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Lifestyle Diary and POIS Summaries / Re: Berlin1984's thread
« Last post by demografx on Today at 08:31:57 PM »
I second Limejuiceā€™s affirmation.
Will head for the doctors office tomorrow and do some more blood tests, does anyone have suggestions of what to test?
Second day of POIS (NE) here now and the oxymeter shows 98% on right finger and 99% on left.

What are your POIS symptoms?

I've only used the reader through one POIS episode so far and the symptoms were very mild but even then my blood oxygen sat at around 95%. Doing deep breathing exercises would quickly bring it up to 98-99%. Now that I'm out of POIS it gives a consistent 98-99%. I'll have to use it again when I'm having worse symptoms, especially shortness of breath.
Lifestyle Diary and POIS Summaries / Re: Berlin1984's thread
« Last post by berlin1984 on Today at 12:33:41 PM »
haha, thank you.
I've been battling this for years and maybe it on and off went better or worse. Let's hope my luck is persistent with getting things in order, right now I'm very confident.
POIS Research / Re: Testosterone-PPARs-PGC1a-Irisin axis
« Last post by Progecitor on Today at 11:56:21 AM »
I tested negatiwe for MG but i hawe all symptomes.
I found out that there is a nonserologic MG..

Hi Hopeoneday!

So I don't have either diabetes or MG, but I was wondering if the common link to POIS could be a kind of irisin resistance which had been already mentioned in the first post. The source of the metabolic stress could be different, however some of the symptoms and inflammatory pathway would still overlap. In my case PPARA agonists so far have been proven to be useful, although I couldn't test some important ones like fenofibrate or palmitoylethanolamide (PEA). I am also unsure if increasing irisin would be beneficial in such a case. Some supplements specifically indicated to raise irisin are saffron, DHM and garlic oil. Saffron has proven beneficial, but it has too many health effects to conclude anything. I have already ordered some Dihydromyricetin (DHM) [marketed for the management of hangover and considered a potent exercise mimetic] to see if it is any good. Sirt1 downregulation may be an effect of irisin resistance as seen in MG. Boosting Sirt1 also works for me. MACA and resveratrol can increase Sirt1 just to mention a few beneficial ones.
By the way I would be interested to know if you have ever tried resveratrol with any success.

Excerpt of the irisin resistance theory:
We hypothesize that the increased irisin levels in T2DM with hypertriglyceridemia in our study might have represented irisin resistance, reflecting a compensatory result to counterbalance the increasing needs for irisin (similar to the increased insulin levels in insulin resistance) and to improve metabolic features.
Importantly, we report for the first time here that fenofibrate treatment administered to T2DM patients with hypertriglyceridemia for 8 weeks resulted in a significant decrease in serum irisin levels, although fenofibrate was reported to increase irisin gene expression in diet-induced male obese mice. We hypothesize that the PPARA agonist fenofibrate could induce the increase of UCP1 and browning of WAT by activating PPARA and that the increased UCP1 levels and browning programme might compensatively inhibit the FNDC5 expression and then reduce the irisin levels.
Second day of POIS (NE) here now and the oxymeter shows 98% on right finger and 99% on left.
I don't believe there's a one size fits all cure for POIS, and won't be for some time. If all the supplements, vitamins, and drugs in the world aren't helping your POIS symptoms and it's preventing you from having meaningful relationships platonically and sexually, I would argue that learning how to enjoy sex without conventional orgasm is well worth it.
Auto-Immune Causes and Treatments / Re: The One: My Story To Finding The Cure
« Last post by Journey on December 01, 2021, 08:59:21 PM »
Try beta-blockers, you likely have high glutamate/adrenaline

A doctor could investigate if beta-blockers might be appropriate, maybe you have high glutama/adrenaline
(moderator edited ^)
General POIS Discussions / Re: Hormone Imbalance
« Last post by Journey on December 01, 2021, 08:54:47 PM »
Journey, I've digged into Ray Peat recently (came through it via the croissant diet / Anti-PUFA stuff) and have to say it's very interesting.
I think I feel better by drinking more orange juice and (goat) milk. Even tried it as a post-pack :-)
For some reason, I can handle more lactose again and I also don't get skin issues from goat milk (but do get it from cow products).

Journey, what are your takeaways fromit?

Boosting metabolism and avoiding stress hormones really seem good for POIS.
It has helped me
We do not need to take control, we need to CURE POIS!
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