POISCENTER
POIS Cause/Treatment Discussions => General Alternative Causes and Treatments of POIS => Topic started by: emirnazim on May 11, 2018, 03:26:14 PM
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I want to share some important thing that happened to me after taking mestinon . my text is too long .sorry I cant help . but I shoud say that as time goes by , I can not be sure that what is my problem . because I saw near 6000 disease or syndrome had written and listed in Wikipedia website . most of them had symptoms like fatigue , insomnia ,headache , irritability , flue like symptoms , fever , muscle weakness or so on . they are very similar .(I didn?t read all of 6000 but took a look near 20 syndrome )
2 days ago I went a neurologist to ask him if I have MG OR CMS OR OTHER Disease and after only just tapping my knee nerve (patella tendon reaction ) , without doing any EMG (muscle and nerve test) test or requesting for ACHR antibody test , he told me you seem ok and you have not GM or CMS .he was not familiar with pois . but said may be you have Hypochondria (disease that patient think he or she has a special disease but there is nothing wrong ) .
Actually when I hear some words like that(you have not any health problem or its only your conception and feeling ) I feel myself very baadd. But despite his woeds I bought and took one mestinon 60 mg (pyridostigmin) .
Befor going on I should list the medications that I have used and took but they were not so effective :
Flouxsetine , propranolol , citalopram, clonozepam(revotril) , olanzapine , Narcofenil(provigil)
Dolouxetine ( had the best effect between those)
Also I should mention that this text is not suggesting any new idea for treatement or I don?t encourage and suggest any one using or testing mentioned medication . because each body has very special features and disorders and allergies .so we should take only healthcare profession words .we know that if we take 2 or 3 different medication together maybe those have interaction and makes us endanger .so please don?t take my words as suggestion
The new medication(mestinon) results were very noticeable and different from the past as below : (NO medication have affected me like this befor)
1- One of very important symptom is sleeping for near half of the day (even after that many hours I felt NOT FRESH).so the first important change that this medication made me happen was SHORTENING the need for sleeping (7 hour sleep a day and feel very fresh and no need to the word ?? MUST TO SLEEP?? . I mean I can stay awake without no effort . I have not experienced it before even by taking NARCOLEPCY DRUG called ??NARCOFENIL?? ).even after O there is no need for more sleep . this effect of mestinon in not written in any source . but may be there is relation between sleep mechanism and cholin .
2- SLEEP ; WAKING UP; AND DEPTH OF SLEEP:
When I wake up , I used to feel confuse near two hour in bed without doing or standing up .(near zero motivation) but after taking this medication , duration(THE TIME ) between waking up and standing on feet lasts up to 5 minutes . when I wake up , I have zero need to continue the rest of sleep .also sleep depth and quality has grown very well that Narcolepsy drug(modafinil ) had not affected like this .
3- One of my very important symptom of my pois is ??Being SLOW?? in every thing. Slow walking ,slow reacting ,eating , even slow car driving (( you know in driving car we don?t need to muscular force and energy because engine does it to us . but I could not drive my car in the speeds above 80 km per hour .I think its related to low speed of processing data in my brain .may be my brain cannot afford the processing information in high speed so it was tolerating to high speed actions ). But after taking this medication , all of a sudden that vanished and I can drive and tend to like driving in fast speeds .my family are saying to me ?? what happen to you . you drive very slow and carefully . but now you are completely opposite . ?? my task doing speed has very improved too . chewing ,eating speed has improved very well .
4- IRRITABILITY and changing in mood after O :
Decreased the duration and intensity of irritability near 40 percent .
5- HEART AND VASCULAR EFFECT : Another very HUGE important effect of this single medication that I would never expect from a (non ? heart and vascular medication) happened to me . I use to or used to get high heart rate even with doing middle heavy tasks and very soon became tired and get asthma like situation . for example walking up the stairs (3 floor for example) make me completely unable to continue the forth and become asthma like . I have done so many heart related medical tests before but results came back nothing(normal) .
But after taking this miracle drug I can do 3 time more than before at least , and without getting tired or asthma . and now I can understand other normal people .(because I was asking myself how they can do this without getting tired).
6- ASTHMA , shortness of breathing , muscular power and duration:
I reached noticeable results . after taking this medication , I can do muscular tasks without getting muscle tire . for example in bathroom when I wash my head , after a short time I used to get tired and my heart used to not allow me do more and had to stop .but now I can rise my hands and do wash my hairs for very longer than before I used to . I also used to have not enough oxygen (or air) during taking bath but now I can . I used to take propranolol (beta blocker for heart ) . but it doesn?t has such a greatest and miracle result as mestinon has .
Another example , when I wash my car (myself ) I used to get tired between the process and used to stop and rest for moments .but now without stopping and breaks I can do it the whole !
7- Motivation , Brain fog and cognitive effect and motivation :
In this term , I can say that my motivation and energy for doing new thins has improved noticeably . especially motivation
Improvement in abovementioned groups by only a single medication that I have never experienced such a vivid and noticeable positive effects , lead me to the idea that may be I have a BIG issue with DEAR CHOLIN . but sure 7 day of experience is not enough to say anything .but what I am sure is that this is not placebo effect .because I took many many medication with hopfully senses to cure but the placebo has not lasted for more than one day till now to me . but its 7th day of taking mestinon . I don?t know if I have cholin deficiency or if I have enough cholin but cannot absorb choline ? if I have genetic mutation in some genes related to CHOLIN .
But now I do have an important clue that many of my symptoms can affected by only and lonely CHOLIN .
I have been reading posts of POISCENTER forum every day. And want to thank all of members and ongoing discussion and specially ?? THIS TYPE ?? he considered me to read about MG AND CMS syndromes . the idea of taking mestinon also came from there to my mind .
Then I also found that mestinon is acting the same way like MYTELAS (both are cholinerase inhibator).mytelas is not available in my country and I don?t know which one can be most effective for me .(if you have idea pls share about the differences). So this type of pois treatment was also mentioned in quantum s CHART OF POIS TYPES
In http://poiscenter.com/forums/index.php?topic=2338.0 as number 4 .
I benefited very very positively from this forum .and I have been reading all the discussion (but my poor English doesn?t let me be fast in reading ). I want to ask all you members specially cholinergic members that what do you suggest for me with abovementioned situation . I ordered one supplement of 1200mg soy lecithin . I am taking 20mg vit B6 .1000 MG omega 3 (fish oil). Sometimes B12 tablet . one garlic a day .one boiled egg a day (near two week). also want to know which other supplement can be beneficial to cholin members . would you suggest B9 ? B2? (if so , please mention the generic and business name of it ). To be honest I have not a good experience and relation with my country doctors . because they don?t know enough or don?t need to know more (because money is coming any way ). for examples non of them suspected me about cholin or other possible related issues . non of their medication has worked . until I discovered and tried it from web(THANK TO THE POISCENTER) . briefly, taking doctors notes and cautions is very important but if they are real DOCTORS !!!!.i am sure that US and European citizens have very standard rules in health systems and my be you citizens have a more educated more standard healthcare system an doctors but me not . for example here in my country doctors do not connected through the computers to patient s whole documented details so that they have NOT a brief and total information of patient health and treatments history . each doctor has his her own office and you can have access to them by paying to them .they don?t need to know about your detailed past health documented history . there are GOVERNMENTAL hospitals .but they too have not connection for your past experiences too .i think this system exist in US OR EUROPEAN OR developed countries . so I have big problem to explain myself to them(SO CALLED DOCTORS ) .they only say there is nothing wrong with you . so I don?t know how to ask them give me the related blood tests or so on (they are denying every thing ) . the only way I found useful will be here I am sure. using other members experiences .so long story short , please give me your suggestions about what type of blood test or other test should I take ? ACHR ab ? genetic DNA mutation ? which codes of DNA is related would you think in terms of CHOLIN ? I also suspected myself having POTS syndrome (NOTE: POTS İS NOT POIS) .because when I read POTS syndrome symptoms ,
http://www.potsuk.org/symptoms
https://en.wikipedia.org/wiki/Postural_orthostatic_tachycardia_syndrome
Many of POTS suffers can treated by MESTINON or prydostigmin.
Not end . CFS SYNDROME
See other POIS member post :
http://poiscenter.com/forums/index.php?topic=2219.msg18216#msg18216
PoTS may be under diagnosed in those with chronic fatigue syndrome (CFS) and is estimated to affect around 25-50% of people with CFS. It has been suggested that these two conditions may be part of the same group of conditions with similar causes.
So in conclusion at least until now I have to distinguish the most real one symptom that I have . but it is possible only by doing genetic DNA tests that I have not had any one .
I should try to know more about POIS , CFS , POTS , MG OR CMS ., Mast cell activation syndrome because they are connected to each one I thinks ?. i will share my experiences as soon as i can find anymore .but do not forget , only a word of your view can help me to reach the fact in shorter time ,
At the end i want to mention that this is only 8 days of experiments . and may be they wear off after some days or special duration for whatever reason . i dont know completely who of members cured by cholin (FLOPPY BANANA AND THIS TYPE maybe) but i want you explain me the difference between mytelase or prydostigmin or huperzin or galantainin or so on ... i confused that wich one is base cure . the only reason why i selected mestinon was i only knew that name and not more types at that time .
i wonder your whole views ? im waiting your views :)
Thank you very much for reading till here the end line ;)
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Fantastic ,wonderful and brilliant job ! 8)
Choline/acetylcholin Pois type seems very clear.
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Hi emirnazim,
If you have a cholinergic type of POIS, lecithin should be beneficial for you, as it has proven to be for other POIS sufferers of the cholinergic type.
It would be interesting to have some details about the dosage you take ( how many mg?) and how you take it ( daily? before O? )
Please, make some follow ups in the coming months, to share if you still have the same level of effectiveness.
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Keep experimenting and keep us updated Emir.
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I wanted to add an update about taking cholinesterase ,mestinon. I take 60 mg mestinon each day .its a tablet . You can not break it to smal sizes . I can say that it has had good results for me till now. Specially decrease the time for sleep . Power of muscles , being fast in doing task, lower brain fog , also should add that I think there is no difference between whether you take it after O or befor .even 6 hour later O too has the same effect I think . I only tried lecithin . But that acted for me something even worsen .but I didn't take it itself only . Took both mestinon and lecithin .regarding to the posts about cholin type. There is many drugs like huperzine A ,alpha gpc , sAME ,mytelase,that I should test .i also should say that I had strangely 3 time of O during 12 hours and that was no pois symptoms unless a little need to rest . I have come the fact that taking fish oil with mestinon help me so much to get ready the next O and high energy.any view?
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Hi, I tried Pyridostigmine after reading your post, because I'm after the idea that ACh or AChE are somehow involved in POIS, went to the drug store and bought some, took 1 tablet (60mg) waited 45 minutes (time of absortion) and then I fapped. I felt ZERO cognitive affectation after it, I was feeling like a normal person should feel after an orgasm, I don't remember the last time I felt this way before, then I went to sleep.
Next day in the morning, I woke up WITHOUT any physical or cognitive symptom. I couldn't explain how or why this worked, since I'm not a medical or chemical sciences professional, maybe we can't recapture acetylcholine after ejaculation due to AChE, dunno but many of the low ACh symptoms match exactly with POIS symptoms.
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Hi, I tried Pyridostigmine after reading your post, because I'm after the idea that ACh or AChE are somehow involved in POIS, went to the drug store and bought some, took 1 tablet (60mg) waited 45 minutes (time of absortion) and then I fapped. I felt ZERO cognitive affectation after it, I was feeling like a normal person should feel after an orgasm, I don't remember the last time I felt this way before, then I went to sleep.
Next day in the morning, I woke up WITHOUT any physical or cognitive symptom. I couldn't explain how or why this worked, since I'm not a medical or chemical sciences professional, maybe we can't recapture acetylcholine after ejaculation due to AChE, dunno but many of the low ACh symptoms match exactly with POIS symptoms.
Wow this is the most straight forward positive result I've ever seen on this forum.
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Happy to read such a good post !
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Well, this is wery good news.
I remeber one man talk about this in thenakecientists, i will found and post.
This could be that some of as hawe myastenia gravis or similar ilnes.
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Hi Emir,
Just sharing an idea. There are also some indications that there is something wrong with vascular sheer stress/NO responses to acetylcholine (injections) or local heating in POTS patients. The results show a vascular endothelial dysfunction in these patients. Just look up papers with keywords: Endothelial dysfunction, POTS, acetylcholine, NO.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511496/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511487/
''Prolongation of ACh‐induced vasodilatation is suggestive of a disturbance to cholinergic pathways'':
https://onlinelibrary.wiley.com/doi/full/10.1046/j.1475-097X.2003.00511.x
https://www.jstage.jst.go.jp/article/avd/7/2/7_ra.14-00048/_article/-char/ja/
http://hyper.ahajournals.org/content/46/5/1103
https://mybiohack.com/blog/postural-orthostatic-tachycardia-syndrome-pots-intolerance
I have also read somewhere on the internet that IL-8 released by endothelial cells could make neutrophils and/or lymphocytes migrate through some layers and alter barrier functions, but can't find that specific paper.
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I hawe POTS, Muon, you are myabe on something.
What is intresting podible couses mosly womens, and they say it is conected to menstrual cicles, and posible couses-Symptoms often begin after major surgery, trauma, or a viral illness.
https://www.medicinenet.com/pot_syndrome/article.htm#what_causes_pot_syndrome
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Hi Emirnazim!
Can you give us an update?
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In this case could be worth to try HIPERZIN A, naturall "withouth side effects".
Enebody hawe ability to and test?
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Hi Emir,
Just sharing an idea. There are also some indications that there is something wrong with vascular sheer stress/NO responses to acetylcholine (injections) or local heating in POTS patients. The results show a vascular endothelial dysfunction in these patients. Just look up papers with keywords: Endothelial dysfunction, POTS, acetylcholine, NO.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511496/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511487/
''Prolongation of ACh‐induced vasodilatation is suggestive of a disturbance to cholinergic pathways'':
https://onlinelibrary.wiley.com/doi/full/10.1046/j.1475-097X.2003.00511.x
https://www.jstage.jst.go.jp/article/avd/7/2/7_ra.14-00048/_article/-char/ja/
http://hyper.ahajournals.org/content/46/5/1103
https://mybiohack.com/blog/postural-orthostatic-tachycardia-syndrome-pots-intolerance
I have also read somewhere on the internet that IL-8 released by endothelial cells could make neutrophils and/or lymphocytes migrate through some layers and alter barrier functions, but can't find that specific paper.
Hi Muon,
Do you think that endothelial cells in the BBB and the testicles-brain-barrier are dysfunctional and thus causing components in the semen to pass through and cause an immunological response ?
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I believe in this line of research related to endothelial dysfunction.
I have circulation problems, have had varicose veins surgery and have low blood pressure.
As I mentioned, one of the physical characteristics that I observed in the members of the facebook group is the small amount of connective tissue which is apparent in the style of the face with prominent cheeks. Low muscle mass also affects the way connective tissue is organized in our body. I believe several physical and metabolic dysfunctions are leading to an autonomic dysfunction and thus altering the relationship between the sympathetic and parasympathetic systems.
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Hello Nas,
Yes that's something that is on my mind, a generalized endothelial dysfunction. However involvement of mast cell activation is on top of my list though. Mast cells can regulate BBB permeability (just look up some papers). They also play a role in late phase allergic/hypersensitivity reactions and can modulate T-cell responses.
Hi Fernando,
You also see patients having connective tissue disorders in conjuction with mast cell activation and autonomic problems. The interaction of connective tissue and mast cells is also a line of research. Perhaps connective tissue mast cells are releasing mediators which weakens this tissue and lead to bad posture.
Mast Cells are found close to small blood vessels in loose connective tissue. They contain large secretory granules of heparin proteoglycan - a weak anticoagulant. They also contain histamine, which promotes an inflammatory reaction when secreted. Release of histamine causes endothelial cells lining venules to contract, weakening the junctions between these cells, and allowing proteins and cells from the plasma to leak through into the connective tissue.
https://histology.leeds.ac.uk/tissue_types/connective/connective_phagocytes.php
A New Disease Cluster: Mast Cell Activation Syndrome, Postural Orthostatic Tachycardia Syndrome, and Ehlers-Danlos Syndrome
https://www.jacionline.org/article/S0091-6749(14)02927-3/abstract
https://www.karger.com/Article/Pdf/233760
I personally have problems with my tendons during POIS episodes including the heel and groin area for example. Perhaps mast cells are being activated and interact with connective tissue. But I wonder if an endothelial dysfunction can weaken the junction between these endothelial cells without the need of histamine/mediator release.
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I personally have problems with my tendons during POIS episodes including the heel and groin area for example. Perhaps mast cells are being activated and interact with connective tissue. But I wonder if an endothelial dysfunction can weaken the junction between these endothelial cells without the need of histamine/mediator release.
That's what's on my mind right now Muon;
Perhaps we have a general endothelial dysfunction caused by lack of Choline/Acetylcholine nutrients. I have yet to try a successful Choline type treatment, I do remember Sam-e being beneficial, but that could explain the success others have with this type of treatment.
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Hi everyone,
So I just tried Orgasm on 60mg Mestenon; I took 60 mg at ~5pm then I took another another tablet at 7:30pm just in case, because Mestenon has a 3 hours range of effectiveness. I also want to add that I already took Mestenon 60mg yesterday and the day before.
Anyways at Orgasm I didn't feel much symptoms but at about 30 minutes symptoms started to pile and become very severe. At the start I didn't think I had symptoms but they slowly piled up to be heavy nausea, brainfog, disconnection and speech problems. On the speech problems at like 10 minutes I barely felt a problem saying anything but as time passed and I kept talking I started noticing a growing difficulty.
Overall though, orgasm usually cripples me into a zombie like state where I can barely say anything or think of anything. This time however, while still symptoms crept slowly afterwards, I feel like I'm not completely crippled. It was kinda similiar in a way to my Sam-e experience but this time I guess it was a much more noticeable of a difference.
I'll update you on my state tomorrow and see how my situation goes.
I am hoping that the effectiveness grows with the contiuous use of Mestenon. Overall the symptoms are decreased about 30 % which is unfortunately not as successful as emornazim's and scrub's.
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I am hoping that the effectiveness grows with the contiuous use of Mestenon. Overall the symptoms are decreased about 30 %.
I am glad to hear this, Nas. You often shared that you have found absolutely nothing so far to relieve your POIS, but not true anymore. You seem to respond to cholinergic support. It may be now a question of refining your method ( dosage, timing of dose, cholinergic add on like lecithin, etc....)
Good luck in refining your method. 30% is already much better than nothing, though.
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Hi everyone,
So I just tried Orgasm on 60mg Mestenon; I took 60 mg at ~5pm then I took another another tablet at 7:30pm just in case, because Mestenon has a 3 hours range of effectiveness. I also want to add that I already took Mestenon 60mg yesterday and the day before.
Anyways at Orgasm I didn't feel much symptoms but at about 30 minutes symptoms started to pile and become very severe. At the start I didn't think I had symptoms but they slowly piled up to be heavy nausea, brainfog, disconnection and speech problems. On the speech problems at like 10 minutes I barely felt a problem saying anything but as time passed and I kept talking I started noticing a growing difficulty.
Overall though, orgasm usually cripples me into a zombie like state where I can barely say anything or think of anything. This time however, while still symptoms crept slowly afterwards, I feel like I'm not completely crippled. It was kinda similiar in a way to my Sam-e experience but this time I guess it was a much more noticeable of a difference.
I'll update you on my state tomorrow and see how my situation goes.
I am hoping that the effectiveness grows with the contiuous use of Mestenon. Overall the symptoms are decreased about 30 % which is unfortunately not as successful as emornazim's and scrub's.
Have you tried any other cholinesterase inhibitors? I had success with Pyridostigmine, but i'm very curious about taking Donepezil or Galantamine, especially Donepezil because it's half life is very long.
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I am hoping that the effectiveness grows with the contiuous use of Mestenon. Overall the symptoms are decreased about 30 %.
Good luck in refining your method. 30% is already much better than nothing, though.
Thank you Quantum and yes Mestenon is definitely the way forward but I feel like it's not enough. I feel like I need more medications to treat different things like inflammation or better way to keep the dosage high enough.
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No scrub, I haven't but I'll probably try donepezil and see how effective it is.
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Hello everyone
I saw all your replyes. Some of you had asked me some questions . Excuse me for my being late . I only want to make an update of my last situation .and will reply on every message ASAP.
Its 45 day lasts from the time i have took mestioNon. After that day i wrote each days details in order to make sure if what is the main cause . I tried so many experiments . The first sign may be is my 45 day invisible state on this pois forum . But dont know whether is it good nor not . During these 45 day . I took so many dietry supplemenet as below . I took mestinon then to make sure if was it really beneficial for me , i stoped taking mestionon for near 15 days then started to take again . In this period i took also B6.- B12 -Fish oil -lecithin- C vit - egg daily one - garlic one glove per day - and cut out the whole cymbala or doluxetine .even i wrote the taking hour and details of these medication , i can not analyze the total information and come to result. But l will try to be more real and accur.
1- mestinon really is working to me ... I mean i can sense the effects of its existence in my body . Specially for cutting down the need for much sleep . Specially for being motivated automatically.specially for increasing the strangh of my muscles .and getting tired not as soon as past time . When i see that POTS syndrome sufferes can not stand in their feet more then one minute , because of their increasing heart rates, i can not say that i had pots syndrom .because when i stand up i dont get faint or much heart rates like 140 130 120 .but i do know that when i stand up my heart is suffering from falling into hard situation .by taking mestinon many signs of that situation weared off. I can now run or walk at fast rates and get not asthma like state as hard as before . One of the other i portant symptoms of pois is high irritability . I think mestinon couldnt help with this but B6 or B12 does . I mean i can feel that after taking b6 and b12 my irritability will wear off . Go off. I think taking one egg and garlic and fish oil have positive effects too . So 7 days ago i stoped mestioNon again and took lecithin two time .1200 mg per each time . I cAn say that taking two of lecithine made me feel good too .like mestinon ' lecithin can help me in the same way .i m of the opinion that i have cholin related problem . But i need taking it every time every day not only after orgasm or befor orgasm . I have not tested for anti ach receptor blood test . I had not droped eye like MG sufferes have .i think the test will come back negative .but dont know why mestinon can help me positively. I ordered hupersine A too .not take yet .but will report the results . I am not familiar with anticholinerase drugs . It will be good if someone helpme to find out the best chois
Very important note :my orgasm rate has increased very much related to the past . I have 3 to 4 time per week Orgasm in average and have no flu like symptom s. Irritability and change in sound or voice of me is the biggest ana noticable symptoms after O
For example we have ;
Mestinon -mytelase-huperzine a -cholin suppliment -lecithin-alpha gpc - ..alpha cbg or so on ...
But dont know which will be good for me .
I saw that someones have tried mestinon with good results .please keep us update of the effects of cholin related medications .
Thank you very much
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Irritability and change in sound or voice of me is the biggest ana noticable symptoms after O
When I tried to orgasm with Mestenon, these were my biggest symptoms and add to that growing difficulty in speaking.
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...mestinon really is working to me ...
Thank you for reporting, emirnazim!
Do you know if this is Rx only (prescription)...or over-the-counter?
Thanks!
Demo
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Hello demografx
What do you mean by over-the -counter
As you know , i m not native english speaker . But if you mean if this is a legal medication , i will say , yes in my country , every body can go to drug store and buy even one box of 150 of that without having a prescription from any doctor . But on the other hand doctors belive that we should take it with prescription . And i agree with that we should be aware of all effects and side effects of that in order to having a healthy treatment . I deeply do not suggest this medication for anyone here .but if anyone is worried about it , he can do it under the control of professional doctors . We should know about all the possible dangers from taking any medication . But i should say that im not a usa or european progressed citizen . I really do know that my country s doctors do not care about life and health .they are o the opinion like this : the more patient ...the more money .
For example one can have a not serious inflammation but doctors may request a ct scann test >:(. You will find that doctor and ct scanner center manager is good friends ;D. And they have a not appear relationship beside theire carrier . So in this situation , i suppose that getting the information through the internet may be is the healthiest way than taking tons of x-rays .but finally i believe that the nature the world the body is working only under the rules .we call it Facts . I think the truth is one.not more . Its possible from my point of view that one can be more near the truth than professionals .the nature do not know and care about the person who prescirebed this medication it is only care about what medication injected through the body . Sorry about long text .i only wanted carry my senses . Finally these are my believes .not suggestion or encouraging others to do some things. :)
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Thank you, emirnazim!
over-the-counter means that a doctor’s prescription is not necessary.
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Thank you for your reply Demografi
Would you please tell me if is it over-counter in your country too ??
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Irritability and change in sound or voice of me is the biggest ana noticable symptoms after O
When I tried to orgasm with Mestenon, these were my biggest symptoms and add to that growing difficulty in speaking.
Hello nas .i have too this problem . Difficulty in finding words
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Thank you for your reply Demografi
Would you please tell me if is it over-counter in your country too ??
Hi emirnazim,
Mestinon is a prescription only drug, here, in North America, and is usually given for myasthena gravis. It is a acetylcholinesterase inhibitor.
The most readily available and well-known natural product that is an acetylcholinesterase inhibitor is huperzine A.
Acetylcholinesterase inhibitors raise the level of acetylcholine by inhibiting the enzyme that is responsible for acetylcholine elimination ( this enzyme is named acetylcholinesterase). So,
acetylcholinesterase inhibitors bring cholinergic support, as more acetylcholine is available at active receptors sites.
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Irritability and change in sound or voice of me is the biggest ana noticable symptoms after O
When I tried to orgasm with Mestenon, these were my biggest symptoms and add to that growing difficulty in speaking.
Hello nas .i have too this problem . Difficulty in finding words
Hi emir
So how do you deal with these symptoms? Mestenon for me doesn't seem to alleviate these problem.
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Hello NAS
I can say that I don't know what the treatment for irritability and changING in voice is.but I suppose that , when I take B12 and B6 tablets , the day after , will have less irritability, and I should add that when I do two time of O (not once) , I will have less irritability .second O is very different thing for me .have much more pleasure (I worried if anyone have same sense about second O? The other thing , and question is , do MG (mynestia Gravis ) experience irritability after taking mestinon ??? Any view
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Hello NAS
I can say that I don't know what the treatment for irritability and changING in voice is.but I suppose that , when I take B12 and B6 tablets , the day after , will have less irritability, and I should add that when I do two time of O (not once) , I will have less irritability .second O is very different thing for me .have much more pleasure (I worried if anyone have same sense about second O? The other thing , and question is , do MG (mynestia Gravis ) experience irritability after taking mestinon ??? Any view
When it comes to the second orgasm part, I'm very much like you emir. The irritability with the first orgasm was so strong I felt I was going to pass out. But later when I did the second orgasm I felt much better ( and yes it is much more pleasurable than the first orgasm ).
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Hi, I tried Pyridostigmine after reading your post, because I'm after the idea that ACh or AChE are somehow involved in POIS, went to the drug store and bought some, took 1 tablet (60mg) waited 45 minutes (time of absortion) and then I fapped. I felt ZERO cognitive affectation after it, I was feeling like a normal person should feel after an orgasm, I don't remember the last time I felt this way before, then I went to sleep.
Next day in the morning, I woke up WITHOUT any physical or cognitive symptom. I couldn't explain how or why this worked, since I'm not a medical or chemical sciences professional, maybe we can't recapture acetylcholine after ejaculation due to AChE, dunno but many of the low ACh symptoms match exactly with POIS symptoms.
Hello scrub
Very very interesting , it was big and good news ... Please keep us uapdate of your views
Are you using now any medication yet.like mestinon or other related medication ?
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Hi Emir,
Just sharing an idea. There are also some indications that there is something wrong with vascular sheer stress/NO responses to acetylcholine (injections) or local heating in POTS patients. The results show a vascular endothelial dysfunction in these patients. Just look up papers with keywords: Endothelial dysfunction, POTS, acetylcholine, NO.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511496/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511487/
''Prolongation of ACh‐induced vasodilatation is suggestive of a disturbance to cholinergic pathways'':
https://onlinelibrary.wiley.com/doi/full/10.1046/j.1475-097X.2003.00511.x
https://www.jstage.jst.go.jp/article/avd/7/2/7_ra.14-00048/_article/-char/ja/
http://hyper.ahajournals.org/content/46/5/1103
https://mybiohack.com/blog/postural-orthostatic-tachycardia-syndrome-pots-intolerance
I have also read somewhere on the internet that IL-8 released by endothelial cells could make neutrophils and/or lymphocytes migrate through some layers and alter barrier functions, but can't find that specific paper.
Hello moun
Thank you very much for your very important information
This is a new topic for me .i ll search and read your papers.
Tank you again for giving the clues . :)
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I want to add some
I forgot to say that one of noticable and measurable effects of mestinon or lecithine taking is , before taking mestinon and lecithin, i used to could swin the one thirds or half of swim pool length . Because my heart dident let me try more , breath were not enough . But now with taking mestinon , i can swim the whole lenght of same pool without stopping .muscular power has increased to. I can get to rest in less time than before . After running ,my heart can get recover or rest mood in less time ,
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Hi emirnazim,
It has been 6 months since you shared about your success with Mestinon. Any update ? Did it stop to work?