Author Topic: This may seem like a familiar place.  (Read 394551 times)

Daveman

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This may seem like a familiar place.
« on: June 22, 2012, 01:57:28 PM »
Hi all,

This may seem like a familiar place, created to cater to the free flow of thought that many are used to.

And what the hay, if anything really good springs forth we can branch it off and create a special thread to deal with that.

BTW everybody, if you use this link ( http://poiscenter.com/forums/?action=.xml;type=atom ) and paste it into your regular EMail client "Outlook or whatever", you will automatically be sent all the latest posts, so it is easy to stay on top of new information. It is called an RSS feed.




« Last Edit: August 03, 2012, 09:24:46 PM by demografx »
WITHOUT RESEARCH THERE WILL BE NO CURE!
Sessions 5 to 9 days, mostly Flu-like, joints, digestion problems, light cognitive.
Niacin has changed my lif though, now 1 day MAX.
Somewhere in this interaction with Niacin is the answer!

Daveman

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Re: This may seem like a familiar place.
« Reply #1 on: June 22, 2012, 02:39:15 PM »
The link to the latest in this thread is:

http://poiscenter.com/forums/index.php?topic=426.0.new
« Last Edit: August 04, 2012, 02:43:31 PM by demografx »
WITHOUT RESEARCH THERE WILL BE NO CURE!
Sessions 5 to 9 days, mostly Flu-like, joints, digestion problems, light cognitive.
Niacin has changed my lif though, now 1 day MAX.
Somewhere in this interaction with Niacin is the answer!

Stef

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Re: This may seem like a familar place.
« Reply #2 on: June 22, 2012, 10:08:00 PM »
This is wonderful, Daveman!!!!!

You are a miracle-worker.  :-)

Stef

 

demografx

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Re: This may seem like a familar place.
« Reply #3 on: June 22, 2012, 11:25:36 PM »
Ditto, Stef!!

T H A N K   Y O U   D A V E M A N !!!
« Last Edit: June 23, 2012, 12:02:23 AM by demografx »
Usually have major POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks associated with it.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business.

demografx

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Re: This may seem like a familar place.
« Reply #4 on: June 22, 2012, 11:33:38 PM »
This place looks and feels so familiar, I want to post...


« Last Edit: June 23, 2012, 12:01:12 AM by demografx »
Usually have major POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks associated with it.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business.

demografx

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Re: This may seem like a familar place.
« Reply #5 on: June 23, 2012, 12:28:03 AM »

I increase my initial pledge from 100 to 400 $, so that I would have given 500 $ totally :) It is the money I will get with my internship. Instead of putting it in a stupid video game and so on, the best investment for the future is to give to NORD !


THANK YOU, HABIBOU!
« Last Edit: June 23, 2012, 12:31:46 AM by demografx »
Usually have major POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks associated with it.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business.

demografx

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Re: This may seem like a familar place.
« Reply #6 on: June 23, 2012, 12:30:26 AM »

I converted another $500 of my pledge to the donated column.


Thank you, B_Daniel for doing that amidst all that medical frustration!

Best,
Demo
« Last Edit: June 23, 2012, 12:42:56 AM by demografx »
Usually have major POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks associated with it.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business.

demografx

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« Last Edit: June 24, 2012, 03:40:48 AM by demografx »
Usually have major POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks associated with it.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business.

demografx

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« Last Edit: June 24, 2012, 03:39:24 AM by demografx »
Usually have major POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks associated with it.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business.

demografx

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Re: This may seem like a familar place.
« Reply #9 on: June 23, 2012, 12:46:17 AM »

I just gave $100.00 for the POIS fund and I will still be donating this amount for each of the next 12 months. I expect that I could give more in the next months, but this amount I guarantee.

I´m giving for POIS because this disease screw up my life and I know that, even that we have chance to descover a cure for our own, our chances will be a lot more with especialist researchs and methods.

I know that a lot of people here don´t have a lot of money but the situation isn't easy for no one. For me, in particular, is more expensive because brasilian coin has a half the value of dolar. Let´s go people, let´s donate.






THANK YOU, FIDALGO!!
Usually have major POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks associated with it.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business.

Daveman

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Re: This may seem like a familar place.
« Reply #10 on: June 23, 2012, 08:11:29 AM »
This is wonderful, Daveman!!!!!

You are a miracle-worker.  :-)

Stef

 

Thanks but as you can see Demo is and always has been the chief miracle worker!!
WITHOUT RESEARCH THERE WILL BE NO CURE!
Sessions 5 to 9 days, mostly Flu-like, joints, digestion problems, light cognitive.
Niacin has changed my lif though, now 1 day MAX.
Somewhere in this interaction with Niacin is the answer!

demografx

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Re: This may seem like a familar place.
« Reply #11 on: June 23, 2012, 12:55:29 PM »
Awww!!! ;D
Usually have major POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks associated with it.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business.

demografx

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« Last Edit: June 24, 2012, 02:16:24 AM by demografx »
Usually have major POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks associated with it.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business.

demografx

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Re: This may seem like a familar place.
« Reply #13 on: June 23, 2012, 08:08:32 PM »
Hi everybody,

Don't let the advertising dissuade you from posting your free-flowing thoughts.

The discussions on this thread can go anywhere and everywhere.

As *you* wish.

Best,
Demo
« Last Edit: June 24, 2012, 03:51:54 AM by demografx »
Usually have major POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks associated with it.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business.

kurtosis

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Re: This may seem like a familar place.
« Reply #14 on: June 25, 2012, 12:28:51 PM »
Just reposting this here as it seems we've moved to a new home :)
Quote
Quote from: daveman on 21/06/2012 19:55:04
The following post
http://poiscenter.com/forums/index.php?topic=423.msg4803#msg4803
is about something I?ve noticed before, that a full and complete ?O? seems to produce less symptoms than a partial or restricted one. In part it could be to do with retro-ejaculation (during a bad ?O?), which for me causes much worse POIS, or it could be to do with the PGD2 and PGE2 cycles. Not being to up on the biology, could somebody check out the referenced post and comment.

It seems that niacin for instance feeds the creation cycle of these prostaglandins, and if we orgasm too early the bad PGs are bolstered, whereas if we wait, the good ones are bolstered. Do I have this right?
In the post above,  the dreamy state he mentions is associated with what I have felt when I ?O? early with too much niacin. However the benefit of the niacin is not as strong when that happens.

However like him, if my ?O?s? are complete (in a  non-niacin scenario) the dreamy state is more prevalent yet my symptoms are less.

Can anyone decipher this?

Good versus bad seems to a complicated determination to make in relation to prostaglandins. I found an interesting article at http://www.pensgard.com/nutrition/4_Prostaglandins.htm
I don't have access to the original article but I did find some references on pubmed to support their description.

We know niacin releases pgd2 into the skin to produce flushing. http://www.ncbi.nlm.nih.gov/pubmed/1373750
Some of our symptoms like gastrointestinal issues could be explained by an overproduction of PGE1. However cognitive impairments from a prostaglandin imbalance may  come from a deficiency of PGE1 (perhaps causing schizophrenia) or an increase in TXA2 causing depression.

There have been a few articles published which hypothesise that schizophrenia could be related to prostaglandin synthesis. Some of which hypothesise that some "successful" anti-schizophrenic drugs work by increasing prolactin levels and encouraging prostaglandin synthesis. However, medical science knows more about the different flavours of prostaglandin now so it's not merely a case of raising levels of all prostaglandins.

The schizophrenia and prostaglandin connection doesn't seem to have gone away. Here are some articles from pubmed.
http://www.ncbi.nlm.nih.gov/pubmed/67391
http://www.ncbi.nlm.nih.gov/pubmed/3520252
http://www.ncbi.nlm.nih.gov/pubmed/20446881
http://www.ncbi.nlm.nih.gov/pubmed/21334179

Mice too http://www.ncbi.nlm.nih.gov/pubmed/19416671
The article about PGE2 receptors in mice is very interesting as it appears medical researchers are figuring out that low levels of PGE2 may be implicated in diseases like ALS and alzheimers.

Niacin stimulates the synthesis of... You guessed it.. PGE2.
http://www.ncbi.nlm.nih.gov/pubmed/22442634

So why would this be related to POIS? Simply because during an O we produce prolactin. Too much or too little would be a problem and would likely indicate a problem with balancing PGE2 levels.
 
A diet with too much trans fatty acids will inhibit prostaglandin production while a diet with enough b vitamins, protein, zinc, vitamin E and essential fatty acids (from fish oil for most people) could regulate production. What the right amount is and whether some unknown disease could affect the levels of synthesis is a mystery to me. It seems that any b vitamin deficiency, nutrient absorption problem or b vitamin deficiency could produce symptoms of cognitive impairment. 

Another problem may be a mutant delta-6-desaturase gene as hypothesised in http://www.ncbi.nlm.nih.gov/pubmed/3520252 or
some variant of a d-6-d malfunction.
(I have no idea whether any conclusive research has been done on the mutant d6d hypothesis but I do know that some research exists showing that arachidonic acid given to early stage alzheimer patients can lead to some improvement on cognitive tests).

If this was the case then there wouldn't be enough omega 6 fatty acids in the diet for prostaglandin synthesis. This seems unlikely given our diets are generally omega-6 rich but I've read some anecdotal reports of people who believe they're suffering from pyroluria (not getting into a discussion about whether this exists) that claim substantial improvements in concentration, anxiety levels and sleeping patterns when they supplement with zinc, b6 and arachidonic acid.

There could be an insufficient amount of ALA in the diet to produce Arachidonic acid or an inability to synthesise AA from ALA. http://en.wikipedia.org/wiki/Linoleic_acid

It's worth noting (after reading http://poiscenter.com/forums/index.php?topic=423.msg4803#msg4803) that liver was used to treat pernicious anaemia in the days before b12 injections and is also high in arachidonic acid.