Recent Posts

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POIS Research / Re: 2025 POIS SCIENTIFIC RESEARCH STUDY
« Last post by demografx on May 13, 2025, 09:29:22 AM »

We now - - finally - - have the green light for the 2025 POIS Scientific Study to begin piloting!
https://tinyurl.com/5pjvsubj
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General POIS Discussions / Re: My take on POIS | Sudden recovery
« Last post by Mac_Diamond on May 12, 2025, 03:39:26 PM »
Hi astar, what anti-inflammation medicines did you take? Anti-inflammatory medicines seem to help some individuals, particularly NSAID's, so it would be a helpful detail/data point.
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So, you're still pois free? You must be in month 4 without POIS now?
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General Alternative Causes and Treatments of POIS / Re: Bipolar Type II
« Last post by Aladin on May 12, 2025, 12:34:15 PM »
I got the diagnosis bipolar 2 twenty years ago, when i went with my symptoms to a psychiatrist; he prescribed me lamoctrigine which made POIS bearable for me during 15 years.  I was never symptom free but i was able to function in society, keep a job, buy an appartment.  A succesful relationship wasn't meant to be, but otherwise, i'm glad i found this.

Recently though, i got ahendonia: loss of all plesasure from orgasm. I don't know wether its linked to the lamoctrigine: the psychiatrist says that it's not a known side effect.
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General Alternative Causes and Treatments of POIS / Re: Bipolar Type II
« Last post by hosamitaha on May 12, 2025, 12:27:41 PM »
hahahahahevery, can you give us an update if this is still working for you?

After about two years of antidepressant treatment, my POIs
 symptoms continued for two days. I changed to a psychiatrist, and she said that based on her experience, my inability to completely cure back and forth was a misdiagnosis. She diagnosed me with bipolar disorder. I recalled my past experiences, during middle and high school, when I suddenly felt good about myself, looked down on others, and was isolated by everyone. I have been in a depressed state from my freshman to sophomore year, but by my junior year, I was full of energy and posted ten posts a day on social media commenting on various things. This is indeed a symptom of bipolar disorder, but I was not aware of it before. At first, the doctor asked me to take sodium valproate, 750mg per day. After taking it for two weeks, the effect was not good, and the POIs symptoms continued for four days. Two weeks ago, I switched to lithium carbonate, which reduced my symptoms by 80%, and I'm sure it's not a placebo because I've already ejaculated twice. I will continue to observe.
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Started replacing my breakfast with 3 carrots and orange juice...fingers crossed this does something.
Atleast i found domething that fills my stomach in the morning without any preparation since i do try to avoid carbs for breakfast.
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POIS Research / Re: Great News - POIS Lab is Almost Ready for the Study !
« Last post by demografx on May 10, 2025, 06:39:22 PM »

I suggest that an eeg be conducted and recorded during the sexual act, the orgasm, and an repeatedly during pois days and then eegs should be compared between controls and poisers


The POIS Science team is actually getting almost every single thing you listed (not over multiple days).
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Custom herbal tincture log

First tincture:
- Tolerated very well. Felt good.
- Was taking intuitive dose amounts, not really accurately measuring anything. Would have been around 7.5mL or so.

Second tincture:
- Moderate side effects from 7.5mL inc. mild headache, increased anxiety/on edge feeling
- Reduced dose to 5mL & seem to be tolerating much better
- Todd recommends low and slow.
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Nicotinamide Experiment
* First dose of Nicotinamide 500mg around 5:30
* Second dose of Nicotinamide 500mg around 6:45
* Began drinking Matcha at 7:30
* Released at 7:50 (medium arousal intensity) and 8:20 (medium to high arousal intensity)

Results:

* Seems to help a bit but definitely not 100%
* Doubtful the matcha tea does anything, given I’ve tested it & lthenaine before. I think we’re getting at least 30% medicinal effect from nicotinamide. Like does seem to be improving something.
* Still needed to take my original stack to feel a lot better, so it would 100% be complimentary

Tbh not really justified in hindsight. I find the nature of pre-packs less than ideal as well.
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Increasing acidity (betaine HCL, vinegar, lemon, etc) appear to be effective for clearing some POIS clusters. Something I will look into. My dr actually suggested Betaine HCL.
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