscenter.com/forums/index.php?topic=544.20 (https://poiscenter.com/forums/index.php?topic=544.20), https://poiscenter.com/forums/index.php?topic=2535.0 (https://poiscenter.com/forums/index.php?topic=2535.0).

Taurine: Frequently mentioned for its potential to increase GABA levels, with reports of reduced anxiety and muscle tremors https://poiscenter.com/forums/index.php?topic=48.0 (https://poiscenter.com/forums/index.php?topic=48.0), https://poiscenter.com/forums/index.php?topic=1430.320 (https://poiscenter.com/forums/index.php?topic=1430.320), https://poiscenter.com/forums/index.php?topic=2855.0 (https://poiscenter.com/forums/index.php?topic=2855.0).

The use of these substances suggests that neurotransmitter imbalances may be involved in POIS. However, the complex interplay of neurotransmitters and their specific roles in POIS remain poorly understood.

8. The Role of the Vagus Nerve in POIS

Discussions about the vagus nerve and its potential involvement in POIS are a recurring theme. Users explore various interventions that affect vagus nerve activity, aiming to regulate the autonomic nervous system and reduce inflammation.

Vagus Nerve Stimulation (VNS): Users report experimenting with both prescribed VNS devices and commercially available stimulators, with some experiencing improvements in symptoms like anxiety, brain fog, and fatigue. https://poiscenter.com/forums/index.php?topic=1478.120 (https://poiscenter.com/forums/index.php?topic=1478.120), https://poiscenter.com/forums/index.php?topic=2331.0 (https://poiscenter.com/forums/index.php?topic=2331.0), https://poiscenter.com/forums/index.php?topic=299.180 (https://poiscenter.com/forums/index.php?topic=299.180)

Cholinergic Medications: Drugs like Pyridostigmine (Mestinon) and Donepezil, which enhance acetylcholine activity, are discussed for their potential to stimulate the vagus nerve and reduce inflammation via the cholinergic anti-inflammatory pathway. https://poiscenter.com/forums/index.php?topic=2332.0 (https://poiscenter.com/forums/index.php?topic=2332.0), https://poiscenter.com/forums/index.php?topic=2551.20 (https://poiscenter.com/forums/index.php?topic=2551.20), https://poiscenter.com/forums/index.php?topic=2682.20 (https://poiscenter.com/forums/index.php?topic=2682.20)

Breathing Techniques: The Wim Hof Method, Buteyko breathing, and other breathing exercises are reported by some users to positively affect vagus nerve activity and alleviate symptoms. https://poiscenter.com/forums/index.php?topic=1980.20 (https://poiscenter.com/forums/index.php?topic=1980.20), https://poiscenter.com/forums/index.php?topic=2219.120 (https://poiscenter.com/forums/index.php?topic=2219.120), https://poiscenter.com/forums/index.php?topic=2722.20 (https://poiscenter.com/forums/index.php?topic=2722.20)

The potential of vagus nerve modulation in POIS management is gaining traction within the community, suggesting a promising direction for future research and treatment development.

9. Mental Health Considerations

The impact of POIS on mental health is a significant theme throughout the forum data. Users frequently discuss symptoms like anxiety, depression, social withdrawal, and obsessive-compulsive behaviors, highlighting the need for a holistic approach to POIS management.

Psychotherapy: Many users report seeking professional help from therapists or counselors to address the psychological and emotional effects of POIS. https://poiscenter.com/forums/index.php?topic=22.300 (https://poiscenter.com/forums/index.php?topic=22.300), https://poiscenter.com/forums/index.php?topic=148.0 (https://poiscenter.com/forums/index.php?topic=148.0), https://poiscenter.com/forums/index.php?topic=1102.40 (https://poiscenter.com/forums/index.php?topic=1102.40)

Antidepressants and Anxiolytics: SSRIs, SNRIs, benzodiazepines, and other psychiatric medications are used by some individuals to manage mood disorders and anxiety associated with POIS. However, users also express concerns about side effects, addiction potential, and the temporary nature of relief. https://poiscenter.com/forums/index.php?topic=26.0 (https://poiscenter.com/forums/index.php?topic=26.0), https://poiscenter.com/forums/index.php?topic=85.20 (https://poiscenter.com/forums/index.php?topic=85.20), https://poiscenter.com/forums/index.php?topic=217.0 (https://poiscenter.com/forums/index.php?topic=217.0)

Mindfulness Practices: Users report using techniques like meditation, yoga, and deep breathing exercises to help manage stress and anxiety, which can exacerbate POIS symptoms. https://poiscenter.com/forums/index.php?topic=22.300 (https://poiscenter.com/forums/index.php?topic=22.300), https://poiscenter.com/forums/index.php?topic=159.0 (https://poiscenter.com/forums/index.php?topic=159.0), https://poiscenter.com/forums/index.php?topic=3112.0 (https://poiscenter.com/forums/index.php?topic=3112.0)

The data emphasizes the importance of addressing the mental health impacts of POIS, alongside physical interventions, to achieve lasting well-being.

10. Dietary Interventions and Food Sensitivities

Users frequently discuss dietary changes and food sensitivities as key factors in managing POIS symptoms. Eliminating trigger foods and adopting anti-inflammatory diets are reported to significantly improve symptoms for some individuals.

Gluten-Free Diet: Many users report improvements in POIS symptoms after eliminating gluten from their diet, suggesting a link between gluten intolerance and POIS. https://poiscenter.com/forums/index.php?topic=14.60 (https://poiscenter.com/forums/index.php?topic=14.60), https://poiscenter.com/forums/index.php?topic=1288.40 (https://poiscenter.com/forums/index.php?topic=1288.40), https://poiscenter.com/forums/index.php?topic=2752.20 (https://poiscenter.com/forums/index.php?topic=2752.20)

Low-FODMAP Diet: This diet, which restricts fermentable carbohydrates, is reported to be beneficial for individuals with digestive issues and POIS symptoms, potentially by improving gut health. https://poiscenter.com/forums/index.php?topic=820.40 (https://poiscenter.com/forums/index.php?topic=820.40), https://poiscenter.com/forums/index.php?topic=2984.60 (https://poiscenter.com/forums/index.php?topic=2984.60), https://poiscenter.com/forums/index.php?topic=4133.0 (https://poiscenter.com/forums/index.php?topic=4133.0)

Carnivore/Ketogenic Diet: Some users find that adopting a diet high in animal products and low in carbohydrates helps alleviate POIS symptoms, possibly due to its anti-inflammatory effects and impact on gut bacteria. https://poiscenter.com/forums/index.php?topic=162.0 (https://poiscenter.com/forums/index.php?topic=162.0), https://poiscenter.com/forums/index.php?topic=3631.0 (https://poiscenter.com/forums/index.php?topic=3631.0), https://poiscenter.com/forums/index.php?topic=3964.220 (https://poiscenter.com/forums/index.php?topic=3964.220)

Low Histamine Diet: While not as extensively discussed as other dietary interventions, a low histamine diet is mentioned by some users as helpful in managing POIS symptoms. Further research is needed to clarify the role of histamine in POIS and the effectiveness of this dietary approach. https://poiscenter.com/forums/index.php?topic=820.40 (https://poiscenter.com/forums/index.php?topic=820.40), https://poiscenter.com/forums/index.php?topic=2060.0 (https://poiscenter.com/forums/index.php?topic=2060.0)

Dietary interventions are often used in conjunction with supplements and medications, demonstrating the interconnectedness of gut health, inflammation, and POIS symptoms.

11. Emerging Treatments and Future Research Directions

Users actively discuss and experiment with emerging treatments for POIS. These include:

Low-Dose Naltrexone (LDN): Gaining attention for its potential to modulate the immune system and reduce inflammation https://poiscenter.com/forums/index.php?topic=2029.20 (https://poiscenter.com/forums/index.php?topic=2029.20), https://poiscenter.com/forums/index.php?topic=2540.20 (https://poiscenter.com/forums/index.php?topic=2540.20), https://poiscenter.com/forums/index.php?topic=2635.0 (https://poiscenter.com/forums/index.php?topic=2635.0).

Vagus Nerve Stimulation (VNS): Theoretical and practical applications are being explored, with some users reporting positive results https://poiscenter.com/forums/index.php?topic=139.20 (https://poiscenter.com/forums/index.php?topic=139.20), https://poiscenter.com/forums/index.php?topic=2058.20 (https://poiscenter.com/forums/index.php?topic=2058.20), https://poiscenter.com/forums/index.php?topic=299.180 (https://poiscenter.com/forums/index.php?topic=299.180).

Fecal Microbiota Transplant (FMT): Considered as a potential method for addressing gut dysbiosis, although the effectiveness and risks are debated https://poiscenter.com/forums/index.php?topic=2800.0 (https://poiscenter.com/forums/index.php?topic=2800.0), https://poiscenter.com/forums/index.php?topic=3208.0 (https://poiscenter.com/forums/index.php?topic=3208.0).

Pregnenolone: Some users report positive experiences with pregnenolone for managing POIS symptoms, suggesting its potential role in regulating neurosteroids and hormonal balance. However, its long-term safety and optimal dosage are not well-established. https://poiscenter.com/forums/index.php?topic=17.860 (https://poiscenter.com/forums/index.php?topic=17.860), https://poiscenter.com/forums/index.php?topic=3681.0 (https://poiscenter.com/forums/index.php?topic=3681.0), https://poiscenter.com/forums/index.php? (https://poiscenter.com/forums/index.php?topic=4208.20)

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Update: I've asked the model to summarize all free full text research papers I could get from PubMed, send me more papers if you got any.

Summary of Research Papers:

• Case of Post-Orgasmic Illness Syndrome Associated with Hypogonadism (https://pubmed.ncbi.nlm.nih.gov/32914071/) (Takeshima et al., 2020)
  
  Quote

  This case report describes a 21-year-old male with POIS and hypogonadism (low testosterone). Treatment with non-steroidal anti-inflammatory drugs (NSAIDs) and testosterone replacement therapy (TRT) successfully alleviated his POIS symptoms. The study suggests a potential link between low testosterone and POIS.
  
• Intralymphatic Immunotherapy with Autologous Semen… (https://pubmed.ncbi.nlm.nih.gov/29550252/) (Kim et al., 2018)
  
  Quote

  This case report details the treatment of a 30-year-old Korean man with POIS using intralymphatic immunotherapy (ILIT) with autologous semen. The treatment led to significant symptom alleviation and confirmation of semen-specific IgE in his blood. This study supports the hypothesis that allergic mechanisms play a role in some POIS cases.
  
• Novel Treatment for Post-Orgasmic Illness Syndrome… (https://pubmed.ncbi.nlm.nih.gov/34747723/) (Huang et al., 2021)
  
  Quote

  This case report presents a novel surgical approach for POIS in a 42-year-old male who had failed previous immunosuppressive therapy. Bilateral epididymectomy and vasoligation resulted in significant symptom relief, particularly of rash and headache. The authors suggest this surgical approach could be considered for those with suspected allergic reactions to semen components.
  
• Post Orgasmic Illness Syndrome (POIS) and DOMS… (https://pubmed.ncbi.nlm.nih.gov/34440637/) (Sonkodi et al., 2021)
  
  Quote

  This paper proposes a new hypothesis for POIS, suggesting that the primary injury is "acute compression proprioceptive axonopathy" in muscle spindles, similar to Delayed Onset Muscle Soreness (DOMS). The study highlights the potential role of spermidine depletion in contributing to the unique symptoms and longer duration of POIS compared to DOMS.
  
• Post orgasmic illness syndrome (POIS) (https://pubmed.ncbi.nlm.nih.gov/27652231/) (Waldinger, 2016)
  
  Quote

  This comprehensive review article by a leading POIS researcher explores the syndrome's symptoms, diagnostic criteria, proposed mechanisms, and potential treatments. It emphasizes the autoimmune or allergic reaction theory as a likely cause of POIS, based on evidence from skin prick tests and hyposensitization therapy.
  
• Post orgasmic illness syndrome successfully managed… (https://pubmed.ncbi.nlm.nih.gov/36033161/) (Shanholtzer et al., 2022)
  
  Quote

  This case report details the successful management of POIS in a 27-year-old male using the over-the-counter antihistamine fexofenadine. The study suggests that this simple medication could be a viable treatment option for some POIS individuals.
  
• Post orgasmic illness syndrome: what do we know… (https://pubmed.ncbi.nlm.nih.gov/31508233/) (Abdessater et al., 2019)
  
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  This review article provides an updated overview of POIS, summarizing existing knowledge on its symptoms, diagnostic criteria, potential mechanisms, differential diagnoses, and management strategies. It discusses various hypotheses, including immune-mediated reactions, opioid withdrawal, and autonomic nervous system dysregulation.
  
• Syndrome de la maladie post-orgasmique (https://pubmed.ncbi.nlm.nih.gov/28431830/) (Bignami et al., 2017)
  
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  This letter to the editor presents three cases of POIS, highlighting the variety of symptoms and the challenges of diagnosis. The authors suggest that transient dysregulation of the autonomic nervous system could be a possible mechanism.
  
• Rare and unusual andrologic syndromes… (https://www.fertstert.org/article/S0015-0282(19)32456-3/fulltext) (Sigman, 2020)
  
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  This introductory article highlights four uncommon andrologic syndromes, including POIS, emphasizing the need for greater awareness among clinicians. It encourages research and better understanding of these rare conditions to improve diagnosis and management.
  

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Table Summary of Research Papers:

Research Paper Title	Key Findings	Proposed Mechanism(s)	Treatment Approaches Investigated
Case of post-orgasmic illness syndrome associated with hypogonadism	POIS symptoms in a 21-year-old male with low testosterone significantly improved with NSAIDs & testosterone therapy.	Hypogonadism (low testosterone) might contribute to POIS.	NSAIDs (celecoxib) followed by testosterone replacement therapy (enanthate, then ointment)
Intralymphatic Immunotherapy with Autologous Semen…	ILIT with autologous semen alleviated symptoms in a 30-year-old Korean male with POIS; semen-specific IgE was found.	Allergic Type I hypersensitivity reaction to components of semen.	Intralymphatic immunotherapy with gradually increasing concentrations of autologous semen
Novel treatment for post-orgasmic illness syndrome…	Bilateral epididymectomy and vasoligation relieved symptoms in a 42-year-old male with POIS unresponsive to medication.	Allergic reaction to sperm or epididymal fluid, potentially aggravated by epididymitis.	Bilateral epididymectomy and vasoligation
Post Orgasmic Illness Syndrome (POIS) and DOMS…	Proposed a new hypothesis linking POIS to DOMS, suggesting both might involve "acute compression proprioceptive axonopathy."	Microdamage to proprioceptive nerves in muscle spindles, compounded by spermidine depletion.	Abstinence, spermidine supplementation, riluzole (neuroprotective drug), and medications improving nerve function.
Post orgasmic illness syndrome (POIS)	Comprehensive review of POIS, its symptoms, diagnostic criteria, and potential mechanisms, emphasizing an autoimmune or allergic etiology.	Autoimmune or allergic reaction to a component in seminal fluid.	Hyposensitization therapy with autologous semen, symptomatic relief with medications, lifestyle modifications
Post orgasmic illness syndrome successfully managed…	Fexofenadine, an over-the-counter antihistamine, significantly reduced POIS symptoms in a 27-year-old male.	Type I and Type IV allergic reaction to components of semen.	Fexofenadine (antihistamine)
Post orgasmic illness syndrome: what do we know…	Review summarizing existing knowledge on POIS, covering various hypotheses, differential diagnoses, and management strategies.	Immunological (allergic), opioid withdrawal, neuroendocrine response, autonomic dysregulation.	Antihistamines, NSAIDs, SSRIs, benzodiazepines, hyposensitization therapy, and intralymphatic immunotherapy.
Syndrome de la maladie post-orgasmique	Presented three cases of POIS, highlighting varied symptoms and inconclusive workup; suggested transient dysregulation of the autonomic nervous system as a possible mechanism.	Transient dysregulation of the autonomic nervous system, potentially other neurological causes.	Neuroleptics, antihistamines, anticholinergics, nicotinamide.
Rare and unusual andrologic syndromes…	Introductory article highlighting four uncommon andrologic syndromes, including POIS, emphasizing the need for greater awareness.	Multiple potential mechanisms depending on the specific syndrome.	Varied, depending on the specific syndrome.

Blood Test Results Found in POIScenter.com Data:
1. Hormone Panels:
Testosterone:
Total T: Values range wildly, from very low (e.g., 15 ng/dL) to high normal (e.g., 952 ng/dL). Many report "normal" without specifics.
Free T: Similarly varied, some with values, others just "low," "normal," etc.
Units are usually ng/dL, but sometimes nmol/L, making direct comparison tricky.
Prolactin: Values are often reported as "high" or "normal", sometimes with specifics (e.g., 27.81 ng/mL).
Cortisol: Mostly morning cortisol, range from "low normal" to "high." A few have 4-point saliva tests (morning, noon, evening, night).
DHEA-S: Less common, some report normal values, others high (e.g., 394.60 ug/dl).
SHBG: Some have low SHBG despite normal total testosterone, making free T calculation important.
FSH & LH: Often part of hormone panels, but results less frequently discussed compared to testosterone or prolactin.
Estradiol & Progesterone: Least common, a few with values (e.g., Estradiol 38 pg/mL), most just "normal" or "high."

2. Complete Blood Count (CBC):
White Blood Cell Count (WBC): Ranges from low (e.g., 4.0 Giga/L) to normal, sometimes just "elevated" without specifics.
Neutrophils: Often low or at the lower end of normal, supporting the "exhausted immune system" theory.
Lymphocytes: Some have low absolute counts, others high percentages, indicating potential immune imbalances.
Red Blood Cell Count (RBC), Hemoglobin, Hematocrit: Often "normal," some have low values indicative of anemia.
Platelets: Mostly reported as normal.

3. Thyroid Panel:
TSH: Most common result, values range from low (e.g., 0.42 uIU/mL) to high (e.g., 8.69 mUI/L).
Free T3 & Free T4: Often part of the panel, but results less frequently discussed.
Reverse T3: Less common, a few mention high values.

4. Inflammatory Markers:
C-Reactive Protein (CRP): Values range from normal (< 1.0 mg/dL) to high (e.g., 77 mg/l), some just "positive."
Erythrocyte Sedimentation Rate (ESR): Similar to CRP, ranges from low (e.g., 2 mm/h) to high (e.g., 60 mm/hr).
Cytokines: Limited data, some with IL-8 elevated, others with normal IL-6, TNF-alpha.

5. Metabolic Panels:
Glucose:
Fasting: Some have high values (e.g., 172 mg/dL) even without diabetes history.
Random: Similarly varied, some normal, some high during POIS episodes.
HbA1c: A few have values (e.g., 5.4%), usually normal despite occasional high glucose readings.
Lipid Panel:
Cholesterol: Total cholesterol ranges from very low (e.g., 98 mg/dL) to high (e.g., 238 mg/dL).
Triglycerides, LDL, HDL: Less frequently discussed, some with values, others just "normal."
Liver Enzymes:
ALT, AST: Some elevated, indicative of liver stress, others normal.
GGT: Less common, a few with elevated values.
Creatinine: Mostly normal, a few with high values suggestive of kidney issues.

6. Vitamins & Minerals:
Vitamin D (25-OH-D): Many have low levels (e.g., 14 ng/mL), even those taking supplements. A few have high levels (e.g., 104 nmol/L).
Vitamin B12: A few with low values, others normal.
Folate: Similar to B12, some deficient, others normal.
Iron: Some have low ferritin despite normal RBC count (hypoferritinemia).
Magnesium, Zinc, etc.: Less commonly reported, results mixed.

7. Other Blood Tests:
Acetylcholinesterase: A few with low levels, most don't mention this test.
Ceruloplasmin: A couple of cases with low levels, potential link to copper metabolism issues.
IgE (total): Some elevated, others normal. Semen-specific IgE is more relevant to potential allergy, and data is mixed there too.
Porphyrins, Cryoglobulins, ANA, etc.: A few instances of each, mostly "normal" or "negative."

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Skin Test Results on poiscenter.com, Grouped by Topic Title
Specific Results Reported:

Topic Title	Link	User	Skin Test Result
Official Desensitization plan Begins!	https://poiscenter.com/forums/index.php?topic=11.0 (https://poiscenter.com/forums/index.php?topic=11.0)	Egordon	Positive at 1:300 dilution
		Egordon	Positive at 1:10 dilution after desensitization
		Dante88	Positive reaction to own semen
		Egordon	Positive for semen allergy at 1:10 dilution
Progesterone	https://poiscenter.com/forums/index.php?topic=16.0 (https://poiscenter.com/forums/index.php?topic=16.0)	FloppyBanana	Negative while not taking any medication
Premature ejaculation	https://poiscenter.com/forums/index.php?topic=139.0 (https://poiscenter.com/forums/index.php?topic=139.0)	Slugishdragonn	Positive, associated with premature ejaculation
Skin Prick / Allergy Test Advice	https://poiscenter.com/forums/index.php?topic=412.0 (https://poiscenter.com/forums/index.php?topic=412.0)	Egordon	Initially negative at 1:40,000 dilution, but positive at 1:150 dilution after over 10 injections
Semen	https://poiscenter.com/forums/index.php?topic=707.0 (https://poiscenter.com/forums/index.php?topic=707.0)	fidalgo	Positive intradermal test with own semen
Success with Desensitization Treatment	https://poiscenter.com/forums/index.php?topic=2045.0 (https://poiscenter.com/forums/index.php?topic=2045.0)	pois1	Positive for both semen skin prick test and subcutaneous test
POIS RFP, 2013	https://poiscenter.com/forums/index.php?topic=1012.0 (https://poiscenter.com/forums/index.php?topic=1012.0)	FloppyBanana	Negative for semen allergy in a subcutaneous semen skin test
Desensitization, Fact or Fiction?	https://poiscenter.com/forums/index.php?topic=795.0 (https://poiscenter.com/forums/index.php?topic=795.0)	Hkoo	Positive at 1:100 dilution concentration
Allergy	https://poiscenter.com/forums/index.php?topic=4319.0 (https://poiscenter.com/forums/index.php?topic=4319.0)	onlyhope	Positive for fresh, frozen, and centrifuged semen at 1/10 (mg/ml) and frozen semen at 1/100 (mg/ml)

Skin Testing Mentioned, but No Specific Results Provided:

Topic Title	Link	User	Notes on Skin Testing
sperm or other part of semen causing allergy	https://poiscenter.com/forums/index.php?topic=43.0 (https://poiscenter.com/forums/index.php?topic=43.0)	-	No specific skin test results mentioned
Prostate	https://poiscenter.com/forums/index.php?topic=32.0 (https://poiscenter.com/forums/index.php?topic=32.0)	-	No specific skin test results mentioned
SKIN PRICK TEST RESULTS	https://poiscenter.com/forums/index.php?topic=117.0 (https://poiscenter.com/forums/index.php?topic=117.0)	-	No specific skin test results mentioned
Immunoglobins (Allergy tests)	https://poiscenter.com/forums/index.php?topic=526.0 (https://poiscenter.com/forums/index.php?topic=526.0)	-	No specific skin test results mentioned
My POIS symptoms	https://poiscenter.com/forums/index.php?topic=1318.0 (https://poiscenter.com/forums/index.php?topic=1318.0)	-	No specific skin test results mentioned, but user reports having allergy tests.
Have you ever had any of these before?	https://poiscenter.com/forums/index.php?topic=247.0 (https://poiscenter.com/forums/index.php?topic=247.0)	-	No specific skin test results mentioned, but a user speculates about chickenpox and POIS onset.
Personal POIS Summaries and Histories.	https://poiscenter.com/forums/index.php?topic=81.0 (https://poiscenter.com/forums/index.php?topic=81.0)	tantalus	No specific skin test results, but provides detailed hormone test results
un thread fran?ais	https://poiscenter.com/forums/index.php?topic=118.0 (https://poiscenter.com/forums/index.php?topic=118.0)	-	No specific skin test results mentioned.
Desensitization/Doctors in the U.S.?	https://poiscenter.com/forums/index.php?topic=926.0 (https://poiscenter.com/forums/index.php?topic=926.0)	overcome	States IgE test suggests low allergy likelihood, but no skin test results given.

Title: Re: Meta analysis on poiscenter.com
Post by: Muon on June 24, 2024, 12:50:46 PM

Suggestion: run an analysis on scientific articles.

Title: Re: Meta analysis on poiscenter.com
Post by: Sisyphus on June 24, 2024, 02:52:06 PM

@mineral Nice work :)

Suggestion: upload all the medical results and other related data of poisers on poisforum to a db then run an analysis.

Title: Re: Meta analysis on poiscenter.com
Post by: Quantum on June 24, 2024, 09:07:42 PM

Interesting analysis.
It fits my personal opinion that there are more than one type of POIS, and that a personalized treatment is needed.

Title: Re: Meta analysis on poiscenter.com
Post by: Warrior on June 25, 2024, 12:36:29 AM

This is awesome!

Title: Re: Meta analysis on poiscenter.com
Post by: mineral on June 25, 2024, 02:26:17 AM

Quote from: Muon on June 24, 2024, 12:50:46 PM

Suggestion: run an analysis on scientific articles.

As a start ,I've updated the post with 11 summaries on research papers I got from PubMed. If you got more valuable data, send me.

Quote from: Quantum on June 24, 2024, 09:07:42 PM

Interesting analysis.
It fits my personal opinion that there are more than one type of POIS, and that a personalized treatment is needed.

Finding a reliable biomarker(s) would be great, maybe IgE levels or tryptase levels, if POIS is MCAS. Without biomarkers POIS can be seen as a psychosomatic disease which might not be true.

Quote from: Sisyphus on June 24, 2024, 02:52:06 PM

@mineral Nice work :)

Suggestion: upload all the medical results and other related data of poisers on poisforum to a db then run an analysis.

Thanks, I might be able to extract medical test results from the user posts and aggregate them, although I don't think there are many in the forum.

Title: Re: Meta analysis on poiscenter.com & research papers
Post by: Muon on June 25, 2024, 03:46:50 AM

https://poiscenter.com/forums/index.php?topic=3127.0

Title: Re: Meta analysis on poiscenter.com
Post by: Hopeoneday on June 25, 2024, 04:55:37 AM

Quote from: mineral on June 25, 2024, 02:26:17 AM

Suggestion: upload all the medical results and other related data of poisers on poisforum to a db then run an analysis.

Thanks, I might be able to extract medical test results from the user posts and aggregate them, although I don't think there are many in the forum.
[/quote]

Nice yob mineral, there are meny common patern in poisers medicall
tests results. Do that!

https://poiscenter.com/forums/index.php?topic=3618.msg37906#msg37906

Title: Re: Meta analysis on poiscenter.com & research papers
Post by: mineral on June 25, 2024, 08:39:36 AM

Quote from: Muon on June 25, 2024, 03:46:50 AM

https://poiscenter.com/forums/index.php?topic=3127.0

Amazing! I will definitely look into those papers.

Quote from: Hopeoneday on June 25, 2024, 04:55:37 AM

Nice yob mineral, there are meny common patern in poisers medicall
tests results. Do that!

https://poiscenter.com/forums/index.php?topic=3618.msg37906#msg37906

I've updated the post with some common test results patterns that emerged from the data. :)

Title: Re: Meta analysis on poiscenter.com & research papers
Post by: Muon on June 25, 2024, 03:28:32 PM

I made a start collecting medical findings from papers but discontinued.
https://poiscenter.com/forums/index.php?topic=4399.0

Title: Re: Meta analysis on poiscenter.com & research papers
Post by: Hopeoneday on July 06, 2024, 06:45:27 PM

This should be sticked.

Title: Re: Meta analysis on poiscenter.com & research papers
Post by: ThisType on July 11, 2024, 02:45:36 PM

Good summary - thanks for pulling this together! 

I would add for the testing the combination of these two tests showed my pois issue:

"Folate, RBC" (methylfolate levels over 120 day average) - Quest diagnostics offers this among others
"Serum Folate" (folic acid levels over last day or two)

Explanation:
Low methylfolate with high serum folate shows you are not processing folic acid to get methyl folate, in my case leading to folate anemia. Folate anemia overlaps a lot of one class of POIS symptoms. 
(Speech difficulty, brain fog, tongue and mouth sores, memory, judgement issues, tiredness, irritability, etc)
https://my.clevelandclinic.org/health/diseases/22198-folate-deficiency