POISCENTER
POIS Cause/Treatment Discussions => General Alternative Causes and Treatments of POIS => Topic started by: portuguese_poiser on February 22, 2019, 12:11:08 PM
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Did you knew about this : http://www.poiscenter.net/index.php?sid=9532caf8d74b3defe1730e6639852eae ?
Maybe we should try to get in contact with them .
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Did you knew about this : http://www.poiscenter.net/index.php?sid=9532caf8d74b3defe1730e6639852eae ?
Maybe we should try to get in contact with them .
We know about them and they know about us. One of their members was the one that recommended niacin.
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CP2, I think we also locked horns when one of their members tried to sell injectable niacin here...with free hypodermics! Do I have the right group?
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It is the right group. I don't remember locking horns with them though. The person who actually discovered niacin posted on here for a while.
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The guy we locked horns with was heavily promoting injection of niacin. He promised to send anyone on this forum free needles from Russia!
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Muon, I don’t know whether to laugh or cry @ your post.
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Muon, I don’t know whether to laugh or cry @ your post.
I'm in the mood for silly comments.
In that case, you need silly music to go along with them!
https://m.youtube.com/watch?v=DA-m6OrZZyk
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LOL, Muon! I need to learn how to dance like that. So I should inject Russian niacin!
Quantum, how do we un-ban this guy!
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I have been told that this dancing behaviour is a side effect of the niacin shots: https://www.youtube.com/watch?v=y90yaLFoYoA
I showed this to my trees
Now they're demiTREES.
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Did you knew about this : http://www.poiscenter.net/index.php?sid=9532caf8d74b3defe1730e6639852eae ?
Maybe we should try to get in contact with them .
I looked a little there.
There is Herman there.
That's the man who was thrown out of
nakedscientists forum.
He helped and helped a lot of people there.
They're good, they try out all sorts of things.
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If he is the Russian offering free needles, he was thrown out of here. Not NSF (Naked Science).
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I have been told that this dancing behaviour is a side effect of the niacin shots: https://www.youtube.com/watch?v=y90yaLFoYoA
I tried dancing like that, it made my POIS worse ;D
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I do not know that Demo.
I only know that it is baned from NSF
forum, this is what I read there,
because it forces trace elements theory.
What is -free needles?
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HOD, one of the Russian forum members (I don’t remember his name) came to POISCenter, very excited about promoting injectable niacin for POIS. He was so excited that he offered to send by mail - free - to any POISCenter member, hypodermic syringes. His promotion went too far and he ignored our warnings that this violates forum rules (promoting products and strongly giving medical advice).
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I do not know that Demo.
I only know that it is baned from NSF
forum, this is what I read there,
because it forces trace elements theory.
What is -free needles?
Herman, he was extremely aggressive about his copper theory and hair testing on NSF.
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They are trying urinoteraphy(cheers) there beside all odher things.
Seriously.
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Herman, he was extremely aggressive about his copper theory and hair testing on NSF.
Hahahaha
Jesus, you can laugh? :o
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I do not know that Demo.
I only know that it is baned from NSF
forum, this is what I read there,
because it forces trace elements theory.
What is -free needles?
Herman, he was extremely aggressive about his copper theory and hair testing on NSF.
CP2, so there were 2 troublemakers from Russia forum?
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I do not know that Demo.
I only know that it is baned from NSF
forum, this is what I read there,
because it forces trace elements theory.
What is -free needles?
Herman, he was extremely aggressive about his copper theory and hair testing on NSF.
CP2, so there were 2 troublemakers from Russia forum?
I believe so. I remember another one trying to sell niacin acid on NSF but it might be the same guy trying to give free needles here. His first post on NSF included a picture of him petting his cat LOL.
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HOD, do you think they know about some of the remedies that are helping on this forum. I am thinking of sharing a list on their site.
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Yes! Now I remember the famous cat petting pic, CP2! Funny!! ;D
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HOD, do you think they know about some of the remedies that are helping on this forum. I am thinking of sharing a list on their site.
Good idea, CP2, just *please* be careful that we don’t attract any more loonies back to POISCenter!
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Yes ,there is information abou types of pois.i sometimes read ruusian forum.I have read posts of German. I think he is crazy.He wrote just a lot of scientist and chemical information,he advice take different vitamins.However his advices almost nevet does not help a lot..
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Russian Poiscenter = Best Poiscenter
What does that mean, Muon?
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HOD, do you think they know about some of the remedies that are helping on this forum. I am thinking of sharing a list on their site.
Good idea, CP2, just *please* be careful that we don’t attract any more loonies back to POISCenter!
Hello! People from the Russian language forum know this site very well and read it. Thank you for creating this site, supporting the forum and many active, not indifferent people. We have a lot less people on the forum, but we try to share any experience that helps overcome this disease. If there is a real solution to this problem, we will be happy to inform you. A disease does not choose a nationality. We will defeat pois by common forces.
Good mood, health, patience and good luck !!!
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How is it going at the Russian Poiscenter forum? Any news regarding POIS over there? Could a Russian speaking member provide an update?
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How is it going at the Russian Poiscenter forum? Any news regarding POIS over there? Could a Russian speaking member provide an update?
With your permission, I’ll email Shep your posted questions above.
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If no one gives a reply within two weeks or so then you may send him an email. Just give it some time first.
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How is it going at the Russian Poiscenter forum? Any news regarding POIS over there? Could a Russian speaking member provide an update?
Just now emailed Shep the above questions.
Thanks, Muon.
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How is it going at the Russian Poiscenter forum? Any news regarding POIS over there? Could a Russian speaking member provide an update?
He replied quickly!
“Hey. There are a lot of discussions on the [Russian] forum, but no special treatment was found to regret. According to the latest theory of "Chorionic therapy with gonadotropin" a person makes 1000-2000 IU two, three times a week for 6 weeks. Another possible theory of the violation of the connection of the hypothalamus, pituitary gland and their serotonin-dopamine reaction and the central nervous system in general, but so far there are no specific conclusions.”
Thanks, Muon!
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Sent previous post to POIS Research Team.
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How is it going at the Russian Poiscenter forum? Any news regarding POIS over there? Could a Russian speaking member provide an update?
He replied quickly!
“Hey. There are a lot of discussions on the [Russian] forum, but no special treatment was found to regret. According to the latest theory of "Chorionic therapy with gonadotropin" a person makes 1000-2000 IU two, three times a week for 6 weeks. Another possible theory of the violation of the connection of the hypothalamus, pituitary gland and their serotonin-dopamine reaction and the central nervous system in general, but so far there are no specific conclusions.”
Thanks, Muon!
Hi Demo! I was waiting for a response from one user of the Russian site, and he answered me.
I would like to ask you to read this theory, and if there is an opportunity to correct it and pass it to the POIS researchers. Publish a post on your site if you want. Thanks! Let me know! Sorry for the English!
"We have a genetic failure of one of the SERT serotonin transporters. There are about 50 of them known, and each is responsible for the capture of serotonin in the synaptic clefts of different parts of the central nervous system. Our case is serotonin from the pineal gland to the hypothalamus, which extinguishes excess sexuality. And since the reverse capture does not works, then serotonin seems to be in short supply, and this gives our hypersexuality (I want sex even when the body does not pull).
Since the hypothalamus regulates stress and endocrinology, it increases serotonin from the pineal gland, but serotonin synthesis is increased everywhere by the side. And this gives the types of POIS. Depending on the characteristics of the exchanges, there are 2 extreme conditions. One thing is when serotonin is always everywhere low, and there are more symptoms with the psyche - insecurity, sociophobia, panic attacks, and great hypersexuality that simply squeezes the body. The second extreme, when the body managed to raise serotonin and muffle mental problems, but then all the inflammations, problems with the gastrointestinal tract and liver, and fog in the head come out.The fog in the head is precisely in this part, since it is from edema of the head, and edema from excessive serotonin in platelets. Well, all the changes are somewhere between these extreme positions. Here is the second case, German very well understood, and if this is your case, then German helps such people. And the pure first case is experiments with tranquilizers and SSRIs, but there will be no breakthrough until SSRIs invent exactly for serotonin in the pineal gland.
What helps us:
Niacin - since it quenches the kinurenine pathway of tryptophan consumption, and tryptophan goes to serotonin.
SSRIs - understandably, increases serotonin in the central nervous system.
NSAIDs - suppress edema in the central nervous system; extinguish inflammation in individual problems.
B1 - works as SSRIs, including.
B6, iron, BH4 - cofactors of enzymes on the path of tryptophan to serotonin.
Alcohol - utilizes serotonin after MAO, NADH is needed there, and without it, NAD is individual.
Cholagogue - purely correct the digestive tract, which is in a spasm from serotonin, well, and accelerate the withdrawal of serotonin through the liver.
Cortozol - we have increased, since it takes tryptophan to niacin.
Estrogen - and it quenches the path of tryptophan to niacin, it is individual.
Of course, I immediately want to extinguish serotonin in the blood, or at least check it with analysis. But no, since we can use numbers))
In one pass through the liver, blood loses 50% of serotonin. Just through the MAO. That is, MAO cannot be small, it is very strong against serotonin.
In one pass through the lungs, blood loses 90% of serotonin. And here the failures of KShchS went, all of our respected alkaloses and acidoses ...
Platelets take 50% of serotonin from the blood in 1-2 minutes.
This is to say that in the blood there is no excess serotonin for more than 1 minute) All excess serotonin in platelets. That means neither measuring nor extinguishing it will fail. And from platelets, serotonin comes out under stress, for example during ejaculation. It compresses blood vessels sharply, and then there is nothing to leave, hours, days, this is the duration of the search. Since the vessels dilated, and cerebral edema went, autoimmune began in individual problem areas.
If it is considered from the side of immunology, then SEIS is an autoimmune to sexual arousal. It was on the surge of neurotransmitters of sexual arousal, and not on semen! "
Thank you! May good luck accompany you!!!
Shep
Author nickname:"slon_ik"
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Thanks for the FW Demo. Some of these parameters can be measured in Berlin if anyone is interested:
https://poiscenter.com/forums/index.php?topic=3207.0
See Serotonin (platelets)/Tryptophan metabolism 391-395:
https://www.imd-berlin.de/fileadmin/user_upload/Anforderungsscheine/SI_Anforderung_IGEL.pdf
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From: Demo
Date: July 1, 2020 at 9:40:41 AM PDT
To: Shep
Subject: Re: POIS
Thank you!!
• sent to POIS Research Team
• posted @ POISCenter.com
Best regards!
Demo
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From: Shep
Date: July 1, 2020 at 9:56:19 AM PDT
To: Demo
Subject: Re[2]: POIS
Thank you, maybe this will push someone on the right path to the root cause.
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Thanks for the FW Demo. Some of these parameters can be measured in Berlin if anyone is interested:
https://poiscenter.com/forums/index.php?topic=3207.0
See Serotonin (platelets)/Tryptophan metabolism 391-395:
https://www.imd-berlin.de/fileadmin/user_upload/Anforderungsscheine/SI_Anforderung_IGEL.pdf
Sent above to Russian POIS Forum
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Hi everyone! Thanks Demo! ;) ;) ;)
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Hi everyone! Thanks Demo! ;) ;) ;)
Welcome, Shep! ;) ;) ;)
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Hi everyone! Thanks Demo! ;) ;) ;)
Welcome, Shep! ;) ;) ;)
Shep, on behalf of all POISCenter members, thank you for your comprehensive summary of news at the Russian POIS Forum!
Everyone, while Shep is visiting here, do you have any questions about slon_ik’s report posted above...or any other questions?
Demo
cc: • POIS Research Team
• Anonymous donors
• Daveman (my co-founder
of this forum)
(https://www.luxxu.net/blog/wp-content/uploads/2018/10/The-Best-Luxury-Hotels-in-Moscow-01.jpg)
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Thanks for the information Shep!
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Thanks for the information Shep!
Thanks for posting, Limejuice!
Sending your kind words to Shep by email.
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Hi Demo! I was waiting for a response from one user of the Russian site, and he answered me.
I would like to ask you to read this theory, and if there is an opportunity to correct it and pass it to the POIS researchers. Publish a post on your site if you want. Thanks! Let me know! Sorry for the English!
"We have a genetic failure of one of the SERT serotonin transporters. There are about 50 of them known, and each is responsible for the capture of serotonin in the synaptic clefts of different parts of the central nervous system. Our case is serotonin from the pineal gland to the hypothalamus, which extinguishes excess sexuality. And since the reverse capture does not works, then serotonin seems to be in short supply, and this gives our hypersexuality (I want sex even when the body does not pull).
Since the hypothalamus regulates stress and endocrinology, it increases serotonin from the pineal gland, but serotonin synthesis is increased everywhere by the side. And this gives the types of POIS. Depending on the characteristics of the exchanges, there are 2 extreme conditions. One thing is when serotonin is always everywhere low, and there are more symptoms with the psyche - insecurity, sociophobia, panic attacks, and great hypersexuality that simply squeezes the body. The second extreme, when the body managed to raise serotonin and muffle mental problems, but then all the inflammations, problems with the gastrointestinal tract and liver, and fog in the head come out.The fog in the head is precisely in this part, since it is from edema of the head, and edema from excessive serotonin in platelets. Well, all the changes are somewhere between these extreme positions. Here is the second case, German very well understood, and if this is your case, then German helps such people. And the pure first case is experiments with tranquilizers and SSRIs, but there will be no breakthrough until SSRIs invent exactly for serotonin in the pineal gland.
Fascinating theory!
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https://translate.google.com/translate?hl=en&sl=ru&tl=en&u=http%3A%2F%2Fpoiscenter.net%2Fviewtopic.php%3Ff%3D9%26t%3D2%26sid%3D03a41acfe319e3bfa2eb4b023ca356a4%26start%3D11090&sandbox=1
Here who want to folow, hit translate again if you sutck next day.
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https://translate.google.com/translate?hl=en&sl=ru&tl=en&u=http%3A%2F%2Fpoiscenter.net%2Fviewtopic.php%3Ff%3D9%26t%3D2%26sid%3D03a41acfe319e3bfa2eb4b023ca356a4%26start%3D11090&sandbox=1
Here who want to folow, hit translate again if you sutck next day.
Thanks, HOD! :)
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Hi Demo! I was waiting for a response from one user of the Russian site, and he answered me.
I would like to ask you to read this theory, and if there is an opportunity to correct it and pass it to the POIS researchers. Publish a post on your site if you want. Thanks! Let me know! Sorry for the English!
"We have a genetic failure of one of the SERT serotonin transporters. There are about 50 of them known, and each is responsible for the capture of serotonin in the synaptic clefts of different parts of the central nervous system. Our case is serotonin from the pineal gland to the hypothalamus, which extinguishes excess sexuality. And since the reverse capture does not works, then serotonin seems to be in short supply, and this gives our hypersexuality (I want sex even when the body does not pull).
Since the hypothalamus regulates stress and endocrinology, it increases serotonin from the pineal gland, but serotonin synthesis is increased everywhere by the side. And this gives the types of POIS. Depending on the characteristics of the exchanges, there are 2 extreme conditions. One thing is when serotonin is always everywhere low, and there are more symptoms with the psyche - insecurity, sociophobia, panic attacks, and great hypersexuality that simply squeezes the body. The second extreme, when the body managed to raise serotonin and muffle mental problems, but then all the inflammations, problems with the gastrointestinal tract and liver, and fog in the head come out.The fog in the head is precisely in this part, since it is from edema of the head, and edema from excessive serotonin in platelets. Well, all the changes are somewhere between these extreme positions. Here is the second case, German very well understood, and if this is your case, then German helps such people. And the pure first case is experiments with tranquilizers and SSRIs, but there will be no breakthrough until SSRIs invent exactly for serotonin in the pineal gland.
Fascinating theory!
Emailed to Shep.
Thank you, Nas
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https://translate.google.com/translate?hl=en&sl=ru&tl=en&u=http%3A%2F%2Fpoiscenter.net%2Fviewtopic.php%3Ff%3D9%26t%3D2%26sid%3D03a41acfe319e3bfa2eb4b023ca356a4%26start%3D11090&sandbox=1
Here who want to folow, hit translate again if you sutck next day.
Sending now to POIS Research Team
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https://translate.google.com/translate?hl=en&sl=ru&tl=en&u=http%3A%2F%2Fpoiscenter.net%2Fviewtopic.php%3Ff%3D9%26t%3D2%26sid%3D03a41acfe319e3bfa2eb4b023ca356a4%26start%3D11090&sandbox=1
Here who want to folow, hit translate again if you sutck next day.
Sending now to POIS Research Team
Here is a shorter link - - which will not break up in email:
https://tinyurl.com/y9nmzw5j
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Hi. We are very glad that you were interested in the theory of slon_ik and you do not pass by. You have more people on the site, maybe someone will continue this in the direction of physical embodiment. I especially wanted to know the opinion of the user nicknamed
nanna1 Thank you! ;)
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Thank you, Shep!
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Thanks for the FW Demo. Some of these parameters can be measured in Berlin if anyone is interested:
https://poiscenter.com/forums/index.php?topic=3207.0
See Serotonin (platelets)/Tryptophan metabolism 391-395:
https://www.imd-berlin.de/fileadmin/user_upload/Anforderungsscheine/SI_Anforderung_IGEL.pdf
OK, I'm in Berlin.
Which of those 391-395 shall I measure
At which state (neutral or in POIS? When?)
What do we expect to get as result to confirm a theory?
I'm not really understanding yet..Is it about excess Tryptophan?
"Here is the second case, German very well understood, and if this is your case, then German helps such people."
What does this mean? :-)
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"Here is the second case, German very well understood, and if this is your case, then German helps such people."
What does this mean? :-)
You had “demografx” as the author because I was quoting Shep. So I changed it to slon_ik (Russian forum member).
Emailing above to Shep :)
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And from platelets, serotonin comes out under stress, for example during ejaculation.
How would this link to https://www.pnas.org/content/115/7/E1550 ?
I'm not a biologist, see the Fig. 6 in the study.
Maybe the orgasm indirectly releases serotonine which then somehow makes the ICs "break" and re-release the pathogens (because they're not bound with the antigen anymore) (?).
Then this would explain my sore throat / weak immune system after orgasm?
(And would explain Transiently Induced Immune Deficiency (https://poiscenter.com/forums/index.php?topic=3151.0), the pathogens are free-flowing after the orgasm)
slon_ik, nanna1, I have no scientific knowledge, please tell me if what I write is bogus then I'll strike it out.
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berlin1984, thanks, emailing your post to Shep!
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How does the success many have had with anti-histamines fit with this theory? Do they effect serotonin directly or indirectly?
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How does the success many have had with anti-histamines fit with this theory? Do they effect serotonin directly or indirectly?
Гистамин, серотонин и простагландины это основные воспалительные агенты. Если уменьшить гистамин, то для серотонина как бы освобождается место. И тогда воспаление POIS начнется уже при большей дозе серотонина. То есть можно уменьшать гистамин или серотонин или пить НПВС, и эффект будет одинаковый. Но у всех разные пропорции воспалительных агентов, поэтому всем помогают разные препараты.
Histamine, serotonin and prostaglandins are the main inflammatory agents. If histamine is reduced, then for serotonin a place is freed up, as it were. And then the inflammation of the POIS will begin with a higher dose of serotonin. That is, you can reduce histamine or serotonin or drink NSAIDs, and the effect will be the same. But everyone has different proportions of inflammatory agents, so different drugs help everyone.
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Я считаю, что основная причина POIS это сбой в регуляции стресса полового возбуждения в ЦНС. Это может быть генетический сбой в гипоталамусе или миндалине. Или могут быть аутоиммунные проблемы на медиаторы полового возбуждения и оргазма. Один из вариантов описан выше, это проблемы с серотонином и тучными клетками.
Я уверен, что POIS не связан с аутоиммунным на сперму, так как тогда бы у нас от спермы были красные пятна коже, а их нет ))
Так же я уверен, что проблема именно в голове. Мы хотим секса больше, чем можем себе позволить. Я это называю гиперсексуальностью. Если бы это было не так, то мы были бы или асексуалами, или импотентами. То есть наш организм не понимает, что не вытягивает стресс полового возбуждения, и это есть основная причина POIS.
I believe that the main reason for POIS is a failure in the regulation of stress of sexual arousal in the central nervous system. This may be a genetic malfunction in the hypothalamus or tonsil. Or there may be autoimmune problems on mediators of sexual arousal and orgasm. One option described above is problems with serotonin and mast cells.
I am sure that POIS is not associated with autoimmune sperm, since then we would have red spots from the sperm of the skin, but they are not))
I'm also sure that the problem is in the head. We want sex more than we can afford. I call this hypersexuality. If this were not so, then we would be either asexuals or impotent. That is, our body does not understand that it does not stretch the stress of sexual arousal, and this is the main reason for POIS.
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slon_ik, thank you for posting!
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Shep, thank you for connecting us!
[sent by email]
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Hi slon_ik,
You may summarize your suggestions regarding what parameter to test for and how to time it in here:
https://poiscenter.com/forums/index.php?topic=3207.0
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Я считаю, что основная причина POIS это сбой в регуляции стресса полового возбуждения в ЦНС. Это может быть генетический сбой в гипоталамусе или миндалине. Или могут быть аутоиммунные проблемы на медиаторы полового возбуждения и оргазма. Один из вариантов описан выше, это проблемы с серотонином и тучными клетками.
Я уверен, что POIS не связан с аутоиммунным на сперму, так как тогда бы у нас от спермы были красные пятна коже, а их нет ))
Так же я уверен, что проблема именно в голове. Мы хотим секса больше, чем можем себе позволить. Я это называю гиперсексуальностью. Если бы это было не так, то мы были бы или асексуалами, или импотентами. То есть наш организм не понимает, что не вытягивает стресс полового возбуждения, и это есть основная причина POIS.
I believe that the main reason for POIS is a failure in the regulation of stress of sexual arousal in the central nervous system. This may be a genetic malfunction in the hypothalamus or tonsil. Or there may be autoimmune problems on mediators of sexual arousal and orgasm. One option described above is problems with serotonin and mast cells.
I am sure that POIS is not associated with autoimmune sperm, since then we would have red spots from the sperm of the skin, but they are not))
I'm also sure that the problem is in the head. We want sex more than we can afford. I call this hypersexuality. If this were not so, then we would be either asexuals or impotent. That is, our body does not understand that it does not stretch the stress of sexual arousal, and this is the main reason for POIS.
Slon the reason I like your theory is because I have pure OCD that started with POIS. I also have many serotonin related issues such as depression anxiety and PTSD.
Do you think we can test the SERT genes genetically to prove if there is a genetic failure?
Low serotonin can also explain the Premature Ejaculation issue many of us suffer from, since increasing serotonin also increases the duration of sex. But I also have POIS from smoking cigarettes, do you think that this can also be related to serotonin?
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Hi slon_ik,
You may summarize your suggestions regarding what parameter to test for and how to time it in here:
https://poiscenter.com/forums/index.php?topic=3207.0
Проблема в том, что померить серотонин невозможно. Можно сделать анализ серотонина в крови, но этот анализ ничего не показывает, так как весь серотонин разлагается от одного прохода крови через печень или легкие. Надо смотреть серотонин в моменте в гипоталамусе, то есть делать биопсию гипоталамуса в момент стресса. Это в реальной жизни сделать невозможно ))
Поэтому просто делать анализы на серотонин нет смысла. Тут нужны серьезные исследования!
The problem is, you can't measure serotonin. A blood serotonin test can be done, but this test does not show anything, since all serotonin is decomposed from one passage of blood through the liver or lungs. It is necessary to watch serotonin in the moment in the hypothalamus, that is, to do a biopsy of the hypothalamus at the moment of stress. It is impossible to do this in real life))
Therefore, it makes no sense to simply do tests for serotonin. Serious research is needed here!
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Slon the reason I like your theory is because I have pure OCD that started with POIS. I also have many serotonin related issues such as depression anxiety and PTSD.
Do you think we can test the SERT genes genetically to prove if there is a genetic failure?
Low serotonin can also explain the Premature Ejaculation issue many of us suffer from, since increasing serotonin also increases the duration of sex. But I also have POIS from smoking cigarettes, do you think that this can also be related to serotonin?
Да, проблемы от курения это косвенное подтверждение того, что у Вас есть проблемы с серотонином.
Но не факт, что именно низкий серотонин есть наши проблемы. Думаю, что вопрос не в количестве серотонина, а в невозможности гипоталамуса правильно реагировать на резкое изменение серотонина. Рассмотрим подробнее. В гипоталамусе сходятся множество путей из разных участков ЦНС, и там есть пути с нейромедиатором серотонином. Сумма серотонина от всех путей дает общий уровень серотонина, который включает реакции на стресс. Кроме того есть фоновый серотонин крови, он маленький. Но если тромбоциты разрушаются под действием воспалительных агентов, то серотонин может резко подняться в крови в области гипоталамуса, и тогда его уровень будет достаточно высоким, чтобы пройти ГЭБ и повлиять на гипоталамус. К тому же, в гипоталамусе есть участки без ГЭБ. И курение так же повышает уровень серотонина в крови.
Но если спустится на уровень SERT, то там все гораздо сложнее. Я не берусь тут рассказать про это )) И я точно не скажу какие нужны анализы и где их делать )) Тут должен работать специалист.
Yes, smoking problems is an indirect confirmation that you have problems with serotonin.
But it's not a fact that low serotonin is our problem. I think that the issue is not in the amount of serotonin, but in the inability of the hypothalamus to properly respond to a sharp change in serotonin. Let's take a closer look. Many pathways from different parts of the central nervous system converge in the hypothalamus, and there are pathways with the neurotransmitter serotonin. The sum of serotonin from all pathways gives the total serotonin level, which includes stress responses. In addition, there is a background blood serotonin, it is small. But if platelets are destroyed by inflammatory agents, then serotonin can rise sharply in the blood in the hypothalamus, and then its level will be high enough to pass the BBB and affect the hypothalamus. In addition, there are areas in the hypothalamus without the BBB. And smoking also increases blood serotonin levels.
But if you go down to the SERT level, then everything is much more complicated there. I'm not going to tell you about it here)) And I won't say exactly what tests are needed and where to do them)) A specialist should work here.
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I believe that the main reason for POIS is a failure in the regulation of stress of sexual arousal in the central nervous system. This may be a genetic malfunction in the hypothalamus or tonsil. Or there may be autoimmune problems on mediators of sexual arousal and orgasm. One option described above is problems with serotonin and mast cells.
I am sure that POIS is not associated with autoimmune sperm, since then we would have red spots from the sperm of the skin, but they are not))
I'm also sure that the problem is in the head. We want sex more than we can afford. I call this hypersexuality. If this were not so, then we would be either asexuals or impotent. That is, our body does not understand that it does not stretch the stress of sexual arousal, and this is the main reason for POIS.
Interesting comment from your part slon_ik, I could completely adhere to it. However, I would like to know if you could ellaborate more about this idea. In your opinion, a skin-prick test would show inflammation or not?
It's nice to see input from our Russian POIS brothers!
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It's nice to see input from our Russian POIS brothers!
(https://www.gbrianbenson.com/wp-content/uploads/2019/01/Yes-sign.jpg)
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Welcome all!
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Thanks, Limejuice!
Shep, slon_ik, anyone from Russian POISCenter: can you tell us anymore about:
Russia to have anti-COVID vaccine ready in 2 weeks (!)
and enough for mass vaccination in early 2021
I just now saw this on TV News plus Newsweek...
Demo
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Interesting comment from your part slon_ik, I could completely adhere to it. However, I would like to know if you could ellaborate more about this idea. In your opinion, a skin-prick test would show inflammation or not?
It's nice to see input from our Russian POIS brothers!
Я так понял, что Вы говорите про кожную пробу со спермой.
В сложных ситуациях я всегда пытаюсь найти простые вопросы, которые все проясняют ))
В данной ситуации вопрос такой. Насколько сильной должна быть кожная реакция на сперму, чтобы вызвать туман в голове на неделю? Извините за подробности, но это возможно только в том случае, если член от спермы распухнет до размеров груши )) Но мы то знаем, что это не так ))
Сперма тут ни при чем. Если тут есть аутоиммунное воспаление, то оно будет именно в голове, потому что там наш туман на неделю!
I understand that you are talking about a skin test with semen.
In difficult situations, I always try to find simple questions that clarify everything))
In this situation, the question is. How severe does a skin reaction to semen have to be to cause head fog for a week? Sorry for the details, but this is possible only if the penis swells from sperm to the size of a pear)) But we know that this is not so))
Sperm has nothing to do with it. If there is autoimmune inflammation, then it will be in the head, because there is our fog for a week!
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Thanks, Limejuice!
Shep, slon_ik, anyone from Russian POISCenter: can you tell us anymore about:
Russia to have anti-COVID vaccine ready in 2 weeks (!)
and enough for mass vaccination in early 2021
I just now saw this on TV News plus Newsweek...
Demo
Извините, но я не знаю подробностей ))
Sorry, but I don't know the details))
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I would say that poiscenter.net is harmful to say the least and it need to be shut down or at least to be completely reorganized.
I wasted 5 years because of this site. I was trying to google something like ~orgasms are giving depression~ 5 years ago and as a Russian speaker i first stumbled across it.
And what you actually see when you first looking at this site?
First you see, on the front page!!!, you see that the whole brunch is dedicated to Вегетососудистая дистония/Dysautonomia. It is not an illness! It is a sham! The title is only recognized in post soviet union countries as legit and basically means general fatigue god knows of what source. Basically the doctors in russia are giving this diagnosis left and right, to all people who are feeling general tiredness, and they giving vitamins or placebo like drugs, only recognized in russia.
You see what impression it gives to a person with a pois who only started suspecting that something is not right with him, and the pois stuff is not the norm? And when they see that it is compared to this sham title on a front page with a whole separated dedicated brunch? It has undermined any words of them for me of pois not being a norm, and put it as their imaginary disease.
The second impression was that the group is actually just a bunch of losers, who were moralizing about how wrong the masturbation is, that feeling bad after orgasm is a norm, a lot of smell of religion, mountains of stupid stuff, I truly felt that stumble across a forum with ~losers in 95% concentration~. Nothing scientific, nothing close to actual pois, very repulsive, silly and not as something taking seriously.
Nail in the coffin was that the forum was looking dead the same way it is looking dead right now.
And i was like, hm, the main forum is all about some smelly people, and i was like, may be it is not actually something wrong with me, may be it is all normal, and i am just on some extreme of a gaussian distribution, and all people more or less are going through the same kind of ~pois loop~. You know how it is hard to recognize pois, when you not saw the actual words, describing it as an actual disease, how it is masterfully disguised as some mental health problem. The biggest mistake for me was the thought that it was all mental related. The most harmful thought.
And i never could speak with my relatives about it, they are very religious, they induced some mental trauma/abuse exactly in this area when i was a kid so conversation with them was not the option. If the only source of what could shed the light for me was so bad, 5 years ago, my logic just decided to put it in the box and forget about it. I was bad in English, where should i took the information then?
In late May this year, god knows why, i decided to google ~orgasms are giving depression~ again. I again stumbled across poiscenter.net and it again almost catched me.
This was truly a miracle for me, i am far better in english now, and from start of the year i read a lot of papers about covid in english. And i was very lucky to stumble across the paper about HCG curing pois. And because i read a lot of papers about covid, actual scientific paper didn't scared me enough (with scare that i would not understand anything), and it started spinning the wheel in me, and i started to understanding pois, i started to search and here i am.
I am wishing all the bad things to people who decided to put that site as they put it. For my 5 completely wasted years. **** you all.
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You probably realize this is coming but I’ll state the obvious - your blaming others for decisions that you made (nobody else but you) and you continued to make bad decisions for 5 years. Instead of pointing the finger at someone else perhaps you should point the finger at yourself.
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Yes, please tell me what should I feel about myself, I am all ears.
For ~special~ people I can repeat.
The main source of information about POIS in Russian is giving false information, it diminishes the problem by comparing it with fake diseases, full of loons, who are talking about cosmic energy, carma, and other stuff from the same opera.
The only feeling that the site evokes is neglect and unseriousness.
And it's dead! It can't be right that the main forum on some hypothetical problem is THIS dead, and the problem itself was actually real.
All of this will frame the same picture in any mind.
Buddy, my 5 years are gone and no one can change it.
The whole post was meant to be about poor souls, who will do the same type of conclusions when they will encounter ~the face of Russian POIS~.
Especially people who can't speak English and this way are limited with resources of information.
And they will do the same kind of conclusion because they are the most logical from all possible.
By incompetence, they are wasting people lives. As they did wasted mine. But I am here only as an example, which unfortunately will definitely be repeated.
Cheers.
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Translated with Google Translate from Maxwell of Russian POISCenter (http://www.poiscenter.net/viewtopic.php?f=19&p=17877&sid=da782426fd7894ea6d8ee10bfdc76149#p17877)
If you read my conclusion after the MRI of the "lumbosacral spine", you can find words like "the anterior and posterior longitudinal ligaments are compacted", which means the so-called "Ossification" written here http://avestasakh.com/ossifikatsiya-zadney-prodolnoy -svyazki-grudnogo-otdela-pozvonochnika and here http://24radiology.ru/kostno-myshechnaya-sistema/ossifikatsiya-zadnej-prodolnoj-svyazki/
... squeezes the spinal vertebral nerve ...
Ossification of the posterior longitudinal ligament of the thoracic spine is a permanent neurological disorder in which the nerves of the spinal canal are compressed as a result of hardening of the posterior longitudinal ligament, the purpose of which is to preserve the structure of the vertebrae in the spine, maintaining its balance and mobility. Including South Korea, in China, Japan and other Asian countries, this disease more often occurs in men over 40 years of age, which must be treated at an early stage due to the impossibility of restoring the functions of the damaged nerve if it is compressed for a long period.
Myelopathy is a dysfunction of the spinal cord associated with abnormal pressure on the spinal cord. Unlike conditions that put pressure on individual nerve roots, this type of damage can lead to loss of nerve function anywhere in the spinal cord below the damaged area.
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Translated with Google Translate from Maxwell of Russian POISCenter (http://www.poiscenter.net/viewtopic.php?f=19&p=17877&sid=da782426fd7894ea6d8ee10bfdc76149#p17877)
This graphic goes with the Maxwell post above.
(http://24radiology.ru/wp-content/uploads/2018/06/00-4.jpg)
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Translated with Google Translate from Maxwell of Russian POISCenter (http://www.poiscenter.net/viewtopic.php?f=19&p=17877&sid=da782426fd7894ea6d8ee10bfdc76149#p17877)
The Immunological Contribution to Heterotopic Ossification Disorders (https://sci-hub.se/10.1007/s11914-015-0258-z)
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How would this link to https://www.pnas.org/content/115/7/E1550 ?
I'm not a biologist, see the Fig. 6 in the study.
Maybe the orgasm indirectly releases serotonine which then somehow makes the ICs "break" and re-release the pathogens (because they're not bound with the antigen anymore) (?).
Apparently they can be measured:
Circulating Immune complexes (CIC) (https://www.imd-berlin.de/leistungsverzeichnis/parameter.html?tx_ajdiagnostics_analyse%5Banalyse%5D=150958&tx_ajdiagnostics_analyse%5Btitle%5D=Zirkulierende%20Immunkomplexe&tx_ajdiagnostics_analyse%5Bsynonym%5D=Autoimmun%20Basis-Rheuma%20Rheumatoide%20Arthritis%20Kollagenosen%20C1q-ZIK%20C3d-ZIK%20Autoimmun%20Rheuma%20Vaskulitis%20%20C1q-ZIK%20C3d-ZIK&tx_ajdiagnostics_analyse%5Baction%5D=showmod&tx_ajdiagnostics_analyse%5Bcontroller%5D=Analyse&cHash=662053d9d65a37f815c87387ede75c43) (Ref (https://poiscenter.com/forums/index.php?topic=2684.msg31172#msg31172)) (Type III hypersensitivity)
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Translated with Google Translate from Maxwell of Russian POISCenter (http://www.poiscenter.net/viewtopic.php?f=19&p=17877&sid=da782426fd7894ea6d8ee10bfdc76149#p17877)
The Immunological Contribution to Heterotopic Ossification Disorders (https://sci-hub.se/10.1007/s11914-015-0258-z)
"We supposed that patients suffering from POIS may have a disorder of the endogenous mu-opioid receptor system". Jiang et al. (https://sci-hub.se/10.1111/jsm.12813)
Opioid signaling in mast cells regulates injury responses associated with heterotopic ossification (https://sci-hub.se/10.1007/s00011-013-0690-4)
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So, if I understand correctly this paper, overexpression of mu-opioid receptor and stimulated opioid signaling cause mast cells activation (and then inflammation, etc.).
If POIS symptoms are caused by mast cells activation, then tramadol, codeine, etc. should aggravate POIS, am I right ? And typical Poisers should experience symptoms of opioid "overdose" rather than "opioid withdrawal", as in Jiang & alii's hypothesis.
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If POIS symptoms are caused by mast cells activation, then tramadol, codeine, etc. should aggravate POIS, am I right ?
Yes I would think so.
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...typical Poisers should experience symptoms of opioid "overdose" rather than "opioid withdrawal"...
Interesting.
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Well, I doubt it is really interesting as I guess that an "overproduction" of endorphins is unlikely in most Poisers, and it's probably a hasty remark (an increase in endogen endorphin production doesn't have the same side effects as an "opioid overdose", right ?). My point was simply that the article wouldn't confirm Jiang's hypothesis if mast cells are involved.
Or could there be an "opioid withdrawal" effect after a stronger-than-usual increase of endorphins following arousal/orgasm ? It really seems unlikely to me - at least in my own case.
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I didn't see anything particularly actionable in that paper, but I just skimmed it.
For me, orgasm seems to give me an endorphin rush - which then leads to POIS. Anything physically stimulating or mentally stimulating does the same - endorphin rush which leads to 'POIS' type episode, although a lesser one. Some of the POIS and CFS/ME symptoms seem to overlap, and I wouldn't be surprised if they were related disorders at the least.
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Translated with Google Translate from Maxwell of Russian POISCenter (http://www.poiscenter.net/viewtopic.php?f=19&p=17877&sid=da782426fd7894ea6d8ee10bfdc76149#p17877)
This graphic goes with the Maxwell post above.
(http://24radiology.ru/wp-content/uploads/2018/06/00-4.jpg)
What type of symptoms did he have that led them doing these type of scans. Does Maxwell have symptoms at the areas of ossification?
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Is there any news from the Russian Poiscenter? Updates?