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Igy78: Where exactly was the endoscopy done, in the large intestine only? I also made an endoscopy there, but they said it look just fine. I think my problems are in the small intestine (SIBO), but they never look there.

Endoscopy of the stomach, i also did 1 year before that endoscopy of intestines, everything was ok in colon, but in stomach was/is world war 3.
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I just met a guy on a fair last week who showed me before-and-after photograps on the large intestine after some months drinking something called "structured water" made by a machine from Japan. The results were amazing. The intestinal pockets that were showing on the before pictures were gone after some months on the water and the intestine looked like getting in to a young state again.
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I had a diverticulitis attack that nearly killed me (inflammation of the intestines).
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Igy78: Where exactly was the endoscopy done, in the large intestine only? I also made an endoscopy there, but they said it look just fine. I think my problems are in the small intestine (SIBO), but they never look there.
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Did not give feedback for a long time, was in hospital in march for 4 days due to eating to much paprika in powder/spice, and i inflamed my pancreas, stomach and liver again. I did an endoscopy and long story short they found chronic erosive gastritis with micro bleedings, doctors also found acute inflamed pancreatitis and fatty liver,  was healing from march with gastritis diet and i feel better, here and there orgasms with improvement, but still had spikes of anxiety and depression, but only if i eat carbs.

Well recently i cut out all of the carbs and i feel amazing, but, i also eliminated carbs 2-3 years a go for test and i did not feel better, because it takes time for pancreas and liver to heal. Only when i'm really really hungry i eat bread but after 4-6 hours symptoms slowly coming back,  so carbs are obviously depleting some B vitamins, or pancreas has problems with amylase or liver can not replenish needed vitamins, or stomach is to sensitive for acidic foods, i am on ppi and i sense , if my stomach is better i have more energy.

Here and there i fuck up with nutella and kinder bueno, one or two days feeling like shit but symptoms goes away. Anyway it will be long journey to heal all that without carbs. 6 months to a year with strong diet with bland low acidic food. Doctor said that any sugar/alcohol/vinegar i take i will set my progress back. Anyway i'm really glad that i am on right track and i do not waste energy on searching what is wrong with me and spending a lot of money for supplements that did not work. Well, all that searching has led me to my diagnose, so it was not in vain.  So if you did not visited a gastroenterologist or had an endoscopy my advice is to do all that.

I am recently on Reddit r/Gastritis, and i found that many people there has the same Pois symptoms, too bad i did not suspect for gastritis 2-3 years a go when i started to had Pois symptoms.
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Did not give feedback for a long time, was in hospital in march for 4 days due to eating to much paprika in powder/spice, and i inflamed my pancreas, stomach and liver again. I was on endoscopy and long story short they found chronic erosive gastritis, acute pancreatitis and fatty liver,  was healing from march with gastritis diet and i feel better, here and there orgasms with improvement, but still had spikes of anxiety and depression, but only if i eat carbs. Well recently i cut out all of the carbs and i feel amazing, only when i'm really really hungry i eat bread but after 4-6 hours symptoms slowly coming back,  so carbs are obviously depleting some B vitamins, or pancreas has problems with amylase or liver can not replenish needed vitamins, or stomach is to sensitive for acidic foods, i am on ppi and i sense it , if my stomach is better i have more energy, here and there i fuck up with nutella and kinder bueno, one or two days feeling like shit but it passes. Anyway it will be long journey to heal all that without carbs. But i'm really glad that i am on right track and i do not wasting energy on searhing what is wrong with me and spending a lot of moeny for suplements that did not work. So if you did not visited a gastroenterologist or had an endoscopy my advice is to do all that.
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This is the most important cue so far regarding POIS, it links together with other issues we experience like slower beard growth, muscle gain (less androgen output due to high Estrogen decreasing androgen output and too much T being converted into it and weaker 5 alpha-reductase and weaker DHT possibly from liver overload (good liver function ensures good Thyroid, 5 alpha-reductase, DHT output)
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General POIS Discussions / Re: always nocturnal emission after gluten diet
« Last post by VSmasher on September 27, 2021, 08:55:14 PM »
My Nocs usually come after I eat a lot of protien or zinc...
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General POIS Discussions / Re: Nausea and slow gastric emptying for the past 3 weeks
« Last post by Quantum on September 27, 2021, 08:30:12 PM »
Have you ever tried liver detox ?    Bill Ballantine tried it and got good results  ;) 
For nausea, there is also ginger

Thanks Quantum - I believe this is an old recipe from Professeur Clairembart to help l'Ombre Jaune with his liver issue ;-)   RIP Henri Vernes!
(Note: above is just an inside joke attempt for older French speaking people - nothing serious)

Nausea and ginger - I think I have overused large quantity of raw organic ginger and actually irritated my sensitive digestive track, I have overused supplements in general too including herbals. So for now I am stopping all supplements and simply eating good organic food and chewing well to let my oesophagus and stomach rest. A long needed reset for me. I may add some liver herbs later like you suggest - milk thistle, artichoke or black radish (it's the season for it) or dandelion root tea.

I noticed recently at the drugstore that Gaviscon also makes a powdered ginger only capsule for nausea. I think this is rather new.

I have a question for you: if one has a sluggish liver would it show in a blood test? I just had a routine one and my results for liver health are good:
ALT (U/L) 16
AST (U/L) 15
GGT (U/L) 14
Albumin (g/dL) 4.4

Thanks for your generous posts and comments. Very appreciated.

Well, that makes sense, maybe L'Ombre Jaune ( The Yellow Shadow) got his nickname because of liver issues, giving him a yellowish complexion ;)


The blood tests you gave results for are testing the general liver health.  When hepatic enzymes like AST and ALT are elevated, it is a sign that the liver is in a form of distress.  So, the doctors will look for hepatitis, bile ducts problems, diabetes, or one of the many other possible causes of elevated enzymes.  However, it is usually not a way to screen for a sluggish liver.

A sluggish liver is more associated with one or more defective enzymatic detox pathways. The liver has a very important detoxification role and is equipped with many enzymes for this detox.  The P450 "multi-enzymatic" complex takes care of phase I, and phase II detox is composed of about 6 different pathways ( methylation, acetylation, sulfonation, and so on).  If you have a less-than-optimal performance somewhere in phase I ( for example, in CYP2A6)
or phase II ( for example, in acetylation), you will sometimes have symptoms of a "sluggish liver".  But, "sluggish liver" is a general term, not specific of what detox function, in particular, is partly defective. The best way to have more information about which pathways are below average in terms of performance is to have your genome sequenced.

I, for one, had confirmation through my genome sequencing that I am a slow acetylator, among other things.  This means that my phase II acetylation pathway is not very efficient.  So, I am intolerant to substances that are metabolized by acetylation, like caffeine ( me taking half a cup of coffee may be like someone else taking several cups of coffee, because my liver has a hard time breaking it down and eliminating it).

When you have your genome data, you can go to a website like  https://geneticgenie.org/ , upload your data, and get a report on your detox functions, among other things.  You can see such reports from members here, in this thread:  https://poiscenter.com/forums/index.php?topic=3694.msg42193#msg42193 , including my own methylation and detox reports, at https://poiscenter.com/forums/index.php?topic=3694.msg42202#msg42202.  In my detox report, you will see two red results at the bottom for the NAT2 gene, which are genetic proofs of my slow acetylator status.

For someone who does not have his genomic data, careful observations about what you have an intolerance to or a hard time to digest may help you identify what hepatic detox pathways have limited efficiency in your own case.  For example, intolerance to alcohol may point to reduced activity of the ALDH2 liver enzyme.  It's a kind of detective work ;)    Obviously, genome mapping puts an end to the guesswork.

And, thanks for your good words about my posts and comments  :)
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When you say you have Gilbert's syndrome, how do you know it? Did you make a genetic test? Is it only because of the high bilirubin in the blood tests? Were you sick with jaundice or some related issue?

I have possibly Gilbert's too. High total bilirubin, conjugated bilirubin is half of the free bilirubin, the doctor said it's Gilbert, I don't have the genetic data to confirm. Never had any problem due to this, *as far as I know*.

Many people have high bilirubin on this forum. A few months ago I spoke elsewhere to someone who claimed to have seen quite many POIS linked to Gilbert's and had a theory about it. In short, problems to break down hormones, notably 3adiol, which then inhibits 5a-reductase and causes low allopregnanolone, GABA-A receptors downregulation, AMPA receptors upregulation and many other consequent problems. I have no idea whether this can be true. As for me, I don't seem to have inhibited 5a-reductase, as I have normal DHT.

Recently I have also read that Naltrexone, an opioid antagonist, could cause high bilirubin as a side effect, so I have wondered if bilirubin problems with Poisers could not be linked to the opioid issues hypothesized by the Chinese doctors in their 2015 POIS paper (see Jiang & alii, Postorgasmic illness syndrome in a Chinese man: no proof for IgE-mediated allergy to semen), and by other people. It may be equally dumb, I don't know.
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