Do they all have to be sublingual? I see the liquids for B12 vitamin, but not for melatonin... D3 would be probably easy as it's sold in capsules.
Hi whateverestest,
The sublingual B12 (https://www.amazon.com/Natrol-Vitamin-Dissolve-Tablets-Strawberry/dp/B00C43H9KU/?th=1) and melatonin (https://www.amazon.com/Natrol-Melatonin-Dissolve-Tablets-Strawberry/dp/B01E14X8JA/ref=sr_1_6?crid=2FBV7Q4MDZY9N&th=1) are usually sold as dissoluble tablets. The vitamin D3 that I use comes as a spray that I spray under my tongue (post (https://poiscenter.com/forums/index.php?topic=2502.msg21497#msg21497)). You don't have to use a sublingual supplement, but many people (including myself) do not absorb supplements well through the stomach. I could get about 70 percent reduction of NE POIS symptoms if I only took these 3 supplements.
Why haven't you included Niacin here can it be added as well? What do you think of it? Can I use ashwagandha with this stack? I use it normally for better sleep...
You can add niacin and/or ashwagandha.
So I see you posted 2 "stacks" here... https://poiscenter.com/forums/index.php?topic=2683.msg23775#msg23775
One for preventing symptoms and one for actually reducing chance of getting NE.
I'm especially curious about the second one. Have you tried it or hear anyone trying it for NE? Either magnesium or beta-alanine? Any success or fail opinions?
This probably deserves some background information: Neurons have on and off states. When a neuron is on, neurotransmitters like catecholamines (dopamine, adrenaline, etc...) and acetylcholine can send signals by binding to their receptors. But when a neuron is turned off, the neuron becomes unresponsive to neurotransmitters even when those neurotransmitters bind to the receptor.
The on state of a neuron is controlled by the NMDA and other glutamate receptors (https://en.wikipedia.org/wiki/Glutamate_receptor#Types). When glutamate and glycine stimulate the NMDA receptor, then a neurotransmitter like dopamine can stimulate the D2-dopamine receptor (signaling sexual pleasure). Or a neurotransmitter like norepinephrine can stimulate the alpha1-adrenergic receptor (signaling ejaculation).
The off state of a neuron is controlled by the glycine and GABA receptors (https://en.wikipedia.org/wiki/GABA_receptor). When GABA stimulates the GABA receptors, then a neurotransmitter like dopamine cannot stimulate the D2-dopamine receptor and norepinephrine is prevented from stimulating the alpha1-adrenergic receptor. So GABA prevents the signals of sexual pleasure and ejaculation.
Also see NMDA and GABA receptors post (https://poiscenter.com/forums/index.php?topic=2711.msg24334#msg24334)
The idea behind taking magnesium threonate and beta-alanine is to block the NMDA receptor with magnesium and stimulate the GABA and glycine receptors with beta-alanine. In principal, this would turn off neurons involved with sexual arousal and prevent wet dreams. I can say that magnesium threonate and beta-alanine reduce libido and make me sleepy. But I have not done enough testing to know if they are any good for NE. I do not know if anybody has used these supplements for NE. I mainly take beta-alanine with my pre-workout exercise shake. POIS from NE is not a problem for me right now.
Could you pleas tell me the approximate amount of magnesium/beta-alanine as well?
Sorry, I do not know what dose or how much would be best. This task might be a question for others in the POIS community.